- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT01799746
Mechanisms of Response to Diesel Exhaust in Subjects With Asthma
연구 개요
상태
정황
상세 설명
The investigators will also characterize selected polymorphisms in glutathione-S-transferase (GST) genes that have been implicated in susceptibility to air pollutants. Outcome measures will include lung function, bronchial responsiveness to bronchodilator, exhaled nitric oxide, induced sputum for inflammatory markers (IL6 and IL8), and exhaled breath condensate for nitrite, 8-isoprostane, 20-HETE (20-hydroxyeicosatetraenoic acid), nitrotyrosine and pH.
In this pilot project, parallel studies are being carried out in the human exposure chambers at two NIEHS centers, the EOHSI-CEED (Environmental and Occupational Health Sciences Institute- Center for Environmental Exposure and Disease) and the Penn-CEET (University of Pennsylvania-Center of Excellence in Environmental Toxicology). The joint project will enable each center to validate research results in a second population and include new biomarkers of pulmonary inflammation. Each center will recruit, consent, and collect data on its own subjects. Only de-identified data will be shared between the centers.
연구 유형
연락처 및 위치
연구 장소
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Pennsylvania
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Philadephia, Pennsylvania, 미국, 19104
- Airways Biology Initiative at Penn Presbyterian Medical Center
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
Inclusion Criteria:
- Subject is an adult male or female between 18 and 55 years of age inclusive.
- Subject must have a prior history of a physician's diagnosis of asthma with reversible airway obstruction (shown by a greater than 12% increase in FEV1 following bronchodilator; or a positive methacholine challenge done following the screening visit. If methacholine challenge is required for qualification, a physician will be on-site for the test. Subject's asthma has been stable for the past six months with no change in asthma therapy.
- The subject has been a non-smoker for the past year and should have less than a 10-pack year history.
- Subject must be free of other significant pulmonary diseases (i.e., cystic fibrosis, tuberculosis, interstitial lung disease and bronchopulmonary dysplasia.
- The subject must be capable of and willing to provide written informed consent.
- The subject is able to understand and comply with protocol requirements and timetables, instructions and protocol-stated restrictions.
The subject has no significant DE exposure that would include occupations such as truck driver, heavy equipment operator and railroad maintenance.
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Exclusion Criteria:
- As a result of the medical interview, physical examination or screening investigations, the physician responsible considers the volunteer unfit for the study.
- The subject has received an investigational drug or participated in any other research trial within 30 days or five half-lives or twice the duration of the biological effect of any drug (whichever is longer) prior to the current study.
- Oral steroids within the last 6 months.
- Less than 12% FEV1 response to bronchodilator or negative methacholine challenge.
- Hospital admission for asthma in past 6 months.
- The subject has a history of alcohol or drug abuse within the last 5 years.
- The subject has history of hepatitis B, hepatitis C or HIV virus.
- The subject has a history of cardiovascular disease including hypertension or says yes to one of the cardiovascular risk questions on the screening questionnaire.
- The subject has a history of diabetes.
- The subject is pregnant or lactating.
The subject has daily exposure to DE, i.e., trucking or heavy machine operators.
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공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
기간 |
---|---|
FEV1 response to bronchodilator, following DE compared with filtered air (primary outcome)
기간: Up to 3 weeks
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Up to 3 weeks
|
2차 결과 측정
결과 측정 |
기간 |
---|---|
Exhaled nitric oxide
기간: Up to 3 weeks
|
Up to 3 weeks
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8-isoprostane in exhaled breath condensate
기간: 1 year
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1 year
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Nitrite in exhaled breath condensate
기간: 1 year
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1 year
|
pH in exhaled breath condensate
기간: 1 year
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1 year
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20-HETE(20-hydroxyeicosatetraenoic acid)levels in exhaled breath condensate
기간: 1 year
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1 year
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Cell differential in induced sputum
기간: 1 year
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1 year
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Glutathione-S-transferase (GST)polymorphisms
기간: Visit 1
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Visit 1
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Peak Flow
기간: Up to 3 weeks
|
Up to 3 weeks
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Forced Vital Capacity (FVC)
기간: Up to 3 weeks
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Up to 3 weeks
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FEV1/FVC ratio
기간: Up to 3 weeks
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Up to 3 weeks
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공동 작업자 및 조사자
수사관
- 수석 연구원: Reynold A Panettieri, Jr., MD, University of Pennsylvania
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
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