Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease (QUIP) and the QUIP-rating scale in a German speaking sample

Catharina Claudia Probst, Lina Marie Winter, Bettina Möller, Heinz Weber, Daniel Weintraub, Karsten Witt, Günther Deuschl, Regina Katzenschlager, Thilo van Eimeren, Catharina Claudia Probst, Lina Marie Winter, Bettina Möller, Heinz Weber, Daniel Weintraub, Karsten Witt, Günther Deuschl, Regina Katzenschlager, Thilo van Eimeren

Abstract

Impulsive-compulsive disorders are frequent in patients with Parkinson's disease (PD). Recently, a screening questionnaire and rating scale were developed for these disorders: the questionnaire for impulsive-compulsive disorders (QUIP) and QUIP-rating scale (QUIP-RS). We assessed the validity of these instruments in the German language in order to reevaluate the benefit and to obtain German screening tools in clinical practice. A convenience sample of 156 patients was assessed in Kiel and Vienna. The patients filled out the QUIP-current, the QUIP-anytime and the QUIP-RS. We validated the questionnaires against a gold standard diagnosis via receiver operating characteristic curves and determined optimal cut-off scores for the instruments. Excluding walkabout, which was not shown to be valid, sensitivities ranged from 60-92 % for the QUIP-current, 68-91 % for the QUIP-anytime, and 73-100 % for the QUIP-RS. Specificities were >71 % for QUIP-current, >69 % for QUIP-anytime and >62 % for QUIP-RS. With its very good sensitivities, the QUIP-RS is a valid instrument to assess impulsive-compulsive disorders and makes an early detection of behavioral disorders in PD possible. The QUIP-anytime was also shown to be a valid screening instrument. Both are expected to prove useful in scientific and clinical practice.

Figures

Fig. 1
Fig. 1
Relative frequencies of the impulsive-compulsive disorders at the time of the interview
Fig. 2
Fig. 2
ROC curves of the impulse control disorder scales of the QUIP-RS

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Source: PubMed

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