Acute Normovolemic Hemodilution in Bone Cancer Surgery
22 juni 2026 bijgewerkt door: Second Affiliated Hospital, School of Medicine, Zhejiang University
The Effect of Acute Normovolemic Hemodilution on Requirement of Allogeneic Red Blood Cell in Patients Undergoing Bone Cancer Surgery
Malignant bone tumors often lead to skeletal complications, known as skeletal related events (SRE).
These complications mainly include pathological fractures, severe pain, and spinal cord compression.
Typically, SRE reduces overall survival rates and is associated with loss of mobility and social functioning, decreased quality of life, and significantly increased healthcare costs.
Surgical resection is an important means of treating malignant bone tumors.
The main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures.
Surgery for malignant bone tumors often requires extensive exploration, osteotomy, and prosthetic reconstruction.
The surgery involves significant trauma and excessive bleeding from the wound.
Therefore, there is a significant risk of perioperative blood loss and transfusion during surgery for malignant bone tumors.
However, blood transfusion also brings transfusion related risks to patients, increases the incidence of postoperative complications, and increases the healthcare burden on patients and society.
Acute normovolemic hemodilution (ANH) may help reduce allogeneic red blood cell transfusion.
However, There is a lack of high-quality evidence to support the use of ANH in bone cancer surgery.
Studie Overzicht
Toestand
Nog niet aan het werven
Conditie
Interventie / Behandeling
Gedetailleerde beschrijving
Malignant bone tumors often lead to skeletal complications, known as skeletal related events (SRE).
These complications mainly include pathological fractures, severe pain, and spinal cord compression.
Typically, SRE reduces overall survival rates and is associated with loss of mobility and social functioning, decreased quality of life, and significantly increased healthcare costs.
Surgical resection is an important means of treating malignant bone tumors.
The main goal of surgical treatment is to maintain the patient's function and mobility by relieving pain, preventing impending fractures and/or nerve compression, or stabilizing pathological fractures.
Surgery for bone cancer often requires extensive exploration, osteotomy, and prosthetic reconstruction.
The surgery involves significant trauma and excessive bleeding from the wound.
Therefore, there is a significant risk of perioperative blood loss and transfusion during surgery for malignant bone tumors.
However, blood transfusion also brings transfusion related risks to patients, increases the incidence of postoperative complications, and increases the healthcare burden on patients and society.
Therefore, it is particularly important to develop a perioperative blood management (PBM) plan for these patients.
Acute normovolemic hemodilution (ANH) may help reduce allogeneic red blood cell transfusion.
However, There is a lack of high-quality evidence to support the use of ANH in bone cancer surgery.
Studietype
Ingrijpend
Inschrijving (Geschat)
420
Fase
- Niet toepasbaar
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
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Zhejiang
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Hangzhou, Zhejiang, China, 310000
- The Second Affiliated Hospital of Zhejiang University anesthesiology department
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Hoofdonderzoeker:
- Min Yan, Doctor
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Contact:
- Min Yan, Doctor
- Telefoonnummer: +86 15888210247
- E-mail: zryanmin@zju.edu.cn
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Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
- Volwassen
- Oudere volwassene
Accepteert gezonde vrijwilligers
Nee
Beschrijving
Inclusion Criteria:
- age 18 more than years;
- undergoing elective bone cancer resection surgery;
- preoperative hemoglobin ≥12 g/dL;
Exclusion Criteria:
- using a tourniquet;
- BMI<18.5 Kg/m^2;
- international normalized ratio (INR) >1.5 or platelet count <100 × 10^9/L;
- cardiopulmonary insufficiency;
- hepatic and renal dysfunction;
- active infectious disease;
- allergy to colloid solution;
- pregnancy;
- declined participation in the study or declined blood transfusion
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: Gerandomiseerd
- Interventioneel model: Parallelle opdracht
- Masker: Enkel
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
|---|---|
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Geen tussenkomst: Control group
Except for not undergoing ANH, other care managements are the same as the experimental group
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Experimenteel: ANH group
Patients in the ANH group had whole blood withdrawn after induction of anesthesia.
Meanwhile, patients receive colloid solution according to the volume of blood withdrawn.
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The whole blood is withdrawn after induction of anesthesia.
Blood is withdrawn from a large-bore catheter and stored in blood bags.
Meanwhile, patients receive colloid solution according to the volume of blood withdrawn.
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Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Perioperative red blood cell transfusion rate
Tijdsspanne: hospital discharge, an average of 10 days
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The number of patients receiving RBCs transfusion from the start of surgery to hospital discharge.
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hospital discharge, an average of 10 days
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Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
The rate of perioperative transfusion of allogeneic blood products
Tijdsspanne: hospital discharge, an average of 10 days
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This includes blood products such as plasma and platelets, erythrocytes
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hospital discharge, an average of 10 days
|
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Wound drainage volume
Tijdsspanne: hospital discharge, an average of 10 days
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Accumulated amount of wound drainage after surgery
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hospital discharge, an average of 10 days
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Unplanned re-operation
Tijdsspanne: hospital discharge, an average of 10 days
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Unplanned re-operation due to bleeding, infection or other reasons
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hospital discharge, an average of 10 days
|
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Perioperative hemoglobin concentration
Tijdsspanne: hospital discharge, an average of 10 days
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hemoglobin concentration during hospitalization
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hospital discharge, an average of 10 days
|
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The coagulation function tests during the perioperative period
Tijdsspanne: hospital discharge, an average of 10 days
|
This includes thromboelastography result
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hospital discharge, an average of 10 days
|
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Complication
Tijdsspanne: hospital discharge, an average of 10 days
|
embolic events, pulmonary complications, infection, acute kidney injury, death.
Diagnose according to radiologic examination, sign and symptom
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hospital discharge, an average of 10 days
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Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start (Geschat)
1 juli 2026
Primaire voltooiing (Geschat)
1 juli 2026
Studie voltooiing (Geschat)
1 mei 2028
Studieregistratiedata
Eerst ingediend
22 juni 2026
Eerst ingediend dat voldeed aan de QC-criteria
22 juni 2026
Eerst geplaatst (Werkelijk)
25 juni 2026
Updates van studierecords
Laatste update geplaatst (Werkelijk)
25 juni 2026
Laatste update ingediend die voldeed aan QC-criteria
22 juni 2026
Laatst geverifieerd
1 juni 2026
Meer informatie
Termen gerelateerd aan deze studie
Andere studie-ID-nummers
- 2026 0947
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Nee
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
Nee
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .