The Evolution of Memories Across Wake and Sleep
Visão geral do estudo
Status
Condições
Intervenção / Tratamento
Descrição detalhada
Goal 1: How do memories evolve across wake and sleep? The investigators are interested in how specific memories are selected for change across periods of wake and sleep, and in characterizing the manner in which those memories change. There has been research into broad areas of memory, such as procedural and declarative memory, but other forms of memory, such as semantic memory, remain unexplored, as well as different subtypes of memory within these broad areas. Additionally, it is presently unknown how memories are selected for subsequent processing during sleep and wake. The investigators aim to characterize which memories change, how they are selected, and how they change differently over periods that include sleep versus periods during which participants remain awake.
Goal 2: How are these changes reflected behaviorally and in the EEG signal? The investigators will employ and develop specific behavioral and electrophysiological tasks and measures that allow one to probe the state of a particular type of memory and determine how it changes over periods of wake and sleep. EEG signals may be informative about the status of a memory during behavioral performance as well as during both waking and sleeping offline states.
Goal 3: What stages and features of sleep affect memory evolution? In the cases in which sleep in particular is found or suspected to influence memories in a unique way, the investigators will assess which stages and features of sleep are involved in that evolution. Generally, this will be accomplished by correlating measures such as time spent in a sleep stage, prominence of particular brain oscillations, or density of spindles with changes in behavior or in other EEG metrics
Tipo de estudo
Inscrição (Antecipado)
Estágio
- Não aplicável
Contactos e Locais
Locais de estudo
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Massachusetts
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Boston, Massachusetts, Estados Unidos, 02215
- Robert Stickgold
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Critérios de participação
Critérios de elegibilidade
Idades elegíveis para estudo
Aceita Voluntários Saudáveis
Gêneros Elegíveis para o Estudo
Descrição
Inclusion Criteria:
- willing and able to follow the protocol
- willing to refrain from alcohol and recreational drugs for the duration of the protocol
- in some cases, English as a first language, normal hearing, and/or normal or corrected to normal vision is required
Exclusion Criteria:
- self-reported sleep disturbances
- a history of mental illness
- the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)
Plano de estudo
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Ciência básica
- Alocação: Randomizado
- Modelo Intervencional: Atribuição Paralela
- Mascaramento: Nenhum (rótulo aberto)
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
|---|---|
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Sem intervenção: Daytime Wake
Subjects are trained and retested during a single period of daytime wake
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Sem intervenção: Overnight sleep
Subjects are trained on one day and tested the next day, after a night of normal sleep
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Experimental: Sleep deprivation
Subjects are trained on one day and tested the next day, after a night of sleep deprivation
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Subjects are kept awake all night.
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Experimental: Soneca diurna
Os indivíduos são treinados e testados novamente após uma soneca diurna
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Participants are given a 90-minute nap opportunity in the early afternoon.
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O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Motor sequence task improvement
Prazo: 4-24 hrs
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The increase in the number of correct sequences typed, from the last three training trials to the first three delayed-test trials, is calculated as a percent improvement.
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4-24 hrs
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Psychomotor vigilance task lapse rate
Prazo: 4-24 hrs
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The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.
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4-24 hrs
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Serial reaction time test improvement
Prazo: 4-24 hrs
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At two time points, separated by a period of wake or sleep, the average reaction time to stimuli in repeated sequence blocks is subtracted from the average reaction time in random blocks.
The percent increase in this difference, from the final blocks in the first test to the first blocks in the second test, is calculated as a percent improvement.
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4-24 hrs
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Visual discrimination task improvement
Prazo: 4-24 hrs
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At two time points, separated by a period of wake or sleep, the interpolated stimulus-mask ISI corresponding to 80% accuracy on the texture discrimination task is determined, and task improvement is calculated as the difference between these thresholds, in ms.
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4-24 hrs
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Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
|---|---|---|
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Sleep architecture (absolute times)
Prazo: 4-24 hrs
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Sleep is recorded with standard polysomnography and the amount of time spent in each wake and sleep stage calculated.
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4-24 hrs
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Sleep architecture (percent times)
Prazo: 4-24 hrs
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The percent of total sleep time spent in each sleep stage is calculated.
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4-24 hrs
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Spindle
Prazo: 4-24 hrs
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The density of sleep spindles per minute of N2 sleep is calculated.
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4-24 hrs
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Sleep microstructure
Prazo: 4-24 hrs
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The EEG spectral power is calculated for N2 and N3 sleep.
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4-24 hrs
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Colaboradores e Investigadores
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Robert Stickgold, PhD, Beth Israel Deaconess Medical Center
Datas de registro do estudo
Datas Principais do Estudo
Início do estudo (Real)
Conclusão Primária (Antecipado)
Conclusão do estudo (Antecipado)
Datas de inscrição no estudo
Enviado pela primeira vez
Enviado pela primeira vez que atendeu aos critérios de CQ
Primeira postagem (Real)
Atualizações de registro de estudo
Última Atualização Postada (Real)
Última atualização enviada que atendeu aos critérios de controle de qualidade
Última verificação
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
Outros números de identificação do estudo
- 2016P000222
- 5R01MH048832-23 (Concessão/Contrato do NIH dos EUA)
Informações sobre medicamentos e dispositivos, documentos de estudo
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