Terapia para pacientes recém-diagnosticados com leucemia linfoblástica aguda
9 de setembro de 2020 atualizado por: St. Jude Children's Research Hospital
Total XV - Estudo de Terapia Total XV para Pacientes Recentemente Diagnosticados com Leucemia Linfoblástica Aguda
O objetivo primário é estimar a sobrevida global livre de eventos de crianças com pelo menos um ano de idade no momento do diagnóstico tratadas com terapia direcionada ao risco e monitorar a taxa de indução de remissão molecular.
Visão geral do estudo
Status
Concluído
Condições
Intervenção / Tratamento
- Medicamento: Prednisona, Dexametasona, Vincristina, Daunorrubicina
- Medicamento: Doxorrubicina, L-asparaginase, PEG-L-asparaginase, Erwinia asparaginase
- Medicamento: Metotrexato, Ciclofosfamida, Citarabina, Etoposido
- Medicamento: Mercaptopurina, Imatinibe
- Procedimento: quimioterapia, quimioterapia intratecal
- Procedimento: terapia com esteroides, transplante de células-tronco hematopoiéticas
Descrição detalhada
Estes são os seguintes objetivos secundários:
- Determinar se a irradiação do SNC pode ser omitida com segurança no contexto da terapia sistêmica utilizada no protocolo.
- Identificar se infusões intravenosas prolongadas (24 horas) de HDMTX produzem maior acúmulo de poliglutamato de metotrexato (MTXPG) do que infusões curtas (4 horas) 42 horas após 1 gm/m2 de HDMTX, estratificado para linhagem (linhagem T vs B) e ploidia (linhagem B hiperdiploide vs não hiperdiploide).
- Determinar se infusões intravenosas prolongadas (24 horas) de HDMTX produzem maiores efeitos antileucêmicos do que infusões curtas (4 horas), com base na inibição da síntese de purina de novo em blastos de medula óssea e na diminuição de blastos circulantes durante a "janela" de 4 dias antes do início da terapia de indução de remissão convencional.
- MRD
- Outros objetivos exploratórios
Detalhes do Plano de Tratamento
O tratamento consistirá em três fases principais, Indução da Remissão, Consolidação e Continuação. O tratamento com uma Janela Upfront HDMTX para fins de pesquisa será opcional.
Todos os pacientes receberão terapia IT no dia 1, a dose depende da idade.
Janela Inicial de Metotrexato de Alta Dose
HDMTX (1 g/m2) como uma infusão de 4 horas versus uma infusão de 24 horas. O resgate de leucovorina será dado.
Indução de remissão
Prednisona 40 mg/m2/dia PO Dias 5 - 32 Vincristina 1,5 mg/m2/semana IV Dias 5, 12, 19, 26 Daunorrubicina 25 mg/m2/semana IV Dias 5, 12 L-asparaginase 10.000 Unidade/m2/dose IM Dias 6, 8, 10, 12, 14, 16 (19, 21, 23) Ciclofosfamida 1000 mg/m2/dose IV Dia 26 Citarabina 75 mg/m2/dose IV Dias 27-30, 34-37 6-Mercaptopurina 60 mg /m2/dose PO Dias 26-39 Imatinib 40 mg/m2 bid para doentes Ph positivos a partir do Dia 22 da indução. A terapia intratecal será administrada no dia 1 e 19, dependendo da idade da dose. Pacientes com alto risco de recidiva do SNC receberão tratamentos IT adicionais nos dias 8 e 26.
Tratamento de consolidação
Dose alvo de metotrexato de alta dose dependendo do status de risco, dias 1, 15, 29 e 43 e mercaptopurina 50 mg/m2/dia, dias 1-56.
Tratamento de reintensificação para pacientes com doença de alto risco:
Pacientes com doença de alto risco terão a opção de transplante de células-tronco hematopoiéticas (HSCT) e podem receber 1-2 ciclos adicionais de tratamento de reintensificação antes de maximizar a morte antileucêmica antes do transplante.
Dexametasona 20 mg/m2 PO dias 1-3 Citarabina 2 g/m2 IV x 4 doses, dias 3-5 Etoposido 100 mg/m2 IV x 5 doses, dias 3-5 L-asparaginase 25.000 Unidades/m2 IM dia 6 Tratamento intratecal Dia 5
Tratamento de continuação (duração de 120 semanas para meninas e 146 semanas para meninos)
O tratamento dependerá da classificação de risco: baixo versus padrão versus alto risco
Semanas de tratamento 1 a 20:
Semana Padrão/Alto Risco Baixo Risco
- DEX + DOX + VCR + 6MP + ASP 6MP + DEX + VCR
- 6MP + ASP 6MP + MTX
- 6MP + ASP 6MP + MTX
- DEX + DOX + VCR + 6MP + ASP 6MP + DEX + VCR
- 6MP + ASP 6MP + MTX
- 6MP + ASP 6MP + MTX
- Reindução I§ Reindução I
- Reindução I Reindução I
- Reindução I Reindução I
- 6MP + ASP 6MP + MTX
- DOX + VCR + 6MP + ASP 6MP + MTX
- 6MP + ASP 6MP + MTX
- 6MP + ASP 6MP + MTX
- DEX + DOX + VCR + 6MP + ASP 6MP + DEX + VCR
- 6MP + ASP 6MP + MTX
- 6MP + ASP 6MP + MTX
- Reindução II Reindução II
- Reindução II Reindução II
- Reindução II Reindução II
Sem quimioterapia 6MP + MTX
Dexametasona 12 mg/m2 (padrão/alto risco) ou 8 mg/m2 (baixo risco) PO diariamente (tid) x 5 dias, Dias 1-5 Doxorrubicina 30 mg/m2 IV, Dia 1 Vincristina 2,0 mg/m2 IV push ( máx. 2 mg), Dia 1 Mercaptopurina 50 mg/m2 PO diariamente x 7 dias (std/alto risco), Dias 1-7 75 mg/m2 PO diariamente x 7 dias (baixo risco), Dias 1-7 L-asparaginase 25.000 Unidade/m2 IM, Dia 1 Metotrexato 40 mg/m2 IV ou IM, Dia 1
Reindução I e II
Esta fase do tratamento será iniciada nas semanas 7 e 17 após o exame da medula óssea confirmar a remissão completa. O tratamento de reindução será administrado duas vezes: semanas 7 a 9 e semanas 17 a 19 para todos os pacientes.
Reindução I para ALL de Risco Padrão/Alto:
Dexametasona 8 mg/m2/dia PO (t.i.d.) Dias 1-8, 15, 21, Vincristina 1,5 mg/m2/semana IV (max 2 mg) Dias 1, 8, 15, Doxorrubicina 30 mg/m2 Dias 1, 8, L-asparaginase 25.000 Unidade/m2 IM Dias 1, 8, 15, Quimioterapia intratecal, dose dependente da idade Dia 1.
Reindução II para ALL Padrão/Alto Risco:
Dexametasona 8 mg/m2/dia PO (t.i.d.) Dias 1-8, 15-21, Vincristina 1,5 mg/m2/semana IV (max 2 mg) Dias 1, 8, 15, L-asparaginase 25.000 Unidade/m2, IM semanal Dias 1, 8, 17, Quimioterapia intratecal, dose dependente da idade Dia 1 Alta dose de citarabina 2 gm/m2 IV a cada 12 Dias 15, 16
Reindução I e II para LLA de baixo risco Dexametasona 8 mg/m2/dia PO (t.i.d.) Dias 1-8, 15-21 Vincristina 1,5 mg/m2/semana IV (máx. 2 mg), Dias 1, 8, 15 L-asparaginase 10.000 Unidade/m2/três vezes por semana IM Dias 2, 4, 6, 8, 10, 12, 15, 17, 19 Doxorrubicina 30 mg/m2/semana IV Dia 1 Quimioterapia intratecal, dose dependente da idade no Dia 1
Tratamento Semanas 21 até o final da terapia Semana Padrão/Alto Risco Baixo Risco
- 6 MP + MTX 6 MP + MTX
- 6 MP + MTX 6 MP + MTX
- Ciclo + Ara-C 6MP + MTX
- DEX + VCR 6MP + DEX + VCR
- 6 MP + MTX 6 MP + MTX
- 6 MP + MTX 6 MP + MTX
- Ciclo + Ara-C 6MP + MTX
- DEX + VCR 6MP + DEX + VCR
Mercaptopurina 75 mg/m2 PO, diariamente x 7 dias, Dias 1-7 Metotrexato 40 mg/m2 IV ou IM, Dia 1 Ciclofosfamida 300 mg/m2 IV, Dia 1 Citarabina 300 mg/m2 IV, Dia 1 Dexametasona 12 mg/m2 (std/alto risco) ou 8 mg/m2 (baixo risco) PO diariamente (tid) x 5, Dia 1-5 Vincristina 2,0 mg/m2 IV push (máx. 2 mg), Dia 1
O mesmo tratamento (semanas 21-28) será repetido por um total de 6 vezes (até a semana 68). Após a semana 68, todos os pacientes receberão 6MP diariamente e MTX semanal com pulsos de dexametasona e vincristina a cada 4 semanas até a semana 100, após a qual serão administrados apenas 6MP e metotrexato. O tratamento intratecal será administrado a cada 8 semanas apenas para pacientes com alto risco de recidiva do SNC após a semana 48 e será descontinuado após a semana 96. A terapia de continuação será descontinuada após 120 semanas em meninas e após 146 semanas em meninos
Os pacientes que atendem aos critérios de LLA de alto risco são candidatos ao transplante alogênico de células-tronco hematopoiéticas. No entanto, se a opção for recusada pelos pacientes ou responsáveis, ou o procedimento for considerado inadequado pelo médico assistente e pelo investigador principal, o paciente permanecerá no estudo e continuará recebendo quimioterapia
Tipo de estudo
Intervencional
Inscrição (Real)
501
Estágio
- Fase 3
Contactos e Locais
Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.
Locais de estudo
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Tennessee
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Memphis, Tennessee, Estados Unidos, 38105
- St Jude Children's Research Hospital
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Texas
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Fort Worth, Texas, Estados Unidos, 76104
- Cook Children's Medical Center
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Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
1 ano a 18 anos (ADULTO, CRIANÇA)
Aceita Voluntários Saudáveis
Não
Gêneros Elegíveis para o Estudo
Tudo
Descrição
Critério de inclusão:
- Diagnóstico de LLA não de células B por imunofenotipagem, conforme determinado pelo padrão de reatividade a um painel de anticorpos monoclonais com citometria de fluxo, bem como morfologia e coloração citoquímica.
- Faixa etária: 1 a 18 anos (inclusive).
Critério de exclusão:
• Tratado anteriormente com quimioterapia por uma semana ou mais.
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: TRATAMENTO
- Alocação: RANDOMIZADO
- Modelo Intervencional: PARALELO
- Mascaramento: NENHUM
Armas e Intervenções
Grupo de Participantes / Braço |
Intervenção / Tratamento |
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OUTRO: 1
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Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
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OUTRO: 2
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Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
Consulte as seções Descrição detalhada para obter detalhes sobre as intervenções de tratamento.
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O que o estudo está medindo?
Medidas de resultados primários
Medida de resultado |
Descrição da medida |
Prazo |
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Sobrevivência geral livre de eventos (EFS)
Prazo: Tempo médio de acompanhamento (intervalo) 5,6 (1,3 a 8,9) anos
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A EFS foi medida desde o início do estudo até a data da primeira falha de tratamento de qualquer tipo (recaída, morte, troca de linhagem ou segunda malignidade) ou até a última data de acompanhamento.
A falha em entrar em remissão foi considerada um evento no tempo zero.
A medição foi determinada pela estimativa de Kaplan-Meyer.
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Tempo médio de acompanhamento (intervalo) 5,6 (1,3 a 8,9) anos
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Remissão Completa Contínua Desde a Terapia da Semana 56.
Prazo: Tempo médio de acompanhamento (intervalo) 4,5 (1 a 7,8) anos
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A CCR foi medida desde o final da semana 56 da terapia até a data da primeira falha do tratamento de qualquer tipo (recaída, morte, troca de linhagem ou segunda malignidade) ou até a última data de acompanhamento.
A medição foi determinada pela estimativa de Kaplan-Meyer.
