Chronic Pain in Children and Adolescents: Diagnosis and Treatment of Primary Pain Disorders in Head, Abdomen, Muscles and Joints

Stefan J Friedrichsdorf, James Giordano, Kavita Desai Dakoji, Andrew Warmuth, Cyndee Daughtry, Craig A Schulz, Stefan J Friedrichsdorf, James Giordano, Kavita Desai Dakoji, Andrew Warmuth, Cyndee Daughtry, Craig A Schulz

Abstract

Primary pain disorders (formerly "functional pain syndromes") are common, under-diagnosed and under-treated in children and teenagers. This manuscript reviews key aspects which support understanding the development of pediatric chronic pain, points to the current pediatric chronic pain terminology, addresses effective treatment strategies, and discusses the evidence-based use of pharmacology. Common symptoms of an underlying pain vulnerability present in the three most common chronic pain disorders in pediatrics: primary headaches, centrally mediated abdominal pain syndromes, and/or chronic/recurrent musculoskeletal and joint pain. A significant number of children with repeated acute nociceptive pain episodes develop chronic pain in addition to or as a result of their underlying medical condition "chronic-on-acute pain." We provide description of the structure and process of our interdisciplinary, rehabilitative pain clinic in Minneapolis, Minnesota, USA with accompanying data in the treatment of chronic pain symptoms that persist beyond the expected time of healing. An interdisciplinary approach combining (1) rehabilitation; (2) integrative medicine/active mind-body techniques; (3) psychology; and (4) normalizing daily school attendance, sports, social life and sleep will be presented. As a result of restored function, pain improves and commonly resolves. Opioids are not indicated for primary pain disorders, and other medications, with few exceptions, are usually not first-line therapy.

Keywords: adolescents; biopsychosocial; children; chronic pain; interdisciplinary treatment; pediatric pain clinic; primary pain disorder.

Conflict of interest statement

S.F. is supported, in part, by the The Mayday Fund, National Institutes of Health/National Cancer Institute, Children’s Hospitals and Clinics of Minnesota Research Grant Program, National Institutes of Health/National Institute of Nursing Research, and the Canadian Partnership against Cancer. J.G. is supported, in part, by the Children’s Hospitals and Clinics of Minneapolis Foundation, the William H. and Ruth Crane Schaefer Endowment, and the Clark Family Foundation. Other authors declare no conflict of interest.

References

    1. Goodman J.E., McGrath P.J. The epidemiology of pain in children and adolescents: A review. Pain. 1991;46:247–264. doi: 10.1016/0304-3959(91)90108-A.
    1. King S., Chambers C.T., Huguet A., MacNevin R.C., McGrath P.J., Parker L., MacDonald A.J. The epidemiology of chronic pain in children and adolescents revisited: A systematic review. Pain. 2011;152:2729–2738. doi: 10.1016/j.pain.2011.07.016.
    1. Stanford E.A., Chambers C.T., Biesanz J.C., Chen E. The frequency, trajectories and predictors of adolescent recurrent pain: A population-based approach. Pain. 2008;138:11–21. doi: 10.1016/j.pain.2007.10.032.
    1. Friedrichsdorf S.J., Postier A., Eull D., Weidner C., Foster L., Gilbert M., Campbell F. Pain outcomes in a US children’s hospital: A prospective cross-sectional survey. Hosp. Pediatr. 2015;5:18–26. doi: 10.1542/hpeds.2014-0084.
    1. Taylor E.M., Boyer K., Campbell F.A. Pain in hospitalized children: A prospective cross-sectional survey of pain prevalence, intensity, assessment and management in a Canadian pediatric teaching hospital. Pain Res. Manag. 2008;13:25–32. doi: 10.1155/2008/478102.
    1. Zhu L.M., Stinson J., Palozzi L., Weingarten K., Hogan M.E., Duong S., Carbajal R., Campbell F.A., Taddio A. Improvements in pain outcomes in a Canadian pediatric teaching hospital following implementation of a multifaceted knowledge translation initiative. Pain Res. Manag. J. Can. Pain Soc. 2012;17:173–179. doi: 10.1155/2012/586589.
    1. Stevens B.J., Harrison D., Rashotte J., Yamada J., Abbott L.K., Coburn G., Stinson J., Le May S. Pain assessment and intensity in hospitalized children in canada. J. Pain. 2012;13:857–865. doi: 10.1016/j.jpain.2012.05.010.
    1. Huguet A., Miro J. The severity of chronic pediatric pain: An epidemiological study. J. Pain. 2008;9:226–236. doi: 10.1016/j.jpain.2007.10.015.
    1. Hechler T., Dobe M., Zernikow B. Commentary: A worldwide call for multimodal inpatient treatment for children and adolescents suffering from chronic pain and pain-related disability. J. Pediatr. Psychol. 2010;35:138–140. doi: 10.1093/jpepsy/jsp066.
    1. Groenewald C.B., Essner B.S., Wright D., Fesinmeyer M.D., Palermo T.M. The economic costs of chronic pain among a cohort of treatment-seeking adolescents in the United States. J. Pain. 2014;15:925–933. doi: 10.1016/j.jpain.2014.06.002.
    1. Hyams J.S., di Lorenzo C., Saps M., Shulman R.J., Staiano A., van Tilburg M. Functional disorders: Children and adolescents. Gastroenterology. 2016 doi: 10.1053/j.gastro.2016.02.015.
    1. Turk D., Okifuji A. Pain terms and taxonomies of pain. In: Bonica J., Loeser J., Chapman C., Turk D., Butler S., editors. Bonica’s Management of Pain. Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2001.
    1. Treede R.D., Rief W., Barke A., Aziz Q., Bennett M.I., Benoliel R., Cohen M., Evers S., Finnerup N.B., First M.B., et al. A classification of chronic pain for ICD-11. Pain. 2015;156:1003–1007. doi: 10.1097/j.pain.0000000000000160.
    1. Force A.P.S.P.C.P.T. Assessment and Management of Children with Chronic Pain. A Position Statement from the American Pain Society. [(accessed on 7 December 2016)]. Available online: .
    1. Woolf C.J. Central sensitization: Implications for the diagnosis and treatment of pain. Pain. 2011;152:S2–S15. doi: 10.1016/j.pain.2010.09.030.
    1. Special Issue “Chronic and Recurrent Pain”. [(accessed on 7 December 2016)]. Available online: .
    1. Hassett A.L., Hilliard P.E., Goesling J., Clauw D.J., Harte S.E., Brummett C.M. Reports of chronic pain in childhood and adolescence among patients at a tertiary care pain clinic. J. Pain. 2013;14:1390–1397. doi: 10.1016/j.jpain.2013.06.010.
    1. Johannes C.B., Le T.K., Zhou X., Johnston J.A., Dworkin R.H. The prevalence of chronic pain in United States adults: Results of an internet-based survey. J. Pain. 2010;11:1230–1239. doi: 10.1016/j.jpain.2010.07.002.
    1. Hotopf M., Mayou R., Wadsworth M., Wessely S. Psychosocial and developmental antecedents of chest pain in young adults. Psychosom. Med. 1999;61:861–867. doi: 10.1097/00006842-199911000-00022.
    1. Hotopf M., Carr S., Mayou R., Wadsworth M., Wessely S. Why do children have chronic abdominal pain, and what happens to them when they grow up? Population based cohort study. BMJ. 1998;316:1196–1200. doi: 10.1136/bmj.316.7139.1196.
    1. Jones G.T., Silman A.J., Power C., Macfarlane G.J. Are common symptoms in childhood associated with chronic widespread body pain in adulthood? Results from the 1958 British birth cohort study. Arthritis Rheum. 2007;56:1669–1675. doi: 10.1002/art.22587.
    1. Power C., Elliott J. Cohort profile: 1958 British birth cohort (National Child Development Study) Int. J. Epidemiol. 2006;35:34–41. doi: 10.1093/ije/dyi183.
    1. Mulvaney S., Lambert E.W., Garber J., Walker L.S. Trajectories of symptoms and impairment for pediatric patients with functional abdominal pain: A 5-year longitudinal study. J. Am. Acad. Child Adolesc. Psychiatry. 2006;45:737–744. doi: 10.1097/10.chi.0000214192.57993.06.
    1. Dunn K.M., Jordan K.P., Mancl L., Drangsholt M.T., Le Resche L. Trajectories of pain in adolescents: A prospective cohort study. Pain. 2011;152:66–73. doi: 10.1016/j.pain.2010.09.006.
    1. Horst S., Shelby G., Anderson J., Acra S., Polk D.B., Saville B.R., Garber J., Walker L.S. Predicting persistence of functional abdominal pain from childhood into young adulthood. Clin. Gastroenterol. Hepatol. 2014;12:2026–2032. doi: 10.1016/j.cgh.2014.03.034.
    1. Shelby G.D., Shirkey K.C., Sherman A.L., Beck J.E., Haman K., Shears A.R., Horst S.N., Smith C.A., Garber J., Walker L.S. Functional abdominal pain in childhood and long-term vulnerability to anxiety disorders. Pediatrics. 2013;132:475–482. doi: 10.1542/peds.2012-2191.
    1. Noel M., Groenewald C.B., Beals-Erickson S.E., Gebert J.T., Palermo T.M. Chronic pain in adolescence and internalizing mental health disorders: A nationally representative study. Pain. 2016;157:1333–1338. doi: 10.1097/j.pain.0000000000000522.
    1. Van Tilburg M.A., Spence N.J., Whitehead W.E., Bangdiwala S., Goldston D.B. Chronic pain in adolescents is associated with suicidal thoughts and behaviors. J. Pain. 2011;12:1032–1039. doi: 10.1016/j.jpain.2011.03.004.
    1. Fisher E., Palermo T.M. Goal pursuit in youth with chronic pain. Children. 2016;3:36. doi: 10.3390/children3040036.
    1. Cunningham N.R., Lynch-Jordan A., Barnett K., Peugh J., Sil S., Goldschneider K., Kashikar-Zuck S. Child pain catastrophizing mediates the relation between parent responses to pain and disability in youth with functional abdominal pain. J. Pediatr. Gastroenterol. Nutr. 2014;59:732–738. doi: 10.1097/MPG.0000000000000529.
    1. Lynch-Jordan A.M., Kashikar-Zuck S., Szabova A., Goldschneider K.R. The interplay of parent and adolescent catastrophizing and its impact on adolescents’ pain, functioning, and pain behavior. Clin. J. Pain. 2013;29:681–688. doi: 10.1097/AJP.0b013e3182757720.
    1. Williams S.E., Blount R.L., Walker L.S. Children’s pain threat appraisal and catastrophizing moderate the impact of parent verbal behavior on children’s symptom complaints. J. Pediatr. Psychol. 2011;36:55–63. doi: 10.1093/jpepsy/jsq043.
    1. Campbell C.M., Witmer K., Simango M., Carteret A., Loggia M.L., Campbell J.N., Haythornthwaite J.A., Edwards R.R. Catastrophizing delays the analgesic effect of distraction. Pain. 2010;149:202–207. doi: 10.1016/j.pain.2009.11.012.
    1. Birnie K.A., Chambers C.T., Chorney J., Fernandez C.V., McGrath P.J. Dyadic analysis of child and parent trait and state pain catastrophizing in the process of Children’s Pain Communication. Pain. 2016;157:938–948. doi: 10.1097/j.pain.0000000000000461.
