Mindfulness-based Stress Reduction for Multiple Sclerosis

Inclusion Criteria:

• Men and women 18 years of age or older
• Definite relapsing remitting, secondary progressive, or primary progressive MS by revised McDonald criteria;
• Expanded Disability Severity Scale ≤ 8 at baseline;
• Stable on MS disease modifying, anxiolytic, or antidepressant medications for three months prior to baseline visit;
• Mild to moderate stress defined by a score of ≥ 10 on the Perceived Stress Scale at screening;
• Ability to read and write in English;
• Willingness to provide informed consent and comply with study activities, including weekly MBSR sessions and daily practice or weekly Education Control classes.

Exclusion Criteria:

• MBSR or cognitive behavioral therapy training within the last 5 years;
• Current regular meditation or yoga practice (weekly or more often);
• MS exacerbation within 30 days of Baseline Visit;
• Mini-Mental Status Examination (MMSE) score of ≤ 26 at Screening Visit;
• Active suicidal ideation (Beck Depression Inventory) at Screening Visit;
• Reported or medically recorded diagnoses of current serious psychological disorders other than depression and anxiety;
• Other current life-threatening or severely disabling physical disorders;
• Positive pregnancy urine test at Baseline and women planning pregnancy during the study period (contraception not required);
• Cancer, other than basal or squamous skin cancers; or
• Inability or unwillingness of individual or legal guardian/representative to give written informed consent.