- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT00344656
Appetite-Related Brain Activity in Women With Anorexia Nervosa
The Study of Appetite-Related Brain Activity With Functional Magnetic Resonance Imaging in Women With Anorexia Nervosa
연구 개요
상세 설명
Anorexia nervosa (AN) is a serious eating disorder that is characterized by an extreme loss of appetite. People with AN view themselves as overweight and cannot bring themselves to eat, even though most are dangerously thin. Functional magnetic resonance imaging (fMRI) is a technique that can be used to determine which parts of the brain are activated by physical stimuli. When a certain stimulus is introduced, blood flow to the corresponding area of the brain increases. This increase in blood flow is depicted on the fMRI scan. A person with AN may have different responses to food when evaluated prior to treatment versus after treatment. This study will use fMRI to compare appetite-related brain activity in women with AN before and after receiving treatment for the disorder.
Participants in this study will undergo two fMRI scans. Participants with AN will have one scan before entering the "weight gain phase" of treatment for AN and another scan upon completion of treatment. Healthy volunteers will undergo scans during a similar time frame. Participants will not be allowed to eat from midnight on the night before the scan until after the fMRI procedure, but they may drink water. During the scan, participants will be shown various objects and real foods; they will also be asked to touch the objects and food with their eyes closed. Each visit will last approximately 45 minutes. Ear protectors will be provided to reduce scanner noise.
연구 유형
등록 (실제)
연락처 및 위치
연구 장소
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New York
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New York, New York, 미국, 10032
- New York State Psychiatric Institute
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
Inclusion Criteria:
For Participants with AN:
- DSM-IV diagnosis of AN (restricting or binge eating/purging subtype)
- Medically stable (not continuing to lose weight and vital signs stable)
For Healthy Participants:
- Currently weighs 80-120% of ideal weight
- no history of binge eating disorder or vomiting
- no current or past psychiatric illness
Exclusion Criteria:
For Participants with AN:
- Currently taking medication
- Current substance abuse or dependence disorder
- History of suicide attempt or other self-injurious behavior within 6 months prior to study entry
- Non-removable metal on or inside the body (e.g., metal pacemaker, surgical clips, metallic-ink tattoos)
For Healthy Participants:
- Current or past psychiatric illness
- History of binge eating or vomiting
- Any significant medical or neurologic illness
- Currently taking medication
- History of drug or alcohol abuse within 3 months prior to study entry
- Non-removable metal on or inside the body (e.g., metal pacemaker, surgical clips, metallic-ink tattoos)
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
코호트 및 개입
그룹/코호트 |
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Subjects and Controls
Patients with DSM-IV Anorexia Nervosa
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공동 작업자 및 조사자
수사관
- 수석 연구원: Laurel Mayer, MD, New York State Psychiatric Institute
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- #4850
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