Care plans for women pregnant using assisted reproductive technologies: a systematic review

Maria P Velez, Candyce Hamel, Brian Hutton, Laura Gaudet, Mark Walker, Micere Thuku, Kelly D Cobey, Misty Pratt, Becky Skidmore, Graeme N Smith, Maria P Velez, Candyce Hamel, Brian Hutton, Laura Gaudet, Mark Walker, Micere Thuku, Kelly D Cobey, Misty Pratt, Becky Skidmore, Graeme N Smith

Abstract

Background: Between 1 and 5% of children in industrialized countries are conceived through Assisted Reproductive Technologies (ART). As infertility and the use of ART may be associated with adverse perinatal outcomes, care plans specific to these pregnancies are needed. We conducted a systematic review to examine the existing care plans specific to women pregnant following Assisted Reproductive Technologies (ART).

Methods: MEDLINE, Embase and the Cochrane Library were searched by a senior information specialist. The population of interest included women becoming pregnant with ART (e.g., Intra-Uterine Insemination, In Vitro Fertilization (IVF), Intracytoplasmic Sperm Injection (ICSI), and surrogacy). All proposed care plans were sought that pertained to any aspect of care during pregnancy and delivery. Only Clinical Practice Guidelines (CPGs) addressing the recommendations and plans for the care of ART pregnant women were included. The search was restricted to the publication dates 2007 to June 12, 2017 when the search was run. The search was not restricted by language, however only English and French language guidelines were considered for inclusion.

Results: After screening 2078 citations, a total of ten CPGs were included. The following key clinical messages were prevalent: (1) although there was no supporting evidence, antenatal care for ART pregnancies should be provided by specialist with knowledge in obstetrics; (2) high-order multiple pregnancies are the greatest risk of ART and selective reduction options should be discussed; (3) there is some evidence of increased risk of congenital abnormalities and prenatal genetic and anatomic screening is recommended, especially in IVF-ICSI pregnancies; (4) due to a lack of or conflicting evidence, treatment of venous thromboembolism, antithrombotic therapy, treatment for hypothyroidism, and women with positive thyroid antibodies is recommended to be the same as in spontaneous pregnancies; and lastly (5) since an increased level of distress is a recognized feature in these pregnancies, psychosocial care and counselling should be considered.

Conclusions: There is a lack of CPGs specific to ART pregnancies. While we identified a small number of recommendations for ART pregnancies, specific interventions and models of care aiming at decreasing adverse maternal and perinatal outcomes following ART should be developed, implemented, and evaluated.

Keywords: Antenatal care; Assisted reproductive technologies; Clinical practice guidelines; Pregnancy; Systematic review.

Conflict of interest statement

Ethics approval and consent to participate

The present study was approved by the Queen’s University Health Sciences & Affiliated Teaching Hospitals Research Ethics Board.

Consent to participate: Not applicable.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flow diagram of study selection

References

    1. Macaluso M, Wright-Schnapp TJ, Chandra A, Johnson R, Satterwhite CL, Pulver A, et al. A public health focus on infertility prevention, detection, and management. Fertility and sterility. 2010;93(1):16. doi: 10.1016/j.fertnstert.2008.09.046.
    1. Buck, Louis GM. Fecundity and Fertility. In: Buck Louis GM, Platt RW, editors. Reproductive and perinatal epidemiology. Oxford New York: Oxford University Press; 2011.
    1. Centers for Disease Control and Prevention. National Public Health Action Plan for the Detection, Prevention, and Management of Infertility. 2014.
    1. Velez MP, Connolly MP, Kadoch IJ, Phillips S, Bissonnette F. Universal coverage of IVF pays off. Human reproduction (Oxford, England) 2014;29(6):13. doi: 10.1093/humrep/deu067.
    1. Reddy UM, Wapner RJ, Rebar RW, Tasca RJ. Infertility, assisted reproductive technology, and adverse pregnancy outcomes: executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol. 2007;109(4):967–977. doi: 10.1097/01.AOG.0000259316.04136.30.
    1. Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril. 2012;98(2):368–377. doi: 10.1016/j.fertnstert.2012.05.019.
    1. Pandey S, Shetty A, Hamilton M, Bhattacharya S, Maheshwari A. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Hum Reprod Update. 2012;18(5):485–503. doi: 10.1093/humupd/dms018.
    1. Messerlian C, Maclagan L, Basso O. Infertility and the risk of adverse pregnancy outcomes: a systematic review and meta-analysis. Human reproduction (Oxford, England) 2013;28(1):125–137. doi: 10.1093/humrep/des347.
    1. Luke B, Stern JE, Hornstein MD, Kotelchuck M, Diop H, Cabral H, et al. Is the wrong question being asked in infertility research? J Assist Reprod Genet. 2016;33(1):3–8. doi: 10.1007/s10815-015-0610-3.
    1. World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. 2016.
    1. Darwiche J, Maillard F, Germond M, Favez N, Lancastle D, de Roten Y, et al. The transition of care from fertility specialists to obstetricians: maternal adjustment and postpartum depressive symptoms. Women's health (London, England) 2013;9(1):109–118. doi: 10.2217/WHE.12.60.
    1. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–269. doi: 10.7326/0003-4819-151-4-200908180-00135.
    1. McGowan J, Sampson M, Salzwedel DM, Cogo E, Foerster V, Lefebvre C. PRESS peer review of electronic search strategies: 2015 guideline statement. J Clin Epidemiol. 2016;75:40–46. doi: 10.1016/j.jclinepi.2016.01.021.
    1. Thomson Reuters . Reference manager 12 [computer program] New York: Thomson Reuters; 2011.
    1. Evidence Partners: DistillerSR [computer program]. Ottawa: Evidence Partners. 2011.
    1. Khangura S, Konnyu K, Cushman R, Grimshaw J, Moher D. Evidence summaries: the evolution of a rapid review approach. Syst Rev. 2012;1:10. doi: 10.1186/2046-4053-1-10.
    1. Brouwers MC, Kho ME, Browman GP, Burgers JS, Cluzeau F, Feder G, et al. AGREE II: advancing guideline development, reporting and evaluation in health care. CMAJ. 2010;182(18):E839–E842. doi: 10.1503/cmaj.090449.
    1. Okun N, Sierra S. Genetics committee. Pregnancy outcomes after assisted human reproduction. J Obstet Gynaecol Can. 2014;36(1):64–83. doi: 10.1016/S1701-2163(15)30685-X.
    1. Chitayat D, Langlois S, Douglas Wilson R. SOGC Genetics committee. Prenatal screening for fetal aneuploidy in singleton pregnancies. J Obstet Gynaecol Can. 2011;33(7):736–750. doi: 10.1016/S1701-2163(16)34961-1.
    1. Thorn P, Wischmann T. German guidelines for psychosocial counselling in the area of gamete donation. Human fertility (Cambridge, England) 2009;12(2):73–80. doi: 10.1080/14647270802712728.
    1. Gameiro S, Boivin J, Dancet E, de Klerk C, Emery M, Lewis-Jones C, et al. ESHRE guideline: routine psychosocial care in infertility and medically assisted reproduction-a guide for fertility staff. Human reproduction (Oxford, England) 2015;30(11):2476–2485. doi: 10.1093/humrep/dev177.
    1. The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. Maternal suitability for models of care, and indications for referral within and between models of care. 2015.
    1. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, et al. 2017 guidelines of the American Thyroid Association for the diagnosis and Management of Thyroid Disease during Pregnancy and the postpartum. Thyroid. 2017;27(3):315–389. doi: 10.1089/thy.2016.0457.
    1. American Society for Reproductive Medicine Subclinical hypothyroidism in the infertile female population: a guideline. Fertil Steril. 2015;104(3):545–553. doi: 10.1016/j.fertnstert.2015.05.028.
    1. American College of Obstetricians and Gynecologists Committee opinion no 671: perinatal risks associated with assisted reproductive technology. Obstet Gynecol. 2016;128(3):e61–e68. doi: 10.1097/AOG.0000000000001643.
    1. Chan WS, Rey E, Kent NE, Corbett T, David M, Douglas MJ, et al. Venous thromboembolism and antithrombotic therapy in pregnancy. J Obstet Gynaecol Can. 2014;36(6):527–553. doi: 10.1016/S1701-2163(15)30569-7.
    1. Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos AM, Vandvik PO. VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e691S–e736S. doi: 10.1378/chest.11-2300.
    1. Woolf SH, Battista RN, Angerson GM, Logan AG, W. E. Canadian Task Force on Preventive Health Care New grades for recommendations from the Canadian Task Force on Preventive Helath Care. CMAJ. 2003;169:207–208.
    1. Scottish Intercollegiate Guidelines Network EH -HC, Edinburgh EH7 5EA. . (Accessed 23, Aug 2017),. 2001–2013.
    1. Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, et al. Grading quality of evidence and strength of recommendations. BMJ (Clinical research ed) 2004;328(7454):1490. doi: 10.1136/bmj.328.7454.1490.
    1. Qaseem A, Snow V, Owens DK, Shekelle P. The development of clinical practice guidelines and guidance statements of the American College of Physicians: summary of methods. Ann Intern Med. 2010;153(3):194–199. doi: 10.7326/0003-4819-153-3-201008030-00010.
    1. ESHRE Psychology and Counselling Guideline Development Group. Routine psychosocial care in infertility and medically assisted reproduction – a guide for fertility staff2015 august 11, 2017.
    1. American College of Obstetricians and Gynecologists ACOG Committee opinion no. 553: multifetal pregnancy reduction. Obstet Gynecol. 2013;121(2 Pt 1):405–410.
    1. Reefhuis J, Honein MA, Schieve LA, Correa A, Hobbs CA, Rasmussen SA. Assisted reproductive technology and major structural birth defects in the United States. Human reproduction (Oxford, England) 2009;24(2):360–366. doi: 10.1093/humrep/den387.
    1. Zhu JL, Basso O, Obel C, Bille C, Olsen J. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ (Clinical research ed) 2006;333(7570):679. doi: 10.1136/.
    1. Wald NJ, White N, Morris JK, Huttly WJ, Canick JA. Serum markers for Down's syndrome in women who have had in vitro fertilisation: implications for antenatal screening. Br J Obstet Gynaecol. 1999;106(12):1304–1306. doi: 10.1111/j.1471-0528.1999.tb08186.x.
    1. Maymon R, Shulman A. Serial first- and second-trimester Down's syndrome screening tests among IVF-versus naturally-conceived singletons. Human reproduction (Oxford, England) 2002;17(4):1081–1085. doi: 10.1093/humrep/17.4.1081.
    1. Muller F, Dreux S, Lemeur A, Sault C, Desgres J, Bernard MA, et al. Medically assisted reproduction and second-trimester maternal serum marker screening for Down syndrome. Prenat Diagn. 2003;23(13):1073–1076. doi: 10.1002/pd.756.
    1. Mara M, Koryntova D, Rezabek K, Kapral A, Drbohlav P, Jirsova S, et al. Thromboembolic complications in patients undergoing in vitro fertilization: retrospective clinical study. Ceska gynekologie. 2004;69(4):312–316.
    1. Simcox LE, Ormesher L, Tower C, Greer IA. Pulmonary thrombo-embolism in pregnancy: diagnosis and management. Breathe (Sheffield, England) 2015;11(4):282–289. doi: 10.1183/20734735.008815.
    1. Aurousseau MH, Samama MM, Belhassen A, Herve F, Hugues JN. Risk of thromboembolism in relation to an in-vitro fertilization programme: three case reports. Human reproduction (Oxford, England) 1995;10(1):94–97. doi: 10.1093/humrep/10.1.94.
    1. Siering U, Eikermann M, Hausner E, Hoffmann-Esser W, Neugebauer EA. Appraisal tools for clinical practice guidelines: a systematic review. PLoS One. 2013;8(12):e82915. doi: 10.1371/journal.pone.0082915.
    1. Bonduelle M, Van Assche E, Joris H, Keymolen K, Devroey P, Van Steirteghem A, et al. Prenatal testing in ICSI pregnancies: incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parameters. Human reproduction (Oxford, England) 2002;17(10):2600–2614. doi: 10.1093/humrep/17.10.2600.
    1. Janvier A, Spelke B, Barrington KJ. The epidemic of multiple gestations and neonatal intensive care unit use: the cost of irresponsibility. J Pediatr. 2011;159(3):409–413. doi: 10.1016/j.jpeds.2011.02.017.
    1. Elster N. Less is more: the risks of multiple births. The Institute for Science, law, and technology working group on reproductive technology. Fertil Steril. 2000;74(4):617–623. doi: 10.1016/S0015-0282(00)00713-5.
    1. Evans MI, Berkowitz RL, Wapner RJ, Carpenter RJ, Goldberg JD, Ayoub MA, et al. Improvement in outcomes of multifetal pregnancy reduction with increased experience. Am J Obstet Gynecol. 2001;184(2):97–103. doi: 10.1067/mob.2001.108074.
    1. Calhoun KC, Barnhart KT, Elovitz MA, Srinivas SK. Evaluating the association between assisted conception and the severity of preeclampsia. ISRN obstetrics and gynecology. 2011;2011:928592. doi: 10.5402/2011/928592.
    1. Healy DL, Breheny S, Halliday J, Jaques A, Rushford D, Garrett C, et al. Prevalence and risk factors for obstetric haemorrhage in 6730 singleton births after assisted reproductive technology in Victoria Australia. Human reproduction (Oxford, England) 2010;25(1):265–274. doi: 10.1093/humrep/dep376.
    1. Welmerink DB, Voigt LF, Daling JR, Mueller BA. Infertility treatment use in relation to selected adverse birth outcomes. Fertil Steril. 2010;94(7):2580–2586. doi: 10.1016/j.fertnstert.2010.03.005.
    1. Smith GN, Walker M, Tessier JL, Millar KG. Increased incidence of preeclampsia in women conceiving by intrauterine insemination with donor versus partner sperm for treatment of primary infertility. Am J Obstet Gynecol. 1997;177(2):455–458. doi: 10.1016/S0002-9378(97)70215-1.
    1. Wiggins DA, Main E. Outcomes of pregnancies achieved by donor egg in vitro fertilization--a comparison with standard in vitro fertilization pregnancies. Am J Obstet Gynecol. 2005;192(6):2002–2006. doi: 10.1016/j.ajog.2005.02.059.
    1. Klatsky PC, Delaney SS, Caughey AB, Tran ND, Schattman GL, Rosenwaks Z. The role of embryonic origin in preeclampsia: a comparison of autologous in vitro fertilization and ovum donor pregnancies. Obstet Gynecol. 2010;116(6):1387–1392. doi: 10.1097/AOG.0b013e3181fb8e59.
    1. Wilson RD, Genetics C, Wilson RD, Audibert F, Brock JA, Carroll J, et al. Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies. J Obstet Gynaecol Can. 2015;37(6):534–552. doi: 10.1016/S1701-2163(15)30230-9.
    1. LeFevre ML. Force USPST. Low-dose aspirin use for the prevention of morbidity and mortality from preeclampsia: U.S. preventive services task force recommendation statement. Ann Intern Med. 2014;161(11):819–826. doi: 10.7326/M14-1884.

Source: PubMed

Patrocinadores e Colaboradores

Condições médicas

Intervenções de drogas

3
Se inscrever