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Mindfulness-based Stress Reduction for Multiple Sclerosis

6. April 2018 aktualisiert von: Angela Senders, ND, MCR, National University of Natural Medicine
The primary purpose of this study is to assess the feasibility of mindfulness-based stress reduction (MBSR) for adults with any type of multiple sclerosis. The secondary objectives are to: 1) Explore the ability of MBSR to improve perceived stress and quality of life compared to an education control group; and 2) Explore the durability of the effects of MBSR over one year.

Studienübersicht

Status

Abgeschlossen

Bedingungen

Intervention / Behandlung

Studientyp

Interventionell

Einschreibung (Tatsächlich)

67

Phase

  • Unzutreffend

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienorte

  • Vereinigte Staaten
    • Oregon
      • Portland, Oregon, Vereinigte Staaten, 97201
        • National College of Natural Medicine

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

18 Jahre und älter (Erwachsene, Älterer Erwachsener)

Akzeptiert gesunde Freiwillige

Nein

Studienberechtigte Geschlechter

Alle

Beschreibung

Inclusion Criteria:

  • Men and women 18 years of age or older
  • Definite relapsing remitting, secondary progressive, or primary progressive MS by revised McDonald criteria;
  • Expanded Disability Severity Scale ≤ 8 at baseline;
  • Stable on MS disease modifying, anxiolytic, or antidepressant medications for three months prior to baseline visit;
  • Mild to moderate stress defined by a score of ≥ 10 on the Perceived Stress Scale at screening;
  • Ability to read and write in English;
  • Willingness to provide informed consent and comply with study activities, including weekly MBSR sessions and daily practice or weekly Education Control classes.

Exclusion Criteria:

  • MBSR or cognitive behavioral therapy training within the last 5 years;
  • Current regular meditation or yoga practice (weekly or more often);
  • MS exacerbation within 30 days of Baseline Visit;
  • Mini-Mental Status Examination (MMSE) score of ≤ 26 at Screening Visit;
  • Active suicidal ideation (Beck Depression Inventory) at Screening Visit;
  • Reported or medically recorded diagnoses of current serious psychological disorders other than depression and anxiety;
  • Other current life-threatening or severely disabling physical disorders;
  • Positive pregnancy urine test at Baseline and women planning pregnancy during the study period (contraception not required);
  • Cancer, other than basal or squamous skin cancers; or
  • Inability or unwillingness of individual or legal guardian/representative to give written informed consent.

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Designdetails

  • Hauptzweck: Unterstützende Pflege
  • Zuteilung: Zufällig
  • Interventionsmodell: Parallele Zuordnung
  • Maskierung: Doppelt

Waffen und Interventionen

Teilnehmergruppe / Arm
Intervention / Behandlung
Experimental: Mindfulness-base Stress Reduction
Mindfulness-based stress reduction is a formalized, experiential, 8-week stress-management program. Participants attend weekly two-hour classes and a half-day retreat during which they learn mindfulness meditation, breath work, yoga postures, self-reflection and awareness.
Verhalten: Mindfulness-based Stress Reduction
Andere Namen:
  • MBSR
Aktiver Komparator: MS Education Control
The MS Education Control program is matched to MBSR for time and attention yet has no overlap with intervention content. Each two-hour class uses a pamphlet published by the National MS Society to present information about a different MS topic such as Fatigue; Bowel and Bladder Problems; Diet; Spasticity; and Nutritional Supplementation: Vitamins, Minerals, and Herbs.
Verhalten: MS Education Control

Was misst die Studie?

Primäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Recruitment: Number of participants enrolled over a ten-month period
Zeitfenster: Recruitment will be tracked monthly with an expected recruitment period of 10 months..
Feasible recruitment is defined as the ability to recruit and enroll 60 participants with multiple sclerosis (MS) over a ten-month time frame. Recruitment rate will be calculated as the proportion of eligible patients who provided informed consent per month.
Recruitment will be tracked monthly with an expected recruitment period of 10 months..
Adherence to Mindfulness-based Stress Reduction (MBSR): Number of Participants who are present for at least 5 of the classes, including the final class, and complete at least 70% of homework.
Zeitfenster: Baseline to 8 weeks
Adherence will be tracked with a sign-in/sign out sheet at each class and with daily homework logs. Attendance will be calculated by a sign in/sign out sheet, being present for at least 75% of a class will count as attended. Homework will be tabulated as both a frequency count (number of days homework was completed) and amount (total number of minutes completed). Participants who are present for at least 5 of the classes, including the final class, and complete at least 70% of homework will be recorded as 'adherent'.
Baseline to 8 weeks
Adoption: Qualitative assessment of facilitators of and barriers to participation in the MBSR program.
Zeitfenster: Week 4 and week 8 of the 8 week intervention.
Adoption is defined as the ability of participants to take part in activities such as yoga poses and meditative exercises. Qualitative outcomes include a brief, semi-structured focus group conducted at the beginning of the MBSR classes during weeks five and eight. Focus groups will address successes and any challenges participants may be experiencing. Focus groups will be audio recorded and transcribed verbatim for qualitative analysis.
Week 4 and week 8 of the 8 week intervention.
Completion: Number of participants with complete follow-up at 12 months post-intervention.
Zeitfenster: 14 months
A feasible completion rate is defined as complete follow-up in at least 70% of enrolled subjects at 12-months post-intervention. Completion indicates acceptability of a long-term trial and will inform future study designs.
14 months

Sekundäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Change from baseline in Perceived Stress Scale at 8 weeks
Zeitfenster: Baseline and 8 weeks
Baseline and 8 weeks
Change in Perceived Stress Scale from 8 weeks to 12 months
Zeitfenster: 8 weeks and 12 months
8 weeks and 12 months
Change from baseline in Short Form-36 Mental Health Subscale to 8 weeks
Zeitfenster: Baseline and 8 weeks
Mental health-related quality of life.
Baseline and 8 weeks
Change in Short Form-36 Mental Health Subscale from 8 weeks to 12 months
Zeitfenster: 8 weeks and 12 months
Mental health-related quality of life.
8 weeks and 12 months
Change in baseline Patient Reported Outcomes Measurement Information System (PROMIS) Anxiety Score to 8 weeks
Zeitfenster: Baseline and 8 weeks
PROMIS Computerized Adaptive Test of Anxiety
Baseline and 8 weeks
Change in PROMIS Anxiety Score from 8 weeks to 12 months
Zeitfenster: 8 weeks and 12 months
PROMIS Computerized Adaptive Test of Anxiety
8 weeks and 12 months
Change in baseline PROMIS Depression Score to 8 weeks
Zeitfenster: Baseline and 8 weeks
PROMIS Computerized Adaptive Test of Depression
Baseline and 8 weeks
Change in PROMIS Depression Score from 8 weeks to 12 months
Zeitfenster: 8 weeks and 12 months
PROMIS Computerized Adaptive Test of Depression
8 weeks and 12 months
Change in baseline PROMIS Fatigue Score to 8 weeks
Zeitfenster: Baseline and 8 weeks
PROMIS Computerized Adaptive Test of Fatigue
Baseline and 8 weeks
Change in PROMIS Fatigue Score from 8 weeks to 12 months
Zeitfenster: 8 weeks and 12 months
PROMIS Computerized Adaptive Test of Fatigue
8 weeks and 12 months
Change in baseline PROMIS Pain Score to 8 weeks
Zeitfenster: Baseline and 8 weeks
PROMIS Computerized Adaptive Test of Pain
Baseline and 8 weeks
Change in PROMIS Pain Score from 8 weeks to 12 months
Zeitfenster: 8 weeks and 12 months
PROMIS Computerized Adaptive Test of Pain
8 weeks and 12 months

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

National University of Natural Medicine

Mitarbeiter

National Institutes of Health (NIH)
National Center for Complementary and Integrative Health (NCCIH)

Publikationen und hilfreiche Links

Die Bereitstellung dieser Publikationen erfolgt freiwillig durch die für die Eingabe von Informationen über die Studie verantwortliche Person. Diese können sich auf alles beziehen, was mit dem Studium zu tun hat.

Allgemeine Veröffentlichungen

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn

1. Mai 2015

Primärer Abschluss (Tatsächlich)

30. Mai 2017

Studienabschluss (Tatsächlich)

30. Mai 2017

Studienanmeldedaten

Zuerst eingereicht

11. Januar 2015

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

13. Januar 2015

Zuerst gepostet (Schätzen)

19. Januar 2015

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Tatsächlich)

9. April 2018

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

6. April 2018

Zuletzt verifiziert

1. April 2018

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Schlüsselwörter

Zusätzliche relevante MeSH-Bedingungen

Andere Studien-ID-Nummern

  • MBSR-MS-001
  • 1K23AT008211-01A1 (US NIH Stipendium/Vertrag)

Diese Informationen wurden ohne Änderungen direkt von der Website clinicaltrials.gov abgerufen. Wenn Sie Ihre Studiendaten ändern, entfernen oder aktualisieren möchten, wenden Sie sich bitte an register@clinicaltrials.gov. Sobald eine Änderung auf clinicaltrials.gov implementiert wird, wird diese automatisch auch auf unserer Website aktualisiert .

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