Beoordeling van het vermogen van combinatiebehandeling met Venetoclax om in de tijd beperkte therapie mogelijk te maken bij chronische lymfatische leukemie
11 november 2026 bijgewerkt door: National Cancer Institute (NCI)
Een gerandomiseerde fase III-studie van de toevoeging van venetoclax aan ibrutinib en obinutuzumab versus ibrutinib en obinutuzumab bij onbehandelde jongere patiënten met chronische lymfatische leukemie (CLL)
This phase III trial studies how well ibrutinib and obinutuzumab with or without venetoclax work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Obinutuzumab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Giving ibrutinib, obinutuzumab, and venetoclax may work better than giving ibrutinib and obinutuzumab in treating patients with chronic lymphocytic leukemia.
Studie Overzicht
Toestand
Actief, niet wervend
Gedetailleerde beschrijving
PRIMARY OBJECTIVE:
I. To compare the progression free survival (PFS) of the time limited administration of the three-drug combination ibrutinib-obinutuzumab-venetoclax (IOV) to ibrutinib-obinutuzumab (IO) in untreated chronic lymphocytic leukemia (CLL) patients younger than 70 years of age.
SECONDARY OBJECTIVES:
I. Evaluate overall survival (OS) of patients based on treatment arm. II. Monitor and assess toxicity of treatment based on treatment arm. III. Compare minimal residual disease (MRD) status as assessed by flow cytometry at baseline and then sequentially during treatment of the two treatment arms.
IV. Collect baseline and response evaluation (after cycle 19) bone marrow and paired blood specimens for evaluation of MRD.
QUALITY OF LIFE (QOL) OBJECTIVES:
I. To compare quality of life (QOL) in CLL patients during the first 19 cycles of treatment among patients on each treatment arm.
II. To compare QOL over the long-term in CLL patients receiving continuous therapy using ibrutinib to that of CLL patients who completed time limited therapy.
III. Evaluate adherence to therapy for the two arms (one of which requires more intense, but shorter duration treatment, and one of which requires less intense, but indefinite duration therapy) and explore how adherence in each arm relates to progression-free survival (PFS).
EXPLORATORY TOBACCO USE OBJECTIVES:
I. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications).
II. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms.
III. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization.
IV. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM A: Patients receive ibrutinib orally (PO) daily on days 1-28 and obinutuzumab intravenously (IV) over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO once daily (QD) on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and computed tomography (CT) scans before and after treatment and collection of blood throughout the study.
ARM B: Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study.
All patients, including those who discontinue therapy early, are followed for response until disease progression, even if non-protocol therapy is initiated. Patients are then followed every 3 months for first 2 years, every 6 months for years 3-5, and then every 12 months for years 6-10. All patients must also be followed through completion of all protocol therapy.
Studietype
Ingrijpend
Inschrijving (Geschat)
720
Fase
- Fase 3
Contacten en locaties
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Studie Locaties
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Jerusalem, Israël, 91031
- Shaare Zedek Medical Center
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Alabama
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Birmingham, Alabama, Verenigde Staten, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, Verenigde Staten, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Verenigde Staten, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Verenigde Staten, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Verenigde Staten, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Verenigde Staten, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Verenigde Staten, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Verenigde Staten, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Verenigde Staten, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Verenigde Staten, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, Verenigde Staten, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Verenigde Staten, 85054
- Mayo Clinic Hospital in Arizona
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Phoenix, Arizona, Verenigde Staten, 85004
- Cancer Center at Saint Joseph's
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Scottsdale, Arizona, Verenigde Staten, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, Verenigde Staten, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, Verenigde Staten, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Verenigde Staten, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Fort Smith, Arkansas, Verenigde Staten, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Verenigde Staten, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Anaheim, California, Verenigde Staten, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Verenigde Staten, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Verenigde Staten, 93420
- PCR Oncology
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Arroyo Grande, California, Verenigde Staten, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Baldwin Park, California, Verenigde Staten, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Verenigde Staten, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, Verenigde Staten, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Costa Mesa, California, Verenigde Staten, 92627
- UC Irvine Health Cancer Center-Newport
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Duarte, California, Verenigde Staten, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, Verenigde Staten, 94568
- Kaiser Permanente Dublin
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Fontana, California, Verenigde Staten, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Verenigde Staten, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Verenigde Staten, 93720
- Kaiser Permanente-Fresno
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Fresno, California, Verenigde Staten, 93720
- Fresno Cancer Center
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Harbor City, California, Verenigde Staten, 90710
- Kaiser Permanente South Bay
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Irvine, California, Verenigde Staten, 92618
- Kaiser Permanente-Irvine
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Long Beach, California, Verenigde Staten, 90822
- Tibor Rubin VA Medical Center
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Los Angeles, California, Verenigde Staten, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Verenigde Staten, 90034
- Kaiser Permanente West Los Angeles
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Modesto, California, Verenigde Staten, 95356
- Kaiser Permanente-Modesto
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Oakland, California, Verenigde Staten, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Verenigde Staten, 94611
- Kaiser Permanente Oakland-Broadway
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Ontario, California, Verenigde Staten, 91761
- Kaiser Permanente-Ontario
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Orange, California, Verenigde Staten, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Palm Springs, California, Verenigde Staten, 92262
- Desert Regional Medical Center
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Palo Alto, California, Verenigde Staten, 94304
- VA Palo Alto Health Care System
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Palo Alto, California, Verenigde Staten, 94304
- Stanford Cancer Institute Palo Alto
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Panorama City, California, Verenigde Staten, 91402
- Kaiser Permanente - Panorama City
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Rancho Cordova, California, Verenigde Staten, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Redwood City, California, Verenigde Staten, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Verenigde Staten, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Verenigde Staten, 92505
- Kaiser Permanente-Riverside
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Rohnert Park, California, Verenigde Staten, 94928
- Rohnert Park Cancer Center
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Roseville, California, Verenigde Staten, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, Verenigde Staten, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, Verenigde Staten, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Verenigde Staten, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Verenigde Staten, 95823
- South Sacramento Cancer Center
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Sacramento, California, Verenigde Staten, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Verenigde Staten, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Verenigde Staten, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, Verenigde Staten, 94115
- Kaiser Permanente-San Francisco
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San Jose, California, Verenigde Staten, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Verenigde Staten, 94577
- Kaiser Permanente San Leandro
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San Luis Obispo, California, Verenigde Staten, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, Verenigde Staten, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, Verenigde Staten, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, Verenigde Staten, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Verenigde Staten, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Maria, California, Verenigde Staten, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Verenigde Staten, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, Verenigde Staten, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, Verenigde Staten, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Verenigde Staten, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, Verenigde Staten, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Verenigde Staten, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Verenigde Staten, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Verenigde Staten, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Verenigde Staten, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Verenigde Staten, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Verenigde Staten, 80045
- Rocky Mountain Regional VA Medical Center
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Boulder, Colorado, Verenigde Staten, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Verenigde Staten, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Verenigde Staten, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Verenigde Staten, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Verenigde Staten, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Verenigde Staten, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Verenigde Staten, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Verenigde Staten, 80220
- Rose Medical Center
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Denver, Colorado, Verenigde Staten, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Verenigde Staten, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Verenigde Staten, 80204
- Denver Health Medical Center
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Denver, Colorado, Verenigde Staten, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Verenigde Staten, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Verenigde Staten, 80209
- The Women's Imaging Center
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Denver, Colorado, Verenigde Staten, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Verenigde Staten, 80220
- Western Surgical Care
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Denver, Colorado, Verenigde Staten, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Verenigde Staten, 80210
- AdventHealth Porter
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Durango, Colorado, Verenigde Staten, 81301
- Mercy Medical Center
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Durango, Colorado, Verenigde Staten, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Verenigde Staten, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Verenigde Staten, 80113
- Swedish Medical Center
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Golden, Colorado, Verenigde Staten, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, Verenigde Staten, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Verenigde Staten, 81501
- Saint Mary's Hospital and Regional Medical Center
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Grand Junction, Colorado, Verenigde Staten, 81505
- Grand Valley Oncology
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Greeley, Colorado, Verenigde Staten, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Verenigde Staten, 80026
- Kaiser Permanente-Rock Creek
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Lafayette, Colorado, Verenigde Staten, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, Verenigde Staten, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, Verenigde Staten, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Verenigde Staten, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Verenigde Staten, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Verenigde Staten, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, Verenigde Staten, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Verenigde Staten, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Verenigde Staten, 80501
- Longmont United Hospital
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Longmont, Colorado, Verenigde Staten, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Verenigde Staten, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Verenigde Staten, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, Verenigde Staten, 80138
- AdventHealth Parker
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Pueblo, Colorado, Verenigde Staten, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Verenigde Staten, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Verenigde Staten, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Verenigde Staten, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Verenigde Staten, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Derby, Connecticut, Verenigde Staten, 06418
- Smilow Cancer Hospital-Derby Care Center
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Fairfield, Connecticut, Verenigde Staten, 06824
- Smilow Cancer Hospital Care Center-Fairfield
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Glastonbury, Connecticut, Verenigde Staten, 06033
- Smilow Cancer Hospital Care Center at Glastonbury
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Guilford, Connecticut, Verenigde Staten, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, Verenigde Staten, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Haven, Connecticut, Verenigde Staten, 06520
- Yale University
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North Haven, Connecticut, Verenigde Staten, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, Verenigde Staten, 06477
- Smilow Cancer Hospital-Orange Care Center
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Trumbull, Connecticut, Verenigde Staten, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, Verenigde Staten, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, Verenigde Staten, 06385
- Smilow Cancer Hospital Care Center - Waterford
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West Haven, Connecticut, Verenigde Staten, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Lewes, Delaware, Verenigde Staten, 19958
- Beebe Medical Center
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Millville, Delaware, Verenigde Staten, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Verenigde Staten, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Verenigde Staten, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Verenigde Staten, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Verenigde Staten, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Verenigde Staten, 19971
- Beebe Health Campus
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Seaford, Delaware, Verenigde Staten, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Verenigde Staten, 19801
- Christiana Care Health System-Wilmington Hospital
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Florida
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Fort Lauderdale, Florida, Verenigde Staten, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, Verenigde Staten, 33308
- Holy Cross Hospital
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Jacksonville, Florida, Verenigde Staten, 32224-9980
- Mayo Clinic in Florida
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Georgia
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Athens, Georgia, Verenigde Staten, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Verenigde Staten, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Verenigde Staten, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Verenigde Staten, 30342
- Emory Saint Joseph's Hospital
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Augusta, Georgia, Verenigde Staten, 30912
- Augusta University Medical Center
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Decatur, Georgia, Verenigde Staten, 30033
- Atlanta VA Medical Center
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Hawaii
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Hilo, Hawaii, Verenigde Staten, 96720
- Island Urology-Hilo
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Honolulu, Hawaii, Verenigde Staten, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Verenigde Staten, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Verenigde Staten, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Verenigde Staten, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Verenigde Staten, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Verenigde Staten, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Verenigde Staten, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Verenigde Staten, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Verenigde Staten, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Verenigde Staten, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Verenigde Staten, 96813
- Island Urology
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Honolulu, Hawaii, Verenigde Staten, 96819
- Kaiser Permanente Moanalua Medical Center
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Lihue, Hawaii, Verenigde Staten, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Verenigde Staten, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Verenigde Staten, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Verenigde Staten, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Verenigde Staten, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Verenigde Staten, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Verenigde Staten, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Verenigde Staten, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Verenigde Staten, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Verenigde Staten, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Verenigde Staten, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Verenigde Staten, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Verenigde Staten, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Verenigde Staten, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Verenigde Staten, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Verenigde Staten, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Verenigde Staten, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, Verenigde Staten, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, Verenigde Staten, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Verenigde Staten, 61704
- Illinois CancerCare-Bloomington
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Burr Ridge, Illinois, Verenigde Staten, 60527
- Loyola Center for Health at Burr Ridge
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Canton, Illinois, Verenigde Staten, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Verenigde Staten, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Verenigde Staten, 62918
- SIH Cancer Institute
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Carthage, Illinois, Verenigde Staten, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Verenigde Staten, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Verenigde Staten, 60611
- Northwestern University
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Chicago, Illinois, Verenigde Staten, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Verenigde Staten, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, Verenigde Staten, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Verenigde Staten, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Verenigde Staten, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Verenigde Staten, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Verenigde Staten, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, Verenigde Staten, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Verenigde Staten, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, Verenigde Staten, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Verenigde Staten, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Verenigde Staten, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Verenigde Staten, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Verenigde Staten, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Verenigde Staten, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Harvey, Illinois, Verenigde Staten, 60426
- Ingalls Memorial Hospital
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Highland Park, Illinois, Verenigde Staten, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Homer Glen, Illinois, Verenigde Staten, 60491
- Loyola Medicine Homer Glen
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Kewanee, Illinois, Verenigde Staten, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, Verenigde Staten, 60045
- Northwestern Medicine Lake Forest Hospital
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Macomb, Illinois, Verenigde Staten, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Verenigde Staten, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Verenigde Staten, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, Verenigde Staten, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Mount Vernon, Illinois, Verenigde Staten, 62864
- SSM Health Good Samaritan
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New Lenox, Illinois, Verenigde Staten, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, Verenigde Staten, 62269
- Cancer Care Center of O'Fallon
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Orland Park, Illinois, Verenigde Staten, 60462
- University of Chicago Medicine-Orland Park
-
Ottawa, Illinois, Verenigde Staten, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, Verenigde Staten, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Verenigde Staten, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Verenigde Staten, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Verenigde Staten, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Verenigde Staten, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Verenigde Staten, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Verenigde Staten, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Verenigde Staten, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, Verenigde Staten, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, Verenigde Staten, 61114
- UW Health Carbone Cancer Center Rockford
-
Skokie, Illinois, Verenigde Staten, 60076
- North Shore Medical Center
-
Springfield, Illinois, Verenigde Staten, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Verenigde Staten, 62702
- Springfield Clinic
-
Springfield, Illinois, Verenigde Staten, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Verenigde Staten, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Verenigde Staten, 61801
- Carle Cancer Center
-
Urbana, Illinois, Verenigde Staten, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Verenigde Staten, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, Verenigde Staten, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Fort Wayne, Indiana, Verenigde Staten, 46845
- Parkview Regional Medical Center
-
Indianapolis, Indiana, Verenigde Staten, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Verenigde Staten, 46219
- Community Cancer Center East
-
Indianapolis, Indiana, Verenigde Staten, 46227
- Community Cancer Center South
-
Indianapolis, Indiana, Verenigde Staten, 46256
- Community Cancer Center North
-
Kokomo, Indiana, Verenigde Staten, 46904
- Community Howard Regional Health
-
Mooresville, Indiana, Verenigde Staten, 46158
- Franciscan Health Mooresville
-
Richmond, Indiana, Verenigde Staten, 47374
- Reid Health
-
Terre Haute, Indiana, Verenigde Staten, 47804
- Union Hospital
-
-
Iowa
-
Ames, Iowa, Verenigde Staten, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Verenigde Staten, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, Verenigde Staten, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, Verenigde Staten, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Verenigde Staten, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Verenigde Staten, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Verenigde Staten, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, Verenigde Staten, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Verenigde Staten, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Verenigde Staten, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Verenigde Staten, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Verenigde Staten, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Verenigde Staten, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Verenigde Staten, 50309
- Blank Children's Hospital
-
Des Moines, Iowa, Verenigde Staten, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Verenigde Staten, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Verenigde Staten, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Verenigde Staten, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Verenigde Staten, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, Verenigde Staten, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Iowa City, Iowa, Verenigde Staten, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, Verenigde Staten, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Verenigde Staten, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Verenigde Staten, 51101
- Siouxland Regional Cancer Center
-
Waterloo, Iowa, Verenigde Staten, 50702
- MercyOne Waterloo Cancer Center
-
West Des Moines, Iowa, Verenigde Staten, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Verenigde Staten, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Coffeyville, Kansas, Verenigde Staten, 67337
- Coffeyville Regional Medical Center
-
Garden City, Kansas, Verenigde Staten, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Verenigde Staten, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Verenigde Staten, 67601
- HaysMed
-
Independence, Kansas, Verenigde Staten, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Verenigde Staten, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Verenigde Staten, 66112
- University of Kansas Cancer Center-West
-
Lawrence, Kansas, Verenigde Staten, 66044
- Lawrence Memorial Hospital
-
Olathe, Kansas, Verenigde Staten, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Verenigde Staten, 66210
- University of Kansas Cancer Center-Overland Park
-
Pittsburg, Kansas, Verenigde Staten, 66762
- Mercy Hospital Pittsburg
-
Salina, Kansas, Verenigde Staten, 67401
- Salina Regional Health Center
-
Topeka, Kansas, Verenigde Staten, 66606
- University of Kansas Health System Saint Francis Campus
-
Westwood, Kansas, Verenigde Staten, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Verenigde Staten, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Verenigde Staten, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Verenigde Staten, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Verenigde Staten, 67214
- Wesley Medical Center
-
-
Kentucky
-
Bardstown, Kentucky, Verenigde Staten, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Verenigde Staten, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Verenigde Staten, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Verenigde Staten, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Verenigde Staten, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Verenigde Staten, 40202
- Jewish Hospital
-
Louisville, Kentucky, Verenigde Staten, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Verenigde Staten, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Verenigde Staten, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Verenigde Staten, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Verenigde Staten, 70836
- Ochsner High Grove
-
New Orleans, Louisiana, Verenigde Staten, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Augusta, Maine, Verenigde Staten, 04330
- Harold Alfond Center for Cancer Care
-
Belfast, Maine, Verenigde Staten, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Verenigde Staten, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Norway, Maine, Verenigde Staten, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, Verenigde Staten, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Verenigde Staten, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Verenigde Staten, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Cumberland, Maryland, Verenigde Staten, 21502
- UPMC Western Maryland
-
-
Massachusetts
-
Boston, Massachusetts, Verenigde Staten, 02111
- Tufts Medical Center
-
Burlington, Massachusetts, Verenigde Staten, 01805
- Lahey Clinic
-
Lowell, Massachusetts, Verenigde Staten, 01854
- Lowell General Hospital
-
Springfield, Massachusetts, Verenigde Staten, 01104
- Mercy Medical Center
-
-
Michigan
-
Adrian, Michigan, Verenigde Staten, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Verenigde Staten, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Brighton, Michigan, Verenigde Staten, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Verenigde Staten, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Verenigde Staten, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Verenigde Staten, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Verenigde Staten, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Verenigde Staten, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Verenigde Staten, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Verenigde Staten, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Verenigde Staten, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Verenigde Staten, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, Verenigde Staten, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Verenigde Staten, 48126
- Henry Ford Medical Center-Fairlane
-
Dearborn, Michigan, Verenigde Staten, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Verenigde Staten, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Verenigde Staten, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Verenigde Staten, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Verenigde Staten, 48054
- Henry Ford River District Hospital
-
Escanaba, Michigan, Verenigde Staten, 49829
- OSF Saint Francis Hospital and Medical Group
-
Farmington Hills, Michigan, Verenigde Staten, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Verenigde Staten, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Verenigde Staten, 48503
- Hurley Medical Center
-
Flint, Michigan, Verenigde Staten, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Verenigde Staten, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Verenigde Staten, 48503
- Cancer Hematology Centers - Flint
-
Grosse Pointe Woods, Michigan, Verenigde Staten, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Verenigde Staten, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Verenigde Staten, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, Verenigde Staten, 49201
- Allegiance Health
-
Lansing, Michigan, Verenigde Staten, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Verenigde Staten, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Verenigde Staten, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Verenigde Staten, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Verenigde Staten, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Verenigde Staten, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, Verenigde Staten, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Novi, Michigan, Verenigde Staten, 48377
- Henry Ford Medical Center-Columbus
-
Pontiac, Michigan, Verenigde Staten, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Verenigde Staten, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Verenigde Staten, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Verenigde Staten, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron, Michigan, Verenigde Staten, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Verenigde Staten, 48060
- Huron Medical Center PC
-
Rochester Hills, Michigan, Verenigde Staten, 48309
- Henry Ford Rochester Hospital
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Verenigde Staten, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Verenigde Staten, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Verenigde Staten, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Verenigde Staten, 48601
- MyMichigan Medical Center Saginaw
-
Shelby, Michigan, Verenigde Staten, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Sterling Heights, Michigan, Verenigde Staten, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights, Michigan, Verenigde Staten, 48312
- Premier Hematology Oncology Care
-
Tawas City, Michigan, Verenigde Staten, 48764
- MyMichigan Medical Center Tawas
-
Troy, Michigan, Verenigde Staten, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Verenigde Staten, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Verenigde Staten, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Verenigde Staten, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Verenigde Staten, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Verenigde Staten, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Verenigde Staten, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Verenigde Staten, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield, Michigan, Verenigde Staten, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, Verenigde Staten, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Ypsilanti, Michigan, Verenigde Staten, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Verenigde Staten, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Verenigde Staten, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Verenigde Staten, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Verenigde Staten, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Verenigde Staten, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Verenigde Staten, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Verenigde Staten, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Verenigde Staten, 55433
- Mercy Hospital
-
Deer River, Minnesota, Verenigde Staten, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Verenigde Staten, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Verenigde Staten, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Verenigde Staten, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Verenigde Staten, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Verenigde Staten, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Verenigde Staten, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Verenigde Staten, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Verenigde Staten, 55432
- Unity Hospital
-
Hibbing, Minnesota, Verenigde Staten, 55746
- Essentia Health Hibbing Clinic
-
Mankato, Minnesota, Verenigde Staten, 56001
- Mayo Clinic Health Systems-Mankato
-
Maple Grove, Minnesota, Verenigde Staten, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Verenigde Staten, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Verenigde Staten, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Verenigde Staten, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Verenigde Staten, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Verenigde Staten, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Verenigde Staten, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Verenigde Staten, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Verenigde Staten, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Verenigde Staten, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Verenigde Staten, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Verenigde Staten, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Verenigde Staten, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Verenigde Staten, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Verenigde Staten, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Verenigde Staten, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Verenigde Staten, 55102
- United Hospital
-
Sandstone, Minnesota, Verenigde Staten, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Verenigde Staten, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Verenigde Staten, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Verenigde Staten, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Verenigde Staten, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Verenigde Staten, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Verenigde Staten, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Verenigde Staten, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Verenigde Staten, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Verenigde Staten, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Hattiesburg, Mississippi, Verenigde Staten, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, Verenigde Staten, 39404
- Forrest General Hospital / Cancer Center
-
-
Missouri
-
Ballwin, Missouri, Verenigde Staten, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Verenigde Staten, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Verenigde Staten, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Verenigde Staten, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Verenigde Staten, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Verenigde Staten, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Verenigde Staten, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, Verenigde Staten, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Columbia, Missouri, Verenigde Staten, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, Verenigde Staten, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Verenigde Staten, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Verenigde Staten, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Verenigde Staten, 64804
- Freeman Health System
-
Joplin, Missouri, Verenigde Staten, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Verenigde Staten, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Verenigde Staten, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Verenigde Staten, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Verenigde Staten, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, Verenigde Staten, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Rolla, Missouri, Verenigde Staten, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Verenigde Staten, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Verenigde Staten, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Verenigde Staten, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Verenigde Staten, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Verenigde Staten, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Verenigde Staten, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Verenigde Staten, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Verenigde Staten, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Verenigde Staten, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Verenigde Staten, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Verenigde Staten, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Verenigde Staten, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Verenigde Staten, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, Verenigde Staten, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Verenigde Staten, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Verenigde Staten, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Verenigde Staten, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Verenigde Staten, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Verenigde Staten, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Verenigde Staten, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Verenigde Staten, 59405
- Great Falls Clinic
-
Great Falls, Montana, Verenigde Staten, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Verenigde Staten, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Verenigde Staten, 59901
- Logan Health Medical Center
-
Missoula, Montana, Verenigde Staten, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Verenigde Staten, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Verenigde Staten, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Verenigde Staten, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Verenigde Staten, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Verenigde Staten, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Verenigde Staten, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Verenigde Staten, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Verenigde Staten, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Verenigde Staten, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Verenigde Staten, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Verenigde Staten, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Verenigde Staten, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Verenigde Staten, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Verenigde Staten, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Verenigde Staten, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Verenigde Staten, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Verenigde Staten, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Verenigde Staten, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Verenigde Staten, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Verenigde Staten, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Verenigde Staten, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Verenigde Staten, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Verenigde Staten, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Verenigde Staten, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Verenigde Staten, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Verenigde Staten, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Verenigde Staten, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Verenigde Staten, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Verenigde Staten, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Verenigde Staten, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Verenigde Staten, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Verenigde Staten, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Verenigde Staten, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Verenigde Staten, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Verenigde Staten, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Verenigde Staten, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Verenigde Staten, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Verenigde Staten, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Verenigde Staten, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Verenigde Staten, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Verenigde Staten, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Verenigde Staten, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Verenigde Staten, 89169
- University Cancer Center
-
Las Vegas, Nevada, Verenigde Staten, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Verenigde Staten, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Verenigde Staten, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Verenigde Staten, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Verenigde Staten, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Verenigde Staten, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Verenigde Staten, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, Verenigde Staten, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Manchester, New Hampshire, Verenigde Staten, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, Verenigde Staten, 03103
- Elliot Hospital
-
-
New Jersey
-
Brick, New Jersey, Verenigde Staten, 08724
- Ocean University Medical Center
-
Lakewood, New Jersey, Verenigde Staten, 08701
- Monmouth Medical Center Southern Campus
-
Long Branch, New Jersey, Verenigde Staten, 07740
- Monmouth Medical Center
-
Manahawkin, New Jersey, Verenigde Staten, 08050
- Southern Ocean County Medical Center
-
Morristown, New Jersey, Verenigde Staten, 07960
- Morristown Medical Center
-
Neptune City, New Jersey, Verenigde Staten, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, Verenigde Staten, 08903
- Rutgers Cancer Institute of New Jersey
-
Red Bank, New Jersey, Verenigde Staten, 07701
- Riverview Medical Center/Booker Cancer Center
-
Summit, New Jersey, Verenigde Staten, 07902
- Overlook Hospital
-
-
New Mexico
-
Albuquerque, New Mexico, Verenigde Staten, 87106
- University of New Mexico Cancer Center
-
Las Cruces, New Mexico, Verenigde Staten, 88011
- Memorial Medical Center-Las Cruces
-
-
New York
-
Auburn, New York, Verenigde Staten, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Buffalo, New York, Verenigde Staten, 14263
- Roswell Park Cancer Institute
-
Camillus, New York, Verenigde Staten, 13031
- Hematology Oncology Associates of CNY at Camillus
-
East Hills, New York, Verenigde Staten, 11548
- The Cancer Institute at Saint Francis Hospital
-
East Syracuse, New York, Verenigde Staten, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, Verenigde Staten, 12801
- Glens Falls Hospital
-
Mineola, New York, Verenigde Staten, 11501
- NYU Langone Hospital - Long Island
-
New York, New York, Verenigde Staten, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Verenigde Staten, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Rochester, New York, Verenigde Staten, 14642
- University of Rochester
-
Syracuse, New York, Verenigde Staten, 13210
- State University of New York Upstate Medical University
-
West Islip, New York, Verenigde Staten, 11795
- Good Samaritan University Hospital
-
-
North Carolina
-
Asheville, North Carolina, Verenigde Staten, 28801
- Mission Hospital
-
Asheville, North Carolina, Verenigde Staten, 28806
- Messino Cancer Centers
-
Cary, North Carolina, Verenigde Staten, 27518
- Waverly Hematology Oncology
-
Chapel Hill, North Carolina, Verenigde Staten, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Verenigde Staten, 28328
- Southeastern Medical Oncology Center-Clinton
-
Durham, North Carolina, Verenigde Staten, 27710
- Duke University Medical Center
-
Goldsboro, North Carolina, Verenigde Staten, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Verenigde Staten, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, Verenigde Staten, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, Verenigde Staten, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Verenigde Staten, 28546
- Onslow Memorial Hospital
-
Pinehurst, North Carolina, Verenigde Staten, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
-
North Dakota
-
Bismarck, North Dakota, Verenigde Staten, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Verenigde Staten, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Verenigde Staten, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Verenigde Staten, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Verenigde Staten, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Verenigde Staten, 58104
- Sanford Medical Center Fargo
-
Jamestown, North Dakota, Verenigde Staten, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, Verenigde Staten, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beavercreek, Ohio, Verenigde Staten, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Verenigde Staten, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Verenigde Staten, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Verenigde Staten, 44708
- Cleveland Clinic Mercy Hospital
-
Centerville, Ohio, Verenigde Staten, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Verenigde Staten, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Verenigde Staten, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Verenigde Staten, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Verenigde Staten, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Verenigde Staten, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Verenigde Staten, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Verenigde Staten, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Verenigde Staten, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Verenigde Staten, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Verenigde Staten, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Verenigde Staten, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Verenigde Staten, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Verenigde Staten, 43228
- Doctors Hospital
-
Columbus, Ohio, Verenigde Staten, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Verenigde Staten, 43215
- Grant Medical Center
-
Columbus, Ohio, Verenigde Staten, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Verenigde Staten, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Verenigde Staten, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Verenigde Staten, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Verenigde Staten, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Verenigde Staten, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Verenigde Staten, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Verenigde Staten, 43016
- Dublin Methodist Hospital
-
Findlay, Ohio, Verenigde Staten, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Verenigde Staten, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Verenigde Staten, 45840
- Orion Cancer Care
-
Franklin, Ohio, Verenigde Staten, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Verenigde Staten, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Verenigde Staten, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Verenigde Staten, 45331
- Wayne Hospital
-
Greenville, Ohio, Verenigde Staten, 45331
- Dayton Physicians LLC-Wayne
-
Grove City, Ohio, Verenigde Staten, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, Verenigde Staten, 45429
- Kettering Medical Center
-
Kettering, Ohio, Verenigde Staten, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Verenigde Staten, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Verenigde Staten, 43130
- Fairfield Medical Center
-
Mansfield, Ohio, Verenigde Staten, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Verenigde Staten, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Verenigde Staten, 43302
- OhioHealth Marion General Hospital
-
Mount Vernon, Ohio, Verenigde Staten, 43050
- Knox Community Hospital
-
Newark, Ohio, Verenigde Staten, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Verenigde Staten, 43055
- Newark Radiation Oncology
-
Perrysburg, Ohio, Verenigde Staten, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Verenigde Staten, 45662
- Southern Ohio Medical Center
-
Springfield, Ohio, Verenigde Staten, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Verenigde Staten, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Verenigde Staten, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Verenigde Staten, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Verenigde Staten, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Verenigde Staten, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Troy, Ohio, Verenigde Staten, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Verenigde Staten, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Verenigde Staten, 44484
- Saint Joseph Warren Hospital
-
Westerville, Ohio, Verenigde Staten, 43081
- Saint Ann's Hospital
-
Wright-Patterson Air Force Base, Ohio, Verenigde Staten, 45433
- Wright-Patterson Medical Center
-
Youngstown, Ohio, Verenigde Staten, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Verenigde Staten, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Verenigde Staten, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Verenigde Staten, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Verenigde Staten, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Verenigde Staten, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Verenigde Staten, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Verenigde Staten, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Verenigde Staten, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Verenigde Staten, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Verenigde Staten, 97420
- Bay Area Hospital
-
Newberg, Oregon, Verenigde Staten, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Verenigde Staten, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Portland, Oregon, Verenigde Staten, 97239
- Oregon Health and Science University
-
Portland, Oregon, Verenigde Staten, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Verenigde Staten, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Verenigde Staten, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, Verenigde Staten, 97756
- Saint Charles Health System-Redmond
-
Salem, Oregon, Verenigde Staten, 97301
- Salem Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, Verenigde Staten, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Verenigde Staten, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Verenigde Staten, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, Verenigde Staten, 19317
- Christiana Care Health System-Concord Health Center
-
Chambersburg, Pennsylvania, Verenigde Staten, 17201
- Chambersburg Hospital
-
Collegeville, Pennsylvania, Verenigde Staten, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, Verenigde Staten, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Verenigde Staten, 18301
- Pocono Medical Center
-
Ephrata, Pennsylvania, Verenigde Staten, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Verenigde Staten, 17522
- Ephrata Community Hospital
-
Exton, Pennsylvania, Verenigde Staten, 19341
- Main Line Health Center-Exton
-
Gettysburg, Pennsylvania, Verenigde Staten, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, Verenigde Staten, 17331
- WellSpan Medical Oncology and Hematology
-
Hazleton, Pennsylvania, Verenigde Staten, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Verenigde Staten, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, Verenigde Staten, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lebanon, Pennsylvania, Verenigde Staten, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, Verenigde Staten, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Verenigde Staten, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Verenigde Staten, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Verenigde Staten, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Verenigde Staten, 19107
- Thomas Jefferson University Hospital
-
Pottstown, Pennsylvania, Verenigde Staten, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, Verenigde Staten, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Verenigde Staten, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Verenigde Staten, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, Verenigde Staten, 16801
- Geisinger Medical Group
-
Wilkes-Barre, Pennsylvania, Verenigde Staten, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove, Pennsylvania, Verenigde Staten, 19090
- Asplundh Cancer Pavilion
-
Wynnewood, Pennsylvania, Verenigde Staten, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Verenigde Staten, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, Verenigde Staten, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Westerly, Rhode Island, Verenigde Staten, 02891
- Smilow Cancer Hospital Care Center - Westerly
-
-
South Carolina
-
Boiling Springs, South Carolina, Verenigde Staten, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Verenigde Staten, 29425
- Medical University of South Carolina
-
Clinton, South Carolina, Verenigde Staten, 29325
- Prisma Health Cancer Institute - Laurens
-
Easley, South Carolina, Verenigde Staten, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Verenigde Staten, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Verenigde Staten, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Verenigde Staten, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Verenigde Staten, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Verenigde Staten, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Verenigde Staten, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Verenigde Staten, 29605
- BI-LO Charities Children's Cancer Center
-
Greenville, South Carolina, Verenigde Staten, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenwood, South Carolina, Verenigde Staten, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Verenigde Staten, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Verenigde Staten, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Verenigde Staten, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Verenigde Staten, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Verenigde Staten, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, Verenigde Staten, 57401
- Avera Cancer Institute-Aberdeen
-
Pierre, South Dakota, Verenigde Staten, 57501
- Avera Cancer Institute at Pierre
-
Sioux Falls, South Dakota, Verenigde Staten, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Verenigde Staten, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Verenigde Staten, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Verenigde Staten, 37404
- Memorial Hospital
-
Hixson, Tennessee, Verenigde Staten, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Ooltewah, Tennessee, Verenigde Staten, 37363
- Memorial GYN Plus
-
-
Texas
-
Amarillo, Texas, Verenigde Staten, 79106
- The Don and Sybil Harrington Cancer Center
-
Bryan, Texas, Verenigde Staten, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Verenigde Staten, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, Verenigde Staten, 75216
- Dallas VA Medical Center
-
Richardson, Texas, Verenigde Staten, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, Verenigde Staten, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Verenigde Staten, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Verenigde Staten, 84321
- Logan Regional Hospital
-
Murray, Utah, Verenigde Staten, 84107
- Intermountain Medical Center
-
Ogden, Utah, Verenigde Staten, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Verenigde Staten, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Verenigde Staten, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Verenigde Staten, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Verenigde Staten, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Verenigde Staten, 84143
- LDS Hospital
-
St. George, Utah, Verenigde Staten, 84770
- Saint George Regional Medical Center
-
-
Virginia
-
Charlottesville, Virginia, Verenigde Staten, 22908
- University of Virginia Cancer Center
-
Fairfax, Virginia, Verenigde Staten, 22031
- Inova Schar Cancer Institute
-
Falls Church, Virginia, Verenigde Staten, 22042
- Inova Fairfax Hospital
-
Lynchburg, Virginia, Verenigde Staten, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Richmond, Virginia, Verenigde Staten, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Verenigde Staten, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Verenigde Staten, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, Verenigde Staten, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Verenigde Staten, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Verenigde Staten, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Verenigde Staten, 98004
- Overlake Medical Center
-
Bellingham, Washington, Verenigde Staten, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Verenigde Staten, 98166
- Saint Anne Hospital
-
Centralia, Washington, Verenigde Staten, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Verenigde Staten, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Verenigde Staten, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Verenigde Staten, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Verenigde Staten, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Verenigde Staten, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Verenigde Staten, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Verenigde Staten, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Verenigde Staten, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Verenigde Staten, 99336
- Kadlec Clinic Hematology and Oncology
-
Kennewick, Washington, Verenigde Staten, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Verenigde Staten, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Verenigde Staten, 98499
- Saint Clare Hospital
-
Longview, Washington, Verenigde Staten, 98632
- PeaceHealth Saint John Medical Center
-
Lynnwood, Washington, Verenigde Staten, 98036
- Virginia Mason Lynnwood Medical Center
-
Port Townsend, Washington, Verenigde Staten, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Verenigde Staten, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Verenigde Staten, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Verenigde Staten, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Renton, Washington, Verenigde Staten, 98055
- Valley Medical Center
-
Seattle, Washington, Verenigde Staten, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Verenigde Staten, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Verenigde Staten, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Verenigde Staten, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Verenigde Staten, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Verenigde Staten, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Verenigde Staten, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Seattle, Washington, Verenigde Staten, 98109
- Fred Hutchinson Cancer Center
-
Seattle, Washington, Verenigde Staten, 98133
- FHCC at Northwest Hospital
-
Sedro-Woolley, Washington, Verenigde Staten, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Verenigde Staten, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Verenigde Staten, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Verenigde Staten, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Verenigde Staten, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Verenigde Staten, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Verenigde Staten, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Verenigde Staten, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Verenigde Staten, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Verenigde Staten, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Verenigde Staten, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Verenigde Staten, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Verenigde Staten, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Verenigde Staten, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Verenigde Staten, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Verenigde Staten, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Charleston, West Virginia, Verenigde Staten, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
-
Wisconsin
-
Antigo, Wisconsin, Verenigde Staten, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Verenigde Staten, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, Verenigde Staten, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Verenigde Staten, 54806
- Northwest Wisconsin Cancer Center
-
Brookfield, Wisconsin, Verenigde Staten, 53045
- Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
-
Burlington, Wisconsin, Verenigde Staten, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Verenigde Staten, 54729
- Marshfield Clinic-Chippewa Center
-
Cudahy, Wisconsin, Verenigde Staten, 53110
- Aurora Saint Luke's South Shore
-
Eau Claire, Wisconsin, Verenigde Staten, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Verenigde Staten, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Verenigde Staten, 54701
- Mayo Clinic Health System-Eau Claire Clinic
-
Fond du Lac, Wisconsin, Verenigde Staten, 54937
- Aurora Health Center-Fond du Lac
-
Franklin, Wisconsin, Verenigde Staten, 53132
- Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
-
Germantown, Wisconsin, Verenigde Staten, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Verenigde Staten, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Verenigde Staten, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Verenigde Staten, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Verenigde Staten, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Verenigde Staten, 54301
- Bellin Memorial Hospital
-
Kenosha, Wisconsin, Verenigde Staten, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Verenigde Staten, 54601
- Gundersen Lutheran Medical Center
-
La Crosse, Wisconsin, Verenigde Staten, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
Ladysmith, Wisconsin, Verenigde Staten, 54848
- Marshfield Medical Center - Ladysmith
-
Madison, Wisconsin, Verenigde Staten, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Verenigde Staten, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, Verenigde Staten, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Verenigde Staten, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Verenigde Staten, 54143
- Saint Vincent Hospital Cancer Center at Marinette
-
Marshfield, Wisconsin, Verenigde Staten, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Verenigde Staten, 54451
- Aspirus Medford Hospital
-
Mequon, Wisconsin, Verenigde Staten, 53097
- Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
-
Milwaukee, Wisconsin, Verenigde Staten, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Verenigde Staten, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Verenigde Staten, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Verenigde Staten, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Verenigde Staten, 53211
- Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
-
Minocqua, Wisconsin, Verenigde Staten, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Verenigde Staten, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Verenigde Staten, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Verenigde Staten, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Verenigde Staten, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Verenigde Staten, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Verenigde Staten, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, Verenigde Staten, 53405
- Ascension All Saints Hospital-Spring Street-Racine
-
Rice Lake, Wisconsin, Verenigde Staten, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Verenigde Staten, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Verenigde Staten, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Verenigde Staten, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Verenigde Staten, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Verenigde Staten, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Verenigde Staten, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Verenigde Staten, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Verenigde Staten, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Verenigde Staten, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, Verenigde Staten, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, Verenigde Staten, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, Verenigde Staten, 53226
- Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
-
West Allis, Wisconsin, Verenigde Staten, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Verenigde Staten, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Verenigde Staten, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Verenigde Staten, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cheyenne, Wyoming, Verenigde Staten, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Verenigde Staten, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Verenigde Staten, 82801
- Welch Cancer Center
-
-
Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
18 jaar tot 69 jaar (Volwassen, Oudere volwassene)
Accepteert gezonde vrijwilligers
Nee
Geslachten die in aanmerking komen voor studie
Allemaal
Beschrijving
Inclusion Criteria:
-
Diagnosis of CLL according to the National Cancer Institute (NCI)/International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria or small lymphocytic lymphoma (SLL) according to the World Health Organization (WHO) criteria. This includes previous documentation of:
-
Biopsy-proven small lymphocytic lymphoma OR
-
Diagnosis of CLL according to the NCI/IWCLL criteria as evidenced by all of the following:
-
Peripheral blood lymphocyte count of greater than 5 x10^9/L
-
Immunophenotype consistent with CLL defined as:
- The predominant population of lymphocytes share both B-cell antigens (CD19, CD20 [typically dim expression], or CD23) as well as CD5 in the absence of other pan-T-cell markers (CD3, CD2, etc).
- Clonality as evidenced by kappa or lambda light chain restriction (typically dim immunoglobulin expression)
-
-
Negative fluorescent in situ hybridization (FISH) analysis for t(11;14)(IgH/CCND1) on peripheral blood or tissue biopsy (e.g. marrow aspirate) or negative immunohistochemical stains for cyclin D1 staining on involved tissue biopsy (e.g. marrow aspirate or lymph node biopsy)
-
-
No prior chemotherapy, BTK inhibitor therapy, venetoclax, small molecule signaling inhibitor, or monoclonal anti-body therapy for treatment of CLL or SLL
-
Has met at least one of the following indications for treatment:
-
Evidence of progressive marrow failure as manifested by the development of worsening anemia (hemoglobin [Hg] < 11 g/dl) and/or thrombocytopenia (platelets < 100 x 10^9/L)
-
Symptomatic or progressive lymphadenopathy, splenomegaly, or hepatomegaly
-
One or more of the following disease-related symptoms:
- Weight loss >= 10% within the previous 6 months
- Grade 2 or 3 fatigue attributed to CLL
- Fevers > 100.5 degree Fahrenheit (F) for 2 weeks without evidence of infection
- Clinically significant night sweats without evidence of infection
-
Progressive lymphocytosis (not due to the effects of corticosteroids) with an increase of > 50% over a two-month period or an anticipated doubling time of less than six months
-
-
Age >= 18 years and < 70
-
Eastern Cooperative Oncology Group (ECOG) performance status between 0-2
-
Life expectancy of >= 12 months
-
No deletion of 17p13 on cytogenetic analysis by FISH
-
Glomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault Formula (obtained =< 14 days prior to registration)
-
Total bilirubin =< 1.5 x upper limit of normal (ULN) unless due to Gilbert's disease. For those with a total bilirubin > 1.5 x ULN, a direct bilirubin should be performed and must be < 1.5 mg/dL for Gilbert's to be diagnosed (obtained =< 14 days prior to registration)
-
Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST])/serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 3.0 x the institutional ULN (obtained =< 14 days prior to registration)
- NOTE: If value is higher due to hepatic involvement by CLL, patient is eligible
-
Prothrombin time (PT)/international normalized ratio (INR) < 1.5 ULN and partial thromboplastin time (PTT) (activated partial thromboplastin time [aPTT]) < 1.5 x ULN (obtained =< 14 days prior to registration)
-
No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment. Patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation
-
No current use of corticosteroids. EXCEPTION: Low doses of steroids (< 10 mg of prednisone or equivalent dose of other steroid; inhaled steroids) used for treatment of non-hematologic medical condition (e.g. chronic adrenal insufficiency) is permitted
-
No previous autoimmune complications (e.g. autoimmune hemolytic anemia or immune thrombocytopenia) that have developed since the initial diagnosis of CLL and have required treatment with high dose corticosteroids (e.g. equivalent of > 20 mg/day of prednisone), monoclonal antibody based therapy, or chemotherapy. Prior use of corticosteroids for reasons other than treatment of autoimmune complications is allowed
-
No other active primary malignancy (other than non-melanomatous skin cancer or carcinoma in situ of the cervix) requiring treatment or limiting expected survival to =< 2 years
- NOTE: If there is a history of prior malignancy, the patient must not currently be receiving other specific treatment (other than hormonal therapy for their cancer)
-
Able to adhere to the study visit schedule and other protocol requirements
-
No major surgery within 4 weeks (28 days) of first dose of study drug or minor surgery within 3 days of first dose of study drug
-
No radiation therapy =< 4 weeks prior to registration to Step 1
-
Patients who are human immunodeficiency virus positive (HIV+) with undetectable HIV viral load are eligible provided they meet all other protocol criteria for participation and are not being treated with protease inhibitors or any non-nucleoside reverse transcriptase inhibitors (NNRTI) that are CYP3A4 inducers; if being treated for HIV, patients should be receiving an alternative antiretroviral therapy (ART) that is not a CYP3A inhibitor
-
Patients must not have any of the following conditions:
- Congestive heart failure or New York Heart Association Functional Classification III or IV congestive heart failure
- History of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to registration
- Recent infections requiring systemic treatment; need to have completed anti-biotic therapy > 14 days before the first dose of study drug
- Cerebral vascular accident or intracranial bleed within the last 6 months
- Infection with known chronic, active hepatitis C
- Positive serology for hepatitis B defined as a positive test for hepatitis B surface antigen (HBsAg); in addition, if negative for HBsAg but hepatitis B core antibody (HBcAb) positive (regardless of hepatitis B surface antibody [HBsAb] status), a hepatitis B deoxyribonucleic acid (DNA) test will be performed and, if positive the subject will be ineligible; if the hepatitis (Hep) B DNA test is negative (i.e. viral load undetectable) then the individual is eligible; if a patient who is HBsAg negative, HBsAb negative, HBcAb positive, and Hep B DNA negative is enrolled, they should be considered for either prophylactic anti-viral therapy (J Clin Oncol. 2013 Aug 1;31(22):2765-72) or careful monitoring for Hep B reactivation (J Clin Oncol. 2014 Nov 20;32(33):3736-43)
-
Patients are not eligible if they require treatment with a strong cytochrome P450 (CYP) 3A inhibitor
-
Patients may not have received the following within 7 days prior to the first dose of study drug:
- Steroid therapy for anti-neoplastic intent
- Strong and moderate CYP3A inhibitors
- Strong and moderate CYP3A inducers
-
Patients may not be on any other investigational agents
-
Patients may not have received warfarin or another vitamin K antagonist in the preceding 30 days
-
Women must not be pregnant or breast-feeding since this study involves investigational agents whose genotoxic, mutagenic, and teratogenic effects on the developing fetus and newborn are unknown.
- All females of childbearing potential must have a blood test within 2 weeks prior to registration to Step 1 to rule out pregnancy. A patient of childbearing potential someone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
Women of childbearing potential and sexually active males must be strongly advised to use accepted and highly effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for:
- 18 months after the last dose of obinutuzumab
- 90 days after the last dose of ibrutinib, and
- 30 days after the last dose of venetoclax Male subjects must also agree to refrain from sperm donation until 90 days after the last dose of protocol treatment
-
Patient must be able to swallow capsules and not have the following conditions:
- Disease significantly affecting gastrointestinal function
- Resection of the stomach or small bowel
- Symptomatic inflammatory bowel disease
- Ulcerative colitis
- Partial or complete bowel obstruction
-
Patient must not be on any other systemic immunosuppressant therapy other than corticosteroids within 28 days of the first dose of study drug
-
Patient must not be vaccinated with live, attenuated vaccines within 4 weeks of first dose of study drug
-
Patient must not have any known bleeding disorders (e.g., von Willebrand's disease) or hemophilia
-
Patient must not have currently active, clinically significant hepatic impairment (>= moderate hepatic impairment according to the NCI/Child Pugh classification)
-
Patient must undergo assessment with Timed Up and Go (TUG) test and comorbidity index
-
Patient must be able to receive xanthine oxidase inhibitor or rasburicase for tumor lysis syndrome (TLS) prophylaxis
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Behandeling
- Toewijzing: Gerandomiseerd
- Interventioneel model: Parallelle opdracht
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
|---|---|
|
Experimenteel: Arm A (ibrutinib, obinutuzumab, venetoclax)
Patients receive ibrutinib PO daily on days 1-28 and obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study. |
Ancillary studies
Andere namen:
Undergo CT
Andere namen:
Given PO
Andere namen:
Undergo collection of blood
Andere namen:
Given PO
Andere namen:
Given IV
Andere namen:
Undergo biopsy
Andere namen:
|
|
Actieve vergelijker: Arm B (ibrutinib, obinutuzumab)
Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study. |
Ancillary studies
Andere namen:
Undergo CT
Andere namen:
Given PO
Andere namen:
Undergo collection of blood
Andere namen:
Given IV
Andere namen:
Undergo biopsy
Andere namen:
|
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Progression-free survival
Tijdsspanne: Time from randomization to progression or death without documented progression, assessed up to 10 years
|
The analysis will be performed using the repeated confidence intervals methodology. At each interim or final analysis, two-sided repeated confidence interval will be constructed using the partial likelihood estimate from stratified Cox proportional hazards model and the critical value based on the Lan-DeMets error-spending function that corresponds to the truncated O'brien-Fleming boundaries. |
Time from randomization to progression or death without documented progression, assessed up to 10 years
|
Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Overall survival
Tijdsspanne: Time from randomization to death due to any cause, assessed up to 10 years
|
A hierarchical testing strategy will be used. The analysis will be performed using the repeated confidence intervals methodology. At each interim or final analysis, two-sided repeated confidence interval will be constructed using the partial likelihood estimate from stratified Cox proportional hazards model and the critical value based on the Lan-DeMets error-spending function that corresponds to the truncated O'brien-Fleming boundaries. |
Time from randomization to death due to any cause, assessed up to 10 years
|
|
Incidence of adverse events
Tijdsspanne: Up to 10 years
|
Graded according to Common Terminology Criteria for Adverse Events version 5.0. |
Up to 10 years
|
Andere uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Minimale residuele ziekte (MRD) analyse
Tijdsspanne: Tot 10 jaar
|
Tot 10 jaar
|
|
|
Quality of life (QOL)
Tijdsspanne: Baseline up to 10 years
|
Assessed using Functional Assessment of Cancer Therapy-General (FACT-G) and the leukemia sub-scale. FACT-G and the leukemia subscale will be analyzed at randomization, on day 1 of cycles 3, 7, 15, at the end of cycle 19, every 6 months for 2 years post response evaluation, at 48 months after randomization and at the time of disease progression. Linear mixed effects models will be used to perform repeated measures regression analysis. Will compare treatment toxicity-related QOL between the two arms. The entire FACT-Leukemia instrument (FACT-G and the leukemia subscale) at baseline will be analyzed using descriptive statistics to assess the impact of CLL on QOL independent of treatment. |
Baseline up to 10 years
|
|
FACT-Leu Trial Outcome Index (TOI) score over time
Tijdsspanne: Baseline up to 10 years
|
Will use linear mixed effects models will be used to perform repeated measures regression analysis to examine the treatment effect and time effect on FACT-Leu TOI score. |
Baseline up to 10 years
|
|
Adherence
Tijdsspanne: Baseline up to 10 years
|
Defined as patients taking 80% or more of their prescribed doses. The ASK-12 Survey will be used to measure the likelihood that a patient will take prescribed medications for patients on both arms at baseline and on day 1 +/- 4 days of the following cycles 3, 7, 15, at the time of response evaluation (end of cycle 19), every 6 months for 2 years post response evaluation, at 48 months after randomization, and at time of disease progression. Descriptive statistics will be used to summarize trend in adherence to prescription. |
Baseline up to 10 years
|
Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Sponsor
Onderzoekers
- Hoofdonderzoeker: Tait D Shanafelt, ECOG-ACRIN Cancer Research Group
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start (Werkelijk)
12 februari 2019
Primaire voltooiing (Geschat)
7 mei 2028
Studie voltooiing (Geschat)
7 mei 2028
Studieregistratiedata
Eerst ingediend
8 oktober 2018
Eerst ingediend dat voldeed aan de QC-criteria
8 oktober 2018
Eerst geplaatst (Werkelijk)
10 oktober 2018
Updates van studierecords
Laatste update geplaatst (Werkelijk)
12 november 2026
Laatste update ingediend die voldeed aan QC-criteria
11 november 2026
Laatst geverifieerd
1 juli 2026
Meer informatie
Termen gerelateerd aan deze studie
Aanvullende relevante MeSH-voorwaarden
- Pathologische processen
- Neoplasmata
- Chronische ziekte
- Ziekte attributen
- Ziekten van het immuunsysteem
- Neoplasmata per histologisch type
- Hematologische ziekten
- Lymfatische ziekten
- Lymfoproliferatieve aandoeningen
- Immunoproliferatieve aandoeningen
- Leukemie, B-cel
- Leukemie, Lymfoïde
- Leukemie
- Pathologische aandoeningen, tekenen en symptomen
- Hemische en lymfatische ziekten
- Leukemie, lymfatische, chronische, B-cel
- Onderzoekstechnieken
- Klinische laboratoriumtechnieken
- Diagnostische technieken en procedures
- Diagnose
- Chirurgische procedures, operatief
- Cytologische technieken
- Cytodiagnose
- Diagnostische technieken, chirurgisch
- Biopsie
- Exemplaarbehandeling
- venetoclax
- Obinutuzumab
- Ibrutinib
Andere studie-ID-nummers
- NCI-2018-02127
- U10CA180820 (Subsidie/contract van de Amerikaanse NIH)
- NCI-2018-02127 (Register-ID: CTRP (Clinical Trial Reporting Program))
- EA9161 (Andere identificatie: CTEP)
- EA9161 (Andere identificatie: ECOG-ACRIN Cancer Research Group)
Plan Individuele Deelnemersgegevens (IPD)
Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?
JA
Beschrijving IPD-plan
NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Ja
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
Nee
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .