Treating Clostridium difficile infection with fecal microbiota transplantation
Johan S Bakken, Thomas Borody, Lawrence J Brandt, Joel V Brill, Daniel C Demarco, Marc Alaric Franzos, Colleen Kelly, Alexander Khoruts, Thomas Louie, Lawrence P Martinelli, Thomas A Moore, George Russell, Christina Surawicz, Fecal Microbiota Transplantation Workgroup, Johan S Bakken, Thomas Borody, Lawrence J Brandt, Joel V Brill, Daniel C Demarco, Marc Alaric Franzos, Colleen Kelly, Alexander Khoruts, Thomas Louie, Lawrence P Martinelli, Thomas A Moore, George Russell, Christina Surawicz, Fecal Microbiota Transplantation Workgroup
Abstract
Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.
Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
Source: PubMed