The Evolution of Memories Across Wake and Sleep
研究概览
详细说明
Goal 1: How do memories evolve across wake and sleep? The investigators are interested in how specific memories are selected for change across periods of wake and sleep, and in characterizing the manner in which those memories change. There has been research into broad areas of memory, such as procedural and declarative memory, but other forms of memory, such as semantic memory, remain unexplored, as well as different subtypes of memory within these broad areas. Additionally, it is presently unknown how memories are selected for subsequent processing during sleep and wake. The investigators aim to characterize which memories change, how they are selected, and how they change differently over periods that include sleep versus periods during which participants remain awake.
Goal 2: How are these changes reflected behaviorally and in the EEG signal? The investigators will employ and develop specific behavioral and electrophysiological tasks and measures that allow one to probe the state of a particular type of memory and determine how it changes over periods of wake and sleep. EEG signals may be informative about the status of a memory during behavioral performance as well as during both waking and sleeping offline states.
Goal 3: What stages and features of sleep affect memory evolution? In the cases in which sleep in particular is found or suspected to influence memories in a unique way, the investigators will assess which stages and features of sleep are involved in that evolution. Generally, this will be accomplished by correlating measures such as time spent in a sleep stage, prominence of particular brain oscillations, or density of spindles with changes in behavior or in other EEG metrics
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习地点
-
-
Massachusetts
-
Boston、Massachusetts、美国、02215
- Robert Stickgold
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- willing and able to follow the protocol
- willing to refrain from alcohol and recreational drugs for the duration of the protocol
- in some cases, English as a first language, normal hearing, and/or normal or corrected to normal vision is required
Exclusion Criteria:
- self-reported sleep disturbances
- a history of mental illness
- the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)
学习计划
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
无干预：Daytime Wake
Subjects are trained and retested during a single period of daytime wake
|
|
|
无干预：Overnight sleep
Subjects are trained on one day and tested the next day, after a night of normal sleep
|
|
|
实验性的：Sleep deprivation
Subjects are trained on one day and tested the next day, after a night of sleep deprivation
|
Subjects are kept awake all night.
|
|
实验性的：白天小睡
受试者接受训练，然后在白天小睡后重新测试
|
Participants are given a 90-minute nap opportunity in the early afternoon.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Motor sequence task improvement
大体时间：4-24 hrs
|
The increase in the number of correct sequences typed, from the last three training trials to the first three delayed-test trials, is calculated as a percent improvement.
|
4-24 hrs
|
|
Psychomotor vigilance task lapse rate
大体时间：4-24 hrs
|
The absolute number of trials in a 5-min test period on which the participant fails to responds with 500ms is calculated as the lapse rate.
|
4-24 hrs
|
|
Serial reaction time test improvement
大体时间：4-24 hrs
|
At two time points, separated by a period of wake or sleep, the average reaction time to stimuli in repeated sequence blocks is subtracted from the average reaction time in random blocks.
The percent increase in this difference, from the final blocks in the first test to the first blocks in the second test, is calculated as a percent improvement.
|
4-24 hrs
|
|
Visual discrimination task improvement
大体时间：4-24 hrs
|
At two time points, separated by a period of wake or sleep, the interpolated stimulus-mask ISI corresponding to 80% accuracy on the texture discrimination task is determined, and task improvement is calculated as the difference between these thresholds, in ms.
|
4-24 hrs
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Sleep architecture (absolute times)
大体时间：4-24 hrs
|
Sleep is recorded with standard polysomnography and the amount of time spent in each wake and sleep stage calculated.
|
4-24 hrs
|
|
Sleep architecture (percent times)
大体时间：4-24 hrs
|
The percent of total sleep time spent in each sleep stage is calculated.
|
4-24 hrs
|
|
Spindle
大体时间：4-24 hrs
|
The density of sleep spindles per minute of N2 sleep is calculated.
|
4-24 hrs
|
|
Sleep microstructure
大体时间：4-24 hrs
|
The EEG spectral power is calculated for N2 and N3 sleep.
|
4-24 hrs
|
合作者和调查者
调查人员
- 首席研究员：Robert Stickgold, PhD、Beth Israel Deaconess Medical Center
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
Sleep deprivation的临床试验
-
Temple UniversityNational Heart, Lung, and Blood Institute (NHLBI)完全的
-
Advancing Clinical Trials in Neonatal Opioid Withdrawal...National Institutes of Health (NIH)完全的