    1. Noel M., Rabbitts J.A., Tai G.G., Palermo T.M. Remembering pain after surgery: A longitudinal examination of the role of pain catastrophizing in children’s and parents’ recall. Pain. 2015;156:800–808. doi: 10.1097/j.pain.0000000000000102.
    1. Simons L.E., Kaczynski K.J., Conroy C., Logan D.E. Fear of pain in the context of intensive pain rehabilitation among children and adolescents with neuropathic pain: Associations with treatment response. J. Pain. 2012;13:1151–1161. doi: 10.1016/j.jpain.2012.08.007.
    1. Zale E.L., Lange K.L., Fields S.A., Ditre J.W. The relation between pain-related fear and disability: A meta-analysis. J. Pain. 2013;14:1019–1030. doi: 10.1016/j.jpain.2013.05.005.
    1. Von Baeyer C.L., Champion G.D. Commentary: Multiple pains as functional pain syndromes. J. Pediatr. Psychol. 2011;36:433–437. doi: 10.1093/jpepsy/jsq123.
    1. Kindler L.L., Bennett R.M., Jones K.D. Central sensitivity syndromes: Mounting pathophysiologic evidence to link fibromyalgia with other common chronic pain disorders. Pain Manag. Nurs. 2011;12:15–24. doi: 10.1016/j.pmn.2009.10.003.
    1. Williams F.M., Spector T.D., MacGregor A.J. Pain reporting at different body sites is explained by a single underlying genetic factor. Rheumatology. 2010;49:1753–1755. doi: 10.1093/rheumatology/keq170.
    1. Mayer E.A., Bushnell M.C. Functional Pain Syndromes: Presentation and Pathophysiology. IASP Press; Seattle, WA, USA: 2009.
    1. Burri A., Ogata S., Vehof J., Williams F. Chronic widespread pain: Clinical comorbidities and psychological correlates. Pain. 2015;156:1458–1464. doi: 10.1097/j.pain.0000000000000182.
    1. Schechter N.L. Functional pain: Time for a new name. JAMA Pediatr. 2014;168:693–694. doi: 10.1001/jamapediatrics.2014.530.
    1. McAbee G.N., Morse A.M., Assadi M. Pediatric aspects of headache classification in the international classification of headache disorders-3 (ichd-3 beta version) Curr. Pain Headache Rep. 2016;20:7. doi: 10.1007/s11916-015-0537-5.
    1. Headache Classification Committee of the International Headache Society The International Classification of Headache Disorders, 3rd Edition (Beta Version) Cephalalgia Int. J. Headache. 2013;33:629–808.
    1. Viswanathan V., Bridges S.J., Whitehouse W., Newton R.W. Childhood headaches: Discrete entities or continuum? Dev. Med. Child Neurol. 1998;40:544–550. doi: 10.1111/j.1469-8749.1998.tb15413.x.
    1. Zebenholzer K., Wober C., Kienbacher C., Wober-Bingol C. Migrainous disorder and headache of the tension-type not fulfilling the criteria: A follow-up study in children and adolescents. Cephalalgia Int. J. Headache. 2000;20:611–616. doi: 10.1111/j.1468-2982.2000.00090.x.
    1. Turner D.P., Smitherman T.A., Black A.K., Penzien D.B., Porter J.A., Lofland K.R., Houle T.T. Are migraine and tension-type headache diagnostic types or points on a severity continuum? An exploration of the latent taxometric structure of headache. Pain. 2015;156:1200–1207. doi: 10.1097/j.pain.0000000000000157.
    1. Andersen S., Petersen M.W., Svendsen A.S., Gazerani P. Pressure pain thresholds assessed over temporalis, masseter, and frontalis muscles in healthy individuals, patients with tension-type headache, and those with migraine—A systematic review. Pain. 2015;156:1409–1423. doi: 10.1097/j.pain.0000000000000219.
    1. Sun H., Bastings E., Temeck J., Smith P.B., Men A., Tandon V., Murphy D., Rodriguez W. Migraine therapeutics in adolescents: A systematic analysis and historic perspectives of triptan trials in adolescents. JAMA Pediatr. 2013;167:243–249. doi: 10.1001/jamapediatrics.2013.872.
    1. Silver S., Gano D., Gerretsen P. Acute treatment of paediatric migraine: A meta-analysis of efficacy. J. Paediatr. Child Health. 2008;44:3–9. doi: 10.1111/j.1440-1754.2007.01206.x.
    1. Damen L., Bruijn J.K., Verhagen A.P., Berger M.Y., Passchier J., Koes B.W. Symptomatic treatment of migraine in children: A systematic review of medication trials. Pediatrics. 2005;116:e295–e302. doi: 10.1542/peds.2004-2742.
    1. Sun-Edelstein C., Bigal M.E., Rapoport A.M. Chronic migraine and medication overuse headache: Clarifying the current international headache society classification criteria. Cephalalgia Int. J. Headache. 2009;29:445–452. doi: 10.1111/j.1468-2982.2008.01753.x.
    1. Bigal M.E., Tepper S.J., Sheftell F.D., Rapoport A.M., Lipton R.B. Chronic daily headache: Correlation between the 2004 and the 1988 international headache society diagnostic criteria. Headache. 2004;44:684–691. doi: 10.1111/j.1526-4610.2004.04128.x.
    1. Limmroth V., Katsarava Z., Fritsche G., Przywara S., Diener H.C. Features of medication overuse headache following overuse of different acute headache drugs. Neurology. 2002;59:1011–1014. doi: 10.1212/WNL.59.7.1011.
    1. MacGregor E.A., Steiner T.J., Davies P.T.G. Guidelines for All Healthcare Professionals in the Diagnosis and Management of Migraine, Tension-Type, Cluster and Medication-Overuse Headache. 3rd ed. [(accessed on 7 December 2016)]. (1st revision) Available online: .
    1. Hering-Hanit R., Gadoth N., Cohen A., Horev Z. Successful withdrawal from analgesic abuse in a group of youngsters with chronic daily headache. J. Child Neurol. 2001;16:448–449. doi: 10.1177/088307380101600613.
    1. Keefer L., Drossman D.A., Guthrie E., Simren M., Tillisch K., Olden K., Whorwell P.J. Centrally mediated disorders of gastrointestinal pain. Gastroenterology. 2016 doi: 10.1053/j.gastro.2016.02.034.
    1. Williams A.E., Heitkemper M., Self M.M., Czyzewski D.I., Shulman R.J. Endogenous inhibition of somatic pain is impaired in girls with irritable bowel syndrome compared with healthy girls. J. Pain. 2013;14:921–930. doi: 10.1016/j.jpain.2013.03.003.
    1. Stabell N., Stubhaug A., Flaegstad T., Mayer E., Naliboff B.D., Nielsen C.S. Widespread hyperalgesia in adolescents with symptoms of irritable bowel syndrome: Results from a large population-based study. J. Pain. 2014;15:898–906. doi: 10.1016/j.jpain.2014.05.007.
    1. Walker L.S., Dengler-Crish C.M., Rippel S., Bruehl S. Functional abdominal pain in childhood and adolescence increases risk for chronic pain in adulthood. Pain. 2010;150:568–572. doi: 10.1016/j.pain.2010.06.018.
    1. Dengler-Crish C.M., Horst S.N., Walker L.S. Somatic complaints in childhood functional abdominal pain are associated with functional gastrointestinal disorders in adolescence and adulthood. J. Pediatr. Gastroenterol. Nutr. 2011;52:162–165. doi: 10.1097/MPG.0b013e3181ec1d2e.
    1. Dengler-Crish C.M., Bruehl S., Walker L.S. Increased wind-up to heat pain in women with a childhood history of functional abdominal pain. Pain. 2011;152:802–808. doi: 10.1016/j.pain.2010.12.032.
    1. Petersen S., Bergstrom E., Brulin C. High prevalence of tiredness and pain in young schoolchildren. Scand. J. Public Health. 2003;31:367–374. doi: 10.1080/14034940210165064.
    1. Watson K.D., Papageorgiou A.C., Jones G.T., Taylor S., Symmons D.P., Silman A.J., Macfarlane G.J. Low back pain in schoolchildren: Occurrence and characteristics. Pain. 2002;97:87–92. doi: 10.1016/S0304-3959(02)00008-8.
    1. Kristjansdottir G. Prevalence of self-reported back pain in school children: A study of sociodemographic differences. Eur. J. Pediatr. 1996;155:984–986. doi: 10.1007/BF02282892.
    1. Smedbraten B.K., Natvig B., Rutle O., Bruusgaard D. Self-reported bodily pain in schoolchildren. Scand. J. Rheumatol. 1998;27:273–276.
    1. Brun Sundblad G.M., Saartok T., Engstrom L.M. Prevalence and co-occurrence of self-rated pain and perceived health in school-children: Age and gender differences. Eur. J. Pain. 2007;11:171–180. doi: 10.1016/j.ejpain.2006.02.006.
    1. Vahasarja V. Prevalence of chronic knee pain in children and adolescents in Northern Finland. Acta Paediatr. 1995;84:803–805. doi: 10.1111/j.1651-2227.1995.tb13760.x.
    1. Mikkelsson M., Salminen J.J., Kautiainen H. Non-specific musculoskeletal pain in preadolescents. Prevalence and 1-year persistence. Pain. 1997;73:29–35. doi: 10.1016/S0304-3959(97)00073-0.
    1. Centers for Disease Control and Prevention Post-Treatment Lyme Disease Syndrome. [(accessed on 7 December 2016)]; Available online:
    1. U.S. National Library of Medicine. Conversion Disorder. [(accessed on 7 December 2016)]; Available online: .
    1. Cottencin O. Conversion disorders: Psychiatric and psychotherapeutic aspects. Neurophysiol. Clin. 2014;44:405–410. doi: 10.1016/j.neucli.2013.09.005.
    1. Lu Q., Krull K.R., Leisenring W., Owen J.E., Kawashima T., Tsao J.C., Zebrack B., Mertens A., Armstrong G.T., Stovall M., et al. Pain in long-term adult survivors of childhood cancers and their siblings: A report from the childhood cancer survivor study. Pain. 2011;152:2616–2624. doi: 10.1016/j.pain.2011.08.006.
    1. Fortier M.A., Chou J., Maurer E.L., Kain Z.N. Acute to chronic postoperative pain in children: Preliminary findings. J. Pediatr. Surg. 2011;46:1700–1705. doi: 10.1016/j.jpedsurg.2011.03.074.
    1. Page M.G., Stinson J., Campbell F., Isaac L., Katz J. Identification of pain-related psychological risk factors for the development and maintenance of pediatric chronic postsurgical pain. J. Pain Res. 2013;6:167–180. doi: 10.2147/JPR.S40846.
    1. Sieberg C.B., Simons L.E., Edelstein M.R., DeAngelis M.R., Pielech M., Sethna N., Hresko M.T. Pain prevalence and trajectories following pediatric spinal fusion surgery. J. Pain. 2013;14:1694–1702. doi: 10.1016/j.jpain.2013.09.005.
    1. Rabbitts J.A., Zhou C., Groenewald C.B., Durkin L., Palermo T.M. Trajectories of postsurgical pain in children: Risk factors and impact of late pain recovery on long-term health outcomes after major surgery. Pain. 2015;156:2383–2389. doi: 10.1097/j.pain.0000000000000281.
    1. Friedrichsdorf S.J. Prevention and treatment of pain in hospitalized infants, children, and teenagers: From myths and morphine to multimodal analgesia; Proceedings of the Pain 2016: Refresher Courses, 16th World Congress on Pain; Yokohama, Japan. 23–30 September 2016; Washington, DC, USA: International Association for the Study of Pain, IASP Press; 2016. pp. 309–319.
    1. World Health Organization WHO-Principles of Acute Pain Management for Children. [(accessed on 7 December 2016)]. Available online: .
    1. Guzman J., Esmail R., Karjalainen K., Malmivaara A., Irvin E., Bombardier C. Multidisciplinary bio-psycho-social rehabilitation for chronic low back pain. Cochrane Database Syst. Rev. 2002 doi: 10.1002/14651858.CD000963.pub3.
    1. Logan D.E., Carpino E.A., Chiang G., Condon M., Firn E., Gaughan V.J., Hogan M., Leslie D.S., Olson K., Sager S., et al. A day-hospital approach to treatment of pediatric complex regional pain syndrome: Initial functional outcomes. Clin. J. Pain. 2012;28:766–774. doi: 10.1097/AJP.0b013e3182457619.
    1. Hechler T., Ruhe A.K., Schmidt P., Hirsch J., Wager J., Dobe M., Krummenauer F., Zernikow B. Inpatient-based intensive interdisciplinary pain treatment for highly impaired children with severe chronic pain: Randomized controlled trial of efficacy and economic effects. Pain. 2014;155:118–128. doi: 10.1016/j.pain.2013.09.015.
    1. Eccleston C., Malleson P.N., Clinch J., Connell H., Sourbut C. Chronic pain in adolescents: Evaluation of a programme of interdisciplinary cognitive behaviour therapy. Arch. Dis. Child. 2003;88:881–885. doi: 10.1136/adc.88.10.881.
    1. Maynard C.S., Amari A., Wieczorek B., Christensen J.R., Slifer K.J. Interdisciplinary behavioral rehabilitation of pediatric pain-associated disability: Retrospective review of an inpatient treatment protocol. J. Pediatr. Psychol. 2010;35:128–137. doi: 10.1093/jpepsy/jsp038.
    1. Palermo T.M., Scher M.S. Treatment of functional impairment in severe somatoform pain disorder: A case example. J. Pediatr. Psychol. 2001;26:429–434. doi: 10.1093/jpepsy/26.7.429.
    1. Lynch M.E., Campbell F., Clark A.J., Dunbar M.J., Goldstein D., Peng P., Stinson J., Tupper H. A systematic review of the effect of waiting for treatment for chronic pain. Pain. 2008;136:97–116. doi: 10.1016/j.pain.2007.06.018.
    1. Thompson L.A., Knapp C.A., Feeg V., Madden V.L., Shenkman E.A. Pediatricians’ management practices for chronic pain. J. Palliat. Med. 2010;13:171–178. doi: 10.1089/jpm.2009.0265.
    1. Simons L.E., Smith A., Ibagon C., Coakley R., Logan D.E., Schechter N., Borsook D., Hill J.C. Pediatric pain screening tool: Rapid identification of risk in youth with pain complaints. Pain. 2015;156:1511–1518. doi: 10.1097/j.pain.0000000000000199.
    1. Society A.P. Pediatric Chronic Pain Programs by State/Province. [(accessed on 7 December 2016)]. Available online: .
    1. Cormier S., Lavigne G.L., Choiniere M., Rainville P. Expectations predict chronic pain treatment outcomes. Pain. 2016;157:329–338. doi: 10.1097/j.pain.0000000000000379.
    1. Lynch-Jordan A.M., Sil S., Peugh J., Cunningham N., Kashikar-Zuck S., Goldschneider K.R. Differential changes in functional disability and pain intensity over the course of psychological treatment for children with chronic pain. Pain. 2014;155:1955–1961. doi: 10.1016/j.pain.2014.06.008.
    1. Sherry D.D., Wallace C.A., Kelley C., Kidder M., Sapp L. Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy. Clin. J. Pain. 1999;15:218–223. doi: 10.1097/00002508-199909000-00009.
    1. Odell S., Logan D.E. Pediatric pain management: The multidisciplinary approach. J. Pain Res. 2013;6:785–790. doi: 10.2147/JPR.S37434.
    1. Lee B.H., Scharff L., Sethna N.F., McCarthy C.F., Scott-Sutherland J., Shea A.M., Sullivan P., Meier P., Zurakowski D., Masek B.J., et al. Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. J. Pediatr. 2002;141:135–140. doi: 10.1067/mpd.2002.124380.
    1. Wilson A.C., Palermo T.M. Physical activity and function in adolescents with chronic pain: A controlled study using actigraphy. J. Pain. 2012;13:121–130. doi: 10.1016/j.jpain.2011.08.008.
    1. Jerstad S.J., Boutelle K.N., Ness K.K., Stice E. Prospective reciprocal relations between physical activity and depression in female adolescents. J. Consult. Clin. Psychol. 2010;78:268–272. doi: 10.1037/a0018793.
    1. Bowering K.J., O’Connell N.E., Tabor A., Catley M.J., Leake H.B., Moseley G.L., Stanton T.R. The effects of graded motor imagery and its components on chronic pain: A systematic review and meta-analysis. J. Pain. 2013;14:3–13. doi: 10.1016/j.jpain.2012.09.007.
    1. Bussing A., Ostermann T., Ludtke R., Michalsen A. Effects of yoga interventions on pain and pain-associated disability: A meta-analysis. J. Pain. 2012;13:1–9. doi: 10.1016/j.jpain.2011.10.001.
    1. Evans S., Moieni M., Taub R., Subramanian S.K., Tsao J.C., Sternlieb B., Zeltzer L.K. Iyengar Yoga for young adults with rheumatoid arthritis: Results from a mixed-methods pilot study. J. Pain Symptom Manag. 2010;39:904–913. doi: 10.1016/j.jpainsymman.2009.09.018.
    1. Vas J., Santos-Rey K., Navarro-Pablo R., Modesto M., Aguilar I., Campos M.A., Aguilar-Velasco J.F., Romero M., Parraga P., Hervas V., et al. Acupuncture for fibromyalgia in primary care: A randomised controlled trial. Acupunct. Med. 2016;34:257–266. doi: 10.1136/acupmed-2015-010950.
    1. Verkamp E.K., Flowers S.R., Lynch-Jordan A.M., Taylor J., Ting T.V., Kashikar-Zuck S. A survey of conventional and complementary therapies used by youth with juvenile-onset fibromyalgia. Pain Manag. Nurs. 2013;14:e244–e250. doi: 10.1016/j.pmn.2012.02.002.
    1. Friedrichsdorf S., Kuttner L., Westendorp K., McCarty R. Integrative Pediatric Palliative Care. Oxford University Press; Oxford, UK: 2010.
    1. Kuttner L., Friedrichsdorf S.J. Therapeutic Hypnosis with Children and Adolescents. 2nd ed. Crown House Publishing Limited; Bethel, CT, USA: 2013. Hypnosis and palliative care; pp. 491–509.
    1. Hunt K., Ernst E. The evidence-base for complementary medicine in children: A critical overview of systematic reviews. Arch. Dis. Child. 2011;96:769–776. doi: 10.1136/adc.2009.179036.
    1. Evans S., Tsao J.C., Zeltzer L.K. Complementary and alternative medicine for acute procedural pain in children. Altern. Ther. Health Med. 2008;14:52–56.
    1. Richardson J., Smith J.E., McCall G., Pilkington K. Hypnosis for procedure-related pain and distress in pediatric cancer patients: A systematic review of effectiveness and methodology related to hypnosis interventions. J. Pain Symptom Manag. 2006;31:70–84. doi: 10.1016/j.jpainsymman.2005.06.010.
    1. Hemington K.S., Coulombe M.A. The periaqueductal gray and descending pain modulation: Why should we study them and what role do they play in chronic pain? J. Neurophysiol. 2015;114:2080–2088. doi: 10.1152/jn.00998.2014.
    1. Valet M., Sprenger T., Boecker H., Willoch F., Rummeny E., Conrad B., Erhard P., Tolle T.R. Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain—An FMRI analysis. Pain. 2004;109:399–408. doi: 10.1016/j.pain.2004.02.033.
    1. Tracey I., Ploghaus A., Gati J.S., Clare S., Smith S., Menon R.S., Matthews P.M. Imaging attentional modulation of pain in the periaqueductal gray in humans. J. Neurosci. 2002;22:2748–2752.
    1. Derbyshire S.W., Osborn J. Modeling pain circuits: How imaging may modify perception. Neuroimaging Clin. N. Am. 2007;17:485–493. doi: 10.1016/j.nic.2007.09.004.
    1. Bingel U., Wanigasekera V., Wiech K., Ni Mhuircheartaigh R., Lee M.C., Ploner M., Tracey I. The effect of treatment expectation on drug efficacy: Imaging the analgesic benefit of the opioid remifentanil. Sci. Transl. Med. 2011;3:70ra14. doi: 10.1126/scitranslmed.3001244.
    1. Yu R., Gollub R.L., Spaeth R., Napadow V., Wasan A., Kong J. Disrupted functional connectivity of the periaqueductal gray in chronic low back pain. Neuroimage Clin. 2014;6:100–108. doi: 10.1016/j.nicl.2014.08.019.
    1. Giordano J. The neurobiology of nociceptive and anti-nociceptive systems. Pain Phys. 2005;8:277–290.
    1. Tegethoff M., Belardi A., Stalujanis E., Meinlschmidt G. Comorbidity of mental disorders and chronic pain: Chronology of onset in adolescents of a national representative cohort. J. Pain. 2015;16:1054–1064. doi: 10.1016/j.jpain.2015.06.009.
    1. Cohen L.L., Vowles K.E., Eccleston C. The impact of adolescent chronic pain on functioning: Disentangling the complex role of anxiety. J. Pain. 2010;11:1039–1046. doi: 10.1016/j.jpain.2009.09.009.
    1. Palermo T.M., Eccleston C., Lewandowski A.S., Williams A.C., Morley S. Randomized controlled trials of psychological therapies for management of chronic pain in children and adolescents: An updated meta-analytic review. Pain. 2010;148:387–397. doi: 10.1016/j.pain.2009.10.004.
    1. Eccleston C., Palermo T.M., Williams A.C., Lewandowski Holley A., Morley S., Fisher E., Law E. Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst. Rev. 2014 doi: 10.1002/14651858.CD003968.pub3.
    1. Kashikar-Zuck S., Sil S., Lynch-Jordan A.M., Ting T.V., Peugh J., Schikler K.N., Hashkes P.J., Arnold L.M., Passo M., Richards-Mauze M.M., et al. Changes in pain coping, catastrophizing, and coping efficacy after cognitive-behavioral therapy in children and adolescents with juvenile fibromyalgia. J. Pain. 2013;14:492–501. doi: 10.1016/j.jpain.2012.12.019.
