Bimatoprost in the treatment of eyelash universalis alopecia areata
Teresa Ojeda Vila, Francisco M Camacho Martinez, Teresa Ojeda Vila, Francisco M Camacho Martinez
Abstract
Objectives: To evaluate topical bimatoprost for eyelash growth in patients with alopecia areata (AA).
Design: A 1-year retrospective study, bilateral eyelash alopecia.
Materials and methods: Forty-one subjects with AA universalis without ocular disease applied 0.03% bimatoprost to the eyelid margin once a day over the course of 1 year.
Results: Thirty-seven subjects completed the study, one patient was eliminated due to conjunctivitis at the beginning of treatment, two patients developed conjunctivitis after 6 months of treatment, and a fourth did not follow directions. Researchers evaluated patients' eyelash growth every 4 months. We observed complete growth in 24.32%, moderate growth in 18.91%, slight growth in 27.02% and without response in 29.72%.
Conclusion: Bimatoprost may be effective and safe in the treatment of eyelash AA. 43.24% of the patients had an acceptable cosmetic response (total and moderate growth).
Limitations: Design without control.
Keywords: Alopecia areata; bimatoprost; eyelash growth; prostaglandins.
Conflict of interest statement
Conflict of Interest: None declared.
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References
- Johnstone MA. Hypertrichosis and increased pigmentation of eyelash and adjacent hair in the región of the ipsilateral eyelids of patients treated with unilateral topical latanoprost. Am J Ophthalmol. 1997;124:544–7.
- Woodward JA, Haggerty CJ, Stinnett SS, Williams ZY. Bimatoprost 0.03% gel for cosmetic eyelash growth and enhancement. J Cosmet Dermatol. 2010;9:96–102.
- Sarifakioglu E, Degim IT, Gorpelioglu C. Determination of the sildenafil effect on the alopecia areata in childhood: An open-pilot comparison study. J Dermatolog Treat. 2006;17:235–7.
- Coronel-Pérez IM, Rodréguez-Rey EM, Camacho-Marténez FM. Latanoprost in the treatment of eyelashes alopecia in alopecia areata universalis. J Eur Acad Dermatol Venereol. 2010;24:481–5.
- Ochoa BE, Sah D, Wang G, Stamper R, Price VH. Instilled bimatoprost ophthalmic solution inpatients with eyelash alopecia areata. J Am Acad Dermatol. 2009;61:530–2.
- Tosti A, Pazzaglia M, Voudouris S, Tosti G. Hypertrichosis of the eyelashes caused by bimatoprost. J Am Acad Dermatol. 2004;51:S149–50.
- Bikowski J, Lau EG, Jacob SE. Eyelash growth: A beneficial side effect of prostaglandin analogues. Cutis. 2010;85:187–8.
- Lim KS, Nau CB, O’Byrne MM, Hodge DO, Toris CB, McLaren JW, et al. Mechanism of action of bimatoprost, latanopros, and tavoprost in healthy subjects. A crossover study. Ophtalmology. 2008;115:790–5. e4.
- Law SK. Bimatoprost in the treatment of eyelash hypotrichosis. Clin Ophthalmol. 2010;4:349–58.
- Wester ST, Lee WW, Shi W. Eyelash growth from application of bimatoprost in gel suspension to the base of the eyelashes. Ophthalmology. 2010;117:1024–31.
- Roseborough I, Lee H, Chwalek J, Stamper RL, Price VH. Lack of efficacy of topical latanoprost and bimatoprost ophthalmic solutions in promoting eyelash growth in patients with alopecia areata. J Am Acad Dermatol. 2009;60:705–6.
- Zaheri S, Hughes B. Successful use of bimatoprost in the treatment of alopecia of the eyelashes. Clin Exp Dermatol. 2010;35:e161–2.
Source: PubMed