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Tempo médio de acompanhamento (intervalo) 4,5 (1 a 7,8) anos
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Medidas de resultados secundários
Medida de resultado |
Descrição da medida |
Prazo |
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Doença Residual Mínima (DRM)
Prazo: Fim da indução (dia 46 medição MRD)
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Detecção de MRD no final da indução onde MRD positivo foi definido como uma ou mais células leucêmicas por 10.000 células mononucleares da medula óssea (> = 0,01%).
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Fim da indução (dia 46 medição MRD)
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Diferença média de poliglutamatos de metotrexato ativo (MTXPG) em células de leucemia entre dois braços (4 horas vs. 24 horas).
Prazo: 42 horas após o início da infusão de alta dose de metotrexato (HDMTX)
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As crianças foram aleatoriamente designadas para receber tratamento inicial de agente único com HDMTX (1g/m^2) como uma infusão de 24 horas ou uma infusão de 4 horas e a medida de resultado foi o acúmulo de MTXPG nas células leucêmicas.
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42 horas após o início da infusão de alta dose de metotrexato (HDMTX)
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Células de leucemia circulantes no sangue periférico mudam de antes da infusão de metotrexato para três dias depois entre dois braços (4 horas vs. 24 horas)
Prazo: Imediatamente antes da infusão de metotrexato e três dias após a infusão subsequente
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Contagens de glóbulos brancos (leucócitos) no sangue periférico por hemograma completo Medição: alteração percentual de células de leucemia desde a linha de base |
Imediatamente antes da infusão de metotrexato e três dias após a infusão subsequente
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Outras medidas de resultado
Medida de resultado |
Descrição da medida |
Prazo |
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Diferença mediana na expressão do gene CASP1 em células de leucemia primária de pacientes em células resistentes a glicocorticóides versus células sensíveis a glicocorticóides
Prazo: Pré-tratamento
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A sensibilidade à prednisolona foi medida em células de leucemia primária da medula óssea coletadas no momento do diagnóstico.
A expressão de CASP1 foi determinada pelo microarray HG-U133A.
Os valores fornecidos são valores de expressão gênica, e a unidade é unidades arbitrárias (AU) definidas como fluorescência escalonada medida em microarray.
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Pré-tratamento
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Diferença mediana na expressão do gene NLRP3 em células de leucemia primária de pacientes em células resistentes a glicocorticóides versus células sensíveis a glicocorticóides
Prazo: Pré-tratamento
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A sensibilidade à prednisolona foi medida em células de leucemia primária da medula óssea coletadas no momento do diagnóstico.
A expressão de NLRP3 foi determinada pelo microarray HG-U133A.
Os valores fornecidos são valores de expressão gênica, e a unidade é unidades arbitrárias (AU) definidas como fluorescência escalonada medida em microarray.
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Pré-tratamento
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Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Ching-Hon Pui, M.D., St. Jude Children's Research Hospital
Publicações e links úteis
A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.
Publicações Gerais
- Ness KK, Kaste SC, Zhu L, Pui CH, Jeha S, Nathan PC, Inaba H, Wasilewski-Masker K, Shah D, Wells RJ, Karlage RE, Robison LL, Cox CL. Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia. Leuk Lymphoma. 2015 Apr;56(4):1004-11. doi: 10.3109/10428194.2014.944519. Epub 2014 Aug 20.
- Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell. 2002 Mar;1(2):133-43. doi: 10.1016/s1535-6108(02)00032-6.
- Coustan-Smith E, Sancho J, Hancock ML, Razzouk BI, Ribeiro RC, Rivera GK, Rubnitz JE, Sandlund JT, Pui CH, Campana D. Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia. Blood. 2002 Oct 1;100(7):2399-402. doi: 10.1182/blood-2002-04-1130.
- Cheok MH, Yang W, Pui CH, Downing JR, Cheng C, Naeve CW, Relling MV, Evans WE. Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nat Genet. 2003 May;34(1):85-90. doi: 10.1038/ng1151. Erratum In: Nat Genet. 2003 Jun;34(2):231.
- Neale GA, Coustan-Smith E, Stow P, Pan Q, Chen X, Pui CH, Campana D. Comparative analysis of flow cytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia. Leukemia. 2004 May;18(5):934-8. doi: 10.1038/sj.leu.2403348.
- Pauley JL, Panetta JC, Schmidt J, Kornegay N, Relling MV, Pui CH. Late-onset delayed excretion of methotrexate. Cancer Chemother Pharmacol. 2004 Aug;54(2):146-52. doi: 10.1007/s00280-004-0797-y. Epub 2004 May 18.
- Pui CH, Relling MV, Sandlund JT, Downing JR, Campana D, Evans WE. Rationale and design of Total Therapy Study XV for newly diagnosed childhood acute lymphoblastic leukemia. Ann Hematol. 2004;83 Suppl 1:S124-6. doi: 10.1007/s00277-004-0850-2.
- Cheng Q, Wu B, Kager L, Panetta JC, Zheng J, Pui CH, Relling MV, Evans WE. A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells. Pharmacogenetics. 2004 Aug;14(8):557-67. doi: 10.1097/01.fpc.0000114761.78957.7e.
- Zaza G, Yang W, Kager L, Cheok M, Downing J, Pui CH, Cheng C, Relling MV, Evans WE. Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis. Blood. 2004 Sep 1;104(5):1435-41. doi: 10.1182/blood-2003-12-4306. Epub 2004 May 13.
- Hijiya N, Onciu M, Howard SC, Zhang Z, Cheng C, Sandlund JT, Kyzer EP, Behm FG, Pui CH. Utility of automated counting to determine absolute neutrophil counts and absolute phagocyte counts for pediatric cancer treatment protocols. Cancer. 2004 Dec 1;101(11):2681-6. doi: 10.1002/cncr.20677.
- Kager L, Cheok M, Yang W, Zaza G, Cheng Q, Panetta JC, Pui CH, Downing JR, Relling MV, Evans WE. Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics. J Clin Invest. 2005 Jan;115(1):110-7. doi: 10.1172/JCI22477.
- Lowe EJ, Pui CH, Hancock ML, Geiger TL, Khan RB, Sandlund JT. Early complications in children with acute lymphoblastic leukemia presenting with hyperleukocytosis. Pediatr Blood Cancer. 2005 Jul;45(1):10-5. doi: 10.1002/pbc.20178.
- McCarville MB, Adelman CS, Li C, Xiong X, Furman WL, Razzouk BI, Pui CH, Sandlund JT. Typhlitis in childhood cancer. Cancer. 2005 Jul 15;104(2):380-7. doi: 10.1002/cncr.21134.
