Valutazione della capacità del trattamento di associazione con Venetoclax di consentire una terapia a tempo limitato nella leucemia linfocitica cronica
11 novembre 2026 aggiornato da: National Cancer Institute (NCI)
Uno studio randomizzato di fase III sull'aggiunta di Venetoclax a Ibrutinib e Obinutuzumab rispetto a Ibrutinib e Obinutuzumab in pazienti più giovani non trattati con leucemia linfocitica cronica (LLC)
This phase III trial studies how well ibrutinib and obinutuzumab with or without venetoclax work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Obinutuzumab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Giving ibrutinib, obinutuzumab, and venetoclax may work better than giving ibrutinib and obinutuzumab in treating patients with chronic lymphocytic leukemia.
Panoramica dello studio
Stato
Attivo, non reclutante
Descrizione dettagliata
PRIMARY OBJECTIVE:
I. To compare the progression free survival (PFS) of the time limited administration of the three-drug combination ibrutinib-obinutuzumab-venetoclax (IOV) to ibrutinib-obinutuzumab (IO) in untreated chronic lymphocytic leukemia (CLL) patients younger than 70 years of age.
SECONDARY OBJECTIVES:
I. Evaluate overall survival (OS) of patients based on treatment arm. II. Monitor and assess toxicity of treatment based on treatment arm. III. Compare minimal residual disease (MRD) status as assessed by flow cytometry at baseline and then sequentially during treatment of the two treatment arms.
IV. Collect baseline and response evaluation (after cycle 19) bone marrow and paired blood specimens for evaluation of MRD.
QUALITY OF LIFE (QOL) OBJECTIVES:
I. To compare quality of life (QOL) in CLL patients during the first 19 cycles of treatment among patients on each treatment arm.
II. To compare QOL over the long-term in CLL patients receiving continuous therapy using ibrutinib to that of CLL patients who completed time limited therapy.
III. Evaluate adherence to therapy for the two arms (one of which requires more intense, but shorter duration treatment, and one of which requires less intense, but indefinite duration therapy) and explore how adherence in each arm relates to progression-free survival (PFS).
EXPLORATORY TOBACCO USE OBJECTIVES:
I. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications).
II. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms.
III. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization.
IV. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM A: Patients receive ibrutinib orally (PO) daily on days 1-28 and obinutuzumab intravenously (IV) over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO once daily (QD) on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and computed tomography (CT) scans before and after treatment and collection of blood throughout the study.
ARM B: Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study.
All patients, including those who discontinue therapy early, are followed for response until disease progression, even if non-protocol therapy is initiated. Patients are then followed every 3 months for first 2 years, every 6 months for years 3-5, and then every 12 months for years 6-10. All patients must also be followed through completion of all protocol therapy.
Tipo di studio
Interventistico
Iscrizione (Stimato)
720
Fase
- Fase 3
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
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Jerusalem, Israele, 91031
- Shaare Zedek Medical Center
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Alabama
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Birmingham, Alabama, Stati Uniti, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, Stati Uniti, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Stati Uniti, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Stati Uniti, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Stati Uniti, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Stati Uniti, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Stati Uniti, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Stati Uniti, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Stati Uniti, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Stati Uniti, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, Stati Uniti, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Stati Uniti, 85054
- Mayo Clinic Hospital in Arizona
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Phoenix, Arizona, Stati Uniti, 85004
- Cancer Center at Saint Joseph's
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Scottsdale, Arizona, Stati Uniti, 85259
- Mayo Clinic in Arizona
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Tucson, Arizona, Stati Uniti, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, Stati Uniti, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Stati Uniti, 85719
- University of Arizona Cancer Center-North Campus
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Arkansas
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Fort Smith, Arkansas, Stati Uniti, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Stati Uniti, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Anaheim, California, Stati Uniti, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Stati Uniti, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Stati Uniti, 93420
- PCR Oncology
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Arroyo Grande, California, Stati Uniti, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Baldwin Park, California, Stati Uniti, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Stati Uniti, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, Stati Uniti, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Costa Mesa, California, Stati Uniti, 92627
- UC Irvine Health Cancer Center-Newport
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Duarte, California, Stati Uniti, 91010
- City of Hope Comprehensive Cancer Center
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Dublin, California, Stati Uniti, 94568
- Kaiser Permanente Dublin
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Fontana, California, Stati Uniti, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Stati Uniti, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Stati Uniti, 93720
- Kaiser Permanente-Fresno
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Fresno, California, Stati Uniti, 93720
- Fresno Cancer Center
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Harbor City, California, Stati Uniti, 90710
- Kaiser Permanente South Bay
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Irvine, California, Stati Uniti, 92618
- Kaiser Permanente-Irvine
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Long Beach, California, Stati Uniti, 90822
- Tibor Rubin VA Medical Center
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Los Angeles, California, Stati Uniti, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Stati Uniti, 90034
- Kaiser Permanente West Los Angeles
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Modesto, California, Stati Uniti, 95356
- Kaiser Permanente-Modesto
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Oakland, California, Stati Uniti, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Stati Uniti, 94611
- Kaiser Permanente Oakland-Broadway
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Ontario, California, Stati Uniti, 91761
- Kaiser Permanente-Ontario
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Orange, California, Stati Uniti, 92868
- UC Irvine Health/Chao Family Comprehensive Cancer Center
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Palm Springs, California, Stati Uniti, 92262
- Desert Regional Medical Center
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Palo Alto, California, Stati Uniti, 94304
- VA Palo Alto Health Care System
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Palo Alto, California, Stati Uniti, 94304
- Stanford Cancer Institute Palo Alto
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Panorama City, California, Stati Uniti, 91402
- Kaiser Permanente - Panorama City
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Rancho Cordova, California, Stati Uniti, 95670
- Kaiser Permanente-Rancho Cordova Cancer Center
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Redwood City, California, Stati Uniti, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Stati Uniti, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Stati Uniti, 92505
- Kaiser Permanente-Riverside
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Rohnert Park, California, Stati Uniti, 94928
- Rohnert Park Cancer Center
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Roseville, California, Stati Uniti, 95678
- The Permanente Medical Group-Roseville Radiation Oncology
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Roseville, California, Stati Uniti, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, Stati Uniti, 95814
- Kaiser Permanente Downtown Commons
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Sacramento, California, Stati Uniti, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Stati Uniti, 95823
- South Sacramento Cancer Center
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Sacramento, California, Stati Uniti, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Stati Uniti, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Stati Uniti, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, Stati Uniti, 94115
- Kaiser Permanente-San Francisco
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San Jose, California, Stati Uniti, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Stati Uniti, 94577
- Kaiser Permanente San Leandro
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San Luis Obispo, California, Stati Uniti, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, Stati Uniti, 92078
- Kaiser Permanente-San Marcos
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San Rafael, California, Stati Uniti, 94903
- Kaiser San Rafael-Gallinas
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San Rafael, California, Stati Uniti, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Stati Uniti, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Maria, California, Stati Uniti, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Stati Uniti, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, Stati Uniti, 94080
- Kaiser Permanente Cancer Treatment Center
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South San Francisco, California, Stati Uniti, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Stati Uniti, 95210
- Kaiser Permanente-Stockton
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Vacaville, California, Stati Uniti, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Stati Uniti, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Stati Uniti, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Stati Uniti, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Stati Uniti, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Stati Uniti, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Stati Uniti, 80045
- Rocky Mountain Regional VA Medical Center
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Boulder, Colorado, Stati Uniti, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Stati Uniti, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Stati Uniti, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Stati Uniti, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Stati Uniti, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Stati Uniti, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Stati Uniti, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Stati Uniti, 80220
