The Effects of Oxytocin on Fairness Perception and Related Prosocial Behaviors
8. september 2026 oppdatert av: Shuxia Yao, University of Electronic Science and Technology of China
The Modulatory Effects of Oxytocin on Fairness Perception and Related Prosocial Behaviors
This study aims to investigate the modulation of intranasally administered oxytocin (24 IU) on human fairness perception and related prosocial behaviors.
Studieoversikt
Status
Rekruttering
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
Fairness preference is a cornerstone of human sociality, often driving individuals to incur personal costs in order to uphold fairness norms.
Oxytocin (OT), a neuropeptide, is considered a potential modulator of prosocial behavior, yet its specific mechanism of action in fairness decision-making remains unclear.
Previous research has predominantly focused on the overall effects of OT on behaviors, without differentiating its roles across distinct processing stages such as cognitive evaluation and emotional anticipation.
Furthermore, there is a lack of systematic investigation into whether its effects are modulated by social context and gain-loss contexts.
Using a randomized, double-blind, placebo-controlled between-subjects design, the present study combines functional magnetic resonance imaging (fMRI) with the Dictator Game (DG) and the Ultimatum Game (UG) to elucidate how intranasal OT influences fairness perception and related prosocial behavior.
The UG additionally involves strategic considerations of the proposer arising from the recipient's ability to reject the offer.
Participants, act as proposers, are instructed to rate their perceived levels of fairness and guilt when receiving advantageous inequity and fair allocations in both gain and loss contexts.
Following ratings, participants make decisions of accepting or rejecting the current allocation.
Their brain activity and behavioral responses will be synchronously recorded during the tasks, and scores of questionnaires including Positive and Negative Affect Schedule, State-Trait Anxiety Inventory, Sensitivity to Punishment and Sensitivity to Reward Questionnaire, Social Value Orientation, Self-Report Altruism Scale, Prosocial Tendencies Measure, Behavioral Inhibition System and Behavioral Activation System Scale, Interpersonal Reactivity Index, Toronto Alexithymia Scale, Beck Depression Inventory-Ⅱ, Guilt and Shame Proneness Scale, Test of Self-Conscious Affect are also collected before the experiment.
Studietype
Intervensjonell
Registrering (Antatt)
80
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiekontakt
- Navn: Shuxia Yao, Dr
- Telefonnummer: 86+18111297596
- E-post: yaoshuxia@uestc.edu.cn
Studiesteder
-
-
Sichuan
-
Chengdu, Sichuan, Kina, 611731
- Rekruttering
- University of Electronic Science and Technology of China (UESTC)
-
Ta kontakt med:
- Shuxia Yao, Dr
- Telefonnummer: 86+18111297596
- E-post: yaoshuxia@uestc.edu.cn
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
- Voksen
Tar imot friske frivillige
Ja
Beskrivelse
Inclusion Criteria:
- Healthy subjects without past or current psychiatric or neurological disorders.
Exclusion Criteria:
- History of head injury; pregnant, menstruating, taking oral contraceptives; medical or psychiatric illness.
- The presence of metal in the body or claustrophobia.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Grunnvitenskap
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Dobbelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Eksperimentell: Oxytocin Group
Mannlige og kvinnelige personer med oksytocinbehandling
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intranasal administration of oxytocin (24IU)
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|
Placebo komparator: placebogruppe
Mannlige og kvinnelige personer med placebo -behandling
|
intranasal administration of placebo (24IU)
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Fairness rating scores
Tidsramme: 1 hour
|
Participants are asked to rate their perceived levels of fairness on a 9-point Likert scale (1 = highly fair, 9 = highly unfair) to the computer's allocation in each trial.
|
1 hour
|
|
Anticipated guilt rating scores
Tidsramme: 1 hour
|
Participants are asked to rate the anticipated guilt they would feel if they accepted the allocation given by the computer in each trial.
Ratings were conducted on a 9-point Likert scale (1 = not at all, 9 = highly guilty).
|
1 hour
|
|
The binary decision to the initial allocation
Tidsramme: 1 hour
|
Participants are asked to makde decisions of accepting or rejecting the allocation provided by the computer in each trial.
|
1 hour
|
|
Brain activity patterns
Tidsramme: 1 hour
|
Brain activity patterns in response to the outcome of the allocation given by computer and the binary decision.
We will examine these brain response patterns via both the conventional univariate analysis and the machine learning-based multivariate pattern analysis (MVPA) approaches.
|
1 hour
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Inequity aversion parameters derived from the Fehr-Schmidt model
Tidsramme: 1 hour
|
Inequity aversion parameters derived from the Fehr-Schmidt model are used to elucidate whether OT would modulate inequity aversion. This model-based analysis was conducted based on choices using hierarchical Bayesian modeling. In the Fehr-Schmidt model, the subjective value of a given allocationis determined by one's own and the other's allocation using the following formula: SV(Mself, Mother) = Mself - βmax{ Mself - Mother, 0}, Mself ≠ Mother where Mself is one's payoff and Mother is the other's payoff. Parameter β represents the weight assigned to inequity. Higher parameter values indicate a stronger degree of inequity aversion in participants. |
1 hour
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Etterforskere
- Hovedetterforsker: Shuxia Yao, Dr, University of Electronic Science and Technology of China
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
5. september 2026
Primær fullføring (Antatt)
30. desember 2026
Studiet fullført (Antatt)
31. desember 2026
Datoer for studieregistrering
Først innsendt
3. september 2026
Først innsendt som oppfylte QC-kriteriene
8. september 2026
Først lagt ut (Faktiske)
11. september 2026
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
11. september 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
8. september 2026
Sist bekreftet
1. september 2026
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- UESTC-neuSCAN-105
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
NEI
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Nei
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Nei
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