Binge-eating disorder diagnosis and treatment: a recap in front of DSM-5

Federico Amianto, Luisa Ottone, Giovanni Abbate Daga, Secondo Fassino, Federico Amianto, Luisa Ottone, Giovanni Abbate Daga, Secondo Fassino

Abstract

Introduction: Binge Eating Disorders is a clinical syndrome recently coded as an autonomous diagnosis in DSM-5. Individuals affected by Binge Eating Disorder (BED) show significantly lower quality of life and perceived health and higher psychological distress compared to the non-BED obese population. BED treatment is complex due to clinical and psychological reasons but also to high drop-out and poor stability of achieved goals. The purpose of this review is to explore the available data on this topic, outlining the state-of-the-art on both diagnostic issues and most effective treatment strategies.

Methods: We identified studies published in the last 6 years searching the MeSH Term "binge eating disorder", with specific regard to classification, diagnosis and treatment, in major computerized literature databases including: Medline, PubMed, PsychINFO and Science Direct.

Results: A total of 233 studies were found and, among them, 71 were selected and included in the review.

Review: Although Binge Eating Disorder diagnostic criteria showed empirical consistency, core psychopathology traits should be taken into account to address treatment strategies. The available body of evidence shows psychological treatments as first line interventions, even if their efficacy on weight loss needs further exploration. Behavioral and self-help interventions evidenced some efficacy in patients with lower psychopathological features. Pharmacological treatment plays an important role, but data are still limited by small samples and short follow-up times. The role of bariatric surgery, a recommended treatment for obesity that is often required also by patients with Binge Eating Disorder, deserves more specific studies. Combining different interventions at the same time does not add significant advantages, planning sequential treatments, with more specific interventions for non-responders, seems to be a more promising strategy.

Conclusions: Despite its recent inclusion in DSM-5 as an autonomous disease, BED diagnosis and treatment strategies deserve further deepening. A multidisciplinary and stepped-care treatment appears as a promising management strategy. Longer and more structured follow-up studies are required, in order to enlighten long term outcomes and to overcome the high dropout rates affecting current studies.

References

    1. American Psychiatric Association . Diagnostic and statistical manual of mental disorders. 5. Washington, DC: American Psychiatric Publishing; 2013.
    1. Amianto F, Lavagnino L, Abbate-Daga G, Fassino S. The forgotten psychosocial dimension of the obesity epidemic. Lancet. 2011;378:e8. doi: 10.1016/S0140-6736(11)61778-9.
    1. Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 2011;378:815–25. doi: 10.1016/S0140-6736(11)60814-3.
    1. Kessler RC, Berglund PA, Chiu WT, Deitz AC, Hudson JI, Shahly V, et al. The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry. 2013;73(9):904–14. doi: 10.1016/j.biopsych.2012.11.020.
    1. Hudson JI, Coit CE, Lalonde JK, Pope HG. By how much will the proposed new DSM-5 criteria increase the prevalence of binge eating disorder? Int J Eat Disorders. 2012;45(1):139–41. doi: 10.1002/eat.20890.
    1. Trace SE, Thornton LM, Root TL, Mazzeo SE, Lichtenstein P, Pedersen NL, et al. Effects of reducing the frequency and duration criteria for binge eating on lifetime prevalence of bulimia nervosa and binge eating disorder: implications for DSM-5. Int J Eat Disord. 2012;45(4):531–6. doi: 10.1002/eat.20955.
    1. Robinson AH, Safer DL. Moderators of Dialectical Behavioural Therapy for Binge Eating Disorder: Results from a Randomized Controlled Trial. Int J Eat Disord. 2012;45(4):597–602. doi: 10.1002/eat.20932.
    1. Peterson CB, Swanson SA, Crow SJ, Mitchell JE, Agras WS, Halmi KA, et al. Longitudinal stability of binge-eating type in eating disorders. Int J Eat Disord. 2012;45(5):664–9. doi: 10.1002/eat.22008.
    1. Castellini G, Lo Sauro C, Mannucci E, Ravaldi C, Rotella CM, Faravelli C, et al. Diagnostic crossover and outcome predictors in eating disorders according to DSM-IV and DSM-V proposed criteria: a 6-year follow-up study. Psychosom Med. 2011;73(3):270–9. doi: 10.1097/PSY.0b013e31820a1838.
    1. Grilo CM, White MA, Gueorguieva R, Wilson GT, Masheb RM. Predictive significance of the overvaluation of shape/weight in obese patients with binge eating disorder: findings from a randomized controlled trial with 12-month follow-up. Psychol Med. 2013;43(6):1335–44. doi: 10.1017/S0033291712002097.
    1. Fassino S, Leombruni P, Pierò A, Abbate-Daga G, Rovera GG. Mood, eating attitudes, and anger in obese women with and without Binge Eating Disorder. J Psychosom Res. 2003;54(6):559–66. doi: 10.1016/S0022-3999(02)00462-2.
    1. Carano A, De Berardis D, Campanella D, Serroni N, Ferri F, Di Iorio G, et al. Alexithymia and suicide ideation in a sample of patients with binge eating disorder. J Psychiatr Pract. 2012;18(1):5–11. doi: 10.1097/01.pra.0000410982.08229.99.
    1. Compare A, Callus E, Grossi E. Mindfulness trait, eating behaviours and body uneasiness: a case–control study of binge eating disorder. Eat Weight Disord. 2012;17(4):e244–51.
    1. Blomquist KK, Ansell EB, White MA, Masheb RM, Grilo CM. Interpersonal problems and developmental trajectories of binge eating disorder. Compr Psychiatry. 2012;53(8):1088–95. doi: 10.1016/j.comppsych.2012.05.003.
    1. Sawaoka T, Barnes RD, Blomquist KK, Masheb RM, Grilo CM. Social anxiety and self-consciousness in binge eating disorder: associations with eating disorder psychopathology. Compr Psychiatry. 2012;53(6):740–5. doi: 10.1016/j.comppsych.2011.10.003.
    1. Schag K, Schönleber J, Teufel M, Zipfel S, Giel KE. Food-related impulsivity in obesity and binge eating disorder - a systematic review. Obes Rev. 2013;14(6):477–95. doi: 10.1111/obr.12017.
    1. Amianto F, Lavagnino L, Leombruni P, Gastaldi F, Abbate Daga G, Fassino S. Hypomania across the binge eating spectrum. A study on hypomanic symptoms in full criteria and sub-threshold binge eating subjects. J Affect Disord. 2011;133:580–3. doi: 10.1016/j.jad.2011.04.049.
    1. Carrard I, Crépin C, Ceschi G, Golay A, Van der Linden M. Relations between pure dietary and dietary-negative affect subtypes and impulsivity and reinforcement sensitivity in binge eating individuals. Eat Behav. 2012;13(1):13–9. doi: 10.1016/j.eatbeh.2011.10.004.
    1. Peterson CB, Miller KB, Crow SJ, Thuras P, Mitchell JE. Subtypes of binge eating disorder based on psychiatric history. Int J Eat Disord. 2005;38(3):273–6. doi: 10.1002/eat.20174.
    1. Folope V, Chapelle C, Grigioni S, Coeffier M, Dechelotte P. Impact of eating disorders and psychological distress on the quality of life of obese people. Nutrition. 2012;28(7–8):e7–13. doi: 10.1016/j.nut.2011.12.005.
    1. Bautista-Díaz ML, Franco-Paredes K, Mancilla-Díaz JM, Alvarez-Raynutrieón G, López-Aguilar X, Ocampo Téllez-Girón T, et al. Body dissatisfaction and socio-cultural factors in women with and without BED: their relation with eating psychopathology. Eat Weight Disord. 2012;17(2):e86–92.
    1. Striegel-Moore RH, Franko DL. Should binge eating disorder be included in the DSM-V? A critical review of the state of the evidence. Annu Rev Clin Psychol. 2008;4:305–24. doi: 10.1146/annurev.clinpsy.4.022007.141149.
    1. Fassino S, Daga G, Pierò A, Delsedime N. Psychological Factors Affecting Eating Disorders. In: Porcelli P, Sonino N, editors. Psychological Factors Affecting Medical Conditions. A New Classification for DSM-V. Adv Psychosom Med. Basel: Karger; 2007. pp. 141–68.
    1. American Psychiatric Association . Diagnostic and statistical manual of mental disorders (IV ed., Text Revision) Washington, DC: American Psychiatric Publishing; 2002.
    1. Thomas JJ, Vartanian LR, Brownell KD. The relationship between eating disorder not otherwise specified (EDNOS) and officially recognized eating disorders: meta-analysis and implications for DSM. Psychol Bull. 2009;135(3):407–33. doi: 10.1037/a0015326.
    1. White MA, Grilo CM. Diagnostic Efficiency of DSM-IV Indicators for Binge Eating Episodes. J Consult Clin Psychol. 2011;79(1):75–83. doi: 10.1037/a0022210.
    1. Grilo CM, Crosby RD, Masheb RM, White MA, Peterson CB, Wonderlich SA, et al. Overvaluation of shape and weight in binge eating disorder, bulimia nervosa, and sub-threshold bulimia nervosa. Behav Res Ther. 2009;47(8):692–6. doi: 10.1016/j.brat.2009.05.001.
    1. Ojserkis R, Sysko R, Goldfein JA, Devlin MJ. Does the overvaluation of shape and weight predict initial symptom severity or treatment outcome among patients with binge eating disorder? Int J Eat Disord. 2012;45(4):603–8. doi: 10.1002/eat.20981.
    1. Fairburn CG, Cooper Z, Shfran R. Cognitive behaviour therapy for eating disorders: a "transdiagnostic" theory and treatment? Behav Res Ther. 2003;41(5):509–28. doi: 10.1016/S0005-7967(02)00088-8.
    1. Gianini LM, White MA, Masheb RM. Eating pathology, emotion regulation, and emotional overeating in obese adults with Binge Eating Disorder. Eat Behav. 2013;14(3):309–13. doi: 10.1016/j.eatbeh.2013.05.008.
    1. Munsch S, Meyer AH, Quartier V, Wilhelm FH. Binge eating in binge eating disorder: a breakdown of emotion regulatory process? Psychiatry Res. 2012;28(195(3)):118–24. doi: 10.1016/j.psychres.2011.07.016.
    1. Masheb RM, Grilo CM, Whites MA. An examination of eating patterns in community women with bulimia nervosa and binge eating disorder. Int J Eat Disord. 2011;44(7):618–24. doi: 10.1002/eat.20853.
    1. Wolfe BE, Baker CW, Smith AT, Kelly-Weeder S. Validity and utility of the current definition of binge eating. Int J Eat Disord. 2009;42(8):674–86. doi: 10.1002/eat.20728.
    1. Thornton LM, Mazzeo SE, Bulik CM. The heritability of eating disorders: methods and current findings. Curr Top Behav Neurosci. 2011;6:141–56. doi: 10.1007/7854_2010_91.
    1. Brambilla F, Samek L, Company M, Lovo F, Cioni L, Mellado C. Multivariate therapeutic approach to binge-eating disorder: combined nutritional, psychological and pharmacological treatment. Int Clin Psychopharmacol. 2009;24(6):312–7. doi: 10.1097/YIC.0b013e32832ac828.
    1. Vocks S, Tuschen-Caffier B, Pietrowsky R, Rustenbach SJ, Kersting A, Herpertz S. Meta-analysis of the effectiveness of psychological and pharmacological treatments for binge eating disorder. Int J Eat Disord. 2010;43(3):205–17.
    1. Fluckinger C, Meyer A, Wampold BE, Gassmann D, Messerli-Burgy N, Munsch S. Predicting premature termination within a randomized controlled trial for binge-eating patients. Behav Ther. 2011;42(4):716–25. doi: 10.1016/j.beth.2011.03.008.
    1. Reas DL, Grilo CM. Review and meta-analysis of pharmacotherapy for binge-eating disorder. Obesity. 2008;16(9):2024–38. doi: 10.1038/oby.2008.333.
    1. Woolhouse H, Knowles A, Crafti N. Adding mindfulness to CBT programs for binge eating: a mixed-methods evaluation. Eat Disord. 2012;20(4):321–39. doi: 10.1080/10640266.2012.691791.
    1. Masheb RM, Grilo CM, Rolls BJ. A randomized controlled trial for obesity and binge eating disorder: low-energy-density dietary counselling and cognitive-behavioural therapy. Behav Res Ther. 2011;49(12):821–9. doi: 10.1016/j.brat.2011.09.006.
    1. Tasca GA, Balfour L, Presniak MD, Bissada H. Outcomes of specific interpersonal problems for binge eating disorder: comparing group psychodynamic interpersonal psychotherapy and group cognitive behavioural therapy. Int J Group Psychother. 2012;62(2):197–218. doi: 10.1521/ijgp.2012.62.2.197.
    1. Wilson GT, Wilfley DE, Agras WS, Bryson SW. Psychological treatments of binge eating disorder. Arch gen psychiatr. 2010;67(1):94–101. doi: 10.1001/archgenpsychiatry.2009.170.
    1. Iacovino JM, Gredysa DM, Altman M, Wilfley DE. Psychological Treatments for Binge Eating Disorder. Curr Psychiatry Rep. 2012;14(4):432–46. doi: 10.1007/s11920-012-0277-8.
    1. Grilo CM, White MA, Wilson GT, Gueorguieva R, Masheb RM. Rapid response predicts 12-month post-treatment outcomes in binge-eating disorder: theoretical and clinical implications. Psychol Med. 2012;42(4):807–17. doi: 10.1017/S0033291711001875.
    1. Zunker C, Peterson CB, Cao L, Mitchell JE, Wonderlich SA, Crow S, et al. A receiver operator characteristics analysis of treatment outcome in binge eating disorder to identify patterns of rapid response. Behav Res Ther. 2010;48(12):1227–31. doi: 10.1016/j.brat.2010.08.007.
    1. Compare A, Calugi S, Marchesini G, Molinari E, Dalle Grave R. Emotion-focused therapy and dietary counselling for obese patients with binge eating disorder: a propensity score-adjusted study. Appetite. 2013;82(3):193–4.
    1. Vancampfort D, Vanderlinden J, De Hert M, Adámkova M, Skjaerven LH, Catalán-Matamoros D, et al. A systematic review on physical therapy interventions for patients with binge eating disorder. Disabil Rehabil. 2013;35(26):2191–6. doi: 10.3109/09638288.2013.771707.
    1. Safer DL, Joyce EE. Does rapid response to two group psychotherapies for binge eating disorder predict abstinence? Behav Res Ther. 2011;49(5):339–45. doi: 10.1016/j.brat.2011.03.001.
    1. Blomquist KK, Barnes RD, White MA, Masheb RM, Morgan PT, Grilo CM. Exploring weight gain in year before treatment for binge eating disorder: a different context for interpreting limited weight losses in treatment studies. Int J Eat Disord. 2011;44(5):435–9. doi: 10.1002/eat.20836.
    1. Masheb RM, White MA, Grilo CM. Substantial weight gains are common prior to treatment-seeking in obese patients with binge eating disorder. Compr Psychiatry. 2013;54(7):880–4. doi: 10.1016/j.comppsych.2013.03.017.
    1. Munsch S, Meyer AH, Biedert E. Efficacy and predictors of long-term treatment success for Cognitive-Behavioural Treatment and Behavioural Weight-Loss-Treatment in overweight individuals with binge eating disorder. Behav Res Ther. 2012;50(12):775–85. doi: 10.1016/j.brat.2012.08.009.
    1. Grilo CM, Masheb RM, Wilson GT, Gueorguieva R, White MA. Cognitive-behavioral therapy, behavioral weight loss, and sequential treatment for obese patients with binge-eating disorder: a randomized controlled trial. J Consult Clin Psychol. 2011;79(5):675–85. doi: 10.1037/a0025049.