- Rose Medical Center
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Denver, Colorado, Stati Uniti, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Stati Uniti, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Stati Uniti, 80204
- Denver Health Medical Center
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Denver, Colorado, Stati Uniti, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Stati Uniti, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Stati Uniti, 80209
- The Women's Imaging Center
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Denver, Colorado, Stati Uniti, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Stati Uniti, 80220
- Western Surgical Care
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Denver, Colorado, Stati Uniti, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Stati Uniti, 80210
- AdventHealth Porter
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Durango, Colorado, Stati Uniti, 81301
- Mercy Medical Center
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Durango, Colorado, Stati Uniti, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Stati Uniti, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Stati Uniti, 80113
- Swedish Medical Center
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Golden, Colorado, Stati Uniti, 80401
- Mountain Blue Cancer Care Center
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Golden, Colorado, Stati Uniti, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Stati Uniti, 81501
- Saint Mary's Hospital and Regional Medical Center
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Grand Junction, Colorado, Stati Uniti, 81505
- Grand Valley Oncology
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Greeley, Colorado, Stati Uniti, 80631
- Banner North Colorado Medical Center
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Lafayette, Colorado, Stati Uniti, 80026
- Kaiser Permanente-Rock Creek
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Lafayette, Colorado, Stati Uniti, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, Stati Uniti, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, Stati Uniti, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Stati Uniti, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Stati Uniti, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Stati Uniti, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, Stati Uniti, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Stati Uniti, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Stati Uniti, 80501
- Longmont United Hospital
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Longmont, Colorado, Stati Uniti, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Stati Uniti, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Stati Uniti, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, Stati Uniti, 80138
- AdventHealth Parker
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Pueblo, Colorado, Stati Uniti, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Stati Uniti, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Stati Uniti, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Stati Uniti, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Stati Uniti, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Derby, Connecticut, Stati Uniti, 06418
- Smilow Cancer Hospital-Derby Care Center
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Fairfield, Connecticut, Stati Uniti, 06824
- Smilow Cancer Hospital Care Center-Fairfield
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Glastonbury, Connecticut, Stati Uniti, 06033
- Smilow Cancer Hospital Care Center at Glastonbury
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Guilford, Connecticut, Stati Uniti, 06437
- Smilow Cancer Hospital Care Center - Guilford
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Hartford, Connecticut, Stati Uniti, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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New Haven, Connecticut, Stati Uniti, 06520
- Yale University
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North Haven, Connecticut, Stati Uniti, 06473
- Yale-New Haven Hospital North Haven Medical Center
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Orange, Connecticut, Stati Uniti, 06477
- Smilow Cancer Hospital-Orange Care Center
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Trumbull, Connecticut, Stati Uniti, 06611
- Smilow Cancer Hospital Care Center-Trumbull
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Waterbury, Connecticut, Stati Uniti, 06708
- Smilow Cancer Hospital-Waterbury Care Center
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Waterford, Connecticut, Stati Uniti, 06385
- Smilow Cancer Hospital Care Center - Waterford
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West Haven, Connecticut, Stati Uniti, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Delaware
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Lewes, Delaware, Stati Uniti, 19958
- Beebe Medical Center
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Millville, Delaware, Stati Uniti, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Stati Uniti, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Stati Uniti, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Stati Uniti, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Stati Uniti, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Stati Uniti, 19971
- Beebe Health Campus
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Seaford, Delaware, Stati Uniti, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Stati Uniti, 19801
- Christiana Care Health System-Wilmington Hospital
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Florida
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Fort Lauderdale, Florida, Stati Uniti, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, Stati Uniti, 33308
- Holy Cross Hospital
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Jacksonville, Florida, Stati Uniti, 32224-9980
- Mayo Clinic in Florida
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Georgia
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Athens, Georgia, Stati Uniti, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Stati Uniti, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Stati Uniti, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Stati Uniti, 30342
- Emory Saint Joseph's Hospital
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Augusta, Georgia, Stati Uniti, 30912
- Augusta University Medical Center
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Decatur, Georgia, Stati Uniti, 30033
- Atlanta VA Medical Center
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Hawaii
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Hilo, Hawaii, Stati Uniti, 96720
- Island Urology-Hilo
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Honolulu, Hawaii, Stati Uniti, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Stati Uniti, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Stati Uniti, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Stati Uniti, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Stati Uniti, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Stati Uniti, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Stati Uniti, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Stati Uniti, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Stati Uniti, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Stati Uniti, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Stati Uniti, 96813
- Island Urology
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Honolulu, Hawaii, Stati Uniti, 96819
- Kaiser Permanente Moanalua Medical Center
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Lihue, Hawaii, Stati Uniti, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Stati Uniti, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Stati Uniti, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Stati Uniti, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Stati Uniti, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Stati Uniti, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Stati Uniti, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Stati Uniti, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Stati Uniti, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Stati Uniti, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Stati Uniti, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Stati Uniti, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Stati Uniti, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Stati Uniti, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Stati Uniti, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Stati Uniti, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Stati Uniti, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, Stati Uniti, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Aurora, Illinois, Stati Uniti, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Stati Uniti, 61704
- Illinois CancerCare-Bloomington
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Burr Ridge, Illinois, Stati Uniti, 60527
- Loyola Center for Health at Burr Ridge
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Canton, Illinois, Stati Uniti, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Stati Uniti, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Stati Uniti, 62918
- SIH Cancer Institute
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Carthage, Illinois, Stati Uniti, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Stati Uniti, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Stati Uniti, 60611
- Northwestern University
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Chicago, Illinois, Stati Uniti, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Stati Uniti, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, Stati Uniti, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Stati Uniti, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Stati Uniti, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Stati Uniti, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Stati Uniti, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, Stati Uniti, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Stati Uniti, 62401
- Carle Physician Group-Effingham
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Eureka, Illinois, Stati Uniti, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Stati Uniti, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Stati Uniti, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Stati Uniti, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Stati Uniti, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Stati Uniti, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Harvey, Illinois, Stati Uniti, 60426
- Ingalls Memorial Hospital
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Highland Park, Illinois, Stati Uniti, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Homer Glen, Illinois, Stati Uniti, 60491
- Loyola Medicine Homer Glen
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Kewanee, Illinois, Stati Uniti, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, Stati Uniti, 60045
