Evaluation of the Efficacy of Rasagiline in Apathy in Drug-naïve Patients With Parkinson's Disease by a Multi-center Study
Evaluation of the Efficacy of Rasagiline in Apathy in Drug-naïve Patients With Parkinson's Disease by a Multi-center, Randomized, Double-blind, Parallel-group, Placebo-controlled Study.
Among the psychiatric symptoms observed in the premotor phase of Parkinson's disease (PD) and/or in "de novo" patients, apathy is relatively frequent (estimated to 23%). However, the neuropathological bases of apathy are still unknown. However, recent data suggests that apathy could be linked to a more specific dopaminergic denervation in the ventral striatum.
Rasagiline increases the bioavailability of striatal endogenous dopamine by blocking the MAO-B. Some recent data suggest rasagiline could be effective to improve apathy in Parkinson's disease.
The primary outcome is to demonstrate a significant reduction of apathy using the Lille apathy rating scale (LARS) in drug naive patients with early diagnosed Parkinson's disease, using a treatment by rasagiline.
Studieoversikt
Status
Intervensjon / Behandling
Detaljert beskrivelse
Study design :
Randomized, double-blind, rasagiline (1 mg) vs placebo study. Parallel group (randomization 1/1). Duration 3 months 16 recruiting centers in France
Population :
50 drug-naïve patients with Parkinson's disease, with apathy. 2 groups : 25 patients with placebo and 25 patients with rasagiline.
3 visits
- Visit 1 : inclusion / randomisation/ first study medication dispensation
- Visit 2 (1.5 month after V1) : first evaluation and second study medication dispensation.
- Visit 3 (3 months after V1, final visit) : second evaluation
Studietype
Registrering (Forventet)
Fase
- Fase 4
Kontakter og plasseringer
Studiesteder
-
-
-
Clermont-Ferrand, Frankrike, 63003
- CHU clermont-ferrand
-
-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- Drug-naïve patients with Parkinson's disease (UKPDBB criteria)
- No dementia (Mattis dementia rating scale > 130; Mini Mental Sate Examination ≥26)
- No depression (MADRS < 15)
- Criteria of apathy from Robert et al (2009)
- At least mild apathy (≥-21 to Lille Apathy Rating Scale)
- Age : 35-70 y
- Affiliation to social security
- Agreement of patients
Exclusion Criteria:
- - Any antiparkinsonian treatment (L.dopa, dopamine agonists, MAO-B-I, amantadine, anticholinergics). Patients treated by dopamine agonists but who have stopped it more than 3 months before their inclusion can be included.
- Ongoing severe psychiatric or somatic diseases
- Others treatments :
- antipsychotics
- antidepressants and anxiolytics (exclusion if the treatment is not stable the month before inclusion)
- psychostimulants (methylphenidate, adrafinil, modafinil, deanol, vitamin C, sulbutiamine, glutamic acid, aspartic acid)
- any contra-indication according to SmPC
- patients under guardianship
- Women without efficient contraception
- Person who participate to an other study
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Dobbelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: rasagiline
Randomized, double-blind, rasagiline (1 mg) vs placebo study.
Parallel group (randomization 1/1).
Duration 3 months 16 recruiting centers in France
|
|
|
Placebo komparator: placebo
Randomized, double-blind, rasagiline (1 mg) vs placebo study.
Parallel group (randomization 1/1).
Duration 3 months 16 recruiting centers in France
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Lille Apathy Rating Scale (LARS) score
Tidsramme: at the visit 3 (after 3 months of treatment)
|
at the visit 3 (after 3 months of treatment)
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Motor assessment : Unified Parkinson's Disease Rating Scale
Tidsramme: at the visit 3 (after 3 months of treatment)
|
at the visit 3 (after 3 months of treatment)
|
|
Depressive and anxiety symptoms : MADRS + Hamilton anxiety scale
Tidsramme: at the visit 3 (after 3 months of treatment)
|
at the visit 3 (after 3 months of treatment)
|
|
Self assessment of apathy : Starkstein
Tidsramme: at the visit 3 (after 3 months of treatment)
|
at the visit 3 (after 3 months of treatment)
|
|
Quality of life : PDQ 39
Tidsramme: at the visit 3 (after 3 months of treatment)
|
at the visit 3 (after 3 months of treatment)
|
|
Cognitive assessment: MATTIS dementia rating scale, MMSE, executive functions battery
Tidsramme: at the visit 3 (after 3 months of treatment)
|
at the visit 3 (after 3 months of treatment)
|
|
Hyperdopaminergic symptoms : Parkinson's disease behavioral scale
Tidsramme: at the visit 3 (after 3 months of treatment)
|
at the visit 3 (after 3 months of treatment)
|
|
Fatigue assessment : Parkinson Fatigue Scale
Tidsramme: at the visit 3 (after 3 months of treatment)
|
at the visit 3 (after 3 months of treatment)
|
Samarbeidspartnere og etterforskere
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Denis PEZET, University Hospital, Clermont-Ferrand
Studierekorddatoer
Studer hoveddatoer
Studiestart
Primær fullføring (Forventet)
Studiet fullført (Forventet)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Hjernesykdommer
- Sykdommer i sentralnervesystemet
- Sykdommer i nervesystemet
- Parkinsonlidelser
- Basal ganglia sykdommer
- Bevegelsesforstyrrelser
- Synukleinopatier
- Nevrodegenerative sykdommer
- Parkinsons sykdom
- Fysiologiske effekter av legemidler
- Molekylære mekanismer for farmakologisk virkning
- Enzymhemmere
- Nevrobeskyttende midler
- Beskyttende agenter
- Monoaminoksidasehemmere
- Rasagilin
Andre studie-ID-numre
- CHU-0138
- 2007-002800-16
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