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Individual Response to Different Volumes of Resistance Training

5. november 2015 oppdatert av: Inland Norway University of Applied Sciences

Determinants of Intra-individual Variation in Adaptability to Resistance Training of Different Volumes

The literature is not clear as to which training volume to employ during initial phases of resistance training programs to ensure optimal muscular adaptations. The purpose of this study is therefore to compare effects of strength training with low versus moderate volume on muscular function and hypertrophy in previously untrained, healthy individuals. Furthermore, the investigators will relate individual variation in responses to proxy markers of individual training state, such as baseline muscular function and muscle fiber type.

The study will include 25 women and 25 men and will consist of a 12-week resistance training protocol. Each study participant will act as their own control, performing both the low- (1-set) and the moderate-volume (3-sets) protocol, allocated to either the dominant or non-dominant leg, in a stratified and randomized fashion.

Primary outcome measures are thigh muscle cross section area and unilateral knee extension strength. Additionally, muscle fiber type composition will be evaluated as well as additional parameters of muscular function.

The primary hypothesis is that low-volume protocols will be beneficial for individuals with glycolytic muscle phenotypes, whereas the opposite will be true for individuals with more aerobic phenotypes.

Studieoversikt

Status

Fullført

Forhold

Intervensjon / Behandling

Studietype

Intervensjonell

Registrering (Faktiske)

42

Fase

  • Ikke aktuelt

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Norge
      • Lillehammer, Norge
        • Lillehammer University College

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 40 år (Voksen)

Tar imot friske frivillige

Ja

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion Criteria:

  • Healthy
  • Non-smoking
  • Able to tolerate resistance exercise training

Exclusion Criteria:

  • Presence or history of cardiovascular, metabolic, endocrine or neuromuscular disease
  • Diagnosed mental health disorder
  • Intolerance to local anesthetic
  • No experience with exercise training
  • Performing regular resistance training (more than 1 session per week during last 12 months)
  • Impaired strength/ neuromuscular function due to previous injury
  • Recurrent pain in lower back, knee or shoulders
  • Taking prescribed medication that may affect outcome of training intervention

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Grunnvitenskap
  • Tildeling: N/A
  • Intervensjonsmodell: Enkeltgruppeoppdrag
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Arm label 1-Set, 3-Set
12-week progressive strength training protocol of different volumes
Atferdsmessig: 12-week progressive strength training protocol
Every study participant will complete 12 weeks of progressive strength training with one leg performing 1-set per exercise per session and the contralateral leg performing 3-sets per exercise per session. Allocation of dominant/non-dominant leg to either 1- or 3-set protocol will be done in a stratified, randomized fashion (stratified with regard to sex and baseline strength).

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Thigh muscle cross-sectional area
Tidsramme: Week 0 (baseline) and 12 (post training intervention)
Changes in muscle cross sectional area of each thigh from baseline to post intervention, assessed by MRI.
Week 0 (baseline) and 12 (post training intervention)
Unilateral knee-extension isometric strength
Tidsramme: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
Time course changes in maximum knee extensor, isometric strength evaluated at 120° knee angle (180° fully extended).
Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Muscle strength
Tidsramme: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
Time course changes in maximum isoinertial strength defined by one-repetition maximum in leg press, knee extension, knee flexion, and bench press.
Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
Knee extensors and flexors force-velocity relationship
Tidsramme: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
Time course changes in torque measured during maximal voluntary isokinetic contraction at 60°, 120° and 240° ∙ sec-1.
Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
Blood hormonal profiles
Tidsramme: Week 0 (baseline), 2 and 12 (post training intervention)
Resting (week 0, 2 and 12) and acutely exercise-induced (week 2) hormonal profiles (testosterone, insulin-like growth factor 1, growth hormone and cortisol) determined in serum from venous blood samples.
Week 0 (baseline), 2 and 12 (post training intervention)
Muscle fiber cross-sectional area
Tidsramme: Week 0 (baseline), 2 and 12 (post training intervention)
Changes in muscle fiber cross-sectional area assessed by immunohistochemistry from muscle biopsy. Determined from muscle biopsy samples (Vastus lateralis).
Week 0 (baseline), 2 and 12 (post training intervention)
Protein expression
Tidsramme: Week 0 (baseline), 2 and 12 (post training intervention)
Changes in relative abundance of contractile protein isoforms (myosin heavy chain). Modification of proteins related to muscle hypertrophy in relation to an acute exercise session (assessed during week 2 of the intervention). Determined from muscle biopsy samples (Vastus lateralis).
Week 0 (baseline), 2 and 12 (post training intervention)
Gene expression
Tidsramme: Week 0 (baseline), 2 and 12 (post training intervention)
Changes in gene expression related to skeletal muscle hypertrophy and structural phenotype measured in steady state conditions (biopsy sampled in resting conditions, week 0, 2 and 12) and in relation to acute exercise (biopsy sampled 1-h after strength exercise, week 2). Determined from muscle biopsy samples (Vastus lateralis).
Week 0 (baseline), 2 and 12 (post training intervention)

Andre resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Body composition changes
Tidsramme: Week 0 (baseline) and 12 (post training intervention)
Changes in body compositions (lean mass and fat mass) from prior intervention to after intervention assessed by dual x-ray absorptiometry scan.
Week 0 (baseline) and 12 (post training intervention)
Habitual physical activity
Tidsramme: Week 0
Self-reported prior habitual physical activity assessed by questionnaire and interview before training intervention
Week 0
Daily nutrient intake
Tidsramme: Week 6
Daily nutrient intake assessed by a 4-day food intake registration.
Week 6

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Inland Norway University of Applied Sciences

Samarbeidspartnere

Sykehuset Innlandet HF
Revmatismesykehuset AS

Etterforskere

  • Hovedetterforsker: Stian Ellefsen, PhD, Inland Norway University of Applied Sciences

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart

1. august 2014

Primær fullføring (Faktiske)

1. april 2015

Studiet fullført (Faktiske)

1. april 2015

Datoer for studieregistrering

Først innsendt

27. juni 2014

Først innsendt som oppfylte QC-kriteriene

30. juni 2014

Først lagt ut (Anslag)

1. juli 2014

Oppdateringer av studieposter

Sist oppdatering lagt ut (Anslag)

6. november 2015

Siste oppdatering sendt inn som oppfylte QC-kriteriene

5. november 2015

Sist bekreftet

1. november 2015

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Andre studie-ID-numre

  • Trainsome 2014#002

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

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