Association of Macronutrients Composition, Physical Activity and Serum Androgen Concentration in Young Women with Polycystic Ovary Syndrome

Małgorzata Mizgier, Rafał Watrowski, Justyna Opydo-Szymaczek, Elżbieta Jodłowska-Siewert, Giovanni Lombardi, Witold Kędzia, Grażyna Jarząbek-Bielecka, Małgorzata Mizgier, Rafał Watrowski, Justyna Opydo-Szymaczek, Elżbieta Jodłowska-Siewert, Giovanni Lombardi, Witold Kędzia, Grażyna Jarząbek-Bielecka

Abstract

The roles of dietary macronutrients and physical activity (PA) in patients with PCOS have not been sufficiently reported, especially in adolescent girls. To address this knowledge gap, we evaluated the associations between serum concentrations of total testosterone (tT), free testosterone (fT), androstenedione (A), dehydroepiandrosterone-sulfate (DHEA-S), sex hormone-binding globulin (SHBG) and dietary macronutrients intake as well as different types and levels of PA. The study population consisted of 96 girls of Caucasian ancestry, aged 14-18 years: 61 participants with polycystic ovary syndrome (PCOS) and 35 healthy controls. Serum tT, fT, A, DHEA-S, and SHBG were determined in fasting blood. Macronutrient intake and PA levels were assessed by using the three-day food record method and the Beliefs and Eating Habits Questionnaire (KomPAN), respectively. We found several positive correlations between dietary macronutrients such as total fat, saturated fatty acids (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA), and hormonal parameters across the entire cohort and in healthy girls. A positive correlation between SHBG and total protein consumption as well as an inverse correlation between SHBG and carbohydrate intake could be determined. No correlation between androgens and macronutrients was found in the PCOS group. In contrast, we observed an inverse correlation between androgen concentrations (except of DHEA-S) and "work/school" and/or "leisure time" PA only in PCOS patients. Moreover, the hormone levels differed according to PA intensity. In conclusion, the impact of diet and PA was strikingly different in adolescents with and without PCOS. These findings indicate that disturbed hormonal homeostasis in PCOS, at least in the youngest patients, likely "overtrump" dietary influences, and otherwise, PA offers a therapeutic potential that requires further evaluation of the long-term effects in randomized studies. (ClinicalTrial.gov Identifier: NCT04738409.).

Keywords: adolescent girls; adolescents; diet; hyperandrogenism; macronutrients; nutrition; physical activity; polycystic ovary syndrome.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Median (25–75%) values of sex hormones in PCOS and CONTROL groups. p values are included when hormone concentrations significantly differed between the two groups.
Figure 2
Figure 2
Median (25–75%) of sex hormone concentrations in groups with low, moderate or high PA (leisure). Significant differences are marked by an asterisk (*).
Figure 3
Figure 3
Median (25–75%) of sex hormone concentrations in groups with low, moderate or high PA (work/school). Significant differences are marked by an asterisk (*).

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