Paraoxonase gene mutations in amyotrophic lateral sclerosis
Nicola Ticozzi, Ashley Lyn LeClerc, Pamela J Keagle, Jonathan D Glass, Anne-Marie Wills, Marka van Blitterswijk, Daryl A Bosco, Ildefonso Rodriguez-Leyva, Cinzia Gellera, Antonia Ratti, Franco Taroni, Diane McKenna-Yasek, Peter C Sapp, Vincenzo Silani, Clement E Furlong, Robert H Brown Jr, John E Landers, Nicola Ticozzi, Ashley Lyn LeClerc, Pamela J Keagle, Jonathan D Glass, Anne-Marie Wills, Marka van Blitterswijk, Daryl A Bosco, Ildefonso Rodriguez-Leyva, Cinzia Gellera, Antonia Ratti, Franco Taroni, Diane McKenna-Yasek, Peter C Sapp, Vincenzo Silani, Clement E Furlong, Robert H Brown Jr, John E Landers
Abstract
Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function.
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Source: PubMed