The Case for Standardizing Cesarean Delivery Technique: Seeing the Forest for the Trees

Joshua D Dahlke, Hector Mendez-Figueroa, Lindsay Maggio, Jeffrey D Sperling, Suneet P Chauhan, Dwight J Rouse, Joshua D Dahlke, Hector Mendez-Figueroa, Lindsay Maggio, Jeffrey D Sperling, Suneet P Chauhan, Dwight J Rouse

Abstract

In this Commentary, we explain the case for a standardized cesarean delivery surgical technique. There are three strong arguments for a standardized approach to cesarean delivery, the most common major abdominal surgery performed in the world. First, standardization within institutions improves safety, efficiency, and effectiveness in health care delivery. Second, surgical training among obstetrics and gynecology residents would become more consistent across hospitals and regions, and proficiency in performing cesarean delivery measurable. Finally, standardization would strengthen future trials of cesarean delivery technique by minimizing the potential for aspects of the surgery which are not being studied to bias results. Before 2013, more than 155 randomized controlled trials, meta-analyses or systematic reviews were published comparing various aspects of cesarean delivery surgical technique. Since 2013, an additional 216 similar studies have strengthened those recommendations and offered evidence to recommend additional cesarean delivery techniques. However, this amount of cesarean delivery technique data creates a forest for the trees problem, making it difficult for a clinician to synthesize this volume of data. In response to this difficulty, we propose a comprehensive, evidence-based and standardized approach to cesarean delivery technique.

Figures

Fig. 1.. Template checklist for standardized cesarean…
Fig. 1.. Template checklist for standardized cesarean delivery technique. IV, intravenous; IU, international units.
Dahlke. Standardizing Cesarean Delivery Technique. Obstet Gynecol 2020.

References

    1. Boerma T, Ronsmans C, Melesse DY, Barros AJD, Barros FC, Juan L, et al. Global epidemiology of use of and disparities in caesarean sections. Lancet 2018;392:1341–8.
    1. Hamilton BE, Martin JA, Osterman MJK. Births: provisional data for 2019. Vital Statistics Rapid Release; no 8. Available at: . Retrieved May 21, 2020.
    1. Berghella V, Baxter JK, Chauhan SP. Evidence-based surgery for cesarean delivery. Am J Obstet Gynecol 2005;193:1607–17.
    1. Dahlke JD, Mendez-Figueroa H, Rouse DJ, Berghella V, Baxter JK, Chauhan SP. Evidence-based surgery for cesarean delivery: an updated systematic review. Am J Obstet Gynecol 2013;209:294–306.
    1. Clinical guidelines and standardization of practice to improve outcomes. ACOG Committee Opinion No. 792. American College of Obstetricians and Gynecologists. Obstet Gynecol 2019;134:e122–5.
    1. Gawande A. Two hundred years of surgery. N Engl J Med 2012;366:1716–23.
    1. Gawande A. Complications: a surgeon's notes on an imperfect science. New York, NY: Picador, 2002.
    1. Malik A, Bell CM, Stukel TA, Urbach DR. Recurrence of inguinal hernias repaired in a large hernia surgical specialty hospital and general hospitals in Ontario, Canada. Can J Surg 2016;59:19–25.
    1. Temming LA, Raghuraman N, Carter EB, Stout MJ, Rampersad RM, Macones GA, et al. Impact of evidence-based interventions on wound complications after cesarean delivery. Am J Obstet Gynecol 2017;217:449.e1–9.
    1. Kawakita T, Iqbal SN, Landy HJ, Huang JC, Fries M. Reducing cesarean delivery surgical site infections: a resident-driven quality initiative. Obstet Gynecol 2019;133:282–8.
    1. Martin EK, Beckmann MM, Barnsbee LN, Halton KA, Merollini K, Graves N. Best practice perioperative strategies and surgical techniques for preventing caesarean section surgical site infections: a systematic review of reviews and meta-analyses. BJOG 2018;125:956–64.
    1. Carter EB, Temming LA, Fowler S, Eppes C, Gross G, Srinivas SK, et al. Evidence-based bundles and cesarean delivery surgical site infections: a systematic review and meta-analysis. Obstet Gynecol 2017;130:735–46.
    1. CORONIS Collaborative Group, Abalos E, Addo V, Brocklehurst P, El Sheikh M, Farrell B, et al. Caesarean section surgical techniques (CORONIS): a fractional, factorial, unmasked, randomised controlled trial. Lancet 2013;382:234–48.
    1. CORONIS Collaborative Group, Abalos E, Oyarzun E, Addo V, Sharma JB, Matthews J, et al. CORONIS—international study of caesarean section surgical techniques: the follow-up study. BMC Pregnancy Childbirth 2013;13:215.
    1. CORONIS Collaborative Group, Abalos E, Addo V, Brocklehurst P, El Sheikh M, Farrell B, et al. Caesarean section surgical techniques: 3 year follow-up of the CORONIS fractional, factorial, unmasked, randomised controlled trial. Lancet 2016;388:62–72.
    1. Caughey AB, Wood SL, Macones GA, Wrench IJ, Huang J, Norman M, et al. Guidelines for intraoperative care in cesarean delivery: enhanced recovery after surgery society recommendations (part 2). Am J Obstet Gynecol 2018;219:533–44.
    1. Pallister M, Ballas J, Kohn J, Eppes CS, Belfort M, Davidson C. A standardized approach to cesarean surgical technique and its effect on operative time and surgical morbidity. Am J Perinatol 2019;36:277–84.
    1. Gupta DM, Boland RJ, Jr, Aron DC. The physician's experience of changing clinical practice: a struggle to unlearn. Implement Sci 2017;12:28.
    1. Nilsen P, Roback K, Broström A, Ellström PE. Creatures of habit: accounting for the role of habit in implementation research on clinical behaviour change. Implement Sci 2012;7:53.
    1. AbdElaal NK, Ellakwa HE, Elhalaby AF, Shaheen AE, Aish AH. Scalpel versus diathermy skin incision in caesarean section. J Obstet Gynaecol 2019;39:340–4.
    1. Saha SP, Bhattarcharjee N, Das Mahanta S, Naskar A, Bhattacharyya SK. A randomized comparative study on modified Joel-Cohen incision versus Pfannenstiel incision for cesarean section. J Turk Ger Gynecol Assoc 2013;14:28–34.
    1. Ghahiry A, Rezaei F, Karimi Khouzani R, Ashrafinia M. Comparative analysis of long-term outcomes of Misgav Ladach technique cesarean section and traditional cesarean section. J Obstet Gynaecol Res 2012;38:1235–9.
    1. Şahin N, Genc M, Turan GA, Kasap E, Güçlü S. A comparison of 2 cesarean section methods, modified Misgav-Ladach and Pfannenstiel-Kerr: a randomized controlled study. Adv Clin Exp Med 2018;27:357–61.
    1. Aabakke AJ, Hare KJ, Krebs L, Secher NJ. Sharp compared with blunt fascial incision at cesarean delivery: a randomized controlled trial with each case as her own control. Eur J Obstet Gynecol Reprod Biol 2014;172:40–5.
    1. Ezechi O, Ezeobi P, Gab-Okafor C, Edet A, Nwokoro C, Akinlade A. Maternal and fetal effect of Misgav Ladach cesarean section in Nigerian women: a randomized control study. Ann Med Health Sci Res 2013;3:577–82.
    1. Mathai M, Hofmeyr GJ, Mathai NE. Abdominal surgical incisions for caesarean section. The Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD004453. doi: 10.1002/14651858.CD004453.pub3.
    1. Elbohoty AE, Gomaa MF, Abdelaleim M, Abd-El-Gawad M, Elmarakby M. Diathermy versus scalpel in transverse abdominal incision in women undergoing repeated cesarean section: a randomized controlled trial. J Obstet Gynaecol Res 2015;41:1541–6.
    1. O'Boyle AL, Mulla BM, Lamb SV, Greer JA, Shippey SH, Rollene NL. Urinary symptoms after bladder flap at the time of primary cesarean delivery: a randomized controlled trial (RTC). Int Urogynecol J 2018;29:223–8.
    1. Aslan Cetin B, Aydogan Mathyk B, Barut S, Zindar Y, Seckin KD, Kadirogullari P. Omission of a bladder flap during cesarean birth in primiparous women. Gynecol Obstet Invest 2018;83:564–8.
    1. O'Neill HA, Egan G, Walsh CA, Cotter AM, Walsh SR. Omission of the bladder flap at caesarean section reduces delivery time without increased morbidity: a meta-analysis of randomised controlled trials. Eur J Obstet Gynecol Reprod Biol 2014;174:20–6.
    1. Asicioglu O, Gungorduk K, Asicioglu BB, Yildirim G, Gungorduk OC, Ark C. Unintended extension of the lower segment uterine incision at cesarean delivery: a randomized comparison of sharp versus blunt techniques. Am J Perinatol 2014;31:837–44.
    1. Ozcan P, Ates S, Guner Can M, Sarioglu Yardimci A, Batmaz G, Kilic G. Is cephalad-caudad blunt expansion of the low transverse uterine incision really associated with less uncontrolled extensions to decrease intra-operative blood loss? A prospective randomised-controlled trial. J Matern Fetal Neonatal Med 2016;29:1952–6.
    1. Xu LL, Chau AM, Zuschmann A. Blunt vs. sharp uterine expansion at lower segment cesarean section delivery: a systematic review with metaanalysis. Am J Obstet Gynecol 2013;208:62.e1–8.
    1. Saad AF, Rahman M, Costantine MM, Saade GR. Blunt versus sharp uterine incision expansion during low transverse cesarean delivery: a metaanalysis. Am J Obstet Gynecol 2014;211:684.e1–11.
    1. Xodo S, Saccone G, Cromi A, Ozcan P, Spagnolo E, Berghella V. Cephalad-caudad versus transverse blunt expansion of the low transverse uterine incision during cesarean delivery. Eur J Obstet Gynecol Reprod Biol 2016;202:75–80.
    1. Dodd JM, Anderson ER, Gates S, Grivell RM. Surgical techniques for uterine incision and uterine closure at the time of caesarean section. The Cochrane Database of Systematic Reviews 2014, Issue 7. Art. No. CD004732. doi: 10.1002/14651858.CD004732.pub3.
    1. Kamel A, El-Mazny A, Salah E, Ramadan W, Hussein AM, Hany A. Manual removal versus spontaneous delivery of the placenta at cesarean section in developing countries: a randomized controlled trial and review of literature. J Matern Fetal Neonatal Med 2018;31:3308–13.
    1. Altraigey A, Ellaithy M, Atia H, Ali I, Kolkailah M, Abbas A. How can methods of placental delivery in cesarean section affect perioperative blood loss? A randomized controlled trial of controlled cord traction versus manual removal of placenta. J Obstet Gynaecol Res 2019;45:133–40.
    1. Gün I, Ozdamar O, Ertuğrul S, Oner O, Atay V. The effect of placental removal method on perioperative hemorrhage at cesarean delivery; a randomized clinical trial. Arch Gynecol Obstet 2013;288:563–7.
    1. Kaya B, Guralp O, Daglar K, Tuten A, Demirol A, Yayci E, et al. Extra-abdominal removal of placenta during cesarean section: a prospective randomized controlled trial of a novel technique. J Perinat Med 2016;44:557–65.
    1. Eke AC, Drnec S, Buras A, Woo J, Martin D, Roth S. Intrauterine cleaning after placental delivery at cesarean section: a randomized controlled trial. J Matern Fetal Neonatal Med 2019;32:236–42.
    1. Alalfy M, Yehia A, Samy A. Routine cervical dilatation at caesarean section and its influence on postoperative pain and complications in obese women: a double blind randomized controlled trial. J Matern Fetal Neonatal Med 2019 Aug 11. [Epub ahead of print].
    1. Dawood AS, Elgergawy A, Elhalwagy A, Ataallah WM, Elbohoty SB, Elshwaikh SL, et al. The impact of mechanical cervical dilatation during elective cesarean section on postpartum scar integrity: a randomized double-blind clinical trial. Int J Womens Health 2019;11:23–9.
    1. El-Sharkawy M, Samy A, Latif D, Mahmoud M, Samir D, Abbas AM. The effect of mechanical cervical dilatation during scheduled cesarean section on the blood loss: a randomized controlled trial. J Matern Fetal Neonatal Med 2018;33:2043–8.
    1. Liabsuetrakul T, Peeyananjarassri K. Mechanical dilatation of the cervix during elective caeserean section before the onset of labour for reducing postoperative morbidity. The Cochrane Database of Systematic Reviews 2018, Issue 8. Art. No.: CD008019. doi: 10.1002/14651858.CD008019.pub3.
    1. Kirscht J, Weiss C, Nickol J, Berlit S, Tuschy B, Hoch B, et al. Dilatation or no dilatation of the cervix during cesarean section (Dondi Trial): a randomized controlled trial. Arch Gynecol Obstet 2017;295:39–43.
    1. El-Khayat W, Elsharkawi M, Hassan A. A randomized controlled trial of uterine exteriorization versus in situ repair of the uterine incision during cesarean delivery. Int J Gynaecol Obstet 2014;127:163–6.
    1. Zaphiratos V, George RB, Boyd JC, Habib AS. Uterine exteriorization compared with in situ repair for cesarean delivery: a systematic review and meta-analysis. Can J Anaesth 2015;62:1209–20.
    1. Abdellah MS, Abbas AM, Ali MK, Mahmoud A, Abdullah SA. Uterine exteriorization versus intraperitoneal repair: effect on intraoperative nausea and vomiting during repeat cesarean delivery—a randomized clinical trial. Facts Views Vis Obgyn 2018;10:131–7.
    1. Kalem Z, Kaya AE, Bakirarar B, Basbug A, Kalem MN. An optimal uterine closure technique for better scar healing and avoiding isthmocele in cesarean section: a randomized controlled study. J Invest Surg 2019 May 9. [Epub ahead of print].
    1. Başbuğ A, Doğan O, Ellibeş Kaya A, Pulatoğlu Ç, Çağlar M. Does suture material affect uterine scar healing after cesarean section? Results from a randomized controlled trial. J Invest Surg 2019;32:763–9.
    1. Sevket O, Ates S, Molla T, Ozkal F, Uysal O, Dansuk R. Hydrosonographic assessment of the effects of 2 different suturing techniques on healing of the uterine scar after cesarean delivery. Int J Gynaecol Obstet 2014;125:219–22.
    1. Bamberg C, Hinkson L, Dudenhausen JW, Bujak V, Kalache KD, Henrich W. Longitudinal transvaginal ultrasound evaluation of cesarean scar niche incidence and depth in the first two years after single- or double-layer uterotomy closure: a randomized controlled trial. Acta Obstet Gynecol Scand 2017;96:1484–9.
    1. Turan C, Büyükbayrak EE, Yilmaz AO, Karsidag YK, Pirimoglu M. Purse-string double-layer closure: a novel technique for repairing the uterine incision during cesarean section. J Obstet Gynaecol Res 2015;41:565–74.
    1. Köstü B, Ercan Ö, Özer A, Bakacak M, Özdemir Ö, Avci F. A comparison of two techniques of uterine closure in caesarean section. J Matern Fetal Neonatal Med 2016;29:1573–6.
    1. Roberge S, Demers S, Girard M, Vikhareva O, Markey S, Chaillet N, et al. Impact of uterine closure on residual myometrial thickness after cesarean: a randomized controlled trial. Am J Obstet Gynecol 2016;214:507.e1–6.
    1. Bennich G, Rudnicki M, Wilken-Jensen C, Lousen T, Lassen PD, Wøjdemann K. Impact of adding a second layer to a single unlocked closure of a Cesarean uterine incision: randomized controlled trial. Ultrasound Obstet Gynecol 2016;47:417–22.
    1. Bamberg C, Dudenhausen JW, Bujak V, Rodekamp E, Brauer M, Hinkson L, et al. A prospective randomized clinical trial of single vs. Double layer closure of hysterotomy at the time of cesarean delivery: the effect on uterine scar thickness. Ultraschall Med 2018;39:343–51.
    1. Stegwee SI, Jordans I, van der Voet LF, van de Ven PM, Ket J, Lambalk CB, et al. Uterine caesarean closure techniques affect ultrasound findings and maternal outcomes: a systematic review and meta-analysis. BJOG 2018;125:1097–108.
    1. Di Spiezio Sardo A, Saccone G, McCurdy R, Bujold E, Bifulco G, Berghella V. Risk of Cesarean scar defect following single- vs double-layer uterine closure: systematic review and meta-analysis of randomized controlled trials. Ultrasound Obstet Gynecol 2017;50:578–83.
    1. Roberge S, Demers S, Berghella V, Chaillet N, Moore L, Bujold E. Impact of single- vs double-layer closure on adverse outcomes and uterine scar defect: a systematic review and metaanalysis. Am J Obstet Gynecol 2014;211:453–60.
    1. Peleg D, Ahmad RS, Warsof SL, Marcus-Braun N, Sciaky-Tamir Y, Ben Shachar I. A randomized clinical trial of knotless barbed suture vs conventional suture for closure of the uterine incision at cesarean delivery. Am J Obstet Gynecol 2018;218:343.e1–7.
    1. Zayed MA, Fouda UM, Elsetohy KA, Zayed SM, Hashem AT, Youssef MA. Barbed sutures versus conventional sutures for uterine closure at cesarean section; a randomized controlled trial. J Matern Fetal Neonatal Med 2019;32:710–7.
