Vurdere evnen til kombinasjonsbehandling med Venetoclax for å tillate tidsbegrenset terapi ved kronisk lymfatisk leukemi
11. november 2026 oppdatert av: National Cancer Institute (NCI)
En randomisert fase III-studie av tillegg av Venetoclax til Ibrutinib og Obinutuzumab versus Ibrutinib og Obinutuzumab hos ubehandlede yngre pasienter med kronisk lymfatisk leukemi (KLL)
This phase III trial studies how well ibrutinib and obinutuzumab with or without venetoclax work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Obinutuzumab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Giving ibrutinib, obinutuzumab, and venetoclax may work better than giving ibrutinib and obinutuzumab in treating patients with chronic lymphocytic leukemia.
Studieoversikt
Status
Aktiv, ikke rekrutterende
Detaljert beskrivelse
PRIMARY OBJECTIVE:
I. To compare the progression free survival (PFS) of the time limited administration of the three-drug combination ibrutinib-obinutuzumab-venetoclax (IOV) to ibrutinib-obinutuzumab (IO) in untreated chronic lymphocytic leukemia (CLL) patients younger than 70 years of age.
SECONDARY OBJECTIVES:
I. Evaluate overall survival (OS) of patients based on treatment arm. II. Monitor and assess toxicity of treatment based on treatment arm. III. Compare minimal residual disease (MRD) status as assessed by flow cytometry at baseline and then sequentially during treatment of the two treatment arms.
IV. Collect baseline and response evaluation (after cycle 19) bone marrow and paired blood specimens for evaluation of MRD.
QUALITY OF LIFE (QOL) OBJECTIVES:
I. To compare quality of life (QOL) in CLL patients during the first 19 cycles of treatment among patients on each treatment arm.
II. To compare QOL over the long-term in CLL patients receiving continuous therapy using ibrutinib to that of CLL patients who completed time limited therapy.
III. Evaluate adherence to therapy for the two arms (one of which requires more intense, but shorter duration treatment, and one of which requires less intense, but indefinite duration therapy) and explore how adherence in each arm relates to progression-free survival (PFS).
EXPLORATORY TOBACCO USE OBJECTIVES:
I. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications).
II. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms.
III. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization.
IV. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM A: Patients receive ibrutinib orally (PO) daily on days 1-28 and obinutuzumab intravenously (IV) over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO once daily (QD) on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and computed tomography (CT) scans before and after treatment and collection of blood throughout the study.
ARM B: Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study.
All patients, including those who discontinue therapy early, are followed for response until disease progression, even if non-protocol therapy is initiated. Patients are then followed every 3 months for first 2 years, every 6 months for years 3-5, and then every 12 months for years 6-10. All patients must also be followed through completion of all protocol therapy.
Studietype
Intervensjonell
Registrering (Antatt)
720
Fase
- Fase 3
Kontakter og plasseringer
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Studiesteder
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Alabama
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Birmingham, Alabama, Forente stater, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, Forente stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forente stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forente stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forente stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forente stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forente stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forente stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forente stater, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Forente stater, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, Forente stater, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Forente stater, 85054
- Mayo Clinic Hospital in Arizona
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Phoenix, Arizona, Forente stater, 85004
- Cancer Center at Saint Joseph's
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Scottsdale, Arizona, Forente stater, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, Forente stater, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, Forente stater, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Forente stater, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Fort Smith, Arkansas, Forente stater, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Forente stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Anaheim, California, Forente stater, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Forente stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Forente stater, 93420
- PCR Oncology
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Arroyo Grande, California, Forente stater, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Baldwin Park, California, Forente stater, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Forente stater, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, Forente stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Costa Mesa, California, Forente stater, 92627
- UC Irvine Health Cancer Center-Newport
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Duarte, California, Forente stater, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, Forente stater, 94568
- Kaiser Permanente Dublin
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Fontana, California, Forente stater, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Forente stater, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Forente stater, 93720
- Kaiser Permanente-Fresno
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Fresno, California, Forente stater, 93720
- Fresno Cancer Center
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Harbor City, California, Forente stater, 90710
- Kaiser Permanente South Bay
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Irvine, California, Forente stater, 92618
- Kaiser Permanente-Irvine
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Long Beach, California, Forente stater, 90822
- Tibor Rubin VA Medical Center
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Los Angeles, California, Forente stater, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Forente stater, 90034
- Kaiser Permanente West Los Angeles
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Modesto, California, Forente stater, 95356
- Kaiser Permanente-Modesto
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Oakland, California, Forente stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forente stater, 94611
- Kaiser Permanente Oakland-Broadway
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Ontario, California, Forente stater, 91761
- Kaiser Permanente-Ontario
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Orange, California, Forente stater, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Palm Springs, California, Forente stater, 92262
- Desert Regional Medical Center
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Palo Alto, California, Forente stater, 94304
- VA Palo Alto Health Care System
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Palo Alto, California, Forente stater, 94304
- Stanford Cancer Institute Palo Alto
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Panorama City, California, Forente stater, 91402
- Kaiser Permanente - Panorama City
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Rancho Cordova, California, Forente stater, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Redwood City, California, Forente stater, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Forente stater, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Forente stater, 92505
- Kaiser Permanente-Riverside
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Rohnert Park, California, Forente stater, 94928
- Rohnert Park Cancer Center
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Roseville, California, Forente stater, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, Forente stater, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, Forente stater, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Forente stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forente stater, 95823
- South Sacramento Cancer Center
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Sacramento, California, Forente stater, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Forente stater, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Forente stater, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, Forente stater, 94115
- Kaiser Permanente-San Francisco
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San Jose, California, Forente stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forente stater, 94577
- Kaiser Permanente San Leandro
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San Luis Obispo, California, Forente stater, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, Forente stater, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, Forente stater, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, Forente stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forente stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Maria, California, Forente stater, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Forente stater, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, Forente stater, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, Forente stater, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Forente stater, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, Forente stater, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Forente stater, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Forente stater, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Forente stater, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Forente stater, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Forente stater, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Forente stater, 80045
- Rocky Mountain Regional VA Medical Center
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Boulder, Colorado, Forente stater, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Forente stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Forente stater, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Forente stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forente stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Forente stater, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Forente stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forente stater, 80220
- Rose Medical Center
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Denver, Colorado, Forente stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forente stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forente stater, 80204
- Denver Health Medical Center
