Spasticity and its contribution to hypertonia in cerebral palsy

Lynn Bar-On, Guy Molenaers, Erwin Aertbeliën, Anja Van Campenhout, Hilde Feys, Bart Nuttin, Kaat Desloovere, Lynn Bar-On, Guy Molenaers, Erwin Aertbeliën, Anja Van Campenhout, Hilde Feys, Bart Nuttin, Kaat Desloovere

Abstract

Spasticity is considered an important neural contributor to muscle hypertonia in children with cerebral palsy (CP). It is most often treated with antispasticity medication, such as Botulinum Toxin-A. However, treatment response is highly variable. Part of this variability may be due to the inability of clinical tests to differentiate between the neural (e.g., spasticity) and nonneural (e.g., soft tissue properties) contributions to hypertonia, leading to the terms "spasticity" and "hypertonia" often being used interchangeably. Recent advancements in instrumented spasticity assessments offer objective measurement methods for distinction and quantification of hypertonia components. These methods can be applied in clinical settings and their results used to fine-tune and improve treatment. We reviewed current advancements and new insights with respect to quantifying spasticity and its contribution to muscle hypertonia in children with CP. First, we revisit what is known about spasticity in children with CP, including the various definitions and its pathophysiology. Second, we summarize the state of the art on instrumented spasticity assessment in CP and review the parameters developed to quantify the neural and nonneural components of hypertonia. Lastly, the impact these quantitative parameters have on clinical decision-making is considered and recommendations for future clinical and research investigations are discussed.

Figures

Figure 1
Figure 1
Neural and nonneural mechanisms contributing to increased resistance to passive motion in an upper motor neuron syndrome.
Figure 2
Figure 2
The major excitatory (red lines), inhibitory (blue lines), and processing (black lines) pathways involved in the reflex regulation contributing to normal trunk and limb muscle tone. Pathways numbered (1) and (2) travel first through interneurons before synapsing with alpha- (α-) motor neurons. GTO: Golgi tendon organ. *Some extrapyramidal tracts (not shown in this figure) also contribute to the maintenance of normal muscle tone and not all pathways shown are necessarily involved in increased stretch reflex due to spasticity.

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