Epidemiology of heart failure

Amy Groenewegen, Frans H Rutten, Arend Mosterd, Arno W Hoes, Amy Groenewegen, Frans H Rutten, Arend Mosterd, Arno W Hoes

Abstract

The heart failure syndrome has first been described as an emerging epidemic about 25 years ago. Today, because of a growing and ageing population, the total number of heart failure patients still continues to rise. However, the case mix of heart failure seems to be evolving. Incidence has stabilized and may even be decreasing in some populations, but alarming opposite trends have been observed in the relatively young, possibly related to an increase in obesity. In addition, a clear transition towards heart failure with a preserved ejection fraction has occurred. Although this transition is partially artificial, due to improved recognition of heart failure as a disorder affecting the entire left ventricular ejection fraction spectrum, links can be made with the growing burden of obesity-related diseases and with the ageing of the population. Similarly, evidence suggests that the number of patients with heart failure may be on the rise in low-income countries struggling under the double burden of communicable diseases and conditions associated with a Western-type lifestyle. These findings, together with the observation that the mortality rate of heart failure is declining less rapidly than previously, indicate we have not reached the end of the epidemic yet. In this review, the evolving epidemiology of heart failure is put into perspective, to discern major trends and project future directions.

Keywords: Epidemiology; Heart failure; Incidence; Mortality; Prevalence.

© 2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

Figures

Figure 1
Figure 1
Prevalence of heart failure in population‐based studies around the world, in percentage, per region. 17 , 25 , 29 , 39 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71
Figure 2
Figure 2
Underlying causes of death by gender and left ventricular ejection fraction in 463 patients in the Framingham Heart Study.140 CVD, cardiovascular disease; CHD, coronary heart disease. Adapted from Lee et al. 140

References

    1. Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol 2013;62:263–271.
    1. Borlaug BA, Redfield MM. Diastolic and systolic heart failure are distinct phenotypes within the heart failure spectrum. Circulation 2011;123:2006–2014.
    1. McMurray JJ. Systolic heart failure. N Engl J Med 2010;362:228–238.
    1. Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, De Boer RA, De Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot JS, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A, Mentz RJ, Nihoyannopoulos P, Papp Z, Parissis J, Pedrazzini T, Rosano G, Rouleau J, Seferovic PM, Shah AM, Starling RC, Tocchetti CG, Trochu JN, Thum T, Zannad F, Brutsaert DL, Segers VF, De Keulenaer GW. The continuous heart failure spectrum: moving beyond an ejection fraction classification. Eur Heart J 2019;40:2155–2163.
    1. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez‐Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2016;18:891–975.
    1. Pfeffer MA, Shah AM, Borlaug BA. Heart failure with preserved ejection fraction in perspective. Circ Res 2019;124:1598–1617.
    1. Di Bari M, Pozzi C, Cavallini MC, Innocenti F, Baldereschi G, de Alfieri W, Antonini E, Pini R, Masotti G, Marchionni N. The diagnosis of heart failure in the community: comparative validation of four sets of criteria in unselected older adults: the ICARe Dicomano study. J Am Coll Cardiol 2004;44:1601–1608.
    1. Rosamond WD, Chang PP, Baggett C, Johnson A, Bertoni AG, Shahar E, Deswal A, Heiss G, Chambless LE. Classification of heart failure in the Atherosclerosis Risk in Communities (ARIC) study: a comparison of diagnostic criteria. Circ Heart Fail 2012;5:152–159.
    1. Pieske B, Tschöpe C, De Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CS, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske‐Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G. How to diagnose heart failure with preserved ejection fraction: the HFA‐PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J 2019;40:3297–3317.
    1. Bertens LCM, Broekhuizen BDL, Naaktgeboren CA, Rutten FH, Hoes AW, van Mourik Y, Moons KGM, Reitsma JB. Use of expert panels to define the reference standard in diagnostic research: a systematic review of published methods and reporting. PLoS Med 2013;10:e1001531.
    1. Bertens LCM, Van Mourik Y, Rutten FH, Cramer MJ, Lammers JW, Hoes AW, Reitsma JB, Moons KG. Staged decision making was an attractive alternative to a plenary approach in panel diagnosis as reference standard. J Clin Epidemiol 2015;68:418–425.
    1. Bankier AA, Levine D, Halpern EF, Kressel HY. Consensus interpretation in imaging research: is there a better way? Radiology 2010;1:14–17.
    1. Obuchowski NA, Zepp RC. Simple steps for improving multiple‐reader studies in radiology. Am J Roentgenol 1996;166:517–521.
    1. Quach S, Blais C, Quan H. Administrative data have high variation in validity for recording heart failure. Can J Cardiol 2010;26:306–312.
    1. Quan H, Li B, Saunders LD, Parsons GA, Nilsson CI, Alibhai A, Ghali WA; IMECCHI Investigators . Assessing validity of ICD‐9‐CM and ICD‐10 administrative data in recording clinical conditions in a unique dually coded database. Health Serv Res 2008;43:1424–1441.
    1. Goff DC, Pandey DK, Chan FA, Ortiz C, Nichaman MZ. Congestive heart failure in the United States. Arch Intern Med 2000;160:197–202.
    1. Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, de Ferranti SD, Ferguson JF, Fornage M, Gillespie C, Isasi CR, Jiménez MC, Jordan LC, Judd SE, Lackland D, Lichtman JH, Lisabeth L, Liu S, Longenecker CT, Lutsey PL, Mackey JS, Matchar DB, Matsushita K, Mussolino ME, Nasir K, O'Flaherty M, Palaniappan LP, Pandey A, Pandey DK, Reeves MJ, Ritchey MD, Rodriguez CJ, Roth GA, Rosamond WD, Sampson UKA, Satou GM, Shah SH, Spartano NL, Tirschwell DL, Tsao CW, Voeks JH, Willey JZ, Wilkins JT, Wu JH, Alger HM, Wong SS, Muntner P; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee . Heart disease and stroke statistics‐2018 update: a report from the American Heart Association. Circulation 2018;137:67–492.
    1. Ezekowitz JA, Kaul P, Bakal JA, Quan H, McAlister FA. Trends in heart failure care: has the incident diagnosis of heart failure shifted from the hospital to the emergency department and outpatient clinics? Eur J Heart Fail 2011;13:142–147.
    1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators . Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990‐2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018;392:1789–1858.
    1. Loehr LR, Rosamond WD, Chang PP, Folsom AR, Chambless LE. Heart failure incidence and survival (from the Atherosclerosis Risk in Communities Study). Am J Cardiol 2008;101:1016–1022.
    1. Jhund PS, Macintyre K, Simpson CR, Lewsey JD, Stewart S, Chalmers JWT, Capewell S, McMurray JJ. Long‐term trends in first hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people. Circulation 2009;119:515–523.
    1. Curtis LH, Whellan DJ, Hammill BG, Hernandez AF, Anstrom KJ, Shea AM, Schulman KA. Incidence and prevalence of heart failure in elderly persons, 1994‐2003. Arch Intern Med 2008;168:418–424.
    1. Bibbins‐Domingo K, Pletcher MJ, Lin F, Vittinghoff E, Gardin JM, Arynchyn A, Lewis CE, Williams OD, Hulley SB. Racial differences in incident heart failure among young adults. N Engl J Med 2009;360:1179–1190.
    1. Yeung DF, Boom NK, Guo H, Lee DS, Schultz SE, Tu JV. Trends in the incidence and outcomes of heart failure in Ontario, Canada: 1997 to 2007. CMAJ 2012;184:E765–E773.
    1. Zarrinkoub R, Wettermark B, Wändell P, Mejhert M, Szulkin R, Ljunggren G, Kahan T. The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden. Eur J Heart Fail 2013;15:995–1002.
    1. Christiansen MN, Køber L, Weeke P, Vasan RS, Jeppesen JL, Smith JG, Gislason GH, Torp‐Pedersen C, Andersson C. Age‐specific trends in incidence, mortality, and comorbidities of heart failure in Denmark, 1995 to 2012. Circulation 2017;135:1214–1223.
    1. Conrad N, Judge A, Tran J, Mohseni H, Hedgecott D, Crespillo AP, Allison M, Hemingway H, Cleland JG, McMurray JJ, Rahimi K. Temporal trends and patterns in heart failure incidence: a population‐based study of 4 million individuals. Lancet 2018;391:572–580.
    1. Christ M, Störk S, Dörr M, Heppner HJ, Müller C, Wachter R, Riemer U. Heart failure epidemiology 2000–2013: insights from the German Federal Health Monitoring System. Eur J Heart Fail 2016;18:1009–1018.
    1. Smeets M, Vaes B, Mamouris P, Van Den Akker M, Van Pottelbergh G, Goderis G, Janssens S, Aertgeerts B, Henrard S. Burden of heart failure in Flemish general practices: a registry‐based study in the Intego database. BMJ Open 2019;9:e022972.
    1. Bahrami H, Kronmal R, Bluemke DA, Olson J, Shea S, Liu K, Burke GL, Lima JA. Differences in the incidence of congestive heart failure by ethnicity. Arch Intern Med 2008;168:2138–2145.
    1. Ho JE, Lyass A, Lee DS, Vasan RS, Kannel WB, Larson MG, Levy D. Predictors of new‐onset heart failure: differences in preserved versus reduced ejection fraction. Circ Heart Fail 2013;6:279–286.
    1. Meyer S, Brouwers FP, Voors AA, Hillege HL, de Boer RA, Gansevoort RT, van der Harst P, Rienstra M, van Gelder IC, van Veldhuisen DJ, van Gilst WH, van der Meer P. Sex differences in new‐onset heart failure. Clin Res Cardiol 2015;104:342–350.
    1. Tsao CW, Lyass A, Enserro D, Larson MG, Ho JE, Kizer JR, Gottdiener JS, Psaty BM, Vasan RS. Temporal trends in the incidence of and mortality associated with heart failure with preserved and reduced ejection fraction. JACC Heart Fail 2018;6:678–685.
    1. Gerber Y, Weston SA, Redfield MM, Chamberlain AM, Manemann SM, Jiang R, Killian JM, Roger VL. A contemporary appraisal of the heart failure epidemic in Olmsted County, Minnesota, 2000 to 2010. JAMA Intern Med 2015;175:996–1004.
    1. van Riet EE, Hoes AW, Wagenaar KP, Limburg A, Landman MA, Rutten FH. Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review. Eur J Heart Fail 2016;18:242–252.
    1. Roger VL. Epidemiology of heart failure. Circ Res 2013;113:646–659.
    1. Mosterd A, Hoes AW. Clinical epidemiology of heart failure. Heart 2007;93:1137–1146.
    1. Bursi F, Weston SA, Redfield MM, Jacobsen SJ, Pakhomov S, Nkomo VT, Meverden RA, Roger VL. Systolic and diastolic heart failure in the community. JAMA 2006;296:2209–2216.
    1. Störk S, Handrock R, Jacob J, Walker J, Calado F, Lahoz R, Hupfer S, Klebs S. Epidemiology of heart failure in Germany: a retrospective database study. Clin Res Cardiol 2017;106:913–922.
    1. Caruana L, Petrie MC, Davie AP, McMurray JJ. Do patients with suspected heart failure and preserved left ventricular systolic function suffer from diastolic heart failure or from misdiagnosis? A prospective descriptive study. BMJ 2000;321:215–218.
    1. Dunlay SM, Roger VL. Understanding the epidemic of heart failure: past, present, and future. Curr Heart Fail Rep 2014;11:404–415.
    1. Roth GA, Forouzanfar MH, Moran AE, Barber R, Nguyen G, Feigin VL, Naghavi M, Mensah GA, Murray CJ. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med 2015;372:1333–1341.
    1. Lazzarini V, Mentz RJ, Fiuzat M, Metra M, O'Connor CM. Heart failure in elderly patients: distinctive features and unresolved issues. Eur J Heart Fail 2013;15:717–723.
    1. Brouwers FP, de Boer RA, van der Harst P, Voors AA, Gansevoort RT, Bakker SJ, Hillege HL, van Veldhuisen DJ, van Gilst WH. Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community‐based cohort: 11‐year follow‐up of PREVEND. Eur Heart J 2013;34:1424–1431.
    1. Smolina K, Wright FL, Rayner M, Goldacre MJ. Determinants of the decline in mortality from acute myocardial infarction in England between 2002 and 2010: linked national database study. BMJ 2012;344:d8059.
    1. Huffman MD, Berry JD, Ning H, Dyer AR, Garside DB, Cai X, Daviglus ML, Lloyd‐Jones DM. Lifetime risk for heart failure among white and black Americans: cardiovascular lifetime risk pooling project. J Am Coll Cardiol 2013;61:1510–1517.
