Mechanism of action of acetyl kidamycin. II. Inhibition of RNA synthesis in HeLa cells
M Okamoto, H Takeshima, K Komiyama, I Umezawa, M Okamoto, H Takeshima, K Komiyama, I Umezawa
Abstract
The effects of acetyl kidamycin on RNA synthesis in HeLa cells were investigated. Acetyl kidamycin inhibited the synthesis of 45S pre-rRNA, heterogeneous nuclear RNA (HnRNA) and small molecular weight RNAs, though not to the same degree. The processing of 45S pre-rRNA into 18S and 28S rRNA and that of HnRNA into mRNA were not affected.
Source: PubMed