    1. Seminowicz D.A., Shpaner M., Keaser M.L., Krauthamer G.M., Mantegna J., Dumas J.A., Newhouse P.A., Filippi C.G., Keefe F.J., Naylor M.R. Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain. J. Pain. 2013;14:1573–1584. doi: 10.1016/j.jpain.2013.07.020.
    1. Forgeron P.A., McGrath P., Stevens B., Evans J., Dick B., Finley G.A., Carlson T. Social information processing in adolescents with chronic pain: My friends don’t really understand me. Pain. 2011;152:2773–2780. doi: 10.1016/j.pain.2011.09.001.
    1. Palermo T.M., Wilson A.C., Lewandowski A.S., Toliver-Sokol M., Murray C.B. Behavioral and psychosocial factors associated with insomnia in adolescents with chronic pain. Pain. 2011;152:89–94. doi: 10.1016/j.pain.2010.09.035.
    1. Palermo T.M., Law E., Churchill S.S., Walker A. Longitudinal course and impact of insomnia symptoms in adolescents with and without chronic pain. J. Pain. 2012;13:1099–1106. doi: 10.1016/j.jpain.2012.08.003.
    1. Letter H.H. Blue Light Has a Dark Side. [(accessed on 7 December 2016)]. Available online: .
    1. Gooley J.J., Chamberlain K., Smith K.A., Khalsa S.B., Rajaratnam S.M., van Reen E., Zeitzer J.M., Czeisler C.A., Lockley S.W. Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. J. Clin. Endocrinol. Metab. 2011;96:E463–E472. doi: 10.1210/jc.2010-2098.
    1. Logan D.E., Simons L.E., Carpino E.A. Too sick for school? Parent influences on school functioning among children with chronic pain. Pain. 2012;153:437–443. doi: 10.1016/j.pain.2011.11.004.
    1. Bernstein G.A., Hektner J.M., Borchardt C.M., McMillan M.H. Treatment of school refusal: One-year follow-up. J. Am. Aca. Child Adolesc. Psychiatry. 2001;40:206–213. doi: 10.1097/00004583-200102000-00015.
    1. King N.J., Bernstein G.A. School refusal in children and adolescents: A review of the past 10 years. J. Am. Aca. Child Adolesc. Psychiatry. 2001;40:197–205. doi: 10.1097/00004583-200102000-00014.
    1. Evans L.D. Functional school refusal subtypes: Anxiety, avoidance, malingering. Psychol. Sch. 2000;37:183–191. doi: 10.1002/(SICI)1520-6807(200003)37:2<183::AID-PITS9>;2-5.
    1. Lewandowski A.S., Palermo T.M., Stinson J., Handley S., Chambers C.T. Systematic review of family functioning in families of children and adolescents with chronic pain. J. Pain. 2010;11:1027–1038. doi: 10.1016/j.jpain.2010.04.005.
    1. Liossi C., White P., Croome N., Hatira P. Pain-related bias in the classification of emotionally ambiguous facial expressions in mothers of children with chronic abdominal pain. Pain. 2012;153:674–681. doi: 10.1016/j.pain.2011.12.004.
    1. Higgins K.S., Birnie K.A., Chambers C.T., Wilson A.C., Caes L., Clark A.J., Lynch M., Stinson J., Campbell-Yeo M. Offspring of parents with chronic pain: A systematic review and meta-analysis of pain, health, psychological, and family outcomes. Pain. 2015;156:2256–2266. doi: 10.1097/j.pain.0000000000000293.
    1. Kaasboll J., Lydersen S., Indredavik M.S. Psychological symptoms in children of parents with chronic pain-the hunt study. Pain. 2012;153:1054–1062. doi: 10.1016/j.pain.2012.02.013.
    1. Peloso P.M. Faster, higher, stronger: To the gold medal podium? Pain. 2014;155:4–5. doi: 10.1016/j.pain.2013.09.021.
    1. Moore R.A., Derry S., Straube S., Ireson-Paine J., Wiffen P.J. Faster, higher, stronger? Evidence for formulation and efficacy for ibuprofen in acute pain. Pain. 2014;155:14–21. doi: 10.1016/j.pain.2013.08.013.
    1. Dowell D., Haegerich T.M., Chou R. Cdc guideline for prescribing opioids for chronic pain—United States, 2016. MMWR Recomm. Rep. 2016;65:1–49. doi: 10.15585/mmwr.rr6501e1.
    1. Schechter N.L., Walco G.A. The potential impact on children of the CDC guideline for prescribing opioids for chronic pain: Above all, do no harm. JAMA Pediatr. 2016;170:425–426. doi: 10.1001/jamapediatrics.2016.0504.
    1. Friedrichsdorf S.J., Nugent A.P. Management of neuropathic pain in children with cancer. Curr. Opin. Support. Palliat. Care. 2013;7:131–138. doi: 10.1097/SPC.0b013e3283615ebe.
    1. Vidor L.P., Torres I.L., Custodio de Souza I.C., Fregni F., Caumo W. Analgesic and sedative effects of melatonin in temporomandibular disorders: A double-blind, randomized, parallel-group, placebo-controlled study. J. Pain Symptom Manag. 2013;46:422–432. doi: 10.1016/j.jpainsymman.2012.08.019.
    1. Schwertner A., Conceicao Dos Santos C.C., Costa G.D., Deitos A., de Souza A., de Souza I.C., Torres I.L., da Cunha Filho J.S., Caumo W. Efficacy of melatonin in the treatment of endometriosis: A phase II, randomized, double-blind, placebo-controlled trial. Pain. 2013;154:874–881. doi: 10.1016/j.pain.2013.02.025.
    1. Finnerup N.B., Attal N., Haroutounian S., McNicol E., Baron R., Dworkin R.H., Gilron I., Haanpaa M., Hansson P., Jensen T.S., et al. Pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis. Lancet Neurol. 2015;14:162–173. doi: 10.1016/S1474-4422(14)70251-0.