    1. Temizkan O, Asicioglu O, Güngördük K, Asicioglu B, Yalcin P, Ayhan I. The effect of peritoneal cavity saline irrigation at cesarean delivery on maternal morbidity and gastrointestinal system outcomes. J Matern Fetal Neonatal Med 2016;29:651–5.
    1. Eke AC, Shukr GH, Chaalan TT, Nashif SK, Eleje GU. Intra-abdominal saline irrigation at cesarean section: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 2016;29:1588–94.
    1. Bamigboye AA, Hofmeyr GJ. Closure versus non-closure of the peritoneum at caesarean section: short- and long-term outcomes. The Cochrane Database of Systematic Reviews 2014, Issue 8. Art. No.: CD000163. doi: 10.1002/14651858.CD000163.pub2.
    1. Kurek Eken M, Özkaya E, Tarhan T, İçöz Ş, Eroğlu Ş, Kahraman ŞT, et al. Effects of closure versus non-closure of the visceral and parietal peritoneum at cesarean section: does it have any effect on postoperative vital signs? A prospective randomized study. J Matern Fetal Neonatal Med 2017;30:922–6.
    1. Omran EF, Meshaal H, Hassan SM, Dieb AS, Nabil H, Saad H. The effect of rectus muscle re-approximation at cesarean delivery on pain perceived after operation: a randomized control trial. J Matern Fetal Neonatal Med 2019;32:3238–43.
    1. Scrafford JD, Reddy B, Rivard C, Vogel RI. Effect of intra-operative glove changing during cesarean section on post-operative complications: a randomized controlled trial. Arch Gynecol Obstet 2018;297:1449–54.
    1. Cernadas M, Smulian JC, Giannina G, Ananth CV. Effects of placental delivery method and intraoperative glove changing on postcesarean febrile morbidity. J Matern Fetal Med 1998;7:100–4.
    1. Turrentine MA, Banks TA. Effect of changing gloves before placental extraction on incidence of postcesarean endometritis. Infect Dis Obstet Gynecol 1996;4:16–9.
    1. Atkinson MW, Owen J, Wren A, Hauth JC. The effect of manual removal of the placenta on post-cesarean endometritis. Obstet Gynecol 1996;87:99–102.
    1. Rezaie Kahkhaie K, Rezaie Keikhaie K, Shahreki Vahed A, Shirazi M, Amjadi N. Randomized comparison of nylon versus absorbing polyglactin 910 for fascial closure in caesarean section. Iran Red Crescent Med J 2014;16:e12580.
    1. Aslan Çetin B, Aydogan Mathyk B, Barut S, Koroglu N, Zindar Y, Konal M, et al. The impact of subcutaneous irrigation on wound complications after cesarean sections: a prospective randomised study. Eur J Obstet Gynecol Reprod Biol 2018;227:67–70.
    1. Corbacioglu Esmer A, Goksedef PC, Akca A, Akbayir O, Dagdeviren H, Turan GY, et al. Role of subcutaneous closure in preventing wound complications after cesarean delivery with Pfannenstiel incision: a randomized clinical trial. J Obstet Gynaecol Res 2014;40:728–35.
    1. Alalfy M, Elgazzar A, Fares T, Nagy O, Ellithy A, Lasheen Y, et al. Effect of subcutaneous tissue closure technique in cesarean section on postoperative wound complications in obese Egyptian women. J Matern Fetal Neonatal Med 2019;32:2452–9.
    1. Pergialiotis V, Prodromidou A, Perrea DN, Doumouchtsis SK. The impact of subcutaneous tissue suturing at caesarean section on wound complications: a meta-analysis. BJOG 2017;124:1018–25.
    1. Miremberg H, Barber E, Tamayev L, Ganer Herman H, Bar J, Kovo M. When is the right time to remove staples after an elective cesarean delivery? A randomized control trial. J Matern Fetal Neonatal Med 2019 Mar 21. [Epub ahead of print].
    1. Madsen AM, Dow ML, Lohse CM, Tessmer-Tuck JA. Absorbable subcuticular staples versus suture for caesarean section closure: a randomised clinical trial. BJOG 2019;126:502–10.
    1. Maged AM, Mohesen MN, Elhalwagy A, Abdelaal H, Almohamady M, Abdellatif AA, et al. Subcuticular interrupted versus continuous skin suturing in elective cesarean section in obese women: a randomized controlled trial. J Matern Fetal Neonatal Med 2018;32:4114–9.
    1. Fleisher J, Khalifeh A, Pettker C, Berghella V, Dabbish N, Mackeen AD. Patient satisfaction and cosmetic outcome in a randomized study of cesarean skin closure. J Matern Fetal Neonatal Med 2019;32:3830–5.
    1. Figueroa D, Jauk VC, Szychowski JM, Garner R, Biggio JR, Andrews WW, et al. Surgical staples compared with subcuticular suture for skin closure after cesarean delivery: a randomized controlled trial [published erratum appears in Obstet Gynecol 2013;121:113]. Obstet Gynecol 2013;121:33–8.
    1. Huppelschoten AG, van Ginderen JC, van den Broek KC, Bouwma AE, Oosterbaan HP. Different ways of subcutaneous tissue and skin closure at cesarean section: a randomized clinical trial on the long-term cosmetic outcome. Acta Obstet Gynecol Scand 2013;92:916–24.
    1. Nuthalapaty FS, Lee CM, Lee JH, Kuper SG, Higdon HL., III A randomized controlled trial of early versus delayed skin staple removal following caesarean section in the obese patient. J Obstet Gynaecol Can 2013;35:426–33.
    1. Aabakke AJ, Krebs L, Pipper CB, Secher NJ. Subcuticular suture compared with staples for skin closure after cesarean delivery: a randomized controlled trial. Obstet Gynecol 2013;122:878–84.
    1. Feese CA, Johnson S, Jones E, Lambers DS. A randomized trial comparing metallic and absorbable staples for closure of a Pfannenstiel incision for cesarean delivery. Am J Obstet Gynecol 2013;209:556.e1–5.
    1. Ibrahim MI, Moustafa GF, Al-Hamid AS, Hussein MR. Superficial incisional surgical site infection rate after cesarean section in obese women: a randomized controlled trial of subcuticular versus interrupted skin suturing. Arch Gynecol Obstet 2014;289:981–6.
    1. Vats U, Pandit Suchitra N. Comparison of efficacy of three suture materials, i.e., Poliglecaprone 25, Polyglactin 910, polyamide, as subcuticular skin stitches in post-cesarean women: a randomized clinical trial. J Obstet Gynaecol 2014;64:14–8.
    1. Mackeen AD, Khalifeh A, Fleisher J, Vogell A, Han C, Sendecki J, et al. Suture compared with staple skin closure after cesarean delivery: a randomized controlled trial. Obstet Gynecol 2014;123:1169–75.
    1. Sharma C, Verma A, Soni A, Thusoo M, Mahajan VK, Verma S. A randomized controlled trial comparing cosmetic outcome after skin closure with staples or subcuticular sutures in emergency cesarean section. Arch Gynecol Obstet 2014;290:655–9.
    1. Shrestha A, Napit J, Neupane B, Sedhai LB. A randomized trial comparing skin closure in cesarean section: interrupted suture with nylon vs subcuticular suture with No 1 polyfilament. J Nepal Health Res Counc 2013;11:240–3.
    1. Mackeen AD, Schuster M, Berghella V. Suture versus staples for skin closure after cesarean: a metaanalysis. Am J Obstet Gynecol 2015;212:621.e1–10.
    1. Zaki MN, Wing DA, McNulty JA. Comparison of staples vs subcuticular suture in class III obese women undergoing cesarean: a randomized controlled trial. Am J Obstet Gynecol 2018;218:451.e1–8.
    1. Buresch AM, Van Arsdale A, Ferzli M, Sahasrabudhe N, Sun M, Bernstein J, et al. Comparison of subcuticular suture type for skin closure after cesarean delivery: a randomized controlled trial. Obstet Gynecol 2017;130:521–6.
    1. Daykan Y, Sharon-Weiner M, Pasternak Y, Tzadikevitch-Geffen K, Markovitch O, Sukenik-Halevy R, et al. Skin closure at cesarean delivery, glue vs subcuticular sutures: a randomized controlled trial. Am J Obstet Gynecol 2017;216:406.e1–5.
    1. Mackeen AD, Khalifeh A, Fleisher J, Han C, Leiby B, Berghella V. Pain associated with cesarean delivery skin closure: a randomized controlled trial. Obstet Gynecol 2015;126:702–7.
    1. de Graaf IM, Oude Rengerink K, Wiersma IC, Donker ME, Mol BW, Pajkrt E. Techniques for wound closure at caesarean section: a randomized clinical trial. Eur J Obstet Gynecol Reprod Biol 2012;165:47–52.

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