Pro-resolving lipid mediators are leads for resolution physiology
Charles N Serhan, Charles N Serhan
Abstract
Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators. Synthetic versions of these mediators have potent bioactions when administered in vivo. In animal experiments, the mediators evoke anti-inflammatory and novel pro-resolving mechanisms, and enhance microbial clearance. Although they have been identified in inflammation resolution, specialized pro-resolving mediators are conserved structures that also function in host defence, pain, organ protection and tissue remodelling. This Review covers the mechanisms of specialized pro-resolving mediators and omega-3 essential fatty acid pathways that could help us to understand their physiological functions.
Figures
![Figure 1. Lipid mediators in the acute…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4263681/bin/nihms646633f1.jpg)
![Figure 2. SPM production in resolving inflammatory…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/4263681/bin/nihms646633f2.jpg)
Source: PubMed