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Denver, Colorado, Forente stater, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Forente stater, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Forente stater, 80209
- The Women's Imaging Center
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Denver, Colorado, Forente stater, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Forente stater, 80220
- Western Surgical Care
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Denver, Colorado, Forente stater, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Forente stater, 80210
- AdventHealth Porter
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Durango, Colorado, Forente stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forente stater, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Forente stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Forente stater, 80113
- Swedish Medical Center
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Golden, Colorado, Forente stater, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, Forente stater, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Forente stater, 81501
- Saint Mary's Hospital and Regional Medical Center
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Grand Junction, Colorado, Forente stater, 81505
- Grand Valley Oncology
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Greeley, Colorado, Forente stater, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Forente stater, 80026
- Kaiser Permanente-Rock Creek
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Lafayette, Colorado, Forente stater, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, Forente stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, Forente stater, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Forente stater, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Forente stater, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Forente stater, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, Forente stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forente stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Forente stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forente stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forente stater, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Forente stater, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, Forente stater, 80138
- AdventHealth Parker
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Pueblo, Colorado, Forente stater, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Forente stater, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Forente stater, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Forente stater, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Forente stater, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Derby, Connecticut, Forente stater, 06418
- Smilow Cancer Hospital-Derby Care Center
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Fairfield, Connecticut, Forente stater, 06824
- Smilow Cancer Hospital Care Center-Fairfield
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Glastonbury, Connecticut, Forente stater, 06033
- Smilow Cancer Hospital Care Center at Glastonbury
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Guilford, Connecticut, Forente stater, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, Forente stater, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Haven, Connecticut, Forente stater, 06520
- Yale University
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North Haven, Connecticut, Forente stater, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, Forente stater, 06477
- Smilow Cancer Hospital-Orange Care Center
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Trumbull, Connecticut, Forente stater, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, Forente stater, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, Forente stater, 06385
- Smilow Cancer Hospital Care Center - Waterford
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West Haven, Connecticut, Forente stater, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Lewes, Delaware, Forente stater, 19958
- Beebe Medical Center
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Millville, Delaware, Forente stater, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Forente stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forente stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forente stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forente stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forente stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forente stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Forente stater, 19801
- Christiana Care Health System-Wilmington Hospital
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Florida
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Fort Lauderdale, Florida, Forente stater, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, Forente stater, 33308
- Holy Cross Hospital
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Jacksonville, Florida, Forente stater, 32224-9980
- Mayo Clinic in Florida
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Georgia
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Athens, Georgia, Forente stater, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Forente stater, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Forente stater, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Forente stater, 30342
- Emory Saint Joseph's Hospital
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Augusta, Georgia, Forente stater, 30912
- Augusta University Medical Center
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Decatur, Georgia, Forente stater, 30033
- Atlanta VA Medical Center
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Hawaii
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Hilo, Hawaii, Forente stater, 96720
- Island Urology-Hilo
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Honolulu, Hawaii, Forente stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forente stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forente stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forente stater, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Forente stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forente stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forente stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forente stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forente stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forente stater, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Forente stater, 96813
- Island Urology
-
Honolulu, Hawaii, Forente stater, 96819
- Kaiser Permanente Moanalua Medical Center
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Lihue, Hawaii, Forente stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Forente stater, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Forente stater, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Forente stater, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Forente stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Forente stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forente stater, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Forente stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Forente stater, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Forente stater, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Forente stater, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Forente stater, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Forente stater, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Forente stater, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Forente stater, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Forente stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Forente stater, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, Forente stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, Forente stater, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Forente stater, 61704
- Illinois CancerCare-Bloomington
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Burr Ridge, Illinois, Forente stater, 60527
- Loyola Center for Health at Burr Ridge
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Canton, Illinois, Forente stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forente stater, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Forente stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forente stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forente stater, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, Forente stater, 60611
- Northwestern University
-
Chicago, Illinois, Forente stater, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Forente stater, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, Forente stater, 61832
- Carle at The Riverfront
-
DeKalb, Illinois, Forente stater, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Forente stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forente stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Forente stater, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, Forente stater, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Forente stater, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, Forente stater, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Forente stater, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Forente stater, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Forente stater, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Forente stater, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Forente stater, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Harvey, Illinois, Forente stater, 60426
- Ingalls Memorial Hospital
-
Highland Park, Illinois, Forente stater, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Homer Glen, Illinois, Forente stater, 60491
- Loyola Medicine Homer Glen
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Kewanee, Illinois, Forente stater, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, Forente stater, 60045
- Northwestern Medicine Lake Forest Hospital
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Macomb, Illinois, Forente stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forente stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Forente stater, 60153
- Loyola University Medical Center
-
Melrose Park, Illinois, Forente stater, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
-
Mount Vernon, Illinois, Forente stater, 62864
- SSM Health Good Samaritan
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New Lenox, Illinois, Forente stater, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, Forente stater, 62269
- Cancer Care Center of O'Fallon
-
Orland Park, Illinois, Forente stater, 60462
- University of Chicago Medicine-Orland Park
-
Ottawa, Illinois, Forente stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, Forente stater, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Forente stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Forente stater, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forente stater, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Forente stater, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Forente stater, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Forente stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forente stater, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Forente stater, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, Forente stater, 61114
- UW Health Carbone Cancer Center Rockford
-
Skokie, Illinois, Forente stater, 60076
- North Shore Medical Center
-
Springfield, Illinois, Forente stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forente stater, 62702
- Springfield Clinic
-
Springfield, Illinois, Forente stater, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Forente stater, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Forente stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forente stater, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Forente stater, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, Forente stater, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Fort Wayne, Indiana, Forente stater, 46845
- Parkview Regional Medical Center
-
Indianapolis, Indiana, Forente stater, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Forente stater, 46219
- Community Cancer Center East
-
Indianapolis, Indiana, Forente stater, 46227
- Community Cancer Center South
-
Indianapolis, Indiana, Forente stater, 46256
- Community Cancer Center North
-
Kokomo, Indiana, Forente stater, 46904
- Community Howard Regional Health
-
Mooresville, Indiana, Forente stater, 46158
- Franciscan Health Mooresville
-
Richmond, Indiana, Forente stater, 47374
- Reid Health
-
Terre Haute, Indiana, Forente stater, 47804
- Union Hospital
-
-
Iowa
-
Ames, Iowa, Forente stater, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Forente stater, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, Forente stater, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, Forente stater, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Forente stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forente stater, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Forente stater, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, Forente stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forente stater, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Forente stater, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Forente stater, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Forente stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forente stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forente stater, 50309
- Blank Children's Hospital
-
Des Moines, Iowa, Forente stater, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Forente stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forente stater, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Forente stater, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Forente stater, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, Forente stater, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Iowa City, Iowa, Forente stater, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, Forente stater, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Forente stater, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Forente stater, 51101
- Siouxland Regional Cancer Center
-
Waterloo, Iowa, Forente stater, 50702
- MercyOne Waterloo Cancer Center
-
West Des Moines, Iowa, Forente stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forente stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Coffeyville, Kansas, Forente stater, 67337
- Coffeyville Regional Medical Center
-
Garden City, Kansas, Forente stater, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Forente stater, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Forente stater, 67601
- HaysMed
-
Independence, Kansas, Forente stater, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Forente stater, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Forente stater, 66112
- University of Kansas Cancer Center-West
-
Lawrence, Kansas, Forente stater, 66044
- Lawrence Memorial Hospital
-
Olathe, Kansas, Forente stater, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Forente stater, 66210
- University of Kansas Cancer Center-Overland Park
-
Pittsburg, Kansas, Forente stater, 66762
- Mercy Hospital Pittsburg
-
Salina, Kansas, Forente stater, 67401
- Salina Regional Health Center
-
Topeka, Kansas, Forente stater, 66606
- University of Kansas Health System Saint Francis Campus
-
Westwood, Kansas, Forente stater, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Forente stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forente stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forente stater, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Forente stater, 67214
- Wesley Medical Center
-
-
Kentucky
-
Bardstown, Kentucky, Forente stater, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Forente stater, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Forente stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forente stater, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Forente stater, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Forente stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forente stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forente stater, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Forente stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forente stater, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Forente stater, 70836
- Ochsner High Grove
-
New Orleans, Louisiana, Forente stater, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Augusta, Maine, Forente stater, 04330
- Harold Alfond Center for Cancer Care
-
Belfast, Maine, Forente stater, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Forente stater, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Norway, Maine, Forente stater, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, Forente stater, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Forente stater, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Forente stater, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Cumberland, Maryland, Forente stater, 21502
- UPMC Western Maryland
-
-
Massachusetts
-
Boston, Massachusetts, Forente stater, 02111
- Tufts Medical Center
-
Burlington, Massachusetts, Forente stater, 01805
- Lahey Clinic
-
Lowell, Massachusetts, Forente stater, 01854
- Lowell General Hospital
-
Springfield, Massachusetts, Forente stater, 01104
- Mercy Medical Center
-
-
Michigan
-
Adrian, Michigan, Forente stater, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Forente stater, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Brighton, Michigan, Forente stater, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Forente stater, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Forente stater, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Forente stater, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Forente stater, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Forente stater, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Forente stater, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Forente stater, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Forente stater, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Forente stater, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, Forente stater, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Forente stater, 48126
- Henry Ford Medical Center-Fairlane
-
Dearborn, Michigan, Forente stater, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Forente stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forente stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Forente stater, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Forente stater, 48054
- Henry Ford River District Hospital
-
Escanaba, Michigan, Forente stater, 49829
- OSF Saint Francis Hospital and Medical Group
-
Farmington Hills, Michigan, Forente stater, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Forente stater, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Forente stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forente stater, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Forente stater, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Forente stater, 48503
- Cancer Hematology Centers - Flint
-
Grosse Pointe Woods, Michigan, Forente stater, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Forente stater, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Forente stater, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, Forente stater, 49201
- Allegiance Health
-
Lansing, Michigan, Forente stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forente stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Forente stater, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Forente stater, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Forente stater, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Forente stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, Forente stater, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Novi, Michigan, Forente stater, 48377
- Henry Ford Medical Center-Columbus
-
Pontiac, Michigan, Forente stater, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Forente stater, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Forente stater, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Forente stater, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron, Michigan, Forente stater, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Forente stater, 48060
- Huron Medical Center PC
-
Rochester Hills, Michigan, Forente stater, 48309
- Henry Ford Rochester Hospital
-
Royal Oak, Michigan, Forente stater, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Forente stater, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Forente stater, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Forente stater, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Forente stater, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Forente stater, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Forente stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Forente stater, 48601
- MyMichigan Medical Center Saginaw
-
Shelby, Michigan, Forente stater, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Sterling Heights, Michigan, Forente stater, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights, Michigan, Forente stater, 48312
- Premier Hematology Oncology Care
-
Tawas City, Michigan, Forente stater, 48764
- MyMichigan Medical Center Tawas
-
