Individual Response to Different Volumes of Resistance Training
Determinants of Intra-individual Variation in Adaptability to Resistance Training of Different Volumes
The literature is not clear as to which training volume to employ during initial phases of resistance training programs to ensure optimal muscular adaptations. The purpose of this study is therefore to compare effects of strength training with low versus moderate volume on muscular function and hypertrophy in previously untrained, healthy individuals. Furthermore, the investigators will relate individual variation in responses to proxy markers of individual training state, such as baseline muscular function and muscle fiber type.
The study will include 25 women and 25 men and will consist of a 12-week resistance training protocol. Each study participant will act as their own control, performing both the low- (1-set) and the moderate-volume (3-sets) protocol, allocated to either the dominant or non-dominant leg, in a stratified and randomized fashion.
Primary outcome measures are thigh muscle cross section area and unilateral knee extension strength. Additionally, muscle fiber type composition will be evaluated as well as additional parameters of muscular function.
The primary hypothesis is that low-volume protocols will be beneficial for individuals with glycolytic muscle phenotypes, whereas the opposite will be true for individuals with more aerobic phenotypes.
연구 개요
연구 유형
등록 (실제)
단계
- 해당 없음
연락처 및 위치
연구 장소
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Lillehammer, 노르웨이
- Lillehammer University College
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Healthy
- Non-smoking
- Able to tolerate resistance exercise training
Exclusion Criteria:
- Presence or history of cardiovascular, metabolic, endocrine or neuromuscular disease
- Diagnosed mental health disorder
- Intolerance to local anesthetic
- No experience with exercise training
- Performing regular resistance training (more than 1 session per week during last 12 months)
- Impaired strength/ neuromuscular function due to previous injury
- Recurrent pain in lower back, knee or shoulders
- Taking prescribed medication that may affect outcome of training intervention
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 해당 없음
- 중재 모델: 단일 그룹 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: Arm label 1-Set, 3-Set
12-week progressive strength training protocol of different volumes
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Every study participant will complete 12 weeks of progressive strength training with one leg performing 1-set per exercise per session and the contralateral leg performing 3-sets per exercise per session.
Allocation of dominant/non-dominant leg to either 1- or 3-set protocol will be done in a stratified, randomized fashion (stratified with regard to sex and baseline strength).
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Thigh muscle cross-sectional area
기간: Week 0 (baseline) and 12 (post training intervention)
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Changes in muscle cross sectional area of each thigh from baseline to post intervention, assessed by MRI.
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Week 0 (baseline) and 12 (post training intervention)
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Unilateral knee-extension isometric strength
기간: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in maximum knee extensor, isometric strength evaluated at 120° knee angle (180° fully extended).
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Muscle strength
기간: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in maximum isoinertial strength defined by one-repetition maximum in leg press, knee extension, knee flexion, and bench press.
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Knee extensors and flexors force-velocity relationship
기간: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in torque measured during maximal voluntary isokinetic contraction at 60°, 120° and 240° ∙ sec-1.
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Blood hormonal profiles
기간: Week 0 (baseline), 2 and 12 (post training intervention)
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Resting (week 0, 2 and 12) and acutely exercise-induced (week 2) hormonal profiles (testosterone, insulin-like growth factor 1, growth hormone and cortisol) determined in serum from venous blood samples.
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Week 0 (baseline), 2 and 12 (post training intervention)
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Muscle fiber cross-sectional area
기간: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in muscle fiber cross-sectional area assessed by immunohistochemistry from muscle biopsy.
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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Protein expression
기간: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in relative abundance of contractile protein isoforms (myosin heavy chain).
Modification of proteins related to muscle hypertrophy in relation to an acute exercise session (assessed during week 2 of the intervention).
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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Gene expression
기간: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in gene expression related to skeletal muscle hypertrophy and structural phenotype measured in steady state conditions (biopsy sampled in resting conditions, week 0, 2 and 12) and in relation to acute exercise (biopsy sampled 1-h after strength exercise, week 2).
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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기타 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Body composition changes
기간: Week 0 (baseline) and 12 (post training intervention)
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Changes in body compositions (lean mass and fat mass) from prior intervention to after intervention assessed by dual x-ray absorptiometry scan.
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Week 0 (baseline) and 12 (post training intervention)
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Habitual physical activity
기간: Week 0
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Self-reported prior habitual physical activity assessed by questionnaire and interview before training intervention
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Week 0
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Daily nutrient intake
기간: Week 6
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Daily nutrient intake assessed by a 4-day food intake registration.
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Week 6
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공동 작업자 및 조사자
수사관
- 수석 연구원: Stian Ellefsen, PhD, Inland Norway University of Applied Sciences
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
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추가 정보
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