    1. Rapsomaniki E, Timmis A, George J, Pujades‐Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A, Hemingway H. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life‐years lost, and age‐specific associations in 1.25 million people. Lancet 2014;383:1899–1911.
    1. Barasa A, Schaufelberger M, Lappas G, Swedberg K, Dellborg M, Rosengren A. Heart failure in young adults: 20‐year trends in hospitalization, aetiology, and case fatality in Sweden. Eur Heart J 2014;35:25–32.
    1. Shah RU, Klein L, Lloyd‐Jones DM. Heart failure in women: epidemiology, biology and treatment. Womens Health (Lond) 2009;5:517–527.
    1. Roger VL, Weston SA, Redfield MM, Hellermann‐Homan JP, Killian J, Yawn BP, Jacobsen SJ. Trends in heart failure incidence and survival in a community‐based population. JAMA 2004;292:344–350.
    1. Stolfo D, Uijl A, Vedin O, Strömberg A, Faxén UL, Rosano GM, Sinagra G, Dahlström U, Savarese G. Sex‐based differences in heart failure across the ejection fraction spectrum: phenotyping, and prognostic and therapeutic implications. JACC Heart Fail 2019;7:505–515.
    1. Lam CS, Arnott C, Beale AL, Chandramouli C, Hilfiker‐Kleiner D, Kaye DM, Ky B, Santema BT, Sliwa K, Voors AA. Sex differences in heart failure. Eur Heart J 2019;40:3859–3868.
    1. Dunlay SM, Roger VL, Redfield MM. Epidemiology of heart failure with preserved ejection fraction. Nat Rev Cardiol 2017;14:591–602.
    1. Ho JE, Enserro D, Brouwers FP, Kizer JR, Shah SJ, Psaty BM, Bartz TM, Santhanakrishnan R, Lee DS, Chan C, Liu K, Blaha MJ, Hillege HL, van der Harst P, van Gilst WH, Kop WJ, Gansevoort RT, Vasan RS, Gardin JM, Levy D, Gottdiener JS, de Boer RA, Larson MG. Predicting heart failure with preserved and reduced ejection fraction: the international collaboration on heart failure subtypes. Circ Heart Fail 2016;9:e003116.
    1. Pandey A, Omar W, Ayers C, LaMonte M, Klein L, Allen N, Kuller LH, Greenland P, Eaton C, Gottdiener JS, Lloyd‐Jones D, Berry JD. Sex and race differences in lifetime risk of heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. Circulation 2018;137:1814–1823.
    1. Savji N, Meijers WC, Bartz TM, Bhambhani V, Cushman M, Nayor M, Kizer JR, Sarma A, Blaha MJ, Gansevoort RT, Gardin JM, Hillege HL, Ji F, Kop WJ, Lau ES, Lee DS, Sadreyev R, van Gilst WH, Wang TJ, Zanni MV, Vasan RS, Allen NB, Psaty BM, van der Harst P, Levy D, Larson M, Shah SJ, de Boer RA, Gottdiener JS, Ho JE. The association of obesity and cardiometabolic traits with incident HFpEF and HFrEF. JACC Heart Fail 2018;6:701–709.
    1. Eaton CB, Pettinger M, Rossouw J, Martin LW, Foraker R, Quddus A, Liu S, Wampler NS, Hank Wu WC, Manson JE, Margolis K, Johnson KC, Allison M, Corbie‐Smith G, Rosamond W, Breathett K, Klein L. Risk factors for incident hospitalized heart failure with preserved versus reduced ejection fraction in a multiracial cohort of postmenopausal women. Circ Heart Fail 2016;9:e002883.
    1. Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA 1979;241:2035–2038.
    1. Ohkuma T, Komorita Y, Peters SAE, Woodward M. Diabetes as a risk factor for heart failure in women and men: a systematic review and meta‐analysis of 47 cohorts including 12 million individuals. Diabetologia 2019;62:1550–1560.
    1. Lin JL, Sung KT, Su CH, Chou TH, Lo CI, Tsai JP, Chang SC, Lai YH, Hu KC, Liu CY, Yun CH, Hung CL, Yeh HI, Lam CSP. Cardiac structural remodeling, longitudinal systolic strain, and torsional mechanics in lean and nonlean dysglycemic Chinese adults. Circ Cardiovasc Imaging 2018;11:e007047.
    1. Chandramouli C, Teng TH, Tay WT, Yap J, MacDonald MR, Tromp J, Yan L, Siswanto B, Reyes EB, Ngarmukos T, Yu CM, Hung CL, Anand I, Richards AM, Ling LH, Regensteiner JG, Lam CS, Anand I, Hung CL, Liew HB, Narasimhan C, Ngarmukos T, Park SW, Reyes E, Siswanto BB, Shimizu W, Zhang S. Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN‐HF registry. Eur J Heart Fail 2019;21:297–307.
    1. Lawson CA, Zaccardi F, Squire I, Ling S, Davies MJ, Lam CS, Khunti K, Kadam UT. 20‐year trends in cause‐specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population‐based study. Lancet 2019;4:E406–E420.
    1. Yusuf S, Rangarajan S, Teo K, Islam S, Li W, Liu L, Bo J, Lou Q, Lu F, Liu T, Yu L, Zhang S, Mony P, Swaminathan S, Mohan V, Gupta R, Kumar R, Vijayakumar K, Lear S, Anand S, Wielgosz A, Diaz R, Avezum A, Lopez‐Jaramillo P, Lanas F, Yusoff K, Ismail N, Iqbal R, Rahman O, Rosengren A, Yusufali A, Kelishadi R, Kruger A, Puoane T, Szuba A, Chifamba J, Oguz A, McQueen M, McKee M, Dagenais G; PURE Investigators . Cardiovascular risk and events in 17 low‐, middle‐, and high‐income countries. N Engl J Med 2014;371:818–827.
    1. Guo L, Guo X, Chang Y, Yang J, Zhang L, Li T, Sun Y. Prevalence and risk factors of heart failure with preserved ejection fraction: a population‐based study in Northeast China. Int J Environ Res Public Health 2016;13:770.
    1. Sahle BW, Owen AJ, Mutowo MP, Krum H, Reid CM. Prevalence of heart failure in Australia: a systematic review. BMC Cardiovasc Disord 2016;16:32.
