The sensitivity to change over time of the Amsterdam IADL Questionnaire(©)
Naomi Koster, Dirk L Knol, Bernard M J Uitdehaag, Philip Scheltens, Sietske A M Sikkes, Naomi Koster, Dirk L Knol, Bernard M J Uitdehaag, Philip Scheltens, Sietske A M Sikkes
Abstract
Introduction: This study aimed to investigate the sensitivity to change over time of a new informant-based instrument to assess instrumental activities of daily living (IADL) during the course of dementia: the Amsterdam IADL Questionnaire(©) (A-IADL-Q).
Methods: Participants (n = 102) were patients and their informants who visited the Alzheimer Center of the VU University Medical Center. Linear mixed models with random effects were used to relate longitudinal change on the A-IADL-Q to diagnosis and to longitudinal change in cognitive measures.
Results: We found longitudinal change on the A-IADL-Q to differ between diagnosis (P = .003), with dementia patients showing the fastest rate of decline (P < .001). In addition, we found longitudinal change on the A-IADL-Q to be related to longitudinal change in cognitive measures (global cognition: P < .001; memory: P = .024; executive functioning: P = .028).
Discussion: Findings indicate the A-IADL-Q is sensitive to change over time in IADL functioning and can be used in evaluating treatment effects and assessing individual disease progress.
Keywords: Alzheimer's disease; Dementia; Instrumental activities of daily living; Mild cognitive impairment; Responsiveness; Subjective cognitive decline.
Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
Source: PubMed