    1. Hauer J.M., Solodiuk J.C. Gabapentin for management of recurrent pain in 22 nonverbal children with severe neurological impairment: A retrospective analysis. J. Palliat. Med. 2015;18:453–456. doi: 10.1089/jpm.2014.0359.
    1. Edwards L., DeMeo S., Hornik C.D., Cotten C.M., Smith P.B., Pizoli C., Hauer J.M., Bidegain M. Gabapentin use in the neonatal intensive care unit. J. Pediatr. 2016;169:310–312. doi: 10.1016/j.jpeds.2015.10.013.
    1. Derry S., Wiffen P.J., Moore R.A., Quinlan J. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst. Rev. 2014;7 doi: 10.1002/14651858.CD010958.pub2.
    1. El-Chammas K., Keyes J., Thompson N., Vijayakumar J., Becher D., Jackson J.L. Pharmacologic treatment of pediatric headaches: A meta-analysis. JAMA Pediatr. 2013;167:250–258. doi: 10.1001/jamapediatrics.2013.508.
    1. Campo J.V., Perel J., Lucas A., Bridge J., Ehmann M., Kalas C., Monk K., Axelson D., Birmaher B., Ryan N., et al. Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: An exploratory study. J. Am. Acad. Child. Adolesc. Psychiatry. 2004;43:1234–1242. doi: 10.1097/01.chi.0000136563.31709.b0.
    1. Caperell K., Pitetti R., Cross K.P. Race and acute abdominal pain in a pediatric emergency department. Pediatrics. 2013;131:1098–1106. doi: 10.1542/peds.2012-3672.
    1. Friedrichsdorf S.J., Drake R., Webster L.M. Textbook of Interdisciplinary Pediatric Palliative Care. Elsevier/Saunders; Philadelphia, PA, USA: 2011. Gastrointestinal symptoms; pp. 311–334.
    1. Friedrichsdorf S.J. Cancer pain management in children. In: Farquhar-Smith P., Wigmore T., editors. Anaesthesia, Intensive Care, and Pain Management for the Cancer Patient. Oxford University Press; Oxford, UK: New York, NY, USA: 2011. pp. 215–227.
    1. Michelson J.D., Addante R.A., Charlson M.D. Multimodal analgesia therapy reduces length of hospitalization in patients undergoing fusions of the ankle and hindfoot. Foot Ankle Int. 2013;34:1526–1534. doi: 10.1177/1071100713496224.
    1. Giordano J. The neuroscience of pain, and the neuroethics of pain care. Neuroethics. 2009;3:89–94. doi: 10.1007/s12152-009-9034-z.
    1. Giordano J. Pain research: Can paradigmatic revision bridge the demands of medicine, scientific philosophy and ethics? Pain Phys. 2004;7:407–410.
    1. Jorgenson L.A., Newsome W.T., Anderson D.J., Bargmann C.I., Brown E.N., Deisseroth K., Donoghue J.P., Hudson K.L., Ling G.S., MacLeish P.R., et al. The brain initiative: Developing technology to catalyse neuroscience discovery. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 2015;370 doi: 10.1098/rstb.2014.0164.
    1. Giordano J., Schatman M.E. Pain medicine from “bench to bedside”: Bridging the disconnect(s) between research and clinical care. J. Humanit. Sci. Healthc. 2011;1:22–40.
    1. Giordano J. Pain: Mind, Meaning, and Medicine. PPM Press; Glen Falls, PA, USA: 2009. p. 48.
    1. Giordano J. Maldynia: Chronic pain as illness, and the need for complementarity in pain care. Forsch. Komplement. 2008;15:277–281. doi: 10.1159/000158572.
    1. Giordano J. Pain and suffering: Körper and leib, and the telos of pain care. Philos. Psychiatry Psychol. 2013;19:279–283.
    1. Giordano J., Benedikter R., Boswell M.V. Pain medicine, biotechnology and market effects: Tools, tekne and moral responsibility. J. Ethics Biol. Eng. Med. 2010;1:135–142. doi: 10.1615/EthicsBiologyEngMed.v1.i2.50.
    1. Desai K., Daughtree C., Friedrichsdorf S.J. An interdisciplinary pain clinic: A year in review (poster); Proceedings of the 10th International Forum on Pediatric Pain (IFPP), White Point Beach Resort; Hunts Point, NS, Canada. 1–4 October 2015.
    1. Friedrichsdorf S.J., Postier A., Eull D., Gilbert M., Desai K., Gibbon C., Flood A. Interdisciplinary pediatric outpatient pain clinic: Improvement in pain, function and predictors of successful graduation. 2016. Unpublished work.
    1. “Little Stars—Treating Chronic Pain in Children”. [(accessed on 7 December 2016)]. Available online: .
    1. Pediatric Pain Clinics in USA and Canada (American Pain Society) [(accessed on 7 December 2016)]. Available online: .
    1. Pain Bytes (Australia) [(accessed on 7 December 2016)]; Available online: .
    1. Persistent (Chronic) Pain 5-min video[164] [(accessed on 7 December 2016)]. Available online: .
    1. Kiran Stordalen and Horst Rechelbacher Pediatric Pain, Palliative and Integrative Medicine Clinic Tour. [(accessed on 7 December 2016)]. Available online: .
    1. Elliot Krane (TED-Talk) The mystery of chronic pain. [(accessed on 7 December 2016)]. Available online: .
    1. The Department of Pain Medicine, Palliative Care, and Integrative Medicine, Children’s Hospitals and Clinics of Minnesota. [(accessed on 7 December 2016)]. Available online: .

Source: PubMed

3
Se inscrever