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The Evolution of Memories Across Wake and Sleep

24 de julio de 2021 actualizado por: Robert Stickgold, Beth Israel Deaconess Medical Center
To further understanding of the relationship between sleep and memory the investigators will address and attempt to answer three questions, (1) how memories evolve across wake and sleep, (2) how different aspects of this memory evolution are reflected both behaviorally and in the EEG signal, and (3) what stages and features of sleep affect memory evolution. Together, these studies will provide a greater breadth and depth of knowledge concerning sleep's role in memory consolidation. Such knowledge would be of practical importance for educational practices, whether in schools, on the job, or in the military, and would also provide valuable information to the fields of sleep medicine and psychiatry, where interactions between sleep disorders and cognitive functioning are of great importance.

Descripción general del estudio

Estado

Activo, no reclutando

Condiciones

Intervención / Tratamiento

Descripción detallada

Goal 1: How do memories evolve across wake and sleep? The investigators are interested in how specific memories are selected for change across periods of wake and sleep, and in characterizing the manner in which those memories change. There has been research into broad areas of memory, such as procedural and declarative memory, but other forms of memory, such as semantic memory, remain unexplored, as well as different subtypes of memory within these broad areas. Additionally, it is presently unknown how memories are selected for subsequent processing during sleep and wake. The investigators aim to characterize which memories change, how they are selected, and how they change differently over periods that include sleep versus periods during which participants remain awake.

Goal 2: How are these changes reflected behaviorally and in the EEG signal? The investigators will employ and develop specific behavioral and electrophysiological tasks and measures that allow one to probe the state of a particular type of memory and determine how it changes over periods of wake and sleep. EEG signals may be informative about the status of a memory during behavioral performance as well as during both waking and sleeping offline states.

Goal 3: What stages and features of sleep affect memory evolution? In the cases in which sleep in particular is found or suspected to influence memories in a unique way, the investigators will assess which stages and features of sleep are involved in that evolution. Generally, this will be accomplished by correlating measures such as time spent in a sleep stage, prominence of particular brain oscillations, or density of spindles with changes in behavior or in other EEG metrics

Tipo de estudio

Intervencionista

Inscripción (Anticipado)

1650

Fase

  • No aplica

Contactos y Ubicaciones

Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.

Ubicaciones de estudio

  • Estados Unidos
    • Massachusetts
      • Boston, Massachusetts, Estados Unidos, 02215
        • Robert Stickgold

Criterios de participación

Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.

Criterio de elegibilidad

Edades elegibles para estudiar

18 años a 40 años (Adulto)

Acepta Voluntarios Saludables

No

Géneros elegibles para el estudio

Todos

Descripción

Inclusion Criteria:

  • willing and able to follow the protocol
  • willing to refrain from alcohol and recreational drugs for the duration of the protocol
  • in some cases, English as a first language, normal hearing, and/or normal or corrected to normal vision is required

Exclusion Criteria:

  • self-reported sleep disturbances
  • a history of mental illness
  • the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)

Plan de estudios

Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.

¿Cómo está diseñado el estudio?

Detalles de diseño

  • Propósito principal: Ciencia básica
  • Asignación: Aleatorizado
  • Modelo Intervencionista: Asignación paralela
  • Enmascaramiento: Ninguno (etiqueta abierta)

Armas e Intervenciones

Grupo de participantes/brazo
Intervención / Tratamiento
Sin intervención: Daytime Wake
Subjects are trained and retested during a single period of daytime wake
Sin intervención: Overnight sleep
Subjects are trained on one day and tested the next day, after a night of normal sleep
Experimental: Sleep deprivation
Subjects are trained on one day and tested the next day, after a night of sleep deprivation
Conductual: Sleep deprivation
Subjects are kept awake all night.
Experimental: Daytime Nap
Subjects are trained and then retested after a daytime nap
Conductual: Nap
Participants are given a 90-minute nap opportunity in the early afternoon.

¿Qué mide el estudio?

Medidas de resultado primarias

Medida de resultado
Medida Descripción
Periodo de tiempo
Motor sequence task improvement
Periodo de tiempo: 4-24 hrs
The increase in the number of correct sequences typed, from the last three training trials to the first three delayed-test trials, is calculated as a percent improvement.
4-24 hrs
Psychomotor vigilance task lapse rate
Periodo de tiempo: 4-24 hrs
The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.
4-24 hrs
Serial reaction time test improvement
Periodo de tiempo: 4-24 hrs
At two time points, separated by a period of wake or sleep, the average reaction time to stimuli in repeated sequence blocks is subtracted from the average reaction time in random blocks. The percent increase in this difference, from the final blocks in the first test to the first blocks in the second test, is calculated as a percent improvement.
4-24 hrs
Visual discrimination task improvement
Periodo de tiempo: 4-24 hrs
At two time points, separated by a period of wake or sleep, the interpolated stimulus-mask ISI corresponding to 80% accuracy on the texture discrimination task is determined, and task improvement is calculated as the difference between these thresholds, in ms.
4-24 hrs

Medidas de resultado secundarias

Medida de resultado
Medida Descripción
Periodo de tiempo
Sleep architecture (absolute times)
Periodo de tiempo: 4-24 hrs
Sleep is recorded with standard polysomnography and the amount of time spent in each wake and sleep stage calculated.
4-24 hrs
Sleep architecture (percent times)
Periodo de tiempo: 4-24 hrs
The percent of total sleep time spent in each sleep stage is calculated.
4-24 hrs
Spindle
Periodo de tiempo: 4-24 hrs
The density of sleep spindles per minute of N2 sleep is calculated.
4-24 hrs
Sleep microstructure
Periodo de tiempo: 4-24 hrs
The EEG spectral power is calculated for N2 and N3 sleep.
4-24 hrs

Colaboradores e Investigadores

Aquí es donde encontrará personas y organizaciones involucradas en este estudio.

Patrocinador

Beth Israel Deaconess Medical Center

Colaboradores

National Institute of Mental Health (NIMH)

Investigadores

  • Investigador principal: Robert Stickgold, PhD, Beth Israel Deaconess Medical Center

Fechas de registro del estudio

Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados ​​por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.

Fechas importantes del estudio

Inicio del estudio (Actual)

1 de marzo de 2016

Finalización primaria (Anticipado)

20 de junio de 2022

Finalización del estudio (Anticipado)

20 de diciembre de 2023

Fechas de registro del estudio

Enviado por primera vez

19 de julio de 2017

Primero enviado que cumplió con los criterios de control de calidad

21 de julio de 2017

Publicado por primera vez (Actual)

24 de julio de 2017

Actualizaciones de registros de estudio

Última actualización publicada (Actual)

30 de julio de 2021

Última actualización enviada que cumplió con los criterios de control de calidad

24 de julio de 2021

Última verificación

1 de julio de 2021

Más información

Términos relacionados con este estudio

Palabras clave

Términos MeSH relevantes adicionales

Otros números de identificación del estudio

  • 2016P000222
  • 5R01MH048832-23 (Subvención/contrato del NIH de EE. UU.)

Información sobre medicamentos y dispositivos, documentos del estudio

Estudia un producto farmacéutico regulado por la FDA de EE. UU.

No

Estudia un producto de dispositivo regulado por la FDA de EE. UU.

No

Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .

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