- Cheng Q, Yang W, Raimondi SC, Pui CH, Relling MV, Evans WE. Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. Nat Genet. 2005 Aug;37(8):878-82. doi: 10.1038/ng1612. Epub 2005 Jul 24.
- Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006 Jan 12;354(2):166-78. doi: 10.1056/NEJMra052603. No abstract available.
- Coustan-Smith E, Ribeiro RC, Stow P, Zhou Y, Pui CH, Rivera GK, Pedrosa F, Campana D. A simplified flow cytometric assay identifies children with acute lymphoblastic leukemia who have a superior clinical outcome. Blood. 2006 Jul 1;108(1):97-102. doi: 10.1182/blood-2006-01-0066. Epub 2006 Mar 14.
- Flotho C, Coustan-Smith E, Pei D, Iwamoto S, Song G, Cheng C, Pui CH, Downing JR, Campana D. Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. Blood. 2006 Aug 1;108(3):1050-7. doi: 10.1182/blood-2006-01-0322. Epub 2006 Apr 20.
- Karimova EJ, Rai SN, Ingle D, Ralph AC, Deng X, Neel MD, Howard SC, Pui CH, Kaste SC. MRI of knee osteonecrosis in children with leukemia and lymphoma: Part 2, clinical and imaging patterns. AJR Am J Roentgenol. 2006 Feb;186(2):477-82. doi: 10.2214/AJR.04.1597.
- Cheng Q, Cheng C, Crews KR, Ribeiro RC, Pui CH, Relling MV, Evans WE. Epigenetic regulation of human gamma-glutamyl hydrolase activity in acute lymphoblastic leukemia cells. Am J Hum Genet. 2006 Aug;79(2):264-74. doi: 10.1086/505645. Epub 2006 Jun 6. Erratum In: Am J Hum Genet. 2010 Jul 9;87(1):161.
- Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, Relling MV, Evans WE, Shurtleff SA, Downing JR. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007 Apr 12;446(7137):758-64. doi: 10.1038/nature05690.
- Hinds PS, Burghen EA, Zhou Y, Zhang L, West N, Bashore L, Pui CH. The Health Utilities Index 3 invalidated when completed by nurses for pediatric oncology patients. Cancer Nurs. 2007 May-Jun;30(3):169-77. doi: 10.1097/01.NCC.0000270700.11425.4d.
- Karimova EJ, Rai SN, Howard SC, Neel M, Britton L, Pui CH, Kaste SC. Femoral head osteonecrosis in pediatric and young adult patients with leukemia or lymphoma. J Clin Oncol. 2007 Apr 20;25(12):1525-31. doi: 10.1200/JCO.2006.07.9947.
- Flotho C, Coustan-Smith E, Pei D, Cheng C, Song G, Pui CH, Downing JR, Campana D. A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia. Blood. 2007 Aug 15;110(4):1271-7. doi: 10.1182/blood-2007-01-068478. Epub 2007 Apr 24.
- Hinds PS, Hockenberry MJ, Gattuso JS, Srivastava DK, Tong X, Jones H, West N, McCarthy KS, Sadeh A, Ash M, Fernandez C, Pui CH. Dexamethasone alters sleep and fatigue in pediatric patients with acute lymphoblastic leukemia. Cancer. 2007 Nov 15;110(10):2321-30. doi: 10.1002/cncr.23039.
- Marchese VG, Connolly BH, Able C, Booten AR, Bowen P, Porter BM, Rai SN, Hancock ML, Pui CH, Howard S, Neel MD, Kaste SC. Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescents, and young adults with acute lymphoblastic leukemia. Phys Ther. 2008 Mar;88(3):341-50. doi: 10.2522/ptj.20070108. Epub 2008 Jan 17.
- Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet. 2008 Mar 22;371(9617):1030-43. doi: 10.1016/S0140-6736(08)60457-2.
- Sorich MJ, Pottier N, Pei D, Yang W, Kager L, Stocco G, Cheng C, Panetta JC, Pui CH, Relling MV, Cheok MH, Evans WE. In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile. PLoS Med. 2008 Apr 15;5(4):e83. doi: 10.1371/journal.pmed.0050083.
- Yang L, Panetta JC, Cai X, Yang W, Pei D, Cheng C, Kornegay N, Pui CH, Relling MV. Asparaginase may influence dexamethasone pharmacokinetics in acute lymphoblastic leukemia. J Clin Oncol. 2008 Apr 20;26(12):1932-9. doi: 10.1200/JCO.2007.13.8404.
- Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, White D, Hughes TP, Le Beau MM, Pui CH, Relling MV, Shurtleff SA, Downing JR. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature. 2008 May 1;453(7191):110-4. doi: 10.1038/nature06866. Epub 2008 Apr 13.
- French D, Yang W, Hamilton LH, Neale G, Fan Y, Downing JR, Cox NJ, Pui CH, Evans WE, Relling MV. Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs. PLoS One. 2008 May 14;3(5):e2144. doi: 10.1371/journal.pone.0002144.
- Kamdem LK, Hamilton L, Cheng C, Liu W, Yang W, Johnson JA, Pui CH, Relling MV. Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia. Pharmacogenet Genomics. 2008 Jun;18(6):507-14. doi: 10.1097/FPC.0b013e3282fc5801.
- Yang JJ, Bhojwani D, Yang W, Cai X, Stocco G, Crews K, Wang J, Morrison D, Devidas M, Hunger SP, Willman CL, Raetz EA, Pui CH, Evans WE, Relling MV, Carroll WL. Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia. Blood. 2008 Nov 15;112(10):4178-83. doi: 10.1182/blood-2008-06-165027. Epub 2008 Sep 2.
- Roberson JR, Raju S, Shelso J, Pui CH, Howard SC. Diabetic ketoacidosis during therapy for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008 Jun;50(6):1207-12. doi: 10.1002/pbc.21505.
- Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB, Ma J, Liu W, Cheng C, Schulman BA, Harvey RC, Chen IM, Clifford RJ, Carroll WL, Reaman G, Bowman WP, Devidas M, Gerhard DS, Yang W, Relling MV, Shurtleff SA, Campana D, Borowitz MJ, Pui CH, Smith M, Hunger SP, Willman CL, Downing JR; Children's Oncology Group. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med. 2009 Jan 29;360(5):470-80. doi: 10.1056/NEJMoa0808253. Epub 2009 Jan 7.
