Individual Response to Different Volumes of Resistance Training
5 november 2015 bijgewerkt door: Inland Norway University of Applied Sciences
Determinants of Intra-individual Variation in Adaptability to Resistance Training of Different Volumes
The literature is not clear as to which training volume to employ during initial phases of resistance training programs to ensure optimal muscular adaptations. The purpose of this study is therefore to compare effects of strength training with low versus moderate volume on muscular function and hypertrophy in previously untrained, healthy individuals. Furthermore, the investigators will relate individual variation in responses to proxy markers of individual training state, such as baseline muscular function and muscle fiber type.
The study will include 25 women and 25 men and will consist of a 12-week resistance training protocol. Each study participant will act as their own control, performing both the low- (1-set) and the moderate-volume (3-sets) protocol, allocated to either the dominant or non-dominant leg, in a stratified and randomized fashion.
Primary outcome measures are thigh muscle cross section area and unilateral knee extension strength. Additionally, muscle fiber type composition will be evaluated as well as additional parameters of muscular function.
The primary hypothesis is that low-volume protocols will be beneficial for individuals with glycolytic muscle phenotypes, whereas the opposite will be true for individuals with more aerobic phenotypes.
Studie Overzicht
Toestand
Voltooid
Conditie
Interventie / Behandeling
Studietype
Ingrijpend
Inschrijving (Werkelijk)
42
Fase
- Niet toepasbaar
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
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Lillehammer, Noorwegen
- Lillehammer University College
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Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
18 jaar tot 40 jaar (Volwassen)
Accepteert gezonde vrijwilligers
Ja
Geslachten die in aanmerking komen voor studie
Allemaal
Beschrijving
Inclusion Criteria:
- Healthy
- Non-smoking
- Able to tolerate resistance exercise training
Exclusion Criteria:
- Presence or history of cardiovascular, metabolic, endocrine or neuromuscular disease
- Diagnosed mental health disorder
- Intolerance to local anesthetic
- No experience with exercise training
- Performing regular resistance training (more than 1 session per week during last 12 months)
- Impaired strength/ neuromuscular function due to previous injury
- Recurrent pain in lower back, knee or shoulders
- Taking prescribed medication that may affect outcome of training intervention
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Fundamentele wetenschap
- Toewijzing: NVT
- Interventioneel model: Opdracht voor een enkele groep
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
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Experimenteel: Arm label 1-Set, 3-Set
12-week progressive strength training protocol of different volumes
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Every study participant will complete 12 weeks of progressive strength training with one leg performing 1-set per exercise per session and the contralateral leg performing 3-sets per exercise per session.
Allocation of dominant/non-dominant leg to either 1- or 3-set protocol will be done in a stratified, randomized fashion (stratified with regard to sex and baseline strength).
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
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Thigh muscle cross-sectional area
Tijdsspanne: Week 0 (baseline) and 12 (post training intervention)
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Changes in muscle cross sectional area of each thigh from baseline to post intervention, assessed by MRI.
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Week 0 (baseline) and 12 (post training intervention)
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Unilateral knee-extension isometric strength
Tijdsspanne: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in maximum knee extensor, isometric strength evaluated at 120° knee angle (180° fully extended).
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
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Muscle strength
Tijdsspanne: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in maximum isoinertial strength defined by one-repetition maximum in leg press, knee extension, knee flexion, and bench press.
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Knee extensors and flexors force-velocity relationship
Tijdsspanne: Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Time course changes in torque measured during maximal voluntary isokinetic contraction at 60°, 120° and 240° ∙ sec-1.
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Week 0 (baseline), 2, 5, 9 (during intervention) and 12 (after training intervention)
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Blood hormonal profiles
Tijdsspanne: Week 0 (baseline), 2 and 12 (post training intervention)
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Resting (week 0, 2 and 12) and acutely exercise-induced (week 2) hormonal profiles (testosterone, insulin-like growth factor 1, growth hormone and cortisol) determined in serum from venous blood samples.
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Week 0 (baseline), 2 and 12 (post training intervention)
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Muscle fiber cross-sectional area
Tijdsspanne: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in muscle fiber cross-sectional area assessed by immunohistochemistry from muscle biopsy.
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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Protein expression
Tijdsspanne: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in relative abundance of contractile protein isoforms (myosin heavy chain).
Modification of proteins related to muscle hypertrophy in relation to an acute exercise session (assessed during week 2 of the intervention).
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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Gene expression
Tijdsspanne: Week 0 (baseline), 2 and 12 (post training intervention)
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Changes in gene expression related to skeletal muscle hypertrophy and structural phenotype measured in steady state conditions (biopsy sampled in resting conditions, week 0, 2 and 12) and in relation to acute exercise (biopsy sampled 1-h after strength exercise, week 2).
Determined from muscle biopsy samples (Vastus lateralis).
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Week 0 (baseline), 2 and 12 (post training intervention)
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Andere uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
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Body composition changes
Tijdsspanne: Week 0 (baseline) and 12 (post training intervention)
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Changes in body compositions (lean mass and fat mass) from prior intervention to after intervention assessed by dual x-ray absorptiometry scan.
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Week 0 (baseline) and 12 (post training intervention)
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Habitual physical activity
Tijdsspanne: Week 0
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Self-reported prior habitual physical activity assessed by questionnaire and interview before training intervention
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Week 0
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Daily nutrient intake
Tijdsspanne: Week 6
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Daily nutrient intake assessed by a 4-day food intake registration.
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Week 6
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Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Onderzoekers
- Hoofdonderzoeker: Stian Ellefsen, PhD, Inland Norway University of Applied Sciences
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start
1 augustus 2014
Primaire voltooiing (Werkelijk)
1 april 2015
Studie voltooiing (Werkelijk)
1 april 2015
Studieregistratiedata
Eerst ingediend
27 juni 2014
Eerst ingediend dat voldeed aan de QC-criteria
30 juni 2014
Eerst geplaatst (Schatting)
1 juli 2014
Updates van studierecords
Laatste update geplaatst (Schatting)
6 november 2015
Laatste update ingediend die voldeed aan QC-criteria
5 november 2015
Laatst geverifieerd
1 november 2015
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Andere studie-ID-nummers
- Trainsome 2014#002
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