- Northwestern Medicine Lake Forest Hospital
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Macomb, Illinois, Stati Uniti, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Stati Uniti, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Stati Uniti, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, Stati Uniti, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Mount Vernon, Illinois, Stati Uniti, 62864
- SSM Health Good Samaritan
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New Lenox, Illinois, Stati Uniti, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, Stati Uniti, 62269
- Cancer Care Center of O'Fallon
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Orland Park, Illinois, Stati Uniti, 60462
- University of Chicago Medicine-Orland Park
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Ottawa, Illinois, Stati Uniti, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, Stati Uniti, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, Stati Uniti, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, Stati Uniti, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Stati Uniti, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, Stati Uniti, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, Stati Uniti, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, Stati Uniti, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Stati Uniti, 61354
- Valley Radiation Oncology
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Princeton, Illinois, Stati Uniti, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, Stati Uniti, 61114
- UW Health Carbone Cancer Center Rockford
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Skokie, Illinois, Stati Uniti, 60076
- North Shore Medical Center
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Springfield, Illinois, Stati Uniti, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Stati Uniti, 62702
- Springfield Clinic
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Springfield, Illinois, Stati Uniti, 62781
- Springfield Memorial Hospital
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Swansea, Illinois, Stati Uniti, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, Stati Uniti, 61801
- Carle Cancer Center
-
Urbana, Illinois, Stati Uniti, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Stati Uniti, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, Stati Uniti, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Fort Wayne, Indiana, Stati Uniti, 46845
- Parkview Regional Medical Center
-
Indianapolis, Indiana, Stati Uniti, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Stati Uniti, 46219
- Community Cancer Center East
-
Indianapolis, Indiana, Stati Uniti, 46227
- Community Cancer Center South
-
Indianapolis, Indiana, Stati Uniti, 46256
- Community Cancer Center North
-
Kokomo, Indiana, Stati Uniti, 46904
- Community Howard Regional Health
-
Mooresville, Indiana, Stati Uniti, 46158
- Franciscan Health Mooresville
-
Richmond, Indiana, Stati Uniti, 47374
- Reid Health
-
Terre Haute, Indiana, Stati Uniti, 47804
- Union Hospital
-
-
Iowa
-
Ames, Iowa, Stati Uniti, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Stati Uniti, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, Stati Uniti, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Boone, Iowa, Stati Uniti, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Stati Uniti, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Stati Uniti, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Stati Uniti, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, Stati Uniti, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Stati Uniti, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Stati Uniti, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Stati Uniti, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Stati Uniti, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Stati Uniti, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Stati Uniti, 50309
- Blank Children's Hospital
-
Des Moines, Iowa, Stati Uniti, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Stati Uniti, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Stati Uniti, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Stati Uniti, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Stati Uniti, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, Stati Uniti, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Iowa City, Iowa, Stati Uniti, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, Stati Uniti, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Stati Uniti, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Stati Uniti, 51101
- Siouxland Regional Cancer Center
-
Waterloo, Iowa, Stati Uniti, 50702
- MercyOne Waterloo Cancer Center
-
West Des Moines, Iowa, Stati Uniti, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Stati Uniti, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Coffeyville, Kansas, Stati Uniti, 67337
- Coffeyville Regional Medical Center
-
Garden City, Kansas, Stati Uniti, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Stati Uniti, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Stati Uniti, 67601
- HaysMed
-
Independence, Kansas, Stati Uniti, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Stati Uniti, 66160
- University of Kansas Cancer Center
-
Kansas City, Kansas, Stati Uniti, 66112
- University of Kansas Cancer Center-West
-
Lawrence, Kansas, Stati Uniti, 66044
- Lawrence Memorial Hospital
-
Olathe, Kansas, Stati Uniti, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Stati Uniti, 66210
- University of Kansas Cancer Center-Overland Park
-
Pittsburg, Kansas, Stati Uniti, 66762
- Mercy Hospital Pittsburg
-
Salina, Kansas, Stati Uniti, 67401
- Salina Regional Health Center
-
Topeka, Kansas, Stati Uniti, 66606
- University of Kansas Health System Saint Francis Campus
-
Westwood, Kansas, Stati Uniti, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Stati Uniti, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Stati Uniti, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Stati Uniti, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Stati Uniti, 67214
- Wesley Medical Center
-
-
Kentucky
-
Bardstown, Kentucky, Stati Uniti, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Stati Uniti, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Stati Uniti, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Stati Uniti, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Stati Uniti, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Stati Uniti, 40202
- Jewish Hospital
-
Louisville, Kentucky, Stati Uniti, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Stati Uniti, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Stati Uniti, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Stati Uniti, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, Stati Uniti, 70836
- Ochsner High Grove
-
New Orleans, Louisiana, Stati Uniti, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Augusta, Maine, Stati Uniti, 04330
- Harold Alfond Center for Cancer Care
-
Belfast, Maine, Stati Uniti, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Stati Uniti, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Norway, Maine, Stati Uniti, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, Stati Uniti, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Stati Uniti, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Stati Uniti, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Cumberland, Maryland, Stati Uniti, 21502
- UPMC Western Maryland
-
-
Massachusetts
-
Boston, Massachusetts, Stati Uniti, 02111
- Tufts Medical Center
-
Burlington, Massachusetts, Stati Uniti, 01805
- Lahey Clinic
-
Lowell, Massachusetts, Stati Uniti, 01854
- Lowell General Hospital
-
Springfield, Massachusetts, Stati Uniti, 01104
- Mercy Medical Center
-
-
Michigan
-
Adrian, Michigan, Stati Uniti, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Stati Uniti, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Brighton, Michigan, Stati Uniti, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Stati Uniti, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Stati Uniti, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Stati Uniti, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Stati Uniti, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Stati Uniti, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Stati Uniti, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Stati Uniti, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Stati Uniti, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Stati Uniti, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, Stati Uniti, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Stati Uniti, 48126
- Henry Ford Medical Center-Fairlane
-
Dearborn, Michigan, Stati Uniti, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Stati Uniti, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Stati Uniti, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Stati Uniti, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Stati Uniti, 48054
- Henry Ford River District Hospital
-
Escanaba, Michigan, Stati Uniti, 49829
- OSF Saint Francis Hospital and Medical Group
-
Farmington Hills, Michigan, Stati Uniti, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Stati Uniti, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Stati Uniti, 48503
- Hurley Medical Center
-
Flint, Michigan, Stati Uniti, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Stati Uniti, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Stati Uniti, 48503
- Cancer Hematology Centers - Flint
-
Grosse Pointe Woods, Michigan, Stati Uniti, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Stati Uniti, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Stati Uniti, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, Stati Uniti, 49201
- Allegiance Health
-
Lansing, Michigan, Stati Uniti, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Stati Uniti, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Stati Uniti, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Stati Uniti, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Stati Uniti, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Stati Uniti, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, Stati Uniti, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Novi, Michigan, Stati Uniti, 48377
- Henry Ford Medical Center-Columbus
-
Pontiac, Michigan, Stati Uniti, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Stati Uniti, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Stati Uniti, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Stati Uniti, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron, Michigan, Stati Uniti, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Stati Uniti, 48060
- Huron Medical Center PC
-
Rochester Hills, Michigan, Stati Uniti, 48309
- Henry Ford Rochester Hospital
-
Royal Oak, Michigan, Stati Uniti, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Stati Uniti, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Stati Uniti, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Stati Uniti, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Stati Uniti, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Stati Uniti, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Stati Uniti, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Stati Uniti, 48601
- MyMichigan Medical Center Saginaw