    1. McGrady M, Krum H, Carrington MJ, Stewart S, Zeitz C, Lee GA, Marwick TH, Haluska BA, Brown A. Heart failure, ventricular dysfunction and risk factor prevalence in Australian Aboriginal peoples: the Heart of the Heart Study. Heart 2012;98:1562–1567.
    1. Ciapponi A, Alcaraz A, Calderón M, Matta MG, Chaparro M, Soto N, Bardach A. Burden of heart failure in Latin America: a systematic review and meta‐analysis. Rev Esp Cardiol (Engl Ed) 2016;69:1051–1060.
    1. Okura Y, Ramadan MM, Ohno Y, Mitsuma W, Tanaka K, Ito M, Suzuki K, Tanabe N, Kodama M, Aizawa Y. Impending epidemic – future projection of heart failure in Japan to the year 2055. Circ J 2008;72:489–491.
    1. Degertekin M, Erol C, Ergene O, Tokgozoglu L, Aksoy M, Erol MK, Eren M, Sahin M, Eroglu E, Mutlu B, Kozan O. Heart fAilure Prevalence and Predictors in TurkeY (HAPPY). Turk Kardiyol Dern Ars 2012;40:298–308.
    1. Government of Canada . Heart Disease in Canada: Highlights from the Canadian Chronic Disease Surveillance System. July 2017. (4 May 2020).
    1. Buja A, Solinas G, Visca M, Federico B, Gini R, Baldo V, Francesconi P, Sartor G, Bellentani M, Damiani G. Prevalence of heart failure and adherence to process indicators: which socio‐demographic determinants are involved? Int J Environ Res Public Health 2016;13:238.
    1. Tromp J, Ferreira JP, Janwanishstaporn S, Shah M, Greenberg B, Zannad F, Lam CS. Heart failure around the world. Eur J Heart Fail 2019;21:1187–1196.
    1. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR; PARADIGM‐HF Investigators and Committees . Angiotensin–neprilysin inhibition versus enalapril in heart failure. N Engl J Med 2014;371:993–1004.
    1. Tromp J, Teng TH, Tay WT, Hung CL, Narasimhan C, Shimizu W, Park SW, Liew HB, Ngarmukos T, Reyes EB, Siswanto BB, Yu CM, Zhang S, Yap J, MacDonald M, Ling LH, Leineweber K, Richards AM, Zile MR, Anand IS, Lam CS; ASIAN‐HF Investigators . Heart failure with preserved ejection fraction in Asia. Eur J Heart Fail 2019;21:23–36.
    1. Crespo‐Leiro MG, Anker SD, Maggioni AP, Coats AJ, Filippatos G, Ruschitzka F, Ferrari R, Piepoli MF, Delgado Jimenez JF, Metra M, Fonseca C, Hradec J, Amir O, Logeart D, Dahlström U, Merkely B, Drozdz J, Goncalvesova E, Hassanein M, Chioncel O, Lainscak M, Seferovic PM, Tousoulis D, Kavoliuniene A, Fruhwald F, Fazlibegovic E, Temizhan A, Gatzov P, Erglis A, Laroche C, Mebazaa A; Heart Failure Association (HFA) of the European Society of Cardiology (ESC) . European Society of Cardiology Heart Failure Long‐Term Registry (ESC‐HF‐LT): 1‐year follow‐up outcomes and differences across regions. Eur J Heart Fail 2016;18:613–625.
    1. Fonarow GC, Albert NM, Curtis AB, Gattis Stough W, Gheorghiade M, Heywood JT, McBride ML, Johnson Inge P, Mehra MR, O'Connor CM, Reynolds D, Walsh MN, Yancy CW. Improving evidence‐based care for heart failure in outpatient cardiology practices: primary results of the registry to improve the use of evidence‐based heart failure therapies in the outpatient setting (IMPROVE HF). Circulation 2010;122:585–596.
    1. Teng TH, Tromp J, Tay WT, Anand I, Ouwerkerk W, Chopra V, Wander GS, Yap JJ, MacDonald MR, Xu CF, Chia YM, Shimizu W, Richards AM, Voors A, Lam CS. Prescribing patterns of evidence‐based heart failure pharmacotherapy and outcomes in the ASIAN‐HF registry: a cohort study. Lancet Glob Health 2018;6:e1008–e1018.
    1. Dokainish H, Teo K, Zhu J, Roy A, AlHabib KF, ElSayed A, Palileo‐Villaneuva L, Lopez‐Jaramillo P, Karaye K, Yusoff K, Orlandini A, Sliwa K, Mondo C, Lanas F, Prabhakaran D, Badr A, Elmaghawry M, Damasceno A, Tibazarwa K, Belley‐Cote E, Balasubramanian K, Islam S, Yacoub MH, Huffman MD, Harkness K, Grinvalds A, McKelvie R, Bangdiwala SI, Yusuf S; INTER‐CHF Investigators . Global mortality variations in patients with heart failure: results from the International Congestive Heart Failure (INTER‐CHF) prospective cohort study. Lancet Glob Health 2017;5:e665–e672.
    1. Lam CS. Heart failure in Southeast Asia: facts and numbers. ESC Heart Fail 2015;2:46–49.
    1. Tromp J, Tay WT, Ouwerkerk W, Teng TH, Yap J, MacDonald MR, Leineweber K, McMurray JJ, Zile MR, Anand IS, Lam CS. Multimorbidity in patients with heart failure from 11 Asian regions: a prospective cohort study using the ASIAN‐HF registry. PLoS Med 2018;15:e1002541.
    1. Bocchi EA. Heart failure in South America. Curr Cardiol Rev 2013;9:147–156.
    1. Thienemann F, Sliwa K, Rockstroh JK. HIV and the heart: the impact of antiretroviral therapy: a global perspective. Eur Heart J 2013;34:3538–3546.
    1. Bocchi EA, Marcondes‐Braga FG, Bacal F, Ferraz AS, Albuquerque D, Rodrigues DDA, Mesquita ET, Vilas‐Boas F, Cruz F, Ramires F, Villacorta H, de Souza Neto JD, Rossi Neto JM, Moura LZ, Beck‐da‐Silva L, Moreira LF, Rohde LE, Montera MW, Simões MV, Moreira M da C, Clausell N, Bestetti R, Mourilhe‐Rocha R, Mangini S, Rassi S, Ayub‐Ferreira SM, Martins SM, Bordignon S, Issa VS. Updating of the Brazilian guideline for chronic heart failure ‐ 2012. Arq Bras Cardiol 2012;98:1–33.
