Comparative AAPOS Validation of the Birefringent Amblyopia Screener with Isolated Small-Angle Strabismus

Robert W Arnold, Robert W Arnold

Abstract

Background: The Rebion blinq binocular birefringent ocular alignment screener was recently commercially released, but it did not yet have validation by American Association for Pediatric Ophthalmology and Strabismus (AAPOS) uniform guidelines.

Methods: Children and adults from a high-risk eye practice had screening by blinq with validation by AAPOS 2003 guidelines. Then, the blinq was compared to the Adaptica 2WIN with CR corneal reflex strabismus estimation by AAPOS 2003 guidelines plus additional efforts to identify patients with diminished binocularity.

Results: Blinq in 100 patients compared to 2003 AAPOS amblyopia risk factors (ARF) had sensitivity 67%, specificity 75% and PPV of 82%. Both blinq and 2WIN were completed by 87 patients median age 6.5 years. Sensitivity, specificity and positive predictive value (PPV) for blinq were 75%, 68% and 81% whereas 2WIN had 91%, 68% and 84%. The blinq referred two young patients with isolated, small-angle strabismic amblyopia that 2WIN refractive function passed.

Conclusion: Despite its non-refractive design to identify binocular foveation, blinq performed well with refractive and strabismic uniform risk factors and a PPV greater than 80%.

Clinical trials registry: NCT04195711.

Keywords: amblyopia; amblyopia risk factor; birefringent; fixation instability; photoscreening; strabismus.

Conflict of interest statement

Dr. Arnold is a board member and President of PDI Check that developed a vision screening game for the Nintendo 3DS and Glacier Medical Software that markets ROP Check cloud-based NICU monitoring software. Dr. Arnold coordinates the Alaska Blind Child Discovery which has received discounted instruments from several vendors. Dr. Arnold is an investigator and protocol developer for the Pediatric Eye Disease Investigator Group. Dr Arnold has a patent PDI Check pending to Robert Arnold and Alex Damarjian. The author reports no other conflicts of interest in this work.

© 2020 Arnold.

Figures

https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6999781/bin/OPTH-14-325-g0001.jpg

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Source: PubMed

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