-
Shelby, Michigan, Stati Uniti, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Sterling Heights, Michigan, Stati Uniti, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Sterling Heights, Michigan, Stati Uniti, 48312
- Premier Hematology Oncology Care
-
Tawas City, Michigan, Stati Uniti, 48764
- MyMichigan Medical Center Tawas
-
Troy, Michigan, Stati Uniti, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Stati Uniti, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Stati Uniti, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Stati Uniti, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Stati Uniti, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Stati Uniti, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Stati Uniti, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Stati Uniti, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield, Michigan, Stati Uniti, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, Stati Uniti, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Ypsilanti, Michigan, Stati Uniti, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Stati Uniti, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Stati Uniti, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Stati Uniti, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Stati Uniti, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Stati Uniti, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Stati Uniti, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Stati Uniti, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Stati Uniti, 55433
- Mercy Hospital
-
Deer River, Minnesota, Stati Uniti, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Stati Uniti, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Stati Uniti, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Stati Uniti, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Stati Uniti, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Stati Uniti, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Stati Uniti, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Stati Uniti, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Stati Uniti, 55432
- Unity Hospital
-
Hibbing, Minnesota, Stati Uniti, 55746
- Essentia Health Hibbing Clinic
-
Mankato, Minnesota, Stati Uniti, 56001
- Mayo Clinic Health Systems-Mankato
-
Maple Grove, Minnesota, Stati Uniti, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Stati Uniti, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Stati Uniti, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Stati Uniti, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Stati Uniti, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Stati Uniti, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Stati Uniti, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Stati Uniti, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Stati Uniti, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Stati Uniti, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Stati Uniti, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Stati Uniti, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Stati Uniti, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Stati Uniti, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Stati Uniti, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Stati Uniti, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Stati Uniti, 55102
- United Hospital
-
Sandstone, Minnesota, Stati Uniti, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Stati Uniti, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Stati Uniti, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Stati Uniti, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Stati Uniti, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Stati Uniti, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Stati Uniti, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Stati Uniti, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Stati Uniti, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Stati Uniti, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Hattiesburg, Mississippi, Stati Uniti, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, Stati Uniti, 39404
- Forrest General Hospital / Cancer Center
-
-
Missouri
-
Ballwin, Missouri, Stati Uniti, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Stati Uniti, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Stati Uniti, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Stati Uniti, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Stati Uniti, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Stati Uniti, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Stati Uniti, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, Stati Uniti, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Columbia, Missouri, Stati Uniti, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, Stati Uniti, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Stati Uniti, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Stati Uniti, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Stati Uniti, 64804
- Freeman Health System
-
Joplin, Missouri, Stati Uniti, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Stati Uniti, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Stati Uniti, 64131
- The University of Kansas Cancer Center-South
-
Kansas City, Missouri, Stati Uniti, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Stati Uniti, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, Stati Uniti, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Rolla, Missouri, Stati Uniti, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Stati Uniti, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Stati Uniti, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Stati Uniti, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Stati Uniti, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Stati Uniti, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Stati Uniti, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Stati Uniti, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Stati Uniti, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Stati Uniti, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Stati Uniti, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Stati Uniti, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Stati Uniti, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Stati Uniti, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, Stati Uniti, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Stati Uniti, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Stati Uniti, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Stati Uniti, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Stati Uniti, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Stati Uniti, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Stati Uniti, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Stati Uniti, 59405
- Great Falls Clinic
-
Great Falls, Montana, Stati Uniti, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Stati Uniti, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Stati Uniti, 59901
- Logan Health Medical Center
-
Missoula, Montana, Stati Uniti, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Stati Uniti, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Stati Uniti, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Stati Uniti, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Stati Uniti, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Stati Uniti, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Stati Uniti, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Stati Uniti, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Stati Uniti, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Stati Uniti, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Stati Uniti, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Stati Uniti, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Stati Uniti, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Stati Uniti, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Stati Uniti, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Stati Uniti, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Stati Uniti, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Stati Uniti, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Stati Uniti, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Stati Uniti, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Stati Uniti, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Stati Uniti, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Stati Uniti, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Stati Uniti, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Stati Uniti, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Stati Uniti, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Stati Uniti, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Stati Uniti, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Stati Uniti, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Stati Uniti, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Stati Uniti, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Stati Uniti, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Stati Uniti, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Stati Uniti, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Stati Uniti, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Stati Uniti, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Stati Uniti, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Stati Uniti, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Stati Uniti, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Stati Uniti, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Stati Uniti, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Stati Uniti, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Stati Uniti, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Stati Uniti, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Stati Uniti, 89169
- University Cancer Center
-
Las Vegas, Nevada, Stati Uniti, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Stati Uniti, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Stati Uniti, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Stati Uniti, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Stati Uniti, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Stati Uniti, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Stati Uniti, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, Stati Uniti, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Manchester, New Hampshire, Stati Uniti, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, Stati Uniti, 03103
- Elliot Hospital
-
-
New Jersey
-
Brick, New Jersey, Stati Uniti, 08724
- Ocean University Medical Center
-
Lakewood, New Jersey, Stati Uniti, 08701
- Monmouth Medical Center Southern Campus
-
Long Branch, New Jersey, Stati Uniti, 07740
- Monmouth Medical Center
-
Manahawkin, New Jersey, Stati Uniti, 08050
- Southern Ocean County Medical Center
-
Morristown, New Jersey, Stati Uniti, 07960
- Morristown Medical Center
-
Neptune City, New Jersey, Stati Uniti, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, Stati Uniti, 08903
- Rutgers Cancer Institute of New Jersey
-
Red Bank, New Jersey, Stati Uniti, 07701
- Riverview Medical Center/Booker Cancer Center
-
Summit, New Jersey, Stati Uniti, 07902
