Mindfulness-based Stress Reduction for Multiple Sclerosis
2018年4月6日 更新者：Angela Senders, ND, MCR、National University of Natural Medicine
The primary purpose of this study is to assess the feasibility of mindfulness-based stress reduction (MBSR) for adults with any type of multiple sclerosis.
The secondary objectives are to: 1) Explore the ability of MBSR to improve perceived stress and quality of life compared to an education control group; and 2) Explore the durability of the effects of MBSR over one year.
調査の概要
研究の種類
介入
入学 (実際)
67
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Oregon
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Portland、Oregon、アメリカ、97201
- National College of Natural Medicine
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
18年歳以上 (大人、高齢者)
健康ボランティアの受け入れ
いいえ
受講資格のある性別
全て
説明
Inclusion Criteria:
- Men and women 18 years of age or older
- Definite relapsing remitting, secondary progressive, or primary progressive MS by revised McDonald criteria;
- Expanded Disability Severity Scale ≤ 8 at baseline;
- Stable on MS disease modifying, anxiolytic, or antidepressant medications for three months prior to baseline visit;
- Mild to moderate stress defined by a score of ≥ 10 on the Perceived Stress Scale at screening;
- Ability to read and write in English;
- Willingness to provide informed consent and comply with study activities, including weekly MBSR sessions and daily practice or weekly Education Control classes.
Exclusion Criteria:
- MBSR or cognitive behavioral therapy training within the last 5 years;
- Current regular meditation or yoga practice (weekly or more often);
- MS exacerbation within 30 days of Baseline Visit;
- Mini-Mental Status Examination (MMSE) score of ≤ 26 at Screening Visit;
- Active suicidal ideation (Beck Depression Inventory) at Screening Visit;
- Reported or medically recorded diagnoses of current serious psychological disorders other than depression and anxiety;
- Other current life-threatening or severely disabling physical disorders;
- Positive pregnancy urine test at Baseline and women planning pregnancy during the study period (contraception not required);
- Cancer, other than basal or squamous skin cancers; or
- Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：支持療法
- 割り当て：ランダム化
- 介入モデル：並列代入
- マスキング：ダブル
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Mindfulness-base Stress Reduction
Mindfulness-based stress reduction is a formalized, experiential, 8-week stress-management program.
Participants attend weekly two-hour classes and a half-day retreat during which they learn mindfulness meditation, breath work, yoga postures, self-reflection and awareness.
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他の名前：
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アクティブコンパレータ：MS Education Control
The MS Education Control program is matched to MBSR for time and attention yet has no overlap with intervention content.
Each two-hour class uses a pamphlet published by the National MS Society to present information about a different MS topic such as Fatigue; Bowel and Bladder Problems; Diet; Spasticity; and Nutritional Supplementation: Vitamins, Minerals, and Herbs.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Recruitment: Number of participants enrolled over a ten-month period
時間枠：Recruitment will be tracked monthly with an expected recruitment period of 10 months..
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Feasible recruitment is defined as the ability to recruit and enroll 60 participants with multiple sclerosis (MS) over a ten-month time frame.
Recruitment rate will be calculated as the proportion of eligible patients who provided informed consent per month.
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Recruitment will be tracked monthly with an expected recruitment period of 10 months..
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Adherence to Mindfulness-based Stress Reduction (MBSR): Number of Participants who are present for at least 5 of the classes, including the final class, and complete at least 70% of homework.
時間枠：Baseline to 8 weeks
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Adherence will be tracked with a sign-in/sign out sheet at each class and with daily homework logs.
Attendance will be calculated by a sign in/sign out sheet, being present for at least 75% of a class will count as attended.
Homework will be tabulated as both a frequency count (number of days homework was completed) and amount (total number of minutes completed).
Participants who are present for at least 5 of the classes, including the final class, and complete at least 70% of homework will be recorded as 'adherent'.
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Baseline to 8 weeks
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Adoption: Qualitative assessment of facilitators of and barriers to participation in the MBSR program.
時間枠：Week 4 and week 8 of the 8 week intervention.
