Glycemic control in youth with diabetes: the SEARCH for diabetes in Youth Study
Diana B Petitti, Georgeanna J Klingensmith, Ronny A Bell, Jeanette S Andrews, Dana Dabelea, Giuseppina Imperatore, Santica Marcovina, Catherine Pihoker, Debra Standiford, Beth Waitzfelder, Elizabeth Mayer-Davis, SEARCH for Diabetes in Youth Study Group, Jean M Lawrence, Ann K Kershnar, Kristi Reynolds, Marlene Y Gonzalez, David J Pettitt, Diana B Petitti, Dana Dabelea, Richard F Hamman, Lisa Testaverde, Georgeanna J Klingensmith, Marian J Rewers, Stephen Daniels, Clifford A Bloch, Jonathan Krakoff, Peter H Bennett, Joquetta A DeGroat, Teresa Coons, Beatriz L Rodriguez, Beth Waitzfelder, Wilfred Fujimoto, J David Curb, Fiona Kennedy, Greg Uramoto, Sorrell Waxman, Teresa Hillier, Richard Chung, Lawrence M Dolan, Michael Seid, Nancy Crimmins, Debra A Standiford, Elizabeth J Mayer-Davis, Joan Thomas, Angela D Liese, Robert McKeown, Robert R Moran, Deborah Truell, Gladys Gaillard-McBride, Deborah Lawler, Malaka Jackson, Lynne Hartel, Yaw Appiagyei-Dankah, Lyndon Key, Sheree Mejia, James Amrhein, Kent Reifschneider, Pam Clark, Mark Parker, I David Schwartz, Catherine Pihoker, Lisa Gilliam, Irl Hirsch, Lenna L Liu, Carolyn Paris, Dimitri Christakis, Beth Loots, Joyce Yi, Stacey Bryant, Michelle Sadler-Greever, Rebecca O'Connor, Ellen Braun-Kelly, Amber Sexton, Corinne Shubin, Carla Greenbaum, Giuseppina Imperatore, Desmond E Williams, Michael M Engelgau, Henry S Kahn, K M Venkat Narayan, Bernice Moore, Barbara Linder, Santica M Marcovina, Vinod P Gaur, Kathy Gadbois, Ronny Bell, Ralph D'Agostino Jr, Douglas Case, Timothy Morgan, Michelle J Naughton, Susan Vestal, Gena Hargis, Andrea Anderson, Cralen Davis, Jeanette Andrews, Jennifer Beyer, Diana B Petitti, Georgeanna J Klingensmith, Ronny A Bell, Jeanette S Andrews, Dana Dabelea, Giuseppina Imperatore, Santica Marcovina, Catherine Pihoker, Debra Standiford, Beth Waitzfelder, Elizabeth Mayer-Davis, SEARCH for Diabetes in Youth Study Group, Jean M Lawrence, Ann K Kershnar, Kristi Reynolds, Marlene Y Gonzalez, David J Pettitt, Diana B Petitti, Dana Dabelea, Richard F Hamman, Lisa Testaverde, Georgeanna J Klingensmith, Marian J Rewers, Stephen Daniels, Clifford A Bloch, Jonathan Krakoff, Peter H Bennett, Joquetta A DeGroat, Teresa Coons, Beatriz L Rodriguez, Beth Waitzfelder, Wilfred Fujimoto, J David Curb, Fiona Kennedy, Greg Uramoto, Sorrell Waxman, Teresa Hillier, Richard Chung, Lawrence M Dolan, Michael Seid, Nancy Crimmins, Debra A Standiford, Elizabeth J Mayer-Davis, Joan Thomas, Angela D Liese, Robert McKeown, Robert R Moran, Deborah Truell, Gladys Gaillard-McBride, Deborah Lawler, Malaka Jackson, Lynne Hartel, Yaw Appiagyei-Dankah, Lyndon Key, Sheree Mejia, James Amrhein, Kent Reifschneider, Pam Clark, Mark Parker, I David Schwartz, Catherine Pihoker, Lisa Gilliam, Irl Hirsch, Lenna L Liu, Carolyn Paris, Dimitri Christakis, Beth Loots, Joyce Yi, Stacey Bryant, Michelle Sadler-Greever, Rebecca O'Connor, Ellen Braun-Kelly, Amber Sexton, Corinne Shubin, Carla Greenbaum, Giuseppina Imperatore, Desmond E Williams, Michael M Engelgau, Henry S Kahn, K M Venkat Narayan, Bernice Moore, Barbara Linder, Santica M Marcovina, Vinod P Gaur, Kathy Gadbois, Ronny Bell, Ralph D'Agostino Jr, Douglas Case, Timothy Morgan, Michelle J Naughton, Susan Vestal, Gena Hargis, Andrea Anderson, Cralen Davis, Jeanette Andrews, Jennifer Beyer
Abstract
Objective: To assess correlates of glycemic control in a diverse population of children and youth with diabetes.
Study design: This was a cross-sectional analysis of data from a 6-center US study of diabetes in youth, including 3947 individuals with type 1 diabetes (T1D) and 552 with type 2 diabetes (T2D), using hemoglobin A(1c) (HbA(1c)) levels to assess glycemic control.
Results: HbA(1c) levels reflecting poor glycemic control (HbA(1c) >or= 9.5%) were found in 17% of youth with T1D and in 27% of those with T2D. African-American, American Indian, Hispanic, and Asian/Pacific Islander youth with T1D were significantly more likely to have higher HbA(1c) levels compared with non-Hispanic white youth (with respective rates for poor glycemic control of 36%, 52%, 27%, and 26% vs 12%). Similarly poor control in these 4 racial/ethnic groups was found in youth with T2D. Longer duration of diabetes was significantly associated with poorer glycemic control in youth with T1D and T2D.
Conclusions: The high percentage of US youth with HbA(1c) levels above the target value and with poor glycemic control indicates an urgent need for effective treatment strategies to improve metabolic status in youth with diabetes.
Source: PubMed