- Overlook Hospital
-
-
New Mexico
-
Albuquerque, New Mexico, Stati Uniti, 87106
- University of New Mexico Cancer Center
-
Las Cruces, New Mexico, Stati Uniti, 88011
- Memorial Medical Center-Las Cruces
-
-
New York
-
Auburn, New York, Stati Uniti, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Buffalo, New York, Stati Uniti, 14263
- Roswell Park Cancer Institute
-
Camillus, New York, Stati Uniti, 13031
- Hematology Oncology Associates of CNY at Camillus
-
East Hills, New York, Stati Uniti, 11548
- The Cancer Institute at Saint Francis Hospital
-
East Syracuse, New York, Stati Uniti, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, Stati Uniti, 12801
- Glens Falls Hospital
-
Mineola, New York, Stati Uniti, 11501
- NYU Langone Hospital - Long Island
-
New York, New York, Stati Uniti, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Stati Uniti, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
Rochester, New York, Stati Uniti, 14642
- University of Rochester
-
Syracuse, New York, Stati Uniti, 13210
- State University of New York Upstate Medical University
-
West Islip, New York, Stati Uniti, 11795
- Good Samaritan University Hospital
-
-
North Carolina
-
Asheville, North Carolina, Stati Uniti, 28801
- Mission Hospital
-
Asheville, North Carolina, Stati Uniti, 28806
- Messino Cancer Centers
-
Cary, North Carolina, Stati Uniti, 27518
- Waverly Hematology Oncology
-
Chapel Hill, North Carolina, Stati Uniti, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Stati Uniti, 28328
- Southeastern Medical Oncology Center-Clinton
-
Durham, North Carolina, Stati Uniti, 27710
- Duke University Medical Center
-
Goldsboro, North Carolina, Stati Uniti, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Stati Uniti, 27534
- Wayne Memorial Hospital
-
Hendersonville, North Carolina, Stati Uniti, 28791
- Margaret R Pardee Memorial Hospital
-
Jacksonville, North Carolina, Stati Uniti, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Jacksonville, North Carolina, Stati Uniti, 28546
- Onslow Memorial Hospital
-
Pinehurst, North Carolina, Stati Uniti, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
-
North Dakota
-
Bismarck, North Dakota, Stati Uniti, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Stati Uniti, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Stati Uniti, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Stati Uniti, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Stati Uniti, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Stati Uniti, 58104
- Sanford Medical Center Fargo
-
Jamestown, North Dakota, Stati Uniti, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, Stati Uniti, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beavercreek, Ohio, Stati Uniti, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Stati Uniti, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Stati Uniti, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Stati Uniti, 44708
- Cleveland Clinic Mercy Hospital
-
Centerville, Ohio, Stati Uniti, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Stati Uniti, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Stati Uniti, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Stati Uniti, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Stati Uniti, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Stati Uniti, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Stati Uniti, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Stati Uniti, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Stati Uniti, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Stati Uniti, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Stati Uniti, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Stati Uniti, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Stati Uniti, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Stati Uniti, 43228
- Doctors Hospital
-
Columbus, Ohio, Stati Uniti, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Stati Uniti, 43215
- Grant Medical Center
-
Columbus, Ohio, Stati Uniti, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Stati Uniti, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Stati Uniti, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Stati Uniti, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Stati Uniti, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Stati Uniti, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Stati Uniti, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Stati Uniti, 43016
- Dublin Methodist Hospital
-
Findlay, Ohio, Stati Uniti, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Stati Uniti, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Stati Uniti, 45840
- Orion Cancer Care
-
Franklin, Ohio, Stati Uniti, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Stati Uniti, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Stati Uniti, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Stati Uniti, 45331
- Wayne Hospital
-
Greenville, Ohio, Stati Uniti, 45331
- Dayton Physicians LLC-Wayne
-
Grove City, Ohio, Stati Uniti, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, Stati Uniti, 45429
- Kettering Medical Center
-
Kettering, Ohio, Stati Uniti, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Stati Uniti, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Stati Uniti, 43130
- Fairfield Medical Center
-
Mansfield, Ohio, Stati Uniti, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Stati Uniti, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Stati Uniti, 43302
- OhioHealth Marion General Hospital
-
Mount Vernon, Ohio, Stati Uniti, 43050
- Knox Community Hospital
-
Newark, Ohio, Stati Uniti, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Stati Uniti, 43055
- Newark Radiation Oncology
-
Perrysburg, Ohio, Stati Uniti, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Stati Uniti, 45662
- Southern Ohio Medical Center
-
Springfield, Ohio, Stati Uniti, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Stati Uniti, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Stati Uniti, 43560
- ProMedica Flower Hospital
-
Toledo, Ohio, Stati Uniti, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Stati Uniti, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Stati Uniti, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Troy, Ohio, Stati Uniti, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Stati Uniti, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Stati Uniti, 44484
- Saint Joseph Warren Hospital
-
Westerville, Ohio, Stati Uniti, 43081
- Saint Ann's Hospital
-
Wright-Patterson Air Force Base, Ohio, Stati Uniti, 45433
- Wright-Patterson Medical Center
-
Youngstown, Ohio, Stati Uniti, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Stati Uniti, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Stati Uniti, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Stati Uniti, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Stati Uniti, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Stati Uniti, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Stati Uniti, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Stati Uniti, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Stati Uniti, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Stati Uniti, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Stati Uniti, 97420
- Bay Area Hospital
-
Newberg, Oregon, Stati Uniti, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Stati Uniti, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Portland, Oregon, Stati Uniti, 97239
- Oregon Health and Science University
-
Portland, Oregon, Stati Uniti, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Stati Uniti, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Stati Uniti, 97227
- Kaiser Permanente Northwest
-
Redmond, Oregon, Stati Uniti, 97756
- Saint Charles Health System-Redmond
-
Salem, Oregon, Stati Uniti, 97301
- Salem Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, Stati Uniti, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Stati Uniti, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Stati Uniti, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, Stati Uniti, 19317
- Christiana Care Health System-Concord Health Center
-
Chambersburg, Pennsylvania, Stati Uniti, 17201
- Chambersburg Hospital
-
Collegeville, Pennsylvania, Stati Uniti, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, Stati Uniti, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Stati Uniti, 18301
- Pocono Medical Center
-
Ephrata, Pennsylvania, Stati Uniti, 17522
- Ephrata Cancer Center
-
Ephrata, Pennsylvania, Stati Uniti, 17522
- Ephrata Community Hospital
-
Exton, Pennsylvania, Stati Uniti, 19341
- Main Line Health Center-Exton
-
Gettysburg, Pennsylvania, Stati Uniti, 17325
- Adams Cancer Center
-
Hanover, Pennsylvania, Stati Uniti, 17331
- WellSpan Medical Oncology and Hematology
-
Hazleton, Pennsylvania, Stati Uniti, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Stati Uniti, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, Stati Uniti, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lebanon, Pennsylvania, Stati Uniti, 17042
- Sechler Family Cancer Center
-
Lewisburg, Pennsylvania, Stati Uniti, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Stati Uniti, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Stati Uniti, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Stati Uniti, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Stati Uniti, 19107
- Thomas Jefferson University Hospital
-
Pottstown, Pennsylvania, Stati Uniti, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, Stati Uniti, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Stati Uniti, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Stati Uniti, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, Stati Uniti, 16801
- Geisinger Medical Group
-
Wilkes-Barre, Pennsylvania, Stati Uniti, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Willow Grove, Pennsylvania, Stati Uniti, 19090
- Asplundh Cancer Pavilion
-
Wynnewood, Pennsylvania, Stati Uniti, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Stati Uniti, 17403
- WellSpan Health-York Cancer Center
-
York, Pennsylvania, Stati Uniti, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Westerly, Rhode Island, Stati Uniti, 02891
- Smilow Cancer Hospital Care Center - Westerly
-
-
South Carolina
-
Boiling Springs, South Carolina, Stati Uniti, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Stati Uniti, 29425
- Medical University of South Carolina
-
Clinton, South Carolina, Stati Uniti, 29325
- Prisma Health Cancer Institute - Laurens
-
Easley, South Carolina, Stati Uniti, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Stati Uniti, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Stati Uniti, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Stati Uniti, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Stati Uniti, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Stati Uniti, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Stati Uniti, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Stati Uniti, 29605
- BI-LO Charities Children's Cancer Center
-
Greenville, South Carolina, Stati Uniti, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenwood, South Carolina, Stati Uniti, 29646
- Self Regional Healthcare
-