Troy, Michigan, Forente stater, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Forente stater, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Forente stater, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Forente stater, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Forente stater, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Forente stater, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Forente stater, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Forente stater, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield, Michigan, Forente stater, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, Forente stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Ypsilanti, Michigan, Forente stater, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Forente stater, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Forente stater, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Forente stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forente stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forente stater, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Forente stater, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Forente stater, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Forente stater, 55433
- Mercy Hospital
-
Deer River, Minnesota, Forente stater, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Forente stater, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forente stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forente stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forente stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Forente stater, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Forente stater, 55432
- Unity Hospital
-
Hibbing, Minnesota, Forente stater, 55746
- Essentia Health Hibbing Clinic
-
Mankato, Minnesota, Forente stater, 56001
- Mayo Clinic Health Systems-Mankato
-
Maple Grove, Minnesota, Forente stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forente stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forente stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forente stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forente stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forente stater, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Forente stater, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Forente stater, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Forente stater, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Forente stater, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Forente stater, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Forente stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forente stater, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Forente stater, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Forente stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forente stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forente stater, 55102
- United Hospital
-
Sandstone, Minnesota, Forente stater, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Forente stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forente stater, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Forente stater, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Forente stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forente stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forente stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forente stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Forente stater, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Forente stater, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Hattiesburg, Mississippi, Forente stater, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, Forente stater, 39404
- Forrest General Hospital / Cancer Center
-
-
Missouri
-
Ballwin, Missouri, Forente stater, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Forente stater, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Forente stater, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Forente stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forente stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forente stater, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Forente stater, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, Forente stater, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Columbia, Missouri, Forente stater, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, Forente stater, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Forente stater, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Forente stater, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Forente stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forente stater, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Forente stater, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Forente stater, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Forente stater, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Forente stater, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, Forente stater, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Rolla, Missouri, Forente stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Forente stater, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Forente stater, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Forente stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forente stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forente stater, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Forente stater, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Forente stater, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Forente stater, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Forente stater, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Forente stater, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Forente stater, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Forente stater, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Forente stater, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, Forente stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Forente stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forente stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forente stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forente stater, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Forente stater, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Forente stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forente stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forente stater, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Forente stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forente stater, 59901
- Logan Health Medical Center
-
Missoula, Montana, Forente stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forente stater, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Forente stater, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Forente stater, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Forente stater, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Forente stater, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Forente stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forente stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forente stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forente stater, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Forente stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Forente stater, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Forente stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forente stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forente stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forente stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forente stater, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Forente stater, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Forente stater, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Forente stater, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Forente stater, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Forente stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forente stater, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Forente stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forente stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forente stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forente stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forente stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forente stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forente stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forente stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forente stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forente stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forente stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forente stater, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Forente stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forente stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forente stater, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Forente stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forente stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forente stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Forente stater, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Forente stater, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Forente stater, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Forente stater, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Forente stater, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Forente stater, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Forente stater, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Forente stater, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Forente stater, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Forente stater, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Forente stater, 89169
- University Cancer Center
-
Las Vegas, Nevada, Forente stater, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Forente stater, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Forente stater, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Forente stater, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Forente stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forente stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forente stater, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, Forente stater, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Manchester, New Hampshire, Forente stater, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, Forente stater, 03103
- Elliot Hospital
-
-
New Jersey
-
Brick, New Jersey, Forente stater, 08724
- Ocean University Medical Center
-
Lakewood, New Jersey, Forente stater, 08701
- Monmouth Medical Center Southern Campus
-
Long Branch, New Jersey, Forente stater, 07740
- Monmouth Medical Center
-
Manahawkin, New Jersey, Forente stater, 08050
- Southern Ocean County Medical Center
-
Morristown, New Jersey, Forente stater, 07960
- Morristown Medical Center
-
Neptune City, New Jersey, Forente stater, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, Forente stater, 08903
- Rutgers Cancer Institute of New Jersey
-
Red Bank, New Jersey, Forente stater, 07701
- Riverview Medical Center/Booker Cancer Center
-
Summit, New Jersey, Forente stater, 07902
- Overlook Hospital
-
-
New Mexico
-
Albuquerque, New Mexico, Forente stater, 87106
- University of New Mexico Cancer Center
-
Las Cruces, New Mexico, Forente stater, 88011
- Memorial Medical Center-Las Cruces
-
-
New York
-
Auburn, New York, Forente stater, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Buffalo, New York, Forente stater, 14263
- Roswell Park Cancer Institute
-
Camillus, New York, Forente stater, 13031
- Hematology Oncology Associates of CNY at Camillus
-
East Hills, New York, Forente stater, 11548
- The Cancer Institute at Saint Francis Hospital
-
East Syracuse, New York, Forente stater, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, Forente stater, 12801
- Glens Falls Hospital
-
Mineola, New York, Forente stater, 11501
- NYU Langone Hospital - Long Island
-
New York, New York, Forente stater, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Forente stater, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Rochester, New York, Forente stater, 14642
- University of Rochester
-
Syracuse, New York, Forente stater, 13210
- State University of New York Upstate Medical University
-
West Islip, New York, Forente stater, 11795
- Good Samaritan University Hospital
-
-
North Carolina
-
Asheville, North Carolina, Forente stater, 28801
- Mission Hospital
-
Asheville, North Carolina, Forente stater, 28806
- Messino Cancer Centers
-
Cary, North Carolina, Forente stater, 27518
- Waverly Hematology Oncology
-
Chapel Hill, North Carolina, Forente stater, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Forente stater, 28328
- Southeastern Medical Oncology Center-Clinton
-
Durham, North Carolina, Forente stater, 27710
- Duke University Medical Center
-
Goldsboro, North Carolina, Forente stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forente stater, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, Forente stater, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, Forente stater, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Forente stater, 28546
- Onslow Memorial Hospital
-
Pinehurst, North Carolina, Forente stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
-
North Dakota
-
Bismarck, North Dakota, Forente stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forente stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Forente stater, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Forente stater, 58104
- Sanford Medical Center Fargo
-
Jamestown, North Dakota, Forente stater, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, Forente stater, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beavercreek, Ohio, Forente stater, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Forente stater, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Forente stater, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Forente stater, 44708
- Cleveland Clinic Mercy Hospital
-
Centerville, Ohio, Forente stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forente stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Forente stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forente stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forente stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forente stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forente stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forente stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forente stater, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Forente stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forente stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Forente stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forente stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forente stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forente stater, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Forente stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forente stater, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Forente stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forente stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forente stater, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Forente stater, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Forente stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forente stater, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Forente stater, 43016
- Dublin Methodist Hospital
-
Findlay, Ohio, Forente stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forente stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forente stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forente stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forente stater, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Forente stater, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Forente stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forente stater, 45331
- Dayton Physicians LLC-Wayne
-
Grove City, Ohio, Forente stater, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, Forente stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forente stater, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Forente stater, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Forente stater, 43130
- Fairfield Medical Center
-
Mansfield, Ohio, Forente stater, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Forente stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forente stater, 43302
- OhioHealth Marion General Hospital
-
Mount Vernon, Ohio, Forente stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forente stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forente stater, 43055
- Newark Radiation Oncology
-
Perrysburg, Ohio, Forente stater, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Forente stater, 45662
- Southern Ohio Medical Center
-
Springfield, Ohio, Forente stater, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Forente stater, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Forente stater, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Forente stater, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Forente stater, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Forente stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Troy, Ohio, Forente stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forente stater, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Forente stater, 44484
- Saint Joseph Warren Hospital
-
Westerville, Ohio, Forente stater, 43081
- Saint Ann's Hospital
-
Wright-Patterson Air Force Base, Ohio, Forente stater, 45433
- Wright-Patterson Medical Center
-
Youngstown, Ohio, Forente stater, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Forente stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forente stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forente stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forente stater, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Forente stater, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Forente stater, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Forente stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forente stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forente stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forente stater, 97420
- Bay Area Hospital
-
Newberg, Oregon, Forente stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forente stater, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Portland, Oregon, Forente stater, 97239
- Oregon Health and Science University
-
Portland, Oregon, Forente stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forente stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forente stater, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, Forente stater, 97756
- Saint Charles Health System-Redmond
-
Salem, Oregon, Forente stater, 97301
- Salem Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forente stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Forente stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Forente stater, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, Forente stater, 19317
- Christiana Care Health System-Concord Health Center
-
Chambersburg, Pennsylvania, Forente stater, 17201
- Chambersburg Hospital
-
Collegeville, Pennsylvania, Forente stater, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, Forente stater, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Forente stater, 18301
- Pocono Medical Center
-
Ephrata, Pennsylvania, Forente stater, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Forente stater, 17522
- Ephrata Community Hospital
-
Exton, Pennsylvania, Forente stater, 19341
- Main Line Health Center-Exton
-
Gettysburg, Pennsylvania, Forente stater, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, Forente stater, 17331
- WellSpan Medical Oncology and Hematology
-
Hazleton, Pennsylvania, Forente stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Forente stater, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, Forente stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lebanon, Pennsylvania, Forente stater, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, Forente stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Forente stater, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Forente stater, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Forente stater, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19107
- Thomas Jefferson University Hospital
-
Pottstown, Pennsylvania, Forente stater, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, Forente stater, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Forente stater, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Forente stater, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, Forente stater, 16801
- Geisinger Medical Group
-
Wilkes-Barre, Pennsylvania, Forente stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove, Pennsylvania, Forente stater, 19090
- Asplundh Cancer Pavilion
-
Wynnewood, Pennsylvania, Forente stater, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Forente stater, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, Forente stater, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Westerly, Rhode Island, Forente stater, 02891
- Smilow Cancer Hospital Care Center - Westerly
-
-
South Carolina
-
Boiling Springs, South Carolina, Forente stater, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Forente stater, 29425
- Medical University of South Carolina
-
Clinton, South Carolina, Forente stater, 29325
- Prisma Health Cancer Institute - Laurens
-
Easley, South Carolina, Forente stater, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Forente stater, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forente stater, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Forente stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Forente stater, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Forente stater, 29605
- BI-LO Charities Children's Cancer Center
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenwood, South Carolina, Forente stater, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Forente stater, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Forente stater, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Forente stater, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Forente stater, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Forente stater, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, Forente stater, 57401
- Avera Cancer Institute-Aberdeen
-
Pierre, South Dakota, Forente stater, 57501
- Avera Cancer Institute at Pierre
-
Sioux Falls, South Dakota, Forente stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forente stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forente stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Forente stater, 37404
- Memorial Hospital
-
Hixson, Tennessee, Forente stater, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Ooltewah, Tennessee, Forente stater, 37363
- Memorial GYN Plus
-
-
Texas
-
Amarillo, Texas, Forente stater, 79106
- The Don and Sybil Harrington Cancer Center
-
Bryan, Texas, Forente stater, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Forente stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, Forente stater, 75216
- Dallas VA Medical Center
-
Richardson, Texas, Forente stater, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, Forente stater, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Forente stater, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Forente stater, 84321
- Logan Regional Hospital
-
Murray, Utah, Forente stater, 84107
- Intermountain Medical Center
-
Ogden, Utah, Forente stater, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Forente stater, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Forente stater, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Forente stater, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Forente stater, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Forente stater, 84143
- LDS Hospital
-
St. George, Utah, Forente stater, 84770
- Saint George Regional Medical Center
-
-
Virginia
-
Charlottesville, Virginia, Forente stater, 22908
- University of Virginia Cancer Center
-
Fairfax, Virginia, Forente stater, 22031
- Inova Schar Cancer Institute
-
Falls Church, Virginia, Forente stater, 22042
- Inova Fairfax Hospital
-
Lynchburg, Virginia, Forente stater, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Richmond, Virginia, Forente stater, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Forente stater, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Forente stater, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, Forente stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Forente stater, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Forente stater, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Forente stater, 98004
- Overlake Medical Center
-
Bellingham, Washington, Forente stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Forente stater, 98166
- Saint Anne Hospital
-
Centralia, Washington, Forente stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forente stater, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Forente stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forente stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forente stater, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Forente stater, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Forente stater, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Forente stater, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Forente stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forente stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Kennewick, Washington, Forente stater, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Forente stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forente stater, 98499
- Saint Clare Hospital
-
Longview, Washington, Forente stater, 98632
- PeaceHealth Saint John Medical Center
-
Lynnwood, Washington, Forente stater, 98036
- Virginia Mason Lynnwood Medical Center
-
Port Townsend, Washington, Forente stater, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Forente stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Forente stater, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Forente stater, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Renton, Washington, Forente stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forente stater, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Forente stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forente stater, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forente stater, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Forente stater, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Forente stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forente stater, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Seattle, Washington, Forente stater, 98109
- Fred Hutchinson Cancer Center
-
Seattle, Washington, Forente stater, 98133
- FHCC at Northwest Hospital
-
Sedro-Woolley, Washington, Forente stater, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Forente stater, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Forente stater, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Forente stater, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Forente stater, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Forente stater, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Forente stater, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Forente stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forente stater, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Forente stater, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Forente stater, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Forente stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Forente stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forente stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forente stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Forente stater, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Charleston, West Virginia, Forente stater, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
-
Wisconsin
-
Antigo, Wisconsin, Forente stater, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Forente stater, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, Forente stater, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Forente stater, 54806
- Northwest Wisconsin Cancer Center
-
Brookfield, Wisconsin, Forente stater, 53045
- Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
-
Burlington, Wisconsin, Forente stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Forente stater, 54729
- Marshfield Clinic-Chippewa Center
-
Cudahy, Wisconsin, Forente stater, 53110
- Aurora Saint Luke's South Shore
-
Eau Claire, Wisconsin, Forente stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Forente stater, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Forente stater, 54701
- Mayo Clinic Health System-Eau Claire Clinic
-
Fond du Lac, Wisconsin, Forente stater, 54937
- Aurora Health Center-Fond du Lac
-
Franklin, Wisconsin, Forente stater, 53132
- Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
-
Germantown, Wisconsin, Forente stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forente stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forente stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forente stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forente stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Forente stater, 54301
- Bellin Memorial Hospital
-
Kenosha, Wisconsin, Forente stater, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Forente stater, 54601
- Gundersen Lutheran Medical Center
-
La Crosse, Wisconsin, Forente stater, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
Ladysmith, Wisconsin, Forente stater, 54848
- Marshfield Medical Center - Ladysmith
-
Madison, Wisconsin, Forente stater, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Forente stater, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, Forente stater, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Forente stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Forente stater, 54143
- Saint Vincent Hospital Cancer Center at Marinette
-
Marshfield, Wisconsin, Forente stater, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Forente stater, 54451
- Aspirus Medford Hospital
-
Mequon, Wisconsin, Forente stater, 53097
- Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
-
Milwaukee, Wisconsin, Forente stater, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Forente stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forente stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forente stater, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Forente stater, 53211
- Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
-
Minocqua, Wisconsin, Forente stater, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Forente stater, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Forente stater, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Forente stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Forente stater, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Forente stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forente stater, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, Forente stater, 53405
- Ascension All Saints Hospital-Spring Street-Racine
-
Rice Lake, Wisconsin, Forente stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forente stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Forente stater, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Forente stater, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Forente stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Forente stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forente stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forente stater, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Forente stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Forente stater, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, Forente stater, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, Forente stater, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, Forente stater, 53226
- Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
-
West Allis, Wisconsin, Forente stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forente stater, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Forente stater, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Forente stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cheyenne, Wyoming, Forente stater, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Forente stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forente stater, 82801
- Welch Cancer Center
-
-
-
-
-
Jerusalem, Israel, 91031
- Shaare Zedek Medical Center
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år til 69 år (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inclusion Criteria:
-
Diagnosis of CLL according to the National Cancer Institute (NCI)/International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria or small lymphocytic lymphoma (SLL) according to the World Health Organization (WHO) criteria. This includes previous documentation of:
-
Biopsy-proven small lymphocytic lymphoma OR
-
Diagnosis of CLL according to the NCI/IWCLL criteria as evidenced by all of the following:
-
Peripheral blood lymphocyte count of greater than 5 x10^9/L
-
Immunophenotype consistent with CLL defined as:
- The predominant population of lymphocytes share both B-cell antigens (CD19, CD20 [typically dim expression], or CD23) as well as CD5 in the absence of other pan-T-cell markers (CD3, CD2, etc).
- Clonality as evidenced by kappa or lambda light chain restriction (typically dim immunoglobulin expression)
-
-
Negative fluorescent in situ hybridization (FISH) analysis for t(11;14)(IgH/CCND1) on peripheral blood or tissue biopsy (e.g. marrow aspirate) or negative immunohistochemical stains for cyclin D1 staining on involved tissue biopsy (e.g. marrow aspirate or lymph node biopsy)
-
-
No prior chemotherapy, BTK inhibitor therapy, venetoclax, small molecule signaling inhibitor, or monoclonal anti-body therapy for treatment of CLL or SLL
-
Has met at least one of the following indications for treatment:
-
Evidence of progressive marrow failure as manifested by the development of worsening anemia (hemoglobin [Hg] < 11 g/dl) and/or thrombocytopenia (platelets < 100 x 10^9/L)
-
Symptomatic or progressive lymphadenopathy, splenomegaly, or hepatomegaly
-
One or more of the following disease-related symptoms:
- Weight loss >= 10% within the previous 6 months
- Grade 2 or 3 fatigue attributed to CLL
- Fevers > 100.5 degree Fahrenheit (F) for 2 weeks without evidence of infection
- Clinically significant night sweats without evidence of infection
-
Progressive lymphocytosis (not due to the effects of corticosteroids) with an increase of > 50% over a two-month period or an anticipated doubling time of less than six months
-
-
Age >= 18 years and < 70
-
Eastern Cooperative Oncology Group (ECOG) performance status between 0-2
-
Life expectancy of >= 12 months
-
No deletion of 17p13 on cytogenetic analysis by FISH
-
Glomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault Formula (obtained =< 14 days prior to registration)
-
Total bilirubin =< 1.5 x upper limit of normal (ULN) unless due to Gilbert's disease. For those with a total bilirubin > 1.5 x ULN, a direct bilirubin should be performed and must be < 1.5 mg/dL for Gilbert's to be diagnosed (obtained =< 14 days prior to registration)
-
Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST])/serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 3.0 x the institutional ULN (obtained =< 14 days prior to registration)
- NOTE: If value is higher due to hepatic involvement by CLL, patient is eligible
-
Prothrombin time (PT)/international normalized ratio (INR) < 1.5 ULN and partial thromboplastin time (PTT) (activated partial thromboplastin time [aPTT]) < 1.5 x ULN (obtained =< 14 days prior to registration)
-
No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment. Patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation
-
No current use of corticosteroids. EXCEPTION: Low doses of steroids (< 10 mg of prednisone or equivalent dose of other steroid; inhaled steroids) used for treatment of non-hematologic medical condition (e.g. chronic adrenal insufficiency) is permitted
-
No previous autoimmune complications (e.g. autoimmune hemolytic anemia or immune thrombocytopenia) that have developed since the initial diagnosis of CLL and have required treatment with high dose corticosteroids (e.g. equivalent of > 20 mg/day of prednisone), monoclonal antibody based therapy, or chemotherapy. Prior use of corticosteroids for reasons other than treatment of autoimmune complications is allowed
-
No other active primary malignancy (other than non-melanomatous skin cancer or carcinoma in situ of the cervix) requiring treatment or limiting expected survival to =< 2 years
- NOTE: If there is a history of prior malignancy, the patient must not currently be receiving other specific treatment (other than hormonal therapy for their cancer)
-
Able to adhere to the study visit schedule and other protocol requirements
-
No major surgery within 4 weeks (28 days) of first dose of study drug or minor surgery within 3 days of first dose of study drug
-
No radiation therapy =< 4 weeks prior to registration to Step 1
-
Patients who are human immunodeficiency virus positive (HIV+) with undetectable HIV viral load are eligible provided they meet all other protocol criteria for participation and are not being treated with protease inhibitors or any non-nucleoside reverse transcriptase inhibitors (NNRTI) that are CYP3A4 inducers; if being treated for HIV, patients should be receiving an alternative antiretroviral therapy (ART) that is not a CYP3A inhibitor
-
Patients must not have any of the following conditions:
- Congestive heart failure or New York Heart Association Functional Classification III or IV congestive heart failure
- History of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to registration
- Recent infections requiring systemic treatment; need to have completed anti-biotic therapy > 14 days before the first dose of study drug
- Cerebral vascular accident or intracranial bleed within the last 6 months
- Infection with known chronic, active hepatitis C
- Positive serology for hepatitis B defined as a positive test for hepatitis B surface antigen (HBsAg); in addition, if negative for HBsAg but hepatitis B core antibody (HBcAb) positive (regardless of hepatitis B surface antibody [HBsAb] status), a hepatitis B deoxyribonucleic acid (DNA) test will be performed and, if positive the subject will be ineligible; if the hepatitis (Hep) B DNA test is negative (i.e. viral load undetectable) then the individual is eligible; if a patient who is HBsAg negative, HBsAb negative, HBcAb positive, and Hep B DNA negative is enrolled, they should be considered for either prophylactic anti-viral therapy (J Clin Oncol. 2013 Aug 1;31(22):2765-72) or careful monitoring for Hep B reactivation (J Clin Oncol. 2014 Nov 20;32(33):3736-43)
-
Patients are not eligible if they require treatment with a strong cytochrome P450 (CYP) 3A inhibitor
-
Patients may not have received the following within 7 days prior to the first dose of study drug:
- Steroid therapy for anti-neoplastic intent
- Strong and moderate CYP3A inhibitors
- Strong and moderate CYP3A inducers
-
Patients may not be on any other investigational agents
-
Patients may not have received warfarin or another vitamin K antagonist in the preceding 30 days
-
Women must not be pregnant or breast-feeding since this study involves investigational agents whose genotoxic, mutagenic, and teratogenic effects on the developing fetus and newborn are unknown.
- All females of childbearing potential must have a blood test within 2 weeks prior to registration to Step 1 to rule out pregnancy. A patient of childbearing potential someone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
Women of childbearing potential and sexually active males must be strongly advised to use accepted and highly effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for:
- 18 months after the last dose of obinutuzumab
- 90 days after the last dose of ibrutinib, and
- 30 days after the last dose of venetoclax Male subjects must also agree to refrain from sperm donation until 90 days after the last dose of protocol treatment
-
Patient must be able to swallow capsules and not have the following conditions:
- Disease significantly affecting gastrointestinal function
- Resection of the stomach or small bowel
- Symptomatic inflammatory bowel disease
- Ulcerative colitis
- Partial or complete bowel obstruction
-
Patient must not be on any other systemic immunosuppressant therapy other than corticosteroids within 28 days of the first dose of study drug
-
Patient must not be vaccinated with live, attenuated vaccines within 4 weeks of first dose of study drug
-
Patient must not have any known bleeding disorders (e.g., von Willebrand's disease) or hemophilia
-
Patient must not have currently active, clinically significant hepatic impairment (>= moderate hepatic impairment according to the NCI/Child Pugh classification)
-
Patient must undergo assessment with Timed Up and Go (TUG) test and comorbidity index
-
Patient must be able to receive xanthine oxidase inhibitor or rasburicase for tumor lysis syndrome (TLS) prophylaxis
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Arm A (ibrutinib, obinutuzumab, venetoclax)
Patients receive ibrutinib PO daily on days 1-28 and obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study. |
Ancillary studies
Andre navn:
Undergo CT
Andre navn:
Given PO
Andre navn:
Undergo collection of blood
Andre navn:
Given PO
Andre navn:
Given IV
Andre navn:
Undergo biopsy
Andre navn:
|
|
Aktiv komparator: Arm B (ibrutinib, obinutuzumab)
Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study. |
Ancillary studies
Andre navn:
Undergo CT
Andre navn:
Given PO
Andre navn:
Undergo collection of blood
Andre navn:
Given IV
Andre navn:
Undergo biopsy
Andre navn:
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Progression-free survival
Tidsramme: Time from randomization to progression or death without documented progression, assessed up to 10 years
|
The analysis will be performed using the repeated confidence intervals methodology. At each interim or final analysis, two-sided repeated confidence interval will be constructed using the partial likelihood estimate from stratified Cox proportional hazards model and the critical value based on the Lan-DeMets error-spending function that corresponds to the truncated O'brien-Fleming boundaries. |
Time from randomization to progression or death without documented progression, assessed up to 10 years
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Overall survival
Tidsramme: Time from randomization to death due to any cause, assessed up to 10 years
|
A hierarchical testing strategy will be used. The analysis will be performed using the repeated confidence intervals methodology. At each interim or final analysis, two-sided repeated confidence interval will be constructed using the partial likelihood estimate from stratified Cox proportional hazards model and the critical value based on the Lan-DeMets error-spending function that corresponds to the truncated O'brien-Fleming boundaries. |
Time from randomization to death due to any cause, assessed up to 10 years
|
|
Incidence of adverse events
Tidsramme: Up to 10 years
|
Graded according to Common Terminology Criteria for Adverse Events version 5.0. |
Up to 10 years
|
Andre resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Minimal residual sykdom (MRD) analyse
Tidsramme: Inntil 10 år
|
Inntil 10 år
|
|
|
Quality of life (QOL)
Tidsramme: Baseline up to 10 years
|
Assessed using Functional Assessment of Cancer Therapy-General (FACT-G) and the leukemia sub-scale. FACT-G and the leukemia subscale will be analyzed at randomization, on day 1 of cycles 3, 7, 15, at the end of cycle 19, every 6 months for 2 years post response evaluation, at 48 months after randomization and at the time of disease progression. Linear mixed effects models will be used to perform repeated measures regression analysis. Will compare treatment toxicity-related QOL between the two arms. The entire FACT-Leukemia instrument (FACT-G and the leukemia subscale) at baseline will be analyzed using descriptive statistics to assess the impact of CLL on QOL independent of treatment. |
Baseline up to 10 years
|
|
FACT-Leu Trial Outcome Index (TOI) score over time
Tidsramme: Baseline up to 10 years
|
Will use linear mixed effects models will be used to perform repeated measures regression analysis to examine the treatment effect and time effect on FACT-Leu TOI score. |
Baseline up to 10 years
|
|
Adherence
Tidsramme: Baseline up to 10 years
|
Defined as patients taking 80% or more of their prescribed doses. The ASK-12 Survey will be used to measure the likelihood that a patient will take prescribed medications for patients on both arms at baseline and on day 1 +/- 4 days of the following cycles 3, 7, 15, at the time of response evaluation (end of cycle 19), every 6 months for 2 years post response evaluation, at 48 months after randomization, and at time of disease progression. Descriptive statistics will be used to summarize trend in adherence to prescription. |
Baseline up to 10 years
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Etterforskere
- Hovedetterforsker: Tait D Shanafelt, ECOG-ACRIN Cancer Research Group
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
12. februar 2019
Primær fullføring (Antatt)
7. mai 2028
Studiet fullført (Antatt)
7. mai 2028
Datoer for studieregistrering
Først innsendt
8. oktober 2018
Først innsendt som oppfylte QC-kriteriene
8. oktober 2018
Først lagt ut (Faktiske)
10. oktober 2018
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
12. november 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
11. november 2026
Sist bekreftet
1. juli 2026
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Patologiske prosesser
- Neoplasmer
- Kronisk sykdom
- Sykdomsattributter
- Sykdommer i immunsystemet
- Neoplasmer etter histologisk type
- Hematologiske sykdommer
- Lymfesykdommer
- Lymfoproliferative lidelser
- Immunproliferative lidelser
- Leukemi, B-celle
- Leukemi, lymfoid
- Leukemi
- Patologiske tilstander, tegn og symptomer
- Hemic og lymfatiske sykdommer
- Leukemi, lymfatisk, kronisk, B-celle
- Undersøkelsesteknikker
- Kliniske laboratorieteknikker
- Diagnostiske teknikker og prosedyrer
- Diagnose
- Kirurgiske prosedyrer, operativ
- Cytologiske teknikker
- Cytodiagnose
- Diagnostiske teknikker, kirurgisk
- Biopsi
- Prøvehåndtering
- Venetoclax
- Obinutuzumab
- Ibrutinib
Andre studie-ID-numre
- NCI-2018-02127
- U10CA180820 (U.S. NIH-stipend/kontrakt)
- NCI-2018-02127 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
- EA9161 (Annen identifikator: CTEP)
- EA9161 (Annen identifikator: ECOG-ACRIN Cancer Research Group)
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
JA
IPD-planbeskrivelse
NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Ja
Studerer et amerikansk FDA-regulert enhetsprodukt
Nei
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .