The Evolution of Memories Across Wake and Sleep
調査の概要
詳細な説明
Goal 1: How do memories evolve across wake and sleep? The investigators are interested in how specific memories are selected for change across periods of wake and sleep, and in characterizing the manner in which those memories change. There has been research into broad areas of memory, such as procedural and declarative memory, but other forms of memory, such as semantic memory, remain unexplored, as well as different subtypes of memory within these broad areas. Additionally, it is presently unknown how memories are selected for subsequent processing during sleep and wake. The investigators aim to characterize which memories change, how they are selected, and how they change differently over periods that include sleep versus periods during which participants remain awake.
Goal 2: How are these changes reflected behaviorally and in the EEG signal? The investigators will employ and develop specific behavioral and electrophysiological tasks and measures that allow one to probe the state of a particular type of memory and determine how it changes over periods of wake and sleep. EEG signals may be informative about the status of a memory during behavioral performance as well as during both waking and sleeping offline states.
Goal 3: What stages and features of sleep affect memory evolution? In the cases in which sleep in particular is found or suspected to influence memories in a unique way, the investigators will assess which stages and features of sleep are involved in that evolution. Generally, this will be accomplished by correlating measures such as time spent in a sleep stage, prominence of particular brain oscillations, or density of spindles with changes in behavior or in other EEG metrics
研究の種類
入学 (予想される)
段階
- 適用できない
連絡先と場所
研究場所
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Massachusetts
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Boston、Massachusetts、アメリカ、02215
- Robert Stickgold
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- willing and able to follow the protocol
- willing to refrain from alcohol and recreational drugs for the duration of the protocol
- in some cases, English as a first language, normal hearing, and/or normal or corrected to normal vision is required
Exclusion Criteria:
- self-reported sleep disturbances
- a history of mental illness
- the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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介入なし：Daytime Wake
Subjects are trained and retested during a single period of daytime wake
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介入なし：Overnight sleep
Subjects are trained on one day and tested the next day, after a night of normal sleep
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実験的：Sleep deprivation
Subjects are trained on one day and tested the next day, after a night of sleep deprivation
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Subjects are kept awake all night.
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実験的：昼寝
被験者は訓練を受け、昼寝後に再検査を受ける
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Participants are given a 90-minute nap opportunity in the early afternoon.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Motor sequence task improvement
時間枠：4-24 hrs
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The increase in the number of correct sequences typed, from the last three training trials to the first three delayed-test trials, is calculated as a percent improvement.
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4-24 hrs
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Psychomotor vigilance task lapse rate
時間枠：4-24 hrs
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The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.
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4-24 hrs
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Serial reaction time test improvement
時間枠：4-24 hrs
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At two time points, separated by a period of wake or sleep, the average reaction time to stimuli in repeated sequence blocks is subtracted from the average reaction time in random blocks.
The percent increase in this difference, from the final blocks in the first test to the first blocks in the second test, is calculated as a percent improvement.
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4-24 hrs
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Visual discrimination task improvement
時間枠：4-24 hrs
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At two time points, separated by a period of wake or sleep, the interpolated stimulus-mask ISI corresponding to 80% accuracy on the texture discrimination task is determined, and task improvement is calculated as the difference between these thresholds, in ms.
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4-24 hrs
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Sleep architecture (absolute times)
時間枠：4-24 hrs
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Sleep is recorded with standard polysomnography and the amount of time spent in each wake and sleep stage calculated.
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4-24 hrs
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Sleep architecture (percent times)
時間枠：4-24 hrs
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The percent of total sleep time spent in each sleep stage is calculated.
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4-24 hrs
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Spindle
時間枠：4-24 hrs
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The density of sleep spindles per minute of N2 sleep is calculated.
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4-24 hrs
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Sleep microstructure
時間枠：4-24 hrs
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The EEG spectral power is calculated for N2 and N3 sleep.
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4-24 hrs
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協力者と研究者
捜査官
- 主任研究者：Robert Stickgold, PhD、Beth Israel Deaconess Medical Center
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (予想される)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
寝るの臨床試験
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Fujian Shengdi Pharmaceutical Co., Ltd.募集
Sleep deprivationの臨床試験
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Leiden UniversityBioClock Consortium; Caring Univeristies完了
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University of Texas at Austin完了