Greer, South Carolina, Stati Uniti, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Stati Uniti, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Stati Uniti, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Stati Uniti, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Stati Uniti, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, Stati Uniti, 57401
- Avera Cancer Institute-Aberdeen
-
Pierre, South Dakota, Stati Uniti, 57501
- Avera Cancer Institute at Pierre
-
Sioux Falls, South Dakota, Stati Uniti, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Stati Uniti, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Stati Uniti, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Stati Uniti, 37404
- Memorial Hospital
-
Hixson, Tennessee, Stati Uniti, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Ooltewah, Tennessee, Stati Uniti, 37363
- Memorial GYN Plus
-
-
Texas
-
Amarillo, Texas, Stati Uniti, 79106
- The Don and Sybil Harrington Cancer Center
-
Bryan, Texas, Stati Uniti, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Stati Uniti, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, Stati Uniti, 75216
- Dallas VA Medical Center
-
Richardson, Texas, Stati Uniti, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, Stati Uniti, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Stati Uniti, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Stati Uniti, 84321
- Logan Regional Hospital
-
Murray, Utah, Stati Uniti, 84107
- Intermountain Medical Center
-
Ogden, Utah, Stati Uniti, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Stati Uniti, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Stati Uniti, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Stati Uniti, 84112
- Huntsman Cancer Institute/University of Utah
-
Salt Lake City, Utah, Stati Uniti, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Stati Uniti, 84143
- LDS Hospital
-
St. George, Utah, Stati Uniti, 84770
- Saint George Regional Medical Center
-
-
Virginia
-
Charlottesville, Virginia, Stati Uniti, 22908
- University of Virginia Cancer Center
-
Fairfax, Virginia, Stati Uniti, 22031
- Inova Schar Cancer Institute
-
Falls Church, Virginia, Stati Uniti, 22042
- Inova Fairfax Hospital
-
Lynchburg, Virginia, Stati Uniti, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Richmond, Virginia, Stati Uniti, 23229
- Virginia Cancer Institute
-
Richmond, Virginia, Stati Uniti, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Stati Uniti, 23970
- VCU Community Memorial Health Center
-
-
Washington
-
Aberdeen, Washington, Stati Uniti, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Stati Uniti, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Stati Uniti, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Stati Uniti, 98004
- Overlake Medical Center
-
Bellingham, Washington, Stati Uniti, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Stati Uniti, 98166
- Saint Anne Hospital
-
Centralia, Washington, Stati Uniti, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Stati Uniti, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Stati Uniti, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Stati Uniti, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Stati Uniti, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Stati Uniti, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Stati Uniti, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Stati Uniti, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Stati Uniti, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Stati Uniti, 99336
- Kadlec Clinic Hematology and Oncology
-
Kennewick, Washington, Stati Uniti, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Stati Uniti, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Stati Uniti, 98499
- Saint Clare Hospital
-
Longview, Washington, Stati Uniti, 98632
- PeaceHealth Saint John Medical Center
-
Lynnwood, Washington, Stati Uniti, 98036
- Virginia Mason Lynnwood Medical Center
-
Port Townsend, Washington, Stati Uniti, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Stati Uniti, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Stati Uniti, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Stati Uniti, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Renton, Washington, Stati Uniti, 98055
- Valley Medical Center
-
Seattle, Washington, Stati Uniti, 98101
- Virginia Mason Medical Center
-
Seattle, Washington, Stati Uniti, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Stati Uniti, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Stati Uniti, 98195
- University of Washington Medical Center - Montlake
-
Seattle, Washington, Stati Uniti, 98112
- Kaiser Permanente Washington
-
Seattle, Washington, Stati Uniti, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Stati Uniti, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Seattle, Washington, Stati Uniti, 98109
- Fred Hutchinson Cancer Center
-
Seattle, Washington, Stati Uniti, 98133
- FHCC at Northwest Hospital
-
Sedro-Woolley, Washington, Stati Uniti, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Stati Uniti, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Stati Uniti, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Stati Uniti, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Stati Uniti, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Stati Uniti, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Stati Uniti, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Stati Uniti, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Stati Uniti, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Stati Uniti, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Stati Uniti, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Stati Uniti, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Stati Uniti, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Stati Uniti, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Stati Uniti, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Stati Uniti, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Charleston, West Virginia, Stati Uniti, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
-
Wisconsin
-
Antigo, Wisconsin, Stati Uniti, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Stati Uniti, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, Stati Uniti, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Stati Uniti, 54806
- Northwest Wisconsin Cancer Center
-
Brookfield, Wisconsin, Stati Uniti, 53045
- Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield
-
Burlington, Wisconsin, Stati Uniti, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Stati Uniti, 54729
- Marshfield Clinic-Chippewa Center
-
Cudahy, Wisconsin, Stati Uniti, 53110
- Aurora Saint Luke's South Shore
-
Eau Claire, Wisconsin, Stati Uniti, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Stati Uniti, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Stati Uniti, 54701
- Mayo Clinic Health System-Eau Claire Clinic
-
Fond du Lac, Wisconsin, Stati Uniti, 54937
- Aurora Health Center-Fond du Lac
-
Franklin, Wisconsin, Stati Uniti, 53132
- Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson
-
Germantown, Wisconsin, Stati Uniti, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Stati Uniti, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Stati Uniti, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Stati Uniti, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Stati Uniti, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Stati Uniti, 54301
- Bellin Memorial Hospital
-
Kenosha, Wisconsin, Stati Uniti, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Stati Uniti, 54601
- Gundersen Lutheran Medical Center
-
La Crosse, Wisconsin, Stati Uniti, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
Ladysmith, Wisconsin, Stati Uniti, 54848
- Marshfield Medical Center - Ladysmith
-
Madison, Wisconsin, Stati Uniti, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Stati Uniti, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, Stati Uniti, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Stati Uniti, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Stati Uniti, 54143
- Saint Vincent Hospital Cancer Center at Marinette
-
Marshfield, Wisconsin, Stati Uniti, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Stati Uniti, 54451
- Aspirus Medford Hospital
-
Mequon, Wisconsin, Stati Uniti, 53097
- Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
-
Milwaukee, Wisconsin, Stati Uniti, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Stati Uniti, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Stati Uniti, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Stati Uniti, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Stati Uniti, 53211
- Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
-
Minocqua, Wisconsin, Stati Uniti, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Stati Uniti, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Stati Uniti, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Stati Uniti, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Stati Uniti, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Stati Uniti, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Stati Uniti, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, Stati Uniti, 53405
- Ascension All Saints Hospital-Spring Street-Racine
-
Rice Lake, Wisconsin, Stati Uniti, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Stati Uniti, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Stati Uniti, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Stati Uniti, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Stati Uniti, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Stati Uniti, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Stati Uniti, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Stati Uniti, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Stati Uniti, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Stati Uniti, 54401
- Marshfield Clinic-Wausau Center
-
Wausau, Wisconsin, Stati Uniti, 54401
- Aspirus Cancer Care-Wausau
-
Wauwatosa, Wisconsin, Stati Uniti, 53226
- Aurora Cancer Care-Milwaukee West
-
Wauwatosa, Wisconsin, Stati Uniti, 53226
- Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa
-
West Allis, Wisconsin, Stati Uniti, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Stati Uniti, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Stati Uniti, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Stati Uniti, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Cheyenne, Wyoming, Stati Uniti, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Stati Uniti, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Stati Uniti, 82801
- Welch Cancer Center
-
-
Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
Da 18 anni a 69 anni (Adulto, Adulto più anziano)
Accetta volontari sani
No
Sessi ammissibili allo studio
Tutto
Descrizione
Inclusion Criteria:
-
Diagnosis of CLL according to the National Cancer Institute (NCI)/International Workshop on Chronic Lymphocytic Leukemia (IWCLL) criteria or small lymphocytic lymphoma (SLL) according to the World Health Organization (WHO) criteria. This includes previous documentation of:
-
Biopsy-proven small lymphocytic lymphoma OR
-
Diagnosis of CLL according to the NCI/IWCLL criteria as evidenced by all of the following:
-
Peripheral blood lymphocyte count of greater than 5 x10^9/L
-
Immunophenotype consistent with CLL defined as:
- The predominant population of lymphocytes share both B-cell antigens (CD19, CD20 [typically dim expression], or CD23) as well as CD5 in the absence of other pan-T-cell markers (CD3, CD2, etc).
