The Evolution of Memories Across Wake and Sleep
연구 개요
상세 설명
Goal 1: How do memories evolve across wake and sleep? The investigators are interested in how specific memories are selected for change across periods of wake and sleep, and in characterizing the manner in which those memories change. There has been research into broad areas of memory, such as procedural and declarative memory, but other forms of memory, such as semantic memory, remain unexplored, as well as different subtypes of memory within these broad areas. Additionally, it is presently unknown how memories are selected for subsequent processing during sleep and wake. The investigators aim to characterize which memories change, how they are selected, and how they change differently over periods that include sleep versus periods during which participants remain awake.
Goal 2: How are these changes reflected behaviorally and in the EEG signal? The investigators will employ and develop specific behavioral and electrophysiological tasks and measures that allow one to probe the state of a particular type of memory and determine how it changes over periods of wake and sleep. EEG signals may be informative about the status of a memory during behavioral performance as well as during both waking and sleeping offline states.
Goal 3: What stages and features of sleep affect memory evolution? In the cases in which sleep in particular is found or suspected to influence memories in a unique way, the investigators will assess which stages and features of sleep are involved in that evolution. Generally, this will be accomplished by correlating measures such as time spent in a sleep stage, prominence of particular brain oscillations, or density of spindles with changes in behavior or in other EEG metrics
연구 유형
등록 (예상)
단계
- 해당 없음
연락처 및 위치
연구 장소
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Massachusetts
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Boston, Massachusetts, 미국, 02215
- Robert Stickgold
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- willing and able to follow the protocol
- willing to refrain from alcohol and recreational drugs for the duration of the protocol
- in some cases, English as a first language, normal hearing, and/or normal or corrected to normal vision is required
Exclusion Criteria:
- self-reported sleep disturbances
- a history of mental illness
- the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 없음(오픈 라벨)
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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간섭 없음: Daytime Wake
Subjects are trained and retested during a single period of daytime wake
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간섭 없음: Overnight sleep
Subjects are trained on one day and tested the next day, after a night of normal sleep
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실험적: Sleep deprivation
Subjects are trained on one day and tested the next day, after a night of sleep deprivation
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Subjects are kept awake all night.
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실험적: 주간 낮잠
피험자는 훈련을 받은 후 낮잠을 자고 다시 테스트를 받습니다.
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Participants are given a 90-minute nap opportunity in the early afternoon.
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Motor sequence task improvement
기간: 4-24 hrs
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The increase in the number of correct sequences typed, from the last three training trials to the first three delayed-test trials, is calculated as a percent improvement.
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4-24 hrs
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Psychomotor vigilance task lapse rate
기간: 4-24 hrs
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The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.
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4-24 hrs
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Serial reaction time test improvement
기간: 4-24 hrs
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At two time points, separated by a period of wake or sleep, the average reaction time to stimuli in repeated sequence blocks is subtracted from the average reaction time in random blocks.
The percent increase in this difference, from the final blocks in the first test to the first blocks in the second test, is calculated as a percent improvement.
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4-24 hrs
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Visual discrimination task improvement
기간: 4-24 hrs
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At two time points, separated by a period of wake or sleep, the interpolated stimulus-mask ISI corresponding to 80% accuracy on the texture discrimination task is determined, and task improvement is calculated as the difference between these thresholds, in ms.
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4-24 hrs
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Sleep architecture (absolute times)
기간: 4-24 hrs
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Sleep is recorded with standard polysomnography and the amount of time spent in each wake and sleep stage calculated.
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4-24 hrs
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Sleep architecture (percent times)
기간: 4-24 hrs
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The percent of total sleep time spent in each sleep stage is calculated.
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4-24 hrs
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Spindle
기간: 4-24 hrs
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The density of sleep spindles per minute of N2 sleep is calculated.
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4-24 hrs
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Sleep microstructure
기간: 4-24 hrs
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The EEG spectral power is calculated for N2 and N3 sleep.
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4-24 hrs
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공동 작업자 및 조사자
수사관
- 수석 연구원: Robert Stickgold, PhD, Beth Israel Deaconess Medical Center
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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