Dengue: the risk to developed and developing countries

T P Monath, T P Monath

Abstract

Dengue viruses are members of the Flaviviridae, transmitted principally in a cycle involving humans and mosquito vectors. In the last 20 years the incidence of dengue fever epidemics has increased and hyperendemic transmission has been established over a geographically expanding area. A severe form, dengue hemorrhagic fever (DHF), is an immunopathologic disease occurring in persons who experience sequential dengue infections. The risk of sequential infections, and consequently the incidence of DHF, has risen dramatically, first in Asia and now in the Americas. At the root of the emergence of dengue as a major health problem are changes in human demography and behavior, leading to unchecked populations of and increased exposure to the principal domestic mosquito vector, Aedes aegypti. Virus-specified factors also influence the epidemiology of dengue. Speculations on future events in the epidemiology, evolution, and biological expression of dengue are presented.

References

    1. J Hist Med Allied Sci. 1971 Jul;26(3):243-62
    1. Science. 1992 Jul 24;257(5069):526-7
    1. Bull World Health Organ. 1980;58(1):1-21
    1. Ann N Y Acad Sci. 1980;354:219-37
    1. Virology. 1983 Jul 30;128(2):271-84
    1. Rev Infect Dis. 1984 Mar-Apr;6(2):251-64
    1. J Gen Virol. 1984 Dec;65 ( Pt 12):2173-81
    1. Am J Trop Med Hyg. 1985 Jan;34(1):170-3
    1. J Gen Virol. 1986 Jan;67 ( Pt 1):209-13
    1. Virology. 1986 Oct 30;154(2):313-24
    1. Bull Pan Am Health Organ. 1986;20(1):24-30
    1. J Gen Virol. 1986 Dec;67 ( Pt 12):2645-61
    1. Rev Saude Publica. 1986 Jun;20(3):244-5
    1. Science. 1988 Jan 29;239(4839):476-81
    1. J Am Mosq Control Assoc. 1987 Sep;3(3):494-501
    1. J Am Mosq Control Assoc. 1986 Jun;2(2):217-9
    1. Am J Trop Med Hyg. 1989 Jun;40(6):571-8
    1. Rev Infect Dis. 1989 May-Jun;11 Suppl 4:S830-9
    1. Virology. 1990 Feb;174(2):479-93
    1. Epidemiol Bull. 1989;10(1):1-8
    1. AIDS Res Hum Retroviruses. 1990 Aug;6(8):993-8
    1. Annu Rev Microbiol. 1990;44:649-88
    1. Southeast Asian J Trop Med Public Health. 1990 Dec;21(4):636-41
    1. Semin Immunol. 1992 Apr;4(2):121-7
    1. N Engl J Med. 1971 Dec 23;285(26):1460-9

Source: PubMed

Patrocinadores e Colaboradores

Condições médicas

Intervenções de drogas

3
Se inscrever