Sarcoidosis-like reaction after neoadjuvant pembrolizumab combined with chemotherapy mimicking disease progression of NSCLC induced encouraging discovery of pathological complete response
Yuequan Shi, Ji Li, Minjiang Chen, Hongsheng Liu, Dongjie Ma, Yuxiao Lin, Mengzhao Wang, Yan Xu, Yuequan Shi, Ji Li, Minjiang Chen, Hongsheng Liu, Dongjie Ma, Yuxiao Lin, Mengzhao Wang, Yan Xu
Abstract
Neoadjuvant chemoimmunotherapy has demonstrated improved efficacy and prognosis in stage IIa-IIIb patients with non-small cell lung cancer (NSCLC). Drug-induced sarcoidosis-like reaction (DISR), an autoimmune reaction, has been reported as a type of immune-related adverse event that may mimic disease progression. Here, we report the case of patient with NSCLC who developed DISR during neoadjuvant chemoimmunotherapy and finally achieved pathological complete response after surgery.
Trial registration: ClinicalTrials.gov NCT02716038 NCT03197467.
Keywords: drug-induced sarcoidosis-like reaction; neoadjuvant chemoimmunotherapy; non-small cell lung cancer; pathological complete response.
Conflict of interest statement
The authors declare that they have no conflict of interest for this article.
© 2021 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.
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References
- Chorti E, Kanaki T, Zimmer L, Hadaschik E, Ugurel S, Gratsias E, et al. Drug‐induced sarcoidosis‐like reaction in adjuvant immunotherapy: Increased rate and mimicker of metastasis. Eur J Cancer. 2020;131:18–26.
- Forde PM, Chaft JE, Smith KN, Anagnostou V, Cottrell TR, Hellmann MD, et al. Neoadjuvant PD‐1 blockade in resectable lung cancer. N Engl J Med. 2018;378(21):1976–86.
- Chopra A, Nautiyal A, Kalkanis A, Judson MA. Drug‐induced sarcoidosis‐like reactions. Chest. 2018;154(3):664–77.
- Gkiozos I, Kopitopoulou A, Kalkanis A, Vamvakaris IN, Judson MA, Syrigos KN. Sarcoidosis‐like reactions induced by checkpoint inhibitors. J Thorac Oncol. 2018;13(8):1076–82.
- Lainez S, Tissot C, Cottier M, Vergnon JM. EBUS‐TBNA can distinguish sarcoid‐like side effect of Nivolumab treatment from tumor progression in non‐small cell lung cancer. Respiration. 2017;94(6):518–21.
- Laino AS, Woods D, Vassallo M, Qian X, Tang H, Wind‐Rotolo M, et al. Serum interleukin‐6 and C‐reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition. J Immunother Cancer. 2020;8(1):e000842.
- Sanmamed MF, Perez‐Gracia JL, Schalper KA, Fusco JP, Gonzalez A, Rodriguez‐Ruiz ME, et al. Changes in serum interleukin‐8 (IL‐8) levels reflect and predict response to anti‐PD‐1 treatment in melanoma and non‐small‐cell lung cancer patients. Ann Oncol. 2017;28(8):1988–95.
- Tetzlaff MT, Nelson KC, Diab A, Staerkel GA, Nagarajan P, Torres‐Cabala CA, et al. Granulomatous/sarcoid‐like lesions associated with checkpoint inhibitors: a marker of therapy response in a subset of melanoma patients. J Immunother Cancer. 2018;6(1):14.
Source: PubMed