- Yang JJ, Cheng C, Yang W, Pei D, Cao X, Fan Y, Pounds SB, Neale G, Trevino LR, French D, Campana D, Downing JR, Evans WE, Pui CH, Devidas M, Bowman WP, Camitta BM, Willman CL, Davies SM, Borowitz MJ, Carroll WL, Hunger SP, Relling MV. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA. 2009 Jan 28;301(4):393-403. doi: 10.1001/jama.2009.7.
- Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, Cheng C, Su X, Rubnitz JE, Basso G, Biondi A, Pui CH, Downing JR, Campana D. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol. 2009 Feb;10(2):147-56. doi: 10.1016/S1470-2045(08)70314-0. Epub 2009 Jan 13.
- Roberson JR, Spraker HL, Shelso J, Zhou Y, Inaba H, Metzger ML, Rubnitz JE, Ribeiro RC, Sandlund JT, Jeha S, Pui CH, Howard SC. Clinical consequences of hyperglycemia during remission induction therapy for pediatric acute lymphoblastic leukemia. Leukemia. 2009 Feb;23(2):245-50. doi: 10.1038/leu.2008.289. Epub 2008 Oct 16.
- French D, Yang W, Cheng C, Raimondi SC, Mullighan CG, Downing JR, Evans WE, Pui CH, Relling MV. Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia. Blood. 2009 May 7;113(19):4512-20. doi: 10.1182/blood-2008-07-172106. Epub 2008 Dec 9.
- Rubnitz JE, Onciu M, Pounds S, Shurtleff S, Cao X, Raimondi SC, Behm FG, Campana D, Razzouk BI, Ribeiro RC, Downing JR, Pui CH. Acute mixed lineage leukemia in children: the experience of St Jude Children's Research Hospital. Blood. 2009 May 21;113(21):5083-9. doi: 10.1182/blood-2008-10-187351. Epub 2009 Jan 8.
- Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Raimondi SC, Onciu M, Coustan-Smith E, Kun LE, Jeha S, Cheng C, Howard SC, Simmons V, Bayles A, Metzger ML, Boyett JM, Leung W, Handgretinger R, Downing JR, Evans WE, Relling MV. Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med. 2009 Jun 25;360(26):2730-41. doi: 10.1056/NEJMoa0900386.
- Mullighan CG, Collins-Underwood JR, Phillips LA, Loudin MG, Liu W, Zhang J, Ma J, Coustan-Smith E, Harvey RC, Willman CL, Mikhail FM, Meyer J, Carroll AJ, Williams RT, Cheng J, Heerema NA, Basso G, Pession A, Pui CH, Raimondi SC, Hunger SP, Downing JR, Carroll WL, Rabin KR. Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. Nat Genet. 2009 Nov;41(11):1243-6. doi: 10.1038/ng.469. Epub 2009 Oct 18.
- Trevino LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, Chan D, Sparreboom A, Giacomini KM, Pui CH, Evans WE, Relling MV. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol. 2009 Dec 10;27(35):5972-8. doi: 10.1200/JCO.2008.20.4156. Epub 2009 Nov 9.
- Spraker HL, Spyridis GP, Pui CH, Howard SC. Conservative management of pancreatic pseudocysts in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2009 Dec;31(12):957-9. doi: 10.1097/MPH.0b013e3181ba9e6a.
- Reddick WE, Glass JO, Johnson DP, Laningham FH, Pui CH. Voxel-based analysis of T2 hyperintensities in white matter during treatment of childhood leukemia. AJNR Am J Neuroradiol. 2009 Nov;30(10):1947-54. doi: 10.3174/ajnr.A1733. Epub 2009 Jul 30.
- Stocco G, Cheok MH, Crews KR, Dervieux T, French D, Pei D, Yang W, Cheng C, Pui CH, Relling MV, Evans WE. Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin Pharmacol Ther. 2009 Feb;85(2):164-72. doi: 10.1038/clpt.2008.154. Epub 2008 Aug 6.
- Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Ingles-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun SC, Song G, Mullighan CC, Levine RL, Rajewsky K, Aifantis I, Bigas A. The Notch/Hes1 pathway sustains NF-kappaB activation through CYLD repression in T cell leukemia. Cancer Cell. 2010 Sep 14;18(3):268-81. doi: 10.1016/j.ccr.2010.08.006.
- Crews KR, Zhou Y, Pauley JL, Howard SC, Jeha S, Relling MV, Pui CH. Effect of allopurinol versus urate oxidase on methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia. Cancer. 2010 Jan 1;116(1):227-32. doi: 10.1002/cncr.24681.
- Yang W, Trevino LR, Yang JJ, Scheet P, Pui CH, Evans WE, Relling MV. ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence. Leukemia. 2010 Apr;24(4):894-6. doi: 10.1038/leu.2009.277. Epub 2010 Jan 7. No abstract available.
- Gutierrez A, Dahlberg SE, Neuberg DS, Zhang J, Grebliunaite R, Sanda T, Protopopov A, Tosello V, Kutok J, Larson RS, Borowitz MJ, Loh ML, Ferrando AA, Winter SS, Mullighan CG, Silverman LB, Chin L, Hunger SP, Sallan SE, Look AT. Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. J Clin Oncol. 2010 Aug 20;28(24):3816-23. doi: 10.1200/JCO.2010.28.3390. Epub 2010 Jul 19.
- Stow P, Key L, Chen X, Pan Q, Neale GA, Coustan-Smith E, Mullighan CG, Zhou Y, Pui CH, Campana D. Clinical significance of low levels of minimal residual disease at the end of remission induction therapy in childhood acute lymphoblastic leukemia. Blood. 2010 Jun 10;115(23):4657-63. doi: 10.1182/blood-2009-11-253435. Epub 2010 Mar 19.
- Panetta JC, Sparreboom A, Pui CH, Relling MV, Evans WE. Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells. PLoS Comput Biol. 2010 Dec 2;6(12):e1001019. doi: 10.1371/journal.pcbi.1001019.
- Campana D. Minimal residual disease in acute lymphoblastic leukemia. Hematology Am Soc Hematol Educ Program. 2010;2010:7-12. doi: 10.1182/asheducation-2010.1.7.
- Caniza MA, Hunger SP, Schrauder A, Valsecchi MG, Pui CH, Masera G; Members of International Study Group of Childhood ALL ( "Ponte di Legno Working Group"). The controversy of varicella vaccination in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2012 Jan;58(1):12-6. doi: 10.1002/pbc.22759. Epub 2010 Sep 16.
- Ashford J, Schoffstall C, Reddick WE, Leone C, Laningham FH, Glass JO, Pei D, Cheng C, Pui CH, Conklin HM. Attention and working memory abilities in children treated for acute lymphoblastic leukemia. Cancer. 2010 Oct 1;116(19):4638-45. doi: 10.1002/cncr.25343.
- Pui CH. Recent research advances in childhood acute lymphoblastic leukemia. J Formos Med Assoc. 2010 Nov;109(11):777-87. doi: 10.1016/S0929-6646(10)60123-4.
- Anghelescu DL, Faughnan LG, Jeha S, Relling MV, Hinds PS, Sandlund JT, Cheng C, Pei D, Hankins G, Pauley JL, Pui CH. Neuropathic pain during treatment for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2011 Dec 15;57(7):1147-53. doi: 10.1002/pbc.23039. Epub 2011 Feb 11.
- Pui CH, Pei D, Campana D, Bowman WP, Sandlund JT, Kaste SC, Ribeiro RC, Rubnitz JE, Coustan-Smith E, Jeha S, Cheng C, Metzger ML, Bhojwani D, Inaba H, Raimondi SC, Onciu M, Howard SC, Leung W, Downing JR, Evans WE, Relling MV. Improved prognosis for older adolescents with acute lymphoblastic leukemia. J Clin Oncol. 2011 Feb 1;29(4):386-91. doi: 10.1200/JCO.2010.32.0325. Epub 2010 Dec 20.
- Rudner LA, Brown KH, Dobrinski KP, Bradley DF, Garcia MI, Smith AC, Downie JM, Meeker ND, Look AT, Downing JR, Gutierrez A, Mullighan CG, Schiffman JD, Lee C, Trede NS, Frazer JK. Shared acquired genomic changes in zebrafish and human T-ALL. Oncogene. 2011 Oct 13;30(41):4289-96. doi: 10.1038/onc.2011.138. Epub 2011 May 9.
- Wang J, Mullighan CG, Easton J, Roberts S, Heatley SL, Ma J, Rusch MC, Chen K, Harris CC, Ding L, Holmfeldt L, Payne-Turner D, Fan X, Wei L, Zhao D, Obenauer JC, Naeve C, Mardis ER, Wilson RK, Downing JR, Zhang J. CREST maps somatic structural variation in cancer genomes with base-pair resolution. Nat Methods. 2011 Jun 12;8(8):652-4. doi: 10.1038/nmeth.1628.
- Andersson AK, Miller DW, Lynch JA, Lemoff AS, Cai Z, Pounds SB, Radtke I, Yan B, Schuetz JD, Rubnitz JE, Ribeiro RC, Raimondi SC, Zhang J, Mullighan CG, Shurtleff SA, Schulman BA, Downing JR. IDH1 and IDH2 mutations in pediatric acute leukemia. Leukemia. 2011 Oct;25(10):1570-7. doi: 10.1038/leu.2011.133. Epub 2011 Jun 7.
- Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL, Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui CH, Baker SD, Brindle PK, Downing JR. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature. 2011 Mar 10;471(7337):235-9. doi: 10.1038/nature09727.
- Kannan S, Fang W, Song G, Mullighan CG, Hammitt R, McMurray J, Zweidler-McKay PA. Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression. Blood. 2011 Mar 10;117(10):2891-900. doi: 10.1182/blood-2009-12-253419. Epub 2011 Jan 11.
- Chen SH, Yang W, Fan Y, Stocco G, Crews KR, Yang JJ, Paugh SW, Pui CH, Evans WE, Relling MV. A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity. Leukemia. 2011 Jan;25(1):66-74. doi: 10.1038/leu.2010.256. Epub 2010 Nov 12.
- Crews KR, Cross SJ, McCormick JN, Baker DK, Molinelli AR, Mullins R, Relling MV, Hoffman JM. Development and implementation of a pharmacist-managed clinical pharmacogenetics service. Am J Health Syst Pharm. 2011 Jan 15;68(2):143-50. doi: 10.2146/ajhp100113.
- Yang JJ, Cheng C, Devidas M, Cao X, Fan Y, Campana D, Yang W, Neale G, Cox NJ, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Willman CL, Bowman WP, Camitta BM, Carroll A, Reaman GH, Carroll WL, Loh M, Hunger SP, Pui CH, Evans WE, Relling MV. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nat Genet. 2011 Mar;43(3):237-41. doi: 10.1038/ng.763. Epub 2011 Feb 6.
- Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N. Functional characterization of liver enhancers that regulate drug-associated transporters. Clin Pharmacol Ther. 2011 Apr;89(4):571-8. doi: 10.1038/clpt.2010.353. Epub 2011 Mar 2.
- Mikkelsen TS, Sparreboom A, Cheng C, Zhou Y, Boyett JM, Raimondi SC, Panetta JC, Bowman WP, Sandlund JT, Pui CH, Relling MV, Evans WE. Shortening infusion time for high-dose methotrexate alters antileukemic effects: a randomized prospective clinical trial. J Clin Oncol. 2011 May 1;29(13):1771-8. doi: 10.1200/JCO.2010.32.5340. Epub 2011 Mar 28.
- Pounds S, Cao X, Cheng C, Yang JJ, Campana D, Pui CH, Evans WE, Relling MV. Integrated analysis of pharmacologic, clinical and SNP microarray data using Projection Onto the Most Interesting Statistical Evidence with Adaptive Permutation Testing. Int J Data Min Bioinform. 2011;5(2):143-57. doi: 10.1504/IJDMB.2011.039174.
- Kawedia JD, Kaste SC, Pei D, Panetta JC, Cai X, Cheng C, Neale G, Howard SC, Evans WE, Pui CH, Relling MV. Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia. Blood. 2011 Feb 24;117(8):2340-7; quiz 2556. doi: 10.1182/blood-2010-10-311969. Epub 2010 Dec 10.
- Coustan-Smith E, Song G, Clark C, Key L, Liu P, Mehrpooya M, Stow P, Su X, Shurtleff S, Pui CH, Downing JR, Campana D. New markers for minimal residual disease detection in acute lymphoblastic leukemia. Blood. 2011 Jun 9;117(23):6267-76. doi: 10.1182/blood-2010-12-324004. Epub 2011 Apr 12.
- Leung W, Campana D, Yang J, Pei D, Coustan-Smith E, Gan K, Rubnitz JE, Sandlund JT, Ribeiro RC, Srinivasan A, Hartford C, Triplett BM, Dallas M, Pillai A, Handgretinger R, Laver JH, Pui CH. High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia. Blood. 2011 Jul 14;118(2):223-30. doi: 10.1182/blood-2011-01-333070. Epub 2011 May 25.
- Dumitrescu L, Brown-Gentry K, Goodloe R, Glenn K, Yang W, Kornegay N, Pui CH, Relling MV, Crawford DC. Evidence for age as a modifier of genetic associations for lipid levels. Ann Hum Genet. 2011 Sep;75(5):589-97. doi: 10.1111/j.1469-1809.2011.00664.x. Epub 2011 Jul 21.
- Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Geng H, Chen S, Thierfelder WE, Mullighan CG, Downing JR, Hsieh P, Pui CH, Relling MV, Evans WE. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat Med. 2011 Sep 25;17(10):1298-303. doi: 10.1038/nm.2430.
- Mikkelsen TS, Thorn CF, Yang JJ, Ulrich CM, French D, Zaza G, Dunnenberger HM, Marsh S, McLeod HL, Giacomini K, Becker ML, Gaedigk R, Leeder JS, Kager L, Relling MV, Evans W, Klein TE, Altman RB. PharmGKB summary: methotrexate pathway. Pharmacogenet Genomics. 2011 Oct;21(10):679-86. doi: 10.1097/FPC.0b013e328343dd93. No abstract available.
- Krull KR, Khan RB, Ness KK, Ledet D, Zhu L, Pui CH, Howard SC, Srivastava DK, Sabin ND, Hudson MM, Morris EB. Symptoms of attention-deficit/hyperactivity disorder in long-term survivors of childhood leukemia. Pediatr Blood Cancer. 2011 Dec 15;57(7):1191-6. doi: 10.1002/pbc.22994. Epub 2011 Jan 28.
- Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012 Jan 11;481(7380):157-63. doi: 10.1038/nature10725.
- Christensen AM, Pauley JL, Molinelli AR, Panetta JC, Ward DA, Stewart CF, Hoffman JM, Howard SC, Pui CH, Pappo AS, Relling MV, Crews KR. Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients. Cancer. 2012 Sep 1;118(17):4321-30. doi: 10.1002/cncr.27378. Epub 2012 Jan 17.
- Bhojwani D, Pei D, Sandlund JT, Jeha S, Ribeiro RC, Rubnitz JE, Raimondi SC, Shurtleff S, Onciu M, Cheng C, Coustan-Smith E, Bowman WP, Howard SC, Metzger ML, Inaba H, Leung W, Evans WE, Campana D, Relling MV, Pui CH. ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy. Leukemia. 2012 Feb;26(2):265-70. doi: 10.1038/leu.2011.227. Epub 2011 Aug 26.
- Kawedia JD, Liu C, Pei D, Cheng C, Fernandez CA, Howard SC, Campana D, Panetta JC, Bowman WP, Evans WE, Pui CH, Relling MV. Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia. Blood. 2012 Feb 16;119(7):1658-64. doi: 10.1182/blood-2011-09-381731. Epub 2011 Nov 23.
- Ciarimboli G, Lancaster CS, Schlatter E, Franke RM, Sprowl JA, Pavenstadt H, Massmann V, Guckel D, Mathijssen RH, Yang W, Pui CH, Relling MV, Herrmann E, Sparreboom A. Proximal tubular secretion of creatinine by organic cation transporter OCT2 in cancer patients. Clin Cancer Res. 2012 Feb 15;18(4):1101-8. doi: 10.1158/1078-0432.CCR-11-2503. Epub 2012 Jan 5.
- Xu H, Cheng C, Devidas M, Pei D, Fan Y, Yang W, Neale G, Scheet P, Burchard EG, Torgerson DG, Eng C, Dean M, Antillon F, Winick NJ, Martin PL, Willman CL, Camitta BM, Reaman GH, Carroll WL, Loh M, Evans WE, Pui CH, Hunger SP, Relling MV, Yang JJ. ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia. J Clin Oncol. 2012 Mar 1;30(7):751-7. doi: 10.1200/JCO.2011.38.0345. Epub 2012 Jan 30.
- Liu C, Kawedia JD, Cheng C, Pei D, Fernandez CA, Cai X, Crews KR, Kaste SC, Panetta JC, Bowman WP, Jeha S, Sandlund JT, Evans WE, Pui CH, Relling MV. Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia. Leukemia. 2012 Nov;26(11):2303-9. doi: 10.1038/leu.2012.102. Epub 2012 Apr 9.
- Pui CH, Pei D, Pappo AS, Howard SC, Cheng C, Sandlund JT, Furman WL, Ribeiro RC, Spunt SL, Rubnitz JE, Jeha S, Hudson MM, Kun LE, Merchant TE, Kocak M, Broniscer A, Metzger ML, Downing JR, Leung W, Evans WE, Gajjar A. Treatment outcomes in black and white children with cancer: results from the SEER database and St Jude Children's Research Hospital, 1992 through 2007. J Clin Oncol. 2012 Jun 1;30(16):2005-12. doi: 10.1200/JCO.2011.40.8617. Epub 2012 Apr 30.
- Ramsey LB, Bruun GH, Yang W, Trevino LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, Relling MV. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012 Jan;22(1):1-8. doi: 10.1101/gr.129668.111. Epub 2011 Dec 6.
- Leung W, Pui CH, Coustan-Smith E, Yang J, Pei D, Gan K, Srinivasan A, Hartford C, Triplett BM, Dallas M, Pillai A, Shook D, Rubnitz JE, Sandlund JT, Jeha S, Inaba H, Ribeiro RC, Handgretinger R, Laver JH, Campana D. Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia. Blood. 2012 Jul 12;120(2):468-72. doi: 10.1182/blood-2012-02-409813. Epub 2012 Apr 19.
- Pui CH, Mullighan CG, Evans WE, Relling MV. Pediatric acute lymphoblastic leukemia: where are we going and how do we get there? Blood. 2012 Aug 9;120(6):1165-74. doi: 10.1182/blood-2012-05-378943. Epub 2012 Jun 22.
- Roberts KG, Morin RD, Zhang J, Hirst M, Zhao Y, Su X, Chen SC, Payne-Turner D, Churchman ML, Harvey RC, Chen X, Kasap C, Yan C, Becksfort J, Finney RP, Teachey DT, Maude SL, Tse K, Moore R, Jones S, Mungall K, Birol I, Edmonson MN, Hu Y, Buetow KE, Chen IM, Carroll WL, Wei L, Ma J, Kleppe M, Levine RL, Garcia-Manero G, Larsen E, Shah NP, Devidas M, Reaman G, Smith M, Paugh SW, Evans WE, Grupp SA, Jeha S, Pui CH, Gerhard DS, Downing JR, Willman CL, Loh M, Hunger SP, Marra MA, Mullighan CG. Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell. 2012 Aug 14;22(2):153-66. doi: 10.1016/j.ccr.2012.06.005.
- Conklin HM, Krull KR, Reddick WE, Pei D, Cheng C, Pui CH. Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia. J Natl Cancer Inst. 2012 Sep 19;104(18):1386-95. doi: 10.1093/jnci/djs344. Epub 2012 Aug 27.
- Stocco G, Yang W, Crews KR, Thierfelder WE, Decorti G, Londero M, Franca R, Rabusin M, Valsecchi MG, Pei D, Cheng C, Paugh SW, Ramsey LB, Diouf B, McCorkle JR, Jones TS, Pui CH, Relling MV, Evans WE. PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity. Hum Mol Genet. 2012 Nov 1;21(21):4793-804. doi: 10.1093/hmg/dds302. Epub 2012 Jul 30.
- Yang JJ, Cheng C, Devidas M, Cao X, Campana D, Yang W, Fan Y, Neale G, Cox N, Scheet P, Borowitz MJ, Winick NJ, Martin PL, Bowman WP, Camitta B, Reaman GH, Carroll WL, Willman CL, Hunger SP, Evans WE, Pui CH, Loh M, Relling MV. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Blood. 2012 Nov 15;120(20):4197-204. doi: 10.1182/blood-2012-07-440107. Epub 2012 Sep 24.
- Anghelescu DL, Burgoyne LL, Faughnan LG, Hankins GM, Smeltzer MP, Pui CH. Prospective randomized crossover evaluation of three anesthetic regimens for painful procedures in children with cancer. J Pediatr. 2013 Jan;162(1):137-41. doi: 10.1016/j.jpeds.2012.06.056. Epub 2012 Aug 9.
- Ramsey LB, Panetta JC, Smith C, Yang W, Fan Y, Winick NJ, Martin PL, Cheng C, Devidas M, Pui CH, Evans WE, Hunger SP, Loh M, Relling MV. Genome-wide study of methotrexate clearance replicates SLCO1B1. Blood. 2013 Feb 7;121(6):898-904. doi: 10.1182/blood-2012-08-452839. Epub 2012 Dec 11.
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Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo (REAL)
8 de julho de 2000
Conclusão Primária (REAL)
1 de novembro de 2010
Conclusão do estudo (REAL)
1 de abril de 2014
Datas de inscrição no estudo
Enviado pela primeira vez
25 de agosto de 2005
Enviado pela primeira vez que atendeu aos critérios de CQ
26 de agosto de 2005
Primeira postagem (ESTIMATIVA)
29 de agosto de 2005
Atualizações de registro de estudo
Última Atualização Postada (REAL)
11 de setembro de 2020
Última atualização enviada que atendeu aos critérios de controle de qualidade
9 de setembro de 2020
Última verificação
1 de setembro de 2020
Mais Informações
Termos relacionados a este estudo
Palavras-chave
Termos MeSH relevantes adicionais
- Doenças do sistema imunológico
- Neoplasias por Tipo Histológico
- Neoplasias
- Distúrbios Linfoproliferativos
- Doenças Linfáticas
- Distúrbios imunoproliferativos
- Leucemia
- Leucemia-Linfoma Linfoblástico de Células Precursoras
- Leucemia Linfóide
- Efeitos Fisiológicos das Drogas
- Mecanismos Moleculares de Ação Farmacológica
- Agentes Anti-Infecciosos
- Agentes Autônomos
- Agentes do Sistema Nervoso Periférico
- Antivirais
- Inibidores da Síntese de Ácido Nucleico
- Inibidores Enzimáticos
- Antiinflamatórios
- Agentes Antirreumáticos
- Antimetabólitos, Antineoplásicos
- Antimetabólitos
- Agentes Antineoplásicos
- Agentes imunossupressores
- Fatores imunológicos
- Moduladores de Tubulina
- Agentes Antimitóticos
- Moduladores de Mitose
- Antieméticos
- Agentes gastrointestinais
- Glicocorticóides
- Hormônios
- Hormônios, Substitutos Hormonais e Antagonistas Hormonais
- Agentes Antineoplásicos Hormonais
- Agentes Antineoplásicos Alquilantes
- Agentes Alquilantes
- Agonistas Mieloablativos
- Agentes Antineoplásicos Fitogênicos
- Inibidores da Topoisomerase II
- Inibidores da Topoisomerase
- Agentes dermatológicos
- Antibióticos, Antineoplásicos
- Agentes de Controle Reprodutivo
- Agentes abortivos, não esteróides
- Agentes abortivos
- Antagonistas do ácido fólico
- Dexametasona
- Ciclofosfamida
- Etoposídeo
- Prednisona
- Doxorrubicina
- Citarabina
- Metotrexato
- Vincristina
- Daunorrubicina
- Asparaginase
- Mercaptopurina
- Pegaspargase
Outros números de identificação do estudo
- TOTXV
- P30CA021765 (Concessão/Contrato do NIH dos EUA)
- F32CA141762 (NIH)
- R37CA036401 (Concessão/Contrato do NIH dos EUA)
Informações sobre medicamentos e dispositivos, documentos de estudo
Estuda um medicamento regulamentado pela FDA dos EUA
Sim
Estuda um produto de dispositivo regulamentado pela FDA dos EUA
Não
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