Individual Response to Different Volumes of Resistance Training
5 novembre 2015 mis à jour par: Inland Norway University of Applied Sciences
Determinants of Intra-individual Variation in Adaptability to Resistance Training of Different Volumes
The literature is not clear as to which training volume to employ during initial phases of resistance training programs to ensure optimal muscular adaptations. The purpose of this study is therefore to compare effects of strength training with low versus moderate volume on muscular function and hypertrophy in previously untrained, healthy individuals. Furthermore, the investigators will relate individual variation in responses to proxy markers of individual training state, such as baseline muscular function and muscle fiber type.
The study will include 25 women and 25 men and will consist of a 12-week resistance training protocol. Each study participant will act as their own control, performing both the low- (1-set) and the moderate-volume (3-sets) protocol, allocated to either the dominant or non-dominant leg, in a stratified and randomized fashion.
Primary outcome measures are thigh muscle cross section area and unilateral knee extension strength. Additionally, muscle fiber type composition will be evaluated as well as additional parameters of muscular function.
The primary hypothesis is that low-volume protocols will be beneficial for individuals with glycolytic muscle phenotypes, whereas the opposite will be true for individuals with more aerobic phenotypes.
Aperçu de l'étude
Statut
Complété
Les conditions
Intervention / Traitement
Type d'étude
Interventionnel
Inscription (Réel)
42
Phase
- N'est pas applicable
Contacts et emplacements
Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.
Lieux d'étude
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Lillehammer, Norvège
- Lillehammer University College
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Critères de participation
Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.
Critère d'éligibilité
Âges éligibles pour étudier
18 ans à 40 ans (Adulte)
Accepte les volontaires sains
Oui
Sexes éligibles pour l'étude
Tout
La description
Inclusion Criteria:
- Healthy
- Non-smoking
- Able to tolerate resistance exercise training
Exclusion Criteria:
- Presence or history of cardiovascular, metabolic, endocrine or neuromuscular disease
- Diagnosed mental health disorder
- Intolerance to local anesthetic
- No experience with exercise training
- Performing regular resistance training (more than 1 session per week during last 12 months)
- Impaired strength/ neuromuscular function due to previous injury
- Recurrent pain in lower back, knee or shoulders
- Taking prescribed medication that may affect outcome of training intervention
Plan d'étude
Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.
Comment l'étude est-elle conçue ?
Détails de conception
- Objectif principal: Science basique
- Répartition: N / A
- Modèle interventionnel: Affectation à un seul groupe
- Masquage: Aucun (étiquette ouverte)
Armes et Interventions
Groupe de participants / Bras |
Intervention / Traitement |
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Expérimental: Arm label 1-Set, 3-Set
12-week progressive strength training protocol of different volumes
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Every study participant will complete 12 weeks of progressive strength training with one leg performing 1-set per exercise per session and the contralateral leg performing 3-sets per exercise per session.
Allocation of dominant/non-dominant leg to either 1- or 3-set protocol will be done in a stratified, randomized fashion (stratified with regard to sex and baseline strength).
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Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Thigh muscle cross-sectional area
Délai: Week 0 (baseline) and 12 (post training intervention)
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Changes in muscle cross sectional area of each thigh from baseline to post intervention, assessed by MRI.
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Week 0 (baseline) and 12 (post training intervention)
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Unilateral knee-extension isometric strength
Délai: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in maximum knee extensor, isometric strength evaluated at 120° knee angle (180° fully extended).
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Mesures de résultats secondaires
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Muscle strength
Délai: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in maximum isoinertial strength defined by one-repetition maximum in leg press, knee extension, knee flexion, and bench press.
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Knee extensors and flexors force-velocity relationship
Délai: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in torque measured during maximal voluntary isokinetic contraction at 60°, 120° and 240° ∙ sec-1.
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Blood hormonal profiles
Délai: Week 0 (baseline), 2 and 12 (post training intervention)
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Resting (week 0, 2 and 12) and acutely exercise-induced (week 2) hormonal profiles (testosterone, insulin-like growth factor 1, growth hormone and cortisol) determined in serum from venous blood samples.
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Week 0 (baseline), 2 and 12 (post training intervention)
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Muscle fiber cross-sectional area
Délai: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in muscle fiber cross-sectional area assessed by immunohistochemistry from muscle biopsy.
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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Protein expression
Délai: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in relative abundance of contractile protein isoforms (myosin heavy chain).
Modification of proteins related to muscle hypertrophy in relation to an acute exercise session (assessed during week 2 of the intervention).
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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Gene expression
Délai: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in gene expression related to skeletal muscle hypertrophy and structural phenotype measured in steady state conditions (biopsy sampled in resting conditions, week 0, 2 and 12) and in relation to acute exercise (biopsy sampled 1-h after strength exercise, week 2).
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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Autres mesures de résultats
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
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Body composition changes
Délai: Week 0 (baseline) and 12 (post training intervention)
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Changes in body compositions (lean mass and fat mass) from prior intervention to after intervention assessed by dual x-ray absorptiometry scan.
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Week 0 (baseline) and 12 (post training intervention)
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Habitual physical activity
Délai: Week 0
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Self-reported prior habitual physical activity assessed by questionnaire and interview before training intervention
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Week 0
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Daily nutrient intake
Délai: Week 6
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Daily nutrient intake assessed by a 4-day food intake registration.
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Week 6
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Collaborateurs et enquêteurs
C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.
Les enquêteurs
- Chercheur principal: Stian Ellefsen, PhD, Inland Norway University of Applied Sciences
Dates d'enregistrement des études
Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.
Dates principales de l'étude
Début de l'étude
1 août 2014
Achèvement primaire (Réel)
1 avril 2015
Achèvement de l'étude (Réel)
1 avril 2015
Dates d'inscription aux études
Première soumission
27 juin 2014
Première soumission répondant aux critères de contrôle qualité
30 juin 2014
Première publication (Estimation)
1 juillet 2014
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Estimation)
6 novembre 2015
Dernière mise à jour soumise répondant aux critères de contrôle qualité
5 novembre 2015
Dernière vérification
1 novembre 2015
Plus d'information
Termes liés à cette étude
Mots clés
Autres numéros d'identification d'étude
- Trainsome 2014#002
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