Comparative Pharmacokinetics of YH14659 in Healthy Male Subjects

Inclusion Criteria:

• Healthy male volunteers of aged between 20 years to 55 years
• Weight: over 50kg, within ±20% of ideal body weight
• Have no history of neither congenital nor chronic disease
• Have no history of abnormal symptoms or opinions as a result of physical examination (medical checkup)
• Eligible subjects with acceptable medical history, physical examination, laboratory tests, ECG during screening period
• Subject who has signed on the written consent

Exclusion Criteria:

• Have a known allergy or hypersensitivity to anti-platelet agents
• Person with hypotension (SBP ≤ 100mmHg or DBP ≤ 50mmHg) or hypertension (SBP ≥ 150mmHg or DBP ≥ 95mmHg), person whose pulse rate is below 45 or over 100 a minute

• Have the following abnormal findings on diagnosis;

  • have AST or ALT > 1.25 times of normal upper limit
  • have total bilirubin > 1.5 times of normal upper limit
  • have higher PT, aPPT, BT than normal range
  • have PLT below 180,000 or above 350,000
• Patients with hemorrhage or predisposition to hemorrhage
• Have disease or history of stomach or intestinal surgery or resection that would potentially alter absorption of orally administered drugs
• Have participated in other clinical studies within 3 months prior to the first administration
• Have used any prescription medications including anti-coagulants, anti-platelet agents, thrombolytic drugs and Prostaglandin E1 agents within 2 weeks prior to the first administration or any over-the-counter, non-prescription preparations within 1 week prior to the first administration
• Patients with aspirin induced asthma(AIA) or history of AIA
• Subject who is judged to be ineligible by principal investigator or sub-investigator