Childhood Autism Risks From Genetics and the Environment (The CHARGE Study)
Environmental Factors in the Etiology of Autism
Studie Overzicht
Toestand
Conditie
Gedetailleerde beschrijving
The causes and contributing factors for autism are poorly understood. Evidence suggests that incidence is increasing, but diagnostic changes and improvements may be playing a role. Both genetic and environmental factors appear to play a role. Autopsy studies demonstrate structural changes in the brain and clinical investigations reveal neurophysiologic differences in information processing in autistic versus normal children. Members of our team recently demonstrated altered levels of certain neuropeptides at birth in children who later developed autism.
This case-control study is the first large-scale epidemiologic investigation of underlying causes for autism and triggers of regression. This study capitalizes on the strengths of the case-control design, which is well suited to examine a broad array of factors for rare conditions that are thought to be multifactorial. Comparisons will be made with both general population controls and mentally retarded children.
The aims are to assess the influence of exogenous exposures, the role of susceptibility factors, and the interplay between these two in the etiology of autism and its phenotypic variation. Chemicals with known or suspected neurodevelopmental toxicity, such as PCB's, certain pesticides, and metals, are being investigated. This study pursues several hypotheses that have recently gained attention, including the combined measles, mumps, rubella vaccine and mercury present in vaccines given during infancy and early childhood. Additionally, biochemical susceptibility is examined through characterization of metabolic, immunologic, and neuronal gene expression profiles and genetic polymorphisms.
Studietype
Inschrijving (Verwacht)
Contacten en locaties
Studie Locaties
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California
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Davis, California, Verenigde Staten, 95616
- University of California
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Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Beschrijving
Inclusion Criteria:
- Children between 2 and 5 years old
- Born in California
- Parents must speak either English or Spanish
- Children must be living with at least one biologic parent
Exclusion Criteria:
- Children not meeting eligibility criteria listed above
- Children not residing in selected geographical areas (please contact for more information about specific study locations)
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Tijdsperspectieven: Ander
Medewerkers en onderzoekers
Onderzoekers
- Hoofdonderzoeker: Isaac N. Pessah, Ph.D., University of California, Davis
- Studie directeur: Irva Hertz-Picciotto, Ph.D., University of California, Davis
Publicaties en nuttige links
Studie record data
Bestudeer belangrijke data
Studie start
Primaire voltooiing (Werkelijk)
Studie voltooiing (Werkelijk)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Schatting)
Updates van studierecords
Laatste update geplaatst (Werkelijk)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- 11269-CP-001
- 200210574-4
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