    1. Ponikowski P, Anker SD, AlHabib KF, Cowie MR, Force TL, Hu S, Jaarsma T, Krum H, Rastogi V, Rohde LE, Samal UC, Shimokawa H, Budi Siswanto B, Sliwa K, Filippatos G. Heart failure: preventing disease and death worldwide. ESC Heart Fail 2014;1:4–25.
    1. Damasceno A, Mayosi BM, Sani M, Ogah OS, Mondo C, Ojji D, Dzudie A, Kouam CK, Suliman A, Schrueder N, Yonga G, Ba SA, Maru F, Alemayehu B, Edwards C, Davison BA, Cotter G, Sliwa K. The causes, treatment, and outcome of acute heart failure in 1006 Africans from 9 countries. Arch Intern Med 2012;172:1386–1394.
    1. Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker‐Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan‐Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere‐Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz‐Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fèvre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gosselin R, Grainger R, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Ma J, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina‐Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi‐Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O'Donnell M, O'Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez‐Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA 3rd, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leòn FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez‐Riera L, Sanman E, Schwebel DC, Scott JG, Segui‐Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, Murray CJ, AlMazroa MA, Memish ZA. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:2163–2196.
    1. Yusuf S, Joseph P, Rangarajan S, Islam S, Mente A, Hystad P, Brauer M, Kutty VR, Gupta R, Wielgosz A, AlHabib KF, Dans A, Lopez‐Jaramillo P, Avezum A, Lanas F, Oguz A, Kruger IM, Diaz R, Yusoff K, Mony P, Chifamba J, Yeates K, Kelishadi R, Yusufali A, Khatib R, Rahman O, Zatonska K, Iqbal R, Wei L, Bo H, Rosengren A, Kaur M, Mohan V, Lear SA, Teo KK, Leong D, O'Donnell M, McKee M, Dagenais G. Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high‐income, middle‐income, and low‐income countries (PURE): a prospective cohort study. Lancet 2020;395:795–808.
    1. Dagenais GR, Leong DP, Rangarajan S, Lanas F, Lopez‐Jaramillo P, Gupta R, Diaz R, Avezum A, Oliveira GBF, Wielgosz A, Parambath SR, Mony P, Alhabib KF, Temizhan A, Ismail N, Chifamba J, Yeates K, Khatib R, Rahman O, Zatonska K, Kazmi K, Wei L, Zhu J, Rosengren A, Vijayakumar K, Kaur M, Mohan V, Yusufali A, Kelishadi R, Teo KK, Joseph P, Yusuf S. Variations in common diseases, hospital admissions, and deaths in middle‐aged adults in 21 countries from five continents (PURE): a prospective cohort study. Lancet 2020;395:785–794.
    1. Kristensen SL, Martinez F, Jhund PS, Arango JL, Belohlavek J, Boytsov S, Cabrera W, Gomez E, Hagège AA, Huang J, Kiatchoosakun S, Kim KS, Mendoza I, Senni M, Squire IB, Vinereanu D, Wong RCC, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR, Packer M, McMurray JJ. Geographic variations in the PARADIGM‐HF heart failure trial. Eur Heart J 2016;37:3167–3174.
    1. Baldi I, Azzolina D, Berchialla P, Gregori D, Scotti L, Corrao G. Comorbidity‐adjusted relative survival in newly hospitalized heart failure patients: a population‐based study. Int J Cardiol 2017;243:385–388.
    1. van Deursen VM, Urso R, Laroche C, Damman K, Dahlström U, Tavazzi L, Maggioni AP, Voors AA. Co‐morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey. Eur J Heart Fail 2014;16:103–111.
    1. Dunlay SM, Weston SA, Jacobsen SJ, Roger VL. Risk factors for heart failure: a population‐based case‐control study. Am J Med 2009;122:1023–1028.
    1. Shafazand M, Rosengren A, Lappas G, Swedberg K, Schaufelberger M. Decreasing trends in the incidence of heart failure after acute myocardial infarction from 1993‐2004: a study of 175 216 patients with a first acute myocardial infarction in Sweden. Eur J Heart Fail 2011;13:135–141.
    1. Rosamond WD, Chambless LE, Heiss G, Mosley TH, Coresh J, Whitsel E, Wagenknecht L, Ni H, Folsom AR. Twenty‐two–year trends in incidence of myocardial infarction, coronary heart disease mortality, and case fatality in 4 US communities, 1987–2008. Circulation 2012;125:1848–1857.
    1. Yeh RW, Sidney S, Chandra M, Sorel M, Selby JV, Go AS. Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med 2010;362:2155–2165.
    1. Zhou B, Danaei G, Stevens GA, Bixby H, Taddei C, Carrillo‐Larco RM, Solomon B, Riley LM, di Cesare M, Iurilli MLC, Rodriguez‐Martinez A, Zhu A, Hajifathalian K, Amuzu A, Banegas JR, Bennett JE, Cameron C, Cho Y, Clarke J, Craig CL, Cruz JJ, Gates L, Giampaoli S, Gregg EW, Hardy R, Hayes AJ, Ikeda N, Jackson RT, Jennings G, Joffres M, Khang YH, Koskinen S, Kuh D, Kujala UM, Laatikainen T, Lehtimäki T, Lopez‐Garcia E, Lundqvist A, Maggi S, Magliano DJ, Mann JI, McLean RM, McLean SB, Miller JC, Morgan K, Neuhauser HK, Niiranen TJ, Noale M, Oh K, Palmieri L, Panza F, Parnell WR, Peltonen M, Raitakari O, Rodríguez‐Artalejo F, Roy JG, Salomaa V, Sarganas G, Servais J, Shaw JE, Shibuya K, Solfrizzi V, Stavreski B, Tan EJ, Turley ML, Vanuzzo D, Viikari‐Juntura E, Weerasekera D, Ezzati M. Long‐term and recent trends in hypertension awareness, treatment, and control in 12 high‐income countries: an analysis of 123 nationally representative surveys. Lancet 2019;394:639–651.
    1. Lip GY, Skjøth F, Overvad K, Rasmussen LH, Larsen TB. Blood pressure and prognosis in patients with incident heart failure: the Diet, Cancer and Health (DCH) cohort study. Clin Res Cardiol 2015;104:1088–1096.
    1. Geiss LS, Wang J, Cheng YJ, Thompson TJ, Barker L, Li Y, Albright AL, Gregg EW. Prevalence and incidence trends for diagnosed diabetes among adults aged 20 to 79 years, United States, 1980‐2012. JAMA 2014;312:1218–1226.
    1. Selvin E, Ali MK. Declines in the incidence of diabetes in the U.S. – real progress or artifact? Diabetes Care 2017;40:1139–1143.
    1. Ather S, Chan W, Bozkurt B, Aguilar D, Ramasubbu K, Zachariah AA, Wehrens XH, Deswal A. Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol 2012;59:998–1005.
    1. Iribarren C, Karter AJ, Go AS, Ferrara A, Liu JY, Sidney S, Selby JV. Glycemic control and heart failure among adult patients with diabetes. Circulation 2001;103:2668–2673.
    1. Amato L, Paolisso G, Cacciatore F, Ferrara N, Ferrara P, Canonico S, Varricchio M. Congestive heart failure predicts the development of non‐insulin‐dependent diabetes mellitus in the elderly. Diabetes Metab 1997;23:213–218.
    1. Boonman‐De Winter LJ, Rutten FH, Cramer MJ, Landman MJ, Liem AH, Rutten GE, Hoes AW. High prevalence of previously unknown heart failure and left ventricular dysfunction in patients with type 2 diabetes. Diabetologia 2012;55:2154–2162.
    1. Reis JP, Allen N, Gunderson EP, Lee JM, Lewis CE, Loria CM, Powell‐Wiley TM, Rana JS, Sidney S, Wei G, Yano Y, Liu K. Excess body mass index‐ and waist circumference‐years and incident cardiovascular disease: the CARDIA study. Obesity 2015;23:879–885.
    1. NCD Risk Factor Collaboration . Trends in adult body‐mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population‐based measurement studies with 19.2 million participants. Lancet 2016;387:1377–1396.
    1. Seo JS, Jin HY, Jang JS, Yang TH, Kim DK, Kim DS. The relationships between body mass index and left ventricular diastolic function in a structurally normal heart with normal ejection fraction. J Cardiovasc Ultrasound 2017;25:5–11.
    1. Streng KW, Nauta JF, Hillege HL, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Metra M, Ng LL, Ponikowski P, Samani NJ, van Veldhuisen DJ, Zwinderman AH, Zannad F, Damman K, van der Meer P, Voors AA. Non‐cardiac comorbidities in heart failure with reduced, mid‐range and preserved ejection fraction. Int J Cardiol 2018;271:132–139.
    1. Packer M. The conundrum of patients with obesity, exercise intolerance, elevated ventricular filling pressures and a measured ejection fraction in the normal range. Eur J Heart Fail 2019;21:156–162.
    1. von Haehling S, Anker SD. Prevalence, incidence and clinical impact of cachexia: facts and numbers – update 2014. J Cachexia Sarcopenia Muscle 2014;5:261–263.
    1. Frantz S, Falcao‐Pires I, Balligand JL, Bauersachs J, Brutsaert D, Ciccarelli M, Dawson D, de Windt LJ, Giacca M, Hamdani N, Hilfiker‐Kleiner D, Hirsch E, Leite‐Moreira A, Mayr M, Thum T, Tocchetti CG, van der Velden J, Varricchi G, Heymans S. The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC. Eur J Heart Fail 2018;20:445–459.
    1. Lourenço AP, Leite‐Moreira AF, Balligand JL, Bauersachs J, Dawson D, de Boer RA, de Windt LJ, Falcão‐Pires I, Fontes‐Carvalho R, Franz S, Giacca M, Hilfiker‐Kleiner D, Hirsch E, Maack C, Mayr M, Pieske B, Thum T, Tocchetti CG, Brutsaert DL, Heymans S. An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. Eur J Heart Fail 2018;20:216–227.
    1. Dick SA, Epelman S. Chronic heart failure and inflammation. Circ Res 2016;119:159–176.
    1. Parikh KS, Sharma K, Fiuzat M, Surks HK, George JT, Honarpour N, Depre C, Desvigne‐Nickens P, Nkulikiyinka R, Lewis GD, Gomberg‐Maitland M, O'Connor CM, Stockbridge N, Califf RM, Konstam MA, Januzzi JL, Solomon SD, Borlaug BA, Shah SJ, Redfield MM, Felker GM. Heart failure with preserved ejection fraction expert panel report: current controversies and implications for clinical trials. JACC Heart Fail 2018;6:619–632.
    1. van Heerebeek L, Hamdani N, Falcão‐Pires I, Leite‐Moreira AF, Begieneman MP, Bronzwaer JG, van der Velden J, Stienen GJ, Laarman GJ, Somsen A, Verheugt FW, Niessen HW, Paulus WJ. Low myocardial protein kinase G activity in heart failure with preserved ejection fraction. Circulation 2012;126:830–839.
    1. Tromp J, Westenbrink BD, Ouwerkerk W, van Veldhuisen DJ, Samani NJ, Ponikowski P, Metra M, Anker SD, Cleland JG, Dickstein K, Filippatos G, van der Harst P, Lang CC, Ng LL, Zannad F, Zwinderman AH, Hillege HL, van der Meer P, Voors AA. Identifying pathophysiological mechanisms in heart failure with reduced versus preserved ejection fraction. J Am Coll Cardiol 2018;72:1081–1090.
    1. Packer M. Do most patients with obesity or type 2 diabetes, and atrial fibrillation, also have undiagnosed heart failure? A critical conceptual framework for understanding mechanisms and improving diagnosis and treatment. Eur J Heart Fail 2020;22:214–227.
    1. Van Linthout S, Tschöpe C. Inflammation – cause or consequence of heart failure or both? Curr Heart Fail Rep 2017;14:251–265.
    1. Vasan RS, Sullivan LM, Roubenoff R, Dinarello CA, Harris T, Benjamin EJ, Sawyer DB, Levy D, Wilson PWF, D'Agostino RB. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation 2003;107:1486–1491.
    1. Edelmann F, Holzendorf V, Wachter R, Nolte K, Schmidt AG, Kraigher‐Krainer E, Duvinage A, Unkelbach I, Düngen HD, Tschöpe C, Herrmann‐Lingen C, Halle M, Hasenfuss G, Gelbrich G, Stough WG, Pieske BM. Galectin‐3 in patients with heart failure with preserved ejection fraction: results from the Aldo‐DHF trial. Eur J Heart Fail 2015;17:214–223.
    1. Tromp J, Khan MA, Klip IT, Meyer S, de Boer RA, Jaarsma T, Hillege H, van Veldhuisen DJ, van der Meer P, Voors AA. Biomarker profiles in heart failure patients with preserved and reduced ejection fraction. J Am Heart Assoc 2017;6:e003989.
    1. Kalogeropoulos A, Georgiopoulou V, Psaty BM, Rodondi N, Smith AL, Harrison DG, Liu Y, Hoffmann U, Bauer DC, Newman AB, Kritchevsky SB, Harris TB, Butler J. Inflammatory markers and incident heart failure risk in older adults: the Health ABC (Health, Aging, and Body Composition) study. J Am Coll Cardiol 2010;55:2129–2137.
    1. de Boer RA, Nayor M, DeFilippi CR, Enserro D, Bhambhani V, Kizer JR, Blaha MJ, Brouwers FP, Cushman M, Lima JA, Bahrami H, van der Harst P, Wang TJ, Gansevoort RT, Fox CS, Gaggin HK, Kop WJ, Liu K, Vasan RS, Psaty BM, Lee DS, Hillege HL, Bartz TM, Benjamin EJ, Chan C, Allison M, Gardin JM, Januzzi JL, Shah SJ, Levy D, Herrington DM, Larson MG, van Gilst WH, Gottdiener JS, Bertoni AG, Ho JE. Association of cardiovascular biomarkers with incident heart failure with preserved and reduced ejection fraction. JAMA Cardiol 2018;3:215–224.
    1. Potter EL, Hopper I, Sen J, Salim A, Marwick TH. Impact of socioeconomic status on incident heart failure and left ventricular dysfunction: systematic review and meta‐analysis. Eur Heart J Qual Care Clin Outcomes 2019;5:169–179.
    1. Havranek EP, Mujahid MS, Barr DA, Blair IV, Cohen MS, Cruz‐Flores S, Davey‐Smith G, Dennison‐Himmelfarb CR, Lauer MS, Lockwood DW, Rosal M, Yancy CW. Social determinants of risk and outcomes for cardiovascular disease. Circulation 2015;132:873–898.
    1. Loucks EB, Pilote L, Lynch JW, Richard H, Almeida ND, Benjamin EJ, Murabito JM. Life course socioeconomic position is associated with inflammatory markers: the Framingham Offspring Study. Soc Sci Med 2010;71:187–195.
    1. Steptoe A, Feldman PJ, Kunz S, Owen N, Willemsen G, Marmot M. Stress responsivity and socioeconomic status: a mechanism for increased cardiovascular disease risk? Eur Heart J 2002;23:1757–1763.
    1. Steptoe A, Kunz‐Ebrecht S, Owen N, Feldman PJ, Willemsen G, Kirschbaum C, Marmot M. Socioeconomic status and stress‐related biological responses over the working day. Psychosom Med 2003;65:461–470.
    1. Filc D, Davidovich N, Novack L, Balicer RD. Is socioeconomic status associated with utilization of health care services in a single‐payer universal health care system? Int J Equity Health 2014;13:115.
    1. Trevisan L, Cautela J, Resseguier N, Laine M, Arques S, Pinto J, Orabona M, Barraud J, Peyrol M, Paganelli F, Bonello L, Thuny F. Prevalence and characteristics of coronary artery disease in heart failure with preserved and mid‐range ejection fractions: a systematic angiography approach. Arch Cardiovasc Dis 2018;111:109–118.
    1. Chamberlain AM, St Sauver JL, Gerber Y, Manemann SM, Boyd CM, Dunlay SM, Rocca WA, Finney Rutten LJ, Jiang R, Weston SA, Roger VL. Multimorbidity in heart failure: a community perspective. Am J Med 2015;128:38–45.
    1. Lam CS, Voors AA, de Boer RA, Solomon SD, van Veldhuisen DJ. Heart failure with preserved ejection fraction: from mechanisms to therapies. Eur Heart J 2018;39:2780–2792.
    1. Iorio A, Senni M, Barbati G, Greene SJ, Poli S, Zambon E, Di Nora C, Cioffi G, Tarantini L, Gavazzi A, Sinagra G, Di Lenarda A. Prevalence and prognostic impact of non‐cardiac co‐morbidities in heart failure outpatients with preserved and reduced ejection fraction: a community‐based study. Eur J Heart Fail 2018;20:1257–1266.
    1. Magnussen C, Niiranen TJ, Ojeda FM, Gianfagna F, Blankenberg S, Vartiainen E, Sans S, Pasterkamp G, Hughes M, Costanzo S, Donati MB, Jousilahti P, Linneberg A, Palosaari T, de Gaetano G, Bobak M, den Ruijter HM, Jørgensen T, Söderberg S, Kuulasmaa K, Zeller T, Iacoviello L, Salomaa V, Schnabel RB. Sex‐specific epidemiology of heart failure risk and mortality in Europe: results from the BiomarCaRE Consortium. JACC Heart Fail 2019;7:204–213.
    1. Heiat A, Gross CP, Krumholz HM. Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med 2002;162:1682–1688.
    1. Jones NN, Roalfe AK, Adoki I, Hobbs FD, Taylor CJ. Survival of patients with chronic heart failure in the community: a systematic review and meta‐analysis. Eur J Heart Fail 2019;21:1306–1325.
    1. Shah KS, Xu H, Matsouaka RA, Bhatt DL, Heidenreich PA, Hernandez AF, Devore AD, Yancy CW, Fonarow GC. Heart failure with preserved, borderline, and reduced ejection fraction: 5‐year outcomes. J Am Coll Cardiol 2017;70:2476–2486.
    1. Koudstaal S, Pujades‐Rodriguez M, Denaxas S, Gho JM, Shah AD, Yu N, Patel RS, Gale CP, Hoes AW, Cleland JG, Asselbergs FW, Hemingway H. Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population‐based linked electronic health record cohort study in 2.1 million people. Eur J Heart Fail 2017;19:1119–1127.
    1. Buddeke J, Bots ML, van Dis I, Liem A, Visseren FL, Vaartjes I. Trends in comorbidity in patients hospitalised for cardiovascular disease. Int J Cardiol 2017;248:382–388.
    1. Pocock SJ, Ariti CA, McMurray JJ, Maggioni A, Køber L, Squire IB, Swedberg K, Dobson J, Poppe KK, Whalley GA, Doughty RN. Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies. Eur Heart J 2013;34:1404–1413.
    1. Lee DS, Gona P, Albano I, Larson MG, Benjamin EJ, Levy D, Kannel WB, Vasan RS. A systematic assessment of causes of death after heart failure onset in the community: impact of age at death, time period, and left ventricular systolic dysfunction. Circ Heart Fail 2011;4:36–43.
    1. Moliner P, Lupón J, de Antonio M, Domingo M, Santiago‐Vacas E, Zamora E, Cediel G, Santesmases J, Díez‐Quevedo C, Troya MI, Boldó M, Altmir S, Alonso N, González B, Núñez J, Bayes‐Genis A. Trends in modes of death in heart failure over the last two decades: less sudden death but cancer deaths on the rise. Eur J Heart Fail 2019;21:1259–1266.
    1. Shen L, Jhund PS, Petrie MC, Claggett BL, Barlera S, Cleland JG, Dargie HJ, Granger CB, Kjekshus J, Køber L, Latini R, Maggioni AP, Packer M, Pitt B, Solomon SD, Swedberg K, Tavazzi L, Wikstrand J, Zannad F, Zile MR, McMurray JJ. Declining risk of sudden death in heart failure. N Engl J Med 2017;377:41–51.
    1. Vaduganathan M, Claggett BL, Chatterjee NA, Anand IS, Sweitzer NK, Fang JC, O'Meara E, Shah SJ, Hegde SM, Desai AS, Lewis EF, Rouleau J, Pitt B, Pfeffer MA, Solomon SD. Sudden death in heart failure with preserved ejection fraction: a competing risks analysis from the TOPCAT trial. JACC Heart Fail 2018;6:653–661.
    1. Adabag S, Rector TS, Anand IS, McMurray JJ, Zile M, Komajda M, McKelvie RS, Massie B, Carson PE. A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction. Eur J Heart Fail 2014;16:1175–1182.
    1. Alla F, Zannad F, Filippatos G. Epidemiology of acute heart failure syndromes. Heart Fail Rev 2007;12:91–95.
    1. Braunwald E. The war against heart failure: the Lancet lecture. Lancet 2015;385:812–824.
    1. Dunlay SM, Redfield MM, Weston SA, Therneau TM, Hall Long K, Shah ND, Roger VL. Hospitalizations after heart failure diagnosis: a community perspective. J Am Coll Cardiol 2009;54:1695–1702.
    1. Steinberg BA, Zhao X, Heidenreich PA, Peterson ED, Bhatt DL, Cannon CP, Hernandez AF, Fonarow GC; Get With the Guidelines Scientific Advisory Committee and Investigators . Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction. Circulation 2012;126:65–75.
    1. Jencks SF, Williams MV, Coleman EA. Rehospitalizations among patients in the Medicare fee‐for‐service program. N Engl J Med 2009;360:1418–1428.
    1. Cheng RK, Cox M, Neely ML, Heidenreich PA, Bhatt DL, Eapen ZJ, Hernandez AF, Butler J, Yancy CW, Fonarow GC. Outcomes in patients with heart failure with preserved, borderline, and reduced ejection fraction in the Medicare population. Am Heart J 2014;168:721–730.e3.
    1. Dharmarajan K, Hsieh AF, Lin Z, Bueno H, Ross JS, Horwitz LI, Barreto‐Filho JA, Kim N, Bernheim SM, Suter LG, Drye EE, Krumholz HM. Diagnoses and timing of 30‐day readmissions after hospitalization for heart failure, acute myocardial infarction, or pneumonia. JAMA 2013;309:355–363.
    1. Patil S, Shah M, Patel B, Agarwal M, Ram P, Alla VM. Readmissions among patients admitted with acute decompensated heart failure based on income quartiles. Mayo Clin Proc 2019;94:1939–1950.
    1. Nichols GA, Reynolds K, Kimes TM, Rosales AG, Chan WW. Comparison of risk of re‐hospitalization, all‐cause mortality, and medical care resource utilization in patients with heart failure and preserved versus reduced ejection fraction. Am J Cardiol 2015;116:1088–1092.
    1. Dharmarajan K, Hsieh AF, Kulkarni VT, Lin Z, Ross JS, Horwitz LI, Kim N, Suter LG, Lin H, Normand SL, Krumholz HM. Trajectories of risk after hospitalization for heart failure, acute myocardial infarction, or pneumonia: retrospective cohort study. BMJ 2015;350:h411.
    1. Mosterd A, Reitsma JB, Grobbee DE. Angiotensin converting enzyme inhibition and hospitalisation rates for heart failure in the Netherlands, 1980 to 1999: the end of an epidemic? Heart 2002;87:75–76.
    1. Lorenzoni G, Azzolina D, Lanera C, Brianti G, Gregori D, Vanuzzo D, Baldi I. Time trends in first hospitalization for heart failure in a community‐based population. Int J Cardiol 2018;271:195–199.
    1. Chen J, Normand SL, Wang Y, Krumholz HM. National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998‐2008. JAMA 2011;306:1669–1678.
    1. Teng TH, Finn J, Hobbs M, Hung J. Heart failure. Circ Heart Fail 2010;3:236–243.
    1. Chen J, Hsieh AF, Dharmarajan K, Masoudi FA, Krumholz HM. National trends in heart failure hospitalization after acute myocardial infarction for Medicare beneficiaries. Circulation 2013;128:2577–2584.
    1. Schmidt M, Ulrichsen SP, Pedersen L, Bøtker HE, Sørensen HT. Thirty‐year trends in heart failure hospitalization and mortality rates and the prognostic impact of co‐morbidity: a Danish nationwide cohort study. Eur J Heart Fail 2016;18:490–499.
    1. Chen J, Dharmarajan K, Wang Y, Krumholz HM. National trends in heart failure hospital stay rates, 2001 to 2009. J Am Coll Cardiol 2013;61:1078–1088.
    1. Ziaeian B, Kominski GF, Ong MK, Mays VM, Brook RH, Fonarow GC. National differences in trends for heart failure hospitalizations by sex and race/ethnicity. Circ Cardiovasc Qual Outcomes 2017;10:e003552.
    1. Chang PP, Wruck LM, Shahar E, Rossi JS, Loehr LR, Russell SD, Agarwal SK, Konety SH, Rodriguez CJ, Rosamond WD. Trends in hospitalizations and survival of acute decompensated heart failure in four US communities (2005–2014). Circulation 2018;138:12–24.
    1. National Guideline Centre (UK) . Chronic Heart Failure in Adults: Diagnosis and Management. London: National Institute for Health and Care Excellence (UK); 2018. (4 May 2020).

Source: PubMed

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