Acetaminophen Before Vaccines for Infants Study (AVIS)
11 oktober 2017 bijgewerkt door: Kaiser Permanente
A Randomized Placebo-controlled Trial of Acetaminophen for Prevention of Post-vaccination Fever in Infants
The purpose of this study is to see whether giving acetaminophen (the medicine in Tylenol) for routine infant vaccinations is helpful in preventing fever or other symptoms.
Studie Overzicht
Toestand
Voltooid
Conditie
Interventie / Behandeling
Gedetailleerde beschrijving
Post-vaccination fever occurs in up to 40% of infants receiving routinely recommended childhood vaccinations.
Although serious events are rare, post-vaccination fever causes discomfort for the child, can lead to medical utilization, can rarely result in febrile seizure, and can cause a working parent to miss time from their job to care for a febrile infant who cannot attend day care.
The benefits of acetaminophen prophylaxis for infants receiving current vaccinations, in terms of reduction of discomfort for the child, improvement of quality-of-life indicators for the parent, or reduction of medical utilization, have not been measured.
This randomized, blinded, placebo-controlled trial will assess the efficacy of prophylaxis with acetaminophen in prevention of fever following routine childhood immunizations.
Studietype
Ingrijpend
Inschrijving (Werkelijk)
374
Fase
- Fase 3
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
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Washington
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Seattle, Washington, Verenigde Staten, 98101
- Group Health Research Institute
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Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
1 maand tot 9 maanden (Kind)
Accepteert gezonde vrijwilligers
Ja
Geslachten die in aanmerking komen voor studie
Allemaal
Beschrijving
Inclusion Criteria:
- Child is a current Group Health enrollee.
- Child will be seen at a Group Health clinic for a Well Child visit that is expected to include 2 or more vaccines after 6 wks and before 10 months of age.
Exclusion Criteria:
- If child was born at less than 36 weeks of gestation, the child is not eligible until 4 months of age or older.
- If the child's birth weight was less than 5.5 pounds (2500 grams), the child is not eligible until 4 months of age or older.
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Preventie
- Toewijzing: Gerandomiseerd
- Interventioneel model: Parallelle opdracht
- Masker: Verdrievoudigen
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
|---|---|
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Actieve vergelijker: Acetaminophen
Children were randomized 1:1 to receive up to five doses of acetaminophen (10-15mg per kg) or placebo following routine vaccinations.
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Children were randomized 1:1 to receive up to five doses of acetaminophen (10-15mg per kg) or placebo following routine vaccinations.
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Placebo-vergelijker: Placebo
Children were randomized 1:1 to receive up to five doses of acetaminophen (10-15mg per kg) or placebo following routine vaccinations.
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Children were randomized 1:1 to receive up to five doses of acetaminophen (10-15mg per kg) or placebo following routine vaccinations.
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
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Fever >=38C Within 32 Hours of Vaccination.
Tijdsspanne: Fever within 32 hours following vaccination
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Fever, defined as rectal temperature >=38C within 32 hours of vaccination.
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Fever within 32 hours following vaccination
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Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
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Fever >=39C Within 32 Hours of Vaccination.
Tijdsspanne: Fever within 32 hours following vaccination
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Fever, defined as rectal temperature >=39C within 32 hours of vaccination.
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Fever within 32 hours following vaccination
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Study Assignment Unblinded
Tijdsspanne: At any time during participation in the study
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The need for unblinding at any time during the study
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At any time during participation in the study
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Medical Utilization
Tijdsspanne: Within 32 hours of vaccination.
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Telephone calls to the consulting nurse or the child's physician that were made due to concerns regarding an acute illness, fever, or possible vaccine reaction and outpatient, urgent care, and emergency room visits that were for evaluation of an acute illness, fever, or a possible vaccine reaction, within 32 hours of vaccination.
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Within 32 hours of vaccination.
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Infant Fussiness
Tijdsspanne: Within 32 hours of vaccination
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Parents were asked to record level of fussiness (compared with the child's usual) within 32 hours of vaccination, using the categories much less than usual, less than usual, about usual, more than usual, and much more than usual.
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Within 32 hours of vaccination
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Parent Time Lost From Sleep
Tijdsspanne: On the night following vaccinations
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Parents were asked about their sleep on the night following the vaccinations.
They were asked to report whether they slept much less than usual, less than usual, about the usual amount, more than usual, or much more than usual on that night.
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On the night following vaccinations
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Infant Time Lost From Sleep
Tijdsspanne: On the night following vaccinations
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Parents were asked about their infant's sleep on the night following the vaccinations.
They were asked to report whether their infant slept much less than usual, less than usual, about the usual amount, more than usual, or much more than usual on that night.
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On the night following vaccinations
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Parent Time Lost From Work
Tijdsspanne: Through the day after vaccination
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Parents were asked to report whether they were scheduled to work on the day of the vaccination visit (but following that visit) or the next day and, if so, whether they had to miss work to care for their infant because of fever, fussiness, or possible vaccine reaction on those days.
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Through the day after vaccination
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Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Sponsor
Medewerkers
Onderzoekers
- Hoofdonderzoeker: Lisa A Jackson, MD, MPH, Kaiser Permanente
Publicaties en nuttige links
De persoon die verantwoordelijk is voor het invoeren van informatie over het onderzoek stelt deze publicaties vrijwillig ter beschikking. Dit kan gaan over alles wat met het onderzoek te maken heeft.
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start
1 mei 2006
Primaire voltooiing (Werkelijk)
1 september 2009
Studie voltooiing (Werkelijk)
1 september 2009
Studieregistratiedata
Eerst ingediend
11 mei 2006
Eerst ingediend dat voldeed aan de QC-criteria
11 mei 2006
Eerst geplaatst (Schatting)
15 mei 2006
Updates van studierecords
Laatste update geplaatst (Werkelijk)
13 oktober 2017
Laatste update ingediend die voldeed aan QC-criteria
11 oktober 2017
Laatst geverifieerd
1 oktober 2017
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- CDC Protocol #4665
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .