Mental Rotation and Motor Imagery Training in Multiple Sclerosis
5. august 2026 opdateret af: Ramazan KURUL, Abant Izzet Baysal University
Mental Rotation and Motor Imagery Training for Upper-Extremity Function in Relapsing-Remitting Multiple Sclerosis: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of sequential laterality, motor imagery, and mental rotation training in individuals with relapsing-remitting multiple sclerosis.
Both groups received conventional physiotherapy, while the intervention group received structured cognitive-motor training and the control group received active visual-attention training.
Studieoversigt
Status
Afsluttet
Betingelser
Detaljeret beskrivelse
Fifty-four participants were randomly assigned to the intervention or control group.
Both groups received 45-minute sessions three times per week for six weeks.
Mental rotation ability was the primary outcome, while upper-extremity function, manual ability, motor imagery, grip strength, dexterity, and information-processing speed were assessed as secondary outcomes.
Assessments were performed before and after the intervention by a researcher blinded to group allocation.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
54
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Bolu, Tyrkiet (Türkiye), 14100
- Abant Izzet Baysal University Faculty of Health Science
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Ingen
Beskrivelse
Inclusion Criteria:
- Diagnosed with definite relapsing-remitting multiple sclerosis by a neurologist according to the revised McDonald criteria
- Not experiencing an acute MS relapse
- Mini Mental State Examination score ≥24
- No clinical MS relapse within the previous 3 months
- No corticosteroid treatment for an MS relapse within the previous 3 months
- Expanded Disability Status Scale score between 1.5 and 6.0
- Modified Ashworth Scale score ≤2
- Sufficient communication ability to understand visual and verbal instructions and follow the training protocol
- Able to attend at least 80% of the planned sessions
- Able to complete the Movement Imagery Questionnaire-3
Exclusion Criteria:
- Any medication change within the previous 3 months
- Uncorrected severe visual or hearing impairment
- A communication disorder preventing the perception of or response to the visual and verbal stimuli used in the study
- Participation in another structured upper-extremity rehabilitation program or interventional study during the study period
- Presence of an additional neurological disorder
- Advanced sensory loss or proprioceptive impairment that could affect participation in the intervention
- Botulinum toxin injection within the previous 3 months
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Dobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: Multicomponent rotation training
Participants received 30 minutes of conventional physiotherapy and 15 minutes of sequential laterality, motor imagery, and mental rotation training, three times per week for six weeks.
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Participants received 30 minutes of conventional physiotherapy followed by 15 minutes of structured training, three times per week for six weeks.
The training progressed sequentially through laterality recognition, motor imagery, and mental rotation.
Laterality training involved identifying right- and left-hand images.
Motor imagery training involved imagining the hand positions and movements shown in the images without performing an observable movement.
Mental rotation training involved mentally rotating figures and selecting the correct response.
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Sham-komparator: Sham training
Participants received 30 minutes of conventional physiotherapy and 15 minutes of active visual-attention training using neutral objects, colors, shapes, and symbols, three times per week for six weeks.
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Participants received 30 minutes of conventional physiotherapy followed by 15 minutes of active visual-attention control training, three times per week for six weeks.
The training included images of neutral objects, colors, geometric shapes, and symbols that did not depict body parts.
Participants classified the images according to color, shape, size, position, or similarity and difference.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
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The Purdue Spatial Visualization Test
Tidsramme: Baseline and immediately after the 6-week intervention.
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The Purdue Spatial Visualization Test a widely used mental rotation tests, consists of 30 three-dimensional spatial perception questions.
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Baseline and immediately after the 6-week intervention.
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
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The Symbol Digit Modalities Test
Tidsramme: Baseline and immediately after the 6-week intervention.
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The Symbol Digit Modalities Test is a widely used assessment tool for measuring information-processing speed in patients with MS.
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Baseline and immediately after the 6-week intervention.
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Nine-Hole Peg Test
Tidsramme: Baseline and immediately after the 6-week intervention.
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In the Nine-Hole Peg Test, nine wooden pegs were placed into a wooden board containing nine holes using one hand.
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Baseline and immediately after the 6-week intervention.
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Kinesthetic and Visual Imagery Questionnaire
Tidsramme: Baseline and immediately after the 6-week intervention.
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Motor imagery ability was evaluated and scored using 20 items examining movements of different body parts in a sitting position, with two subscales assessing kinesthetic and visual imagery abilities.
The total score ranges from 10 to 50, with each subscale ranging from 5 to 25.
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Baseline and immediately after the 6-week intervention.
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Grip Strength
Tidsramme: Baseline and immediately after the 6-week intervention
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Grip strength was assessed using a Jamar hand dynamometer.
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Baseline and immediately after the 6-week intervention
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Abilhand
Tidsramme: Baseline and immediately after the 6-week intervention.
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Abilhand is a patient-reported scale used to determine the perceived level of difficulty individuals experience when using their hands during activities of daily living.
The Abilhand total raw score ranges from 0 to 46, with higher scores indicating better self-perceived manual ability in performing daily bimanual activities.
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Baseline and immediately after the 6-week intervention.
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The Action Research Arm Test (ARAT)
Tidsramme: Baseline and immediately after the 6-week intervention.
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The Action Research Arm Test was used to evaluate upper extremity functional capacity and consists of four subdomains: grasp, grip, pinch, and gross movement.
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Baseline and immediately after the 6-week intervention.
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Enes Tayyip Benli, phd, Abant Izzet Baysal University
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
15. februar 2024
Primær færdiggørelse (Faktiske)
15. januar 2026
Studieafslutning (Faktiske)
15. februar 2026
Datoer for studieregistrering
Først indsendt
30. juli 2026
Først indsendt, der opfyldte QC-kriterier
5. august 2026
Først opslået (Faktiske)
6. august 2026
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
6. august 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
5. august 2026
Sidst verificeret
1. august 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- AIBU-FTR-BENLI-010
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