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Adoption is defined as the ability of participants to take part in activities such as yoga poses and meditative exercises.
Qualitative outcomes include a brief, semi-structured focus group conducted at the beginning of the MBSR classes during weeks five and eight.
Focus groups will address successes and any challenges participants may be experiencing.
Focus groups will be audio recorded and transcribed verbatim for qualitative analysis.
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Week 4 and week 8 of the 8 week intervention.
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Completion: Number of participants with complete follow-up at 12 months post-intervention.
時間枠：14 months
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A feasible completion rate is defined as complete follow-up in at least 70% of enrolled subjects at 12-months post-intervention.
Completion indicates acceptability of a long-term trial and will inform future study designs.
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14 months
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Change from baseline in Perceived Stress Scale at 8 weeks
時間枠：Baseline and 8 weeks
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Baseline and 8 weeks
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Change in Perceived Stress Scale from 8 weeks to 12 months
時間枠：8 weeks and 12 months
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8 weeks and 12 months
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Change from baseline in Short Form-36 Mental Health Subscale to 8 weeks
時間枠：Baseline and 8 weeks
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Mental health-related quality of life.
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Baseline and 8 weeks
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Change in Short Form-36 Mental Health Subscale from 8 weeks to 12 months
時間枠：8 weeks and 12 months
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Mental health-related quality of life.
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8 weeks and 12 months
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Change in baseline Patient Reported Outcomes Measurement Information System (PROMIS) Anxiety Score to 8 weeks
時間枠：Baseline and 8 weeks
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PROMIS Computerized Adaptive Test of Anxiety
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Baseline and 8 weeks
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Change in PROMIS Anxiety Score from 8 weeks to 12 months
時間枠：8 weeks and 12 months
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PROMIS Computerized Adaptive Test of Anxiety
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8 weeks and 12 months
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Change in baseline PROMIS Depression Score to 8 weeks
時間枠：Baseline and 8 weeks
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PROMIS Computerized Adaptive Test of Depression
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Baseline and 8 weeks
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Change in PROMIS Depression Score from 8 weeks to 12 months
時間枠：8 weeks and 12 months
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PROMIS Computerized Adaptive Test of Depression
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8 weeks and 12 months
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Change in baseline PROMIS Fatigue Score to 8 weeks
時間枠：Baseline and 8 weeks
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PROMIS Computerized Adaptive Test of Fatigue
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Baseline and 8 weeks
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Change in PROMIS Fatigue Score from 8 weeks to 12 months
時間枠：8 weeks and 12 months
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PROMIS Computerized Adaptive Test of Fatigue
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8 weeks and 12 months
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Change in baseline PROMIS Pain Score to 8 weeks
時間枠：Baseline and 8 weeks
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PROMIS Computerized Adaptive Test of Pain
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Baseline and 8 weeks
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Change in PROMIS Pain Score from 8 weeks to 12 months
時間枠：8 weeks and 12 months
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PROMIS Computerized Adaptive Test of Pain
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8 weeks and 12 months
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
一般刊行物
- Senders A, Bourdette D, Hanes D, Yadav V, Shinto L. Perceived stress in multiple sclerosis: the potential role of mindfulness in health and well-being. J Evid Based Complementary Altern Med. 2014 Apr;19(2):104-11. doi: 10.1177/2156587214523291. Epub 2014 Feb 20.
- Senders A, Sando K, Wahbeh H, Peterson Hiller A, Shinto L. Managing psychological stress in the multiple sclerosis medical visit: Patient perspectives and unmet needs. J Health Psychol. 2016 Aug;21(8):1676-87. doi: 10.1177/1359105314562084. Epub 2014 Dec 19.
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始
2015年5月1日
一次修了 (実際)
2017年5月30日
研究の完了 (実際)
2017年5月30日
試験登録日
最初に提出
2015年1月11日
QC基準を満たした最初の提出物
2015年1月13日
最初の投稿 (見積もり)
2015年1月19日
学習記録の更新
投稿された最後の更新 (実際)
2018年4月9日
QC基準を満たした最後の更新が送信されました
2018年4月6日
最終確認日
2018年4月1日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。