Prognostic utility of vitamin D in acute coronary syndrome patients in coastal Norway

Patrycja A Naesgaard, Volker Pönitz, Hildegunn Aarsetoey, Trygve Brügger-Andersen, Heidi Grundt, William S Harris, Harry Staines, Dennis W T Nilsen, Patrycja A Naesgaard, Volker Pönitz, Hildegunn Aarsetoey, Trygve Brügger-Andersen, Heidi Grundt, William S Harris, Harry Staines, Dennis W T Nilsen

Abstract

Background: An inverse relationship between cardiovascular risk and levels of vitamin D and omega-3 index may exist.

Objectives: To evaluate the prognostic utility of serum 25-hydroxyvitamin D [25(OH)D] in 871 patients with suspected acute coronary syndrome (ACS) and to assess the seasonal correlation between 25(OH)D and the omega-3 index in 456 ACS patients from southwestern Norway.

Results: In the univariate analysis the hazard ratio (HR) at 2-year follow-up for all-cause mortality in the highest as compared to the lowest quartile of 25(OH)D in the total population was 0.61 (95% confidence interval (CI), 0.37-1.00), P = 0.050. At 7-year follow-up, the corresponding HR for all-cause mortality was 0.66 (95% CI, 0.49-0.90), P = 0.008, and for females alone 0.51 (95% CI, 0.32-0.83), P = 0.006. Quartile survival did not differ in the multivariable analysis, whereas 25(OH)D < 40 nM (<16 ng/mL) was found to be independently related to mortality. Seasonal differences in 25(OH)D, but not for the omega-3 index, were noted, and the two biomarkers were positively correlated, especially during winter-spring; Pearson's correlation coefficient was 0.358, P < 0.001.

Conclusion: Vitamin D levels are related to survival, especially in females, and correlate with the omega-3 index.

Figures

Figure 1
Figure 1
Kaplan-Meier plots for seven-year total mortality of 25(OH)D quartiles in the total patient population.
Figure 2
Figure 2
Kaplan-Meier plots for seven-year total mortality of 25(OH)D quartiles in the TnT positive patient population.
Figure 3
Figure 3
Kaplan-Meier plots for seven-year total mortality of 25(OH)D quartiles in females.

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Source: PubMed

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