    1. Leombruni P, Ottone L, Lavagnino L, Siccardi S, Nicotra B, Migliore F, et al. Group psychoeducational psychotherapy in Binge Eating Disorder. Minerva Psichiatr. 2010;51(3):135–44.
    1. Balestrieri M, Isola M, Baiano M, Ciano R. Psychoeducation in Binge Eating Disorder and EDNOS: a pilot study on the efficacy of a 10-week and a 1-year continuation treatment. Eat Weight Disord. 2013;18(1):45–51. doi: 10.1007/s40519-013-0014-2.
    1. Grilo CM, Masheb RM, Crosby RD. Predictors and moderators of response to cognitive behavioural therapy and medication for the treatment of binge eating disorder. J Consult Clin Psychol. 2012;80(5):897–906. doi: 10.1037/a0027001.
    1. Vanderlinden J, Adriaensen A, Vancampfort D, Pieters G, Probst M, Vansteelandt K. A cognitive- behavioural therapeutic program for patients with obesity and binge eating disorder: short- and long- term follow-up data of a prospective study. Behav Modif. 2012;36(5):670–86. doi: 10.1177/0145445512439313.
    1. Ricca V, Castellini G, Mannucci E, Lo Sauro C, Ravaldi C, Rotella CM, et al. Comparison of individual and group cognitive behavioral therapy for binge eating disorder. A randomized, three-year follow-up study. Appetite. 2010;55(3):656–65. doi: 10.1016/j.appet.2010.09.019.
    1. Schlup B, Meyer AH, Munsch S. A non-randomized direct comparison of cognitive-behavioural short- and long-term treatment for binge eating disorder. Obes Facts. 2010;3(4):261–6. doi: 10.1159/000319538.
    1. Deumens RA, Noorthoorn EO, Verbraak MJ. Predictors for treatment outcome of binge eating with obesity: a naturalistic study. Eat Disord. 2012;20(4):276–87. doi: 10.1080/10640266.2012.689207.
    1. Striegel-Moore RH, Wilson GT, DeBar L, Perrin N, Lynch F, Rosselli F, et al. Cognitive behavioural guided self-help for the treatment of recurrent binge eating. J Consult Clin Psychol. 2010;78(3):312–21. doi: 10.1037/a0018915.
    1. Wilson GT, Zandberg LJ. Cognitive–behavioral guided self-help for eating disorders: Effectiveness and scalability. Clin Psychol Rev. 2012;32(4):343–57. doi: 10.1016/j.cpr.2012.03.001.
    1. Carrard I, Crépin C, Rouget P, Lam T, Golay A, Van der Linden M. Randomised controlled trial of a guided self-help treatment on the Internet for binge eating disorder. Behav Res Ther. 2011;49(8):482–91. doi: 10.1016/j.brat.2011.05.004.
    1. Peterson CB, Mitchell JE, Crow SJ, Crosby RD, Wonderlich SA. The efficacy of self-help group treatment and therapist-led group treatment for binge eating disorder. Am J Psychiatry. 2009;166(12):1347–54. doi: 10.1176/appi.ajp.2009.09030345.
    1. Klein AS, Skinner JB, Hawley KM. Adapted group-based dialectical behaviour therapy for binge eating in a practicing clinic: clinical outcomes and attrition. Eur Eat Disord Rev. 2012;20(3):e148–53. doi: 10.1002/erv.2165.
    1. Safer DL, Robinson AH, Jo B. Outcome from a randomized controlled trial of group therapy for binge eating disorder: comparing dialectical behaviour therapy adapted for binge eating to an active comparison group therapy. Behav Ther. 2010;41(1):106–20. doi: 10.1016/j.beth.2009.01.006.
    1. Masson PC, von Ranson KM, Wallace LM, Safer DL. A randomized wait-list controlled pilot study of dialectical behaviour therapy guided self-help for binge eating disorder. Behav Res Ther. 2013;51(11):723–8. doi: 10.1016/j.brat.2013.08.001.
    1. Hilbert A, Bishop ME, Stein RI, Tanofsky-Kraff M, Swenson AK, Welch RR, et al. Long-term efficacy of psychological treatments for binge eating disorder. Br J Psychiatry. 2012;200(3):232–7. doi: 10.1192/bjp.bp.110.089664.
    1. McElroy SL, Guerdjikova AI, Mori N, O'Melia AM. Pharmacological management of binge eating disorder: current and emerging treatment options. Ther Clin Risk Manag. 2012;8:219–41. doi: 10.2147/TCRM.S25574.
    1. Blom TJ, Mingione CJ, Guerdjikova AI, Keck PE, Jr, Welge JA, McElroy SL. Placebo response in binge eating disorder: a pooled analysis of 10 clinical trials from one research group. Eur Eat Disord Rev. 2014;22(2):140–6. doi: 10.1002/erv.2277.
    1. Leombruni P, Pierò A, Lavagnino L, Brustolin A, Campisi S, Fassino S. A randomized, double-blind trial comparing sertraline and fluoxetine 6-month treatment in obese patients with Binge Eating Disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(6):1599–605. doi: 10.1016/j.pnpbp.2008.06.005.
    1. Calandra C, Russo RG, Luca M. Bupropion versus sertraline in the treatment of depressive patients with binge eating disorder: retrospective cohort study. Psychiatr Q. 2012;83(2):177–85. doi: 10.1007/s11126-011-9192-0.
    1. Guerdjikova AI, McElroy SL, Winstanley EL, Nelson EB, Mori N, McCoy J, et al. Duloxetine in the treatment of binge eating disorder with depressive disorders: a placebo-controlled trial. Int J Eat Disord. 2012;45(2):281–9. doi: 10.1002/eat.20946.
    1. Leombruni P, Lavagnino L, Gastaldi F, Vasile A, Fassino S. Duloxetine in obese binge eater outpatients: preliminary results from a 12-week open trial. Hum Psychopharmacol. 2009;24(6):483–8. doi: 10.1002/hup.1040.
    1. Arbaizar B, Gomez-Acebo I, Llorca J. Efficacy of topiramate in bulimia nervosa and binge-eating disorder: a systematic review. Gen Hosp Psychiatry. 2008;30(5):471–5. doi: 10.1016/j.genhosppsych.2008.02.002.
    1. Marazziti D, Corsi M, Baroni S, Consoli G, Catena-Dell'Osso M. Latest advancements in the pharmacological treatment of binge eating disorder. Eur Rev Med Pharmacol Sci. 2012;16(15):2102–7.
    1. Guerdjikova AI, McElroy SL, Welge JA, Nelson E, Keck PE, Hudson JI. Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial. Int Clin Psychopharmacol. 2009;24(3):150–8. doi: 10.1097/YIC.0b013e328329c7b5.
    1. McElroy SL, Guerdjikova AI, Winstanley EL, O'Melia AM, Mori N, McCoy J, et al. Acamprosate in the treatment of binge eating disorder: a placebo-controlled trial. Int J Eat Disord. 2011;44(1):81–90. doi: 10.1002/eat.20876.
    1. McElroy SL, Guerdjikova AI, Winstanley EL, O'Melia AM, Mori N, Keck PE, et al. Sodium oxybate in the treatment of binge eating disorder: an open-label, prospective study. Int J Eat Disord. 2011;44(3):262–8. doi: 10.1002/eat.20798.
    1. Expert panel report Guidelines for the management of overweight and obesity in adults. Obesity. 2013;22(S2):1973–739X.
    1. American Psychiatric Association Practice Guideline for the treatment of patients with Eating Disorders. Am J Psychiatry. 2006;163:7.
    1. Faulconbridge LF, Wadden TA, Thomas JG, Jones-Corneille LR, Sarwer DB, Fabricatore AN. Changes in depression and quality of life in obese individuals with binge eating disorder: bariatric surgery versus lifestyle modification. Surg Obes Relat Dis. 2013;9(5):790–6. doi: 10.1016/j.soard.2012.10.010.
    1. Wadden TA, Faulconbridge LF, Jones-Corneille LR, Sarwer DB, Fabricatore AN, Thomas JG, et al. Binge eating disorder and the outcome of bariatric surgery at one year: a prospective, observational study. Obesity. 2011;19(6):1220–8. doi: 10.1038/oby.2010.336.
    1. Beck NN, Mehlsen M, Støving RK. Psychological characteristics and associations with weight outcomes two years after gastric bypass surgery: Postoperative eating disorder symptoms are associated with weight loss outcomes. Eat Behav. 2012;13(4):394–7. doi: 10.1016/j.eatbeh.2012.06.001.
    1. Ashton K, Heinberg L, Windover A, Merrell J. Positive response to binge eating intervention enhances postoperative weight loss. Surg Obes Relat Dis. 2011;7(3):315–20. doi: 10.1016/j.soard.2010.12.005.
    1. Devlin MJ, Goldfein JA, Petkova E, Jiang H, Raizman PS, Wolk S, Mayer L, Carino J, Bellace D, Kamenetz C, Dobrow I, Walsh BT. Cognitive behavioral therapy and fluoxetine as adjuncts to group behavioral therapy for binge eating disorder. Obes Res. 2005;13:1077–1088. doi: 10.1038/oby.2005.126.

Source: PubMed

3
Se inscrever