- Clonality as evidenced by kappa or lambda light chain restriction (typically dim immunoglobulin expression)
-
-
Negative fluorescent in situ hybridization (FISH) analysis for t(11;14)(IgH/CCND1) on peripheral blood or tissue biopsy (e.g. marrow aspirate) or negative immunohistochemical stains for cyclin D1 staining on involved tissue biopsy (e.g. marrow aspirate or lymph node biopsy)
-
-
No prior chemotherapy, BTK inhibitor therapy, venetoclax, small molecule signaling inhibitor, or monoclonal anti-body therapy for treatment of CLL or SLL
-
Has met at least one of the following indications for treatment:
-
Evidence of progressive marrow failure as manifested by the development of worsening anemia (hemoglobin [Hg] < 11 g/dl) and/or thrombocytopenia (platelets < 100 x 10^9/L)
-
Symptomatic or progressive lymphadenopathy, splenomegaly, or hepatomegaly
-
One or more of the following disease-related symptoms:
- Weight loss >= 10% within the previous 6 months
- Grade 2 or 3 fatigue attributed to CLL
- Fevers > 100.5 degree Fahrenheit (F) for 2 weeks without evidence of infection
- Clinically significant night sweats without evidence of infection
-
Progressive lymphocytosis (not due to the effects of corticosteroids) with an increase of > 50% over a two-month period or an anticipated doubling time of less than six months
-
-
Age >= 18 years and < 70
-
Eastern Cooperative Oncology Group (ECOG) performance status between 0-2
-
Life expectancy of >= 12 months
-
No deletion of 17p13 on cytogenetic analysis by FISH
-
Glomerular filtration rate (GFR) > 40 mL/minute as calculated by the Cockcroft-Gault Formula (obtained =< 14 days prior to registration)
-
Total bilirubin =< 1.5 x upper limit of normal (ULN) unless due to Gilbert's disease. For those with a total bilirubin > 1.5 x ULN, a direct bilirubin should be performed and must be < 1.5 mg/dL for Gilbert's to be diagnosed (obtained =< 14 days prior to registration)
-
Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST])/serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 3.0 x the institutional ULN (obtained =< 14 days prior to registration)
- NOTE: If value is higher due to hepatic involvement by CLL, patient is eligible
-
Prothrombin time (PT)/international normalized ratio (INR) < 1.5 ULN and partial thromboplastin time (PTT) (activated partial thromboplastin time [aPTT]) < 1.5 x ULN (obtained =< 14 days prior to registration)
-
No active hemolytic anemia requiring immunosuppressive therapy or other pharmacologic treatment. Patients who have a positive Coombs test but no evidence of hemolysis are NOT excluded from participation
-
No current use of corticosteroids. EXCEPTION: Low doses of steroids (< 10 mg of prednisone or equivalent dose of other steroid; inhaled steroids) used for treatment of non-hematologic medical condition (e.g. chronic adrenal insufficiency) is permitted
-
No previous autoimmune complications (e.g. autoimmune hemolytic anemia or immune thrombocytopenia) that have developed since the initial diagnosis of CLL and have required treatment with high dose corticosteroids (e.g. equivalent of > 20 mg/day of prednisone), monoclonal antibody based therapy, or chemotherapy. Prior use of corticosteroids for reasons other than treatment of autoimmune complications is allowed
-
No other active primary malignancy (other than non-melanomatous skin cancer or carcinoma in situ of the cervix) requiring treatment or limiting expected survival to =< 2 years
- NOTE: If there is a history of prior malignancy, the patient must not currently be receiving other specific treatment (other than hormonal therapy for their cancer)
-
Able to adhere to the study visit schedule and other protocol requirements
-
No major surgery within 4 weeks (28 days) of first dose of study drug or minor surgery within 3 days of first dose of study drug
-
No radiation therapy =< 4 weeks prior to registration to Step 1
-
Patients who are human immunodeficiency virus positive (HIV+) with undetectable HIV viral load are eligible provided they meet all other protocol criteria for participation and are not being treated with protease inhibitors or any non-nucleoside reverse transcriptase inhibitors (NNRTI) that are CYP3A4 inducers; if being treated for HIV, patients should be receiving an alternative antiretroviral therapy (ART) that is not a CYP3A inhibitor
-
Patients must not have any of the following conditions:
- Congestive heart failure or New York Heart Association Functional Classification III or IV congestive heart failure
- History of myocardial infarction, unstable angina, or acute coronary syndrome within 6 months prior to registration
- Recent infections requiring systemic treatment; need to have completed anti-biotic therapy > 14 days before the first dose of study drug
- Cerebral vascular accident or intracranial bleed within the last 6 months
- Infection with known chronic, active hepatitis C
- Positive serology for hepatitis B defined as a positive test for hepatitis B surface antigen (HBsAg); in addition, if negative for HBsAg but hepatitis B core antibody (HBcAb) positive (regardless of hepatitis B surface antibody [HBsAb] status), a hepatitis B deoxyribonucleic acid (DNA) test will be performed and, if positive the subject will be ineligible; if the hepatitis (Hep) B DNA test is negative (i.e. viral load undetectable) then the individual is eligible; if a patient who is HBsAg negative, HBsAb negative, HBcAb positive, and Hep B DNA negative is enrolled, they should be considered for either prophylactic anti-viral therapy (J Clin Oncol. 2013 Aug 1;31(22):2765-72) or careful monitoring for Hep B reactivation (J Clin Oncol. 2014 Nov 20;32(33):3736-43)
-
Patients are not eligible if they require treatment with a strong cytochrome P450 (CYP) 3A inhibitor
-
Patients may not have received the following within 7 days prior to the first dose of study drug:
- Steroid therapy for anti-neoplastic intent
- Strong and moderate CYP3A inhibitors
- Strong and moderate CYP3A inducers
-
Patients may not be on any other investigational agents
-
Patients may not have received warfarin or another vitamin K antagonist in the preceding 30 days
-
Women must not be pregnant or breast-feeding since this study involves investigational agents whose genotoxic, mutagenic, and teratogenic effects on the developing fetus and newborn are unknown.
- All females of childbearing potential must have a blood test within 2 weeks prior to registration to Step 1 to rule out pregnancy. A patient of childbearing potential someone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
-
Women of childbearing potential and sexually active males must be strongly advised to use accepted and highly effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for:
- 18 months after the last dose of obinutuzumab
- 90 days after the last dose of ibrutinib, and
- 30 days after the last dose of venetoclax Male subjects must also agree to refrain from sperm donation until 90 days after the last dose of protocol treatment
-
Patient must be able to swallow capsules and not have the following conditions:
- Disease significantly affecting gastrointestinal function
- Resection of the stomach or small bowel
- Symptomatic inflammatory bowel disease
- Ulcerative colitis
- Partial or complete bowel obstruction
-
Patient must not be on any other systemic immunosuppressant therapy other than corticosteroids within 28 days of the first dose of study drug
-
Patient must not be vaccinated with live, attenuated vaccines within 4 weeks of first dose of study drug
-
Patient must not have any known bleeding disorders (e.g., von Willebrand's disease) or hemophilia
-
Patient must not have currently active, clinically significant hepatic impairment (>= moderate hepatic impairment according to the NCI/Child Pugh classification)
-
Patient must undergo assessment with Timed Up and Go (TUG) test and comorbidity index
-
Patient must be able to receive xanthine oxidase inhibitor or rasburicase for tumor lysis syndrome (TLS) prophylaxis
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Trattamento
- Assegnazione: Randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Nessuno (etichetta aperta)
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
|---|---|
|
Sperimentale: Arm A (ibrutinib, obinutuzumab, venetoclax)
Patients receive ibrutinib PO daily on days 1-28 and obinutuzumab IV over 4 hours on days 1, 2, 8, and 15 of cycle 1 and on day 1 of cycles 2-6. Patients also receive venetoclax PO QD on days 1-28 of cycles 3-14. Treatment repeats every 28 days for up to 19 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study. |
Ancillary studies
Altri nomi:
Undergo CT
Altri nomi:
Given PO
Altri nomi:
Undergo collection of blood
Altri nomi:
Given PO
Altri nomi:
Given IV
Altri nomi:
Undergo biopsy
Altri nomi:
|
|
Comparatore attivo: Arm B (ibrutinib, obinutuzumab)
Patients receive ibrutinib PO and obinutuzumab as in arm A. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo biopsy and CT scans before and after treatment and collection of blood throughout the study. |
Ancillary studies
Altri nomi:
Undergo CT
Altri nomi:
Given PO
Altri nomi:
Undergo collection of blood
Altri nomi:
Given IV
Altri nomi:
Undergo biopsy
Altri nomi:
|
Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Progression-free survival
Lasso di tempo: Time from randomization to progression or death without documented progression, assessed up to 10 years
|
The analysis will be performed using the repeated confidence intervals methodology. At each interim or final analysis, two-sided repeated confidence interval will be constructed using the partial likelihood estimate from stratified Cox proportional hazards model and the critical value based on the Lan-DeMets error-spending function that corresponds to the truncated O'brien-Fleming boundaries. |
Time from randomization to progression or death without documented progression, assessed up to 10 years
|
Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Overall survival
Lasso di tempo: Time from randomization to death due to any cause, assessed up to 10 years
|
A hierarchical testing strategy will be used. The analysis will be performed using the repeated confidence intervals methodology. At each interim or final analysis, two-sided repeated confidence interval will be constructed using the partial likelihood estimate from stratified Cox proportional hazards model and the critical value based on the Lan-DeMets error-spending function that corresponds to the truncated O'brien-Fleming boundaries. |
Time from randomization to death due to any cause, assessed up to 10 years
|
|
Incidence of adverse events
Lasso di tempo: Up to 10 years
|
Graded according to Common Terminology Criteria for Adverse Events version 5.0. |
Up to 10 years
|
Altre misure di risultato
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
|
Analisi della malattia minima residua (MRD).
Lasso di tempo: Fino a 10 anni
|
Fino a 10 anni
|
|
|
Quality of life (QOL)
Lasso di tempo: Baseline up to 10 years
|
Assessed using Functional Assessment of Cancer Therapy-General (FACT-G) and the leukemia sub-scale. FACT-G and the leukemia subscale will be analyzed at randomization, on day 1 of cycles 3, 7, 15, at the end of cycle 19, every 6 months for 2 years post response evaluation, at 48 months after randomization and at the time of disease progression. Linear mixed effects models will be used to perform repeated measures regression analysis. Will compare treatment toxicity-related QOL between the two arms. The entire FACT-Leukemia instrument (FACT-G and the leukemia subscale) at baseline will be analyzed using descriptive statistics to assess the impact of CLL on QOL independent of treatment. |
Baseline up to 10 years
|
|
FACT-Leu Trial Outcome Index (TOI) score over time
Lasso di tempo: Baseline up to 10 years
|
Will use linear mixed effects models will be used to perform repeated measures regression analysis to examine the treatment effect and time effect on FACT-Leu TOI score. |
Baseline up to 10 years
|
|
Adherence
Lasso di tempo: Baseline up to 10 years
|
Defined as patients taking 80% or more of their prescribed doses. The ASK-12 Survey will be used to measure the likelihood that a patient will take prescribed medications for patients on both arms at baseline and on day 1 +/- 4 days of the following cycles 3, 7, 15, at the time of response evaluation (end of cycle 19), every 6 months for 2 years post response evaluation, at 48 months after randomization, and at time of disease progression. Descriptive statistics will be used to summarize trend in adherence to prescription. |
Baseline up to 10 years
|
Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Investigatori
- Investigatore principale: Tait D Shanafelt, ECOG-ACRIN Cancer Research Group
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
12 febbraio 2019
Completamento primario (Stimato)
7 maggio 2028
Completamento dello studio (Stimato)
7 maggio 2028
Date di iscrizione allo studio
Primo inviato
8 ottobre 2018
Primo inviato che soddisfa i criteri di controllo qualità
8 ottobre 2018
Primo Inserito (Effettivo)
10 ottobre 2018
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
12 novembre 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
11 novembre 2026
Ultimo verificato
1 luglio 2026
Maggiori informazioni
Termini relativi a questo studio
Termini MeSH pertinenti aggiuntivi
- Processi patologici
- Neoplasie
- Malattia cronica
- Attributi della malattia
- Malattie del sistema immunitario
- Neoplasie per tipo istologico
- Malattie ematologiche
- Malattie linfatiche
- Malattie linfoproliferative
- Disturbi immunoproliferativi
- Leucemia, cellule B
- Leucemia, linfoide
- Leucemia
- Condizioni patologiche, segni e sintomi
- Malattie emiche e linfatiche
- Leucemia, linfocitica, cronica, cellule B
- Tecniche investigative
- Tecniche di laboratorio clinico
- Tecniche e procedure diagnostiche
- Diagnosi
- Procedure chirurgiche, operative
- Tecniche citologiche
- Citodiagnosi
- Tecniche diagnostiche, chirurgiche
- Biopsia
- Gestione dei campioni
- Venetoclax
- obinutuzumab
- Ibrutinib
Altri numeri di identificazione dello studio
- NCI-2018-02127
- U10CA180820 (Sovvenzione/contratto NIH degli Stati Uniti)
- NCI-2018-02127 (Identificatore di registro: CTRP (Clinical Trial Reporting Program))
- EA9161 (Altro identificatore: CTEP)
- EA9161 (Altro identificatore: ECOG-ACRIN Cancer Research Group)
Piano per i dati dei singoli partecipanti (IPD)
Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?
SÌ
Descrizione del piano IPD
NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
Sì
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .