The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States
Colleen S Kraft, Angela L Hewlett, Scott Koepsell, Anne M Winkler, Christopher J Kratochvil, LuAnn Larson, Jay B Varkey, Aneesh K Mehta, G Marshall Lyon 3rd, Rachel J Friedman-Moraco, Vincent C Marconi, Charles E Hill, James N Sullivan, Daniel W Johnson, Steven J Lisco, Mark J Mulligan, Timothy M Uyeki, Anita K McElroy, Tara Sealy, Shelley Campbell, Christina Spiropoulou, Ute Ströher, Ian Crozier, Richard Sacra, Michael J Connor Jr, Viranuj Sueblinvong, Harold A Franch, Philip W Smith, Bruce S Ribner, Nebraska Biocontainment Unit and the Emory Serious Communicable Diseases Unit, Philip Smith, Angela Hewlett, Shelly Schwedhelm, Kate Boulter, Elizabeth Beam, Shawn Gibbs, John Lowe, Chris Kratochvil, James Sullivan, Dan Johnson, Steve Lisco, Craig Piquette, Kristina Bailey, Joseph Auxier, Brian Boer, Travis Hanson, Julia Kaseman, M Salman Khan, Ji Hyun Rhee, Adam Wells, Diana Florescu, Andre Kalil, Mark Rupp, Valerie Becker, Bridget Boeckman, Erica Elder, Abby Fitch, Elizabeth Flood, Meagan Freml, Roman Frigge, Kelly Ann Hanzlik, Lois Jensen, Nicole Kraus, Drew Molacek, Jerry Nevins, Alicia Parker, Jeff Peters, Cheryl Rand, Karen Roesler, Kendall Ryalls, Morgan Shradar, Amanda Strain, Timothy Sunderman, Jennifer Sundermeier, John Swanhorst, Angela Vasa, Jean Bellinghausen, Frank Freihaut, Susan Denny, Lauren Mainelli, Dee Pinkney, Deborah Ray, Jay Jevne, Kalen Knight, Derrick McCroy, Ralph Nadeau, Anna Nightser, Pete Iwen, Tony Sambol, Vicki Herrera, David Morgan, Sarah Trotter, Amy Kerby, Sue Peters, Timothy Southern, Caitlin Murphy, Rosanna Morris, Sue Nuss, Theresa Franco, Connie Ogden, Julie Lazure, Dawn Straub, Scott Koepsell, Steve Hinrichs, Troy Plumb, Marius Florescu, John Becker, Jenna Souchek, Jon Beck, Luann Larson, Peggy Heires, Bruce Gordon, Gail Paulsen, Barb Wolford, Jill Petersen, Nedra Marion, Kim Hayes, Kate Tyner, Taylor Wilson, Paul Baltes, Jenny Nowatzke, Jonathan Nguyen, Paul Turner, Barb Boonstra, Katelyn Jelden, Randy Portrey, Doug Stringfield, Bryan Scofield, Gary Svanda, Jolene Horihan, Chris Dahl, Megan Bruno, Kelsey Malm, Ron Litz, Jessica Fehringer, Katie Paladino, Tammy Opp, Sonia Bell, Anne Adams, Mary Beth Allen, Robert Bachman, William Bornstein, Dee Cantrell, Pam Cosper, Nancye Feistritzer, John Fox, Bryce Gartland, Jen Goodman, Susan Grant, Dallis Howard-Crow, Ira Horowitz, David Pugh, Chad Ritenour, Toni Ash, Christopher Barnes, Jason Calhoun, Lauren Chapman, Tracey Daye, Haley Durr, Shunasee Evans, Janice Gentry, Jan Ginnane, Susan Grant, Chris Haynes, Carolyn Hill, Dustin Hillis, Crystal Johnson, Jessica Loomis, Josia Mamora, Laura Mitchell, Jill Morgan, Nancy Osakwe, Jacqueline Owen, Sarah Piazza, Kristina Shirley, Jodi Siddens, Carrie Silas, Jason Slabach, Elaina Tirador, Donnette Todd, Sharon Vanairsdale, Nicole Brammer, Juli Buchanan, Eileen Burd, John Cardella, Brenda Eaves, Crystal Evans, Krista Hostetler, Karen Jenkins, Maureen Lindsey, Jordan Magee, Randall Powers, James Ritchie, Emily Ryan, Shannon Bonds, Amir Emamifar, Tish Kuban, Jan Pack, Susan Rogers, George Golston, Sean Kaufman, Patricia Olinger, Sean Olinger, Kalpana Rengarajan, Scott Thomaston, Emily Beck, Paula Desroches, Cynthia Hall, Celeste Walker, Connie Bryant, Betsy Hackman, Regina Howard, Marolyn Jones, Jeff Broughton, Brian Frisle, Robert Jackson, Jerry Lewis, Robin Brown-Haithco, Miranda Lynn Gartin, Erica Geralds-Washington, Rhonda James-Jones, Donald Miller, Dan Stark, Gentrice McGee, Porcia Jones, Linda Scott-Harris, James Cain, Roderick Davis, Tyrone Johnson, Tyrone Pickett, Anthony Shaw, Tenina Truesdale, Jim Blum, Laureen Hill, Jon Sevransky, Joel Zivot, Seth Walker, Matthew Klopman, Ricky Matkins, Cathy Meechan, Paul Meechan, Kathy Schwock, Jen Schuck, Kathy Stack, Francis Wolf, Bruce Bray, Alex Isakov, Sam Shartar, Wade Miles, Aaro Jamison, John Arevalo, Gail Stallings, Janet Christenbury, Vince Dollard, Melanie De Gennaro, Holly Korschun, Nancy Seideman, Tom Ziegler, Daniel P Griffith, Nisha Dave, Susan Wall, Melida Hall, Dwania McGhee, Tim Clarke, Rachel Vaught, Katrina Peterson-Pileri, Colleen S Kraft, Angela L Hewlett, Scott Koepsell, Anne M Winkler, Christopher J Kratochvil, LuAnn Larson, Jay B Varkey, Aneesh K Mehta, G Marshall Lyon 3rd, Rachel J Friedman-Moraco, Vincent C Marconi, Charles E Hill, James N Sullivan, Daniel W Johnson, Steven J Lisco, Mark J Mulligan, Timothy M Uyeki, Anita K McElroy, Tara Sealy, Shelley Campbell, Christina Spiropoulou, Ute Ströher, Ian Crozier, Richard Sacra, Michael J Connor Jr, Viranuj Sueblinvong, Harold A Franch, Philip W Smith, Bruce S Ribner, Nebraska Biocontainment Unit and the Emory Serious Communicable Diseases Unit, Philip Smith, Angela Hewlett, Shelly Schwedhelm, Kate Boulter, Elizabeth Beam, Shawn Gibbs, John Lowe, Chris Kratochvil, James Sullivan, Dan Johnson, Steve Lisco, Craig Piquette, Kristina Bailey, Joseph Auxier, Brian Boer, Travis Hanson, Julia Kaseman, M Salman Khan, Ji Hyun Rhee, Adam Wells, Diana Florescu, Andre Kalil, Mark Rupp, Valerie Becker, Bridget Boeckman, Erica Elder, Abby Fitch, Elizabeth Flood, Meagan Freml, Roman Frigge, Kelly Ann Hanzlik, Lois Jensen, Nicole Kraus, Drew Molacek, Jerry Nevins, Alicia Parker, Jeff Peters, Cheryl Rand, Karen Roesler, Kendall Ryalls, Morgan Shradar, Amanda Strain, Timothy Sunderman, Jennifer Sundermeier, John Swanhorst, Angela Vasa, Jean Bellinghausen, Frank Freihaut, Susan Denny, Lauren Mainelli, Dee Pinkney, Deborah Ray, Jay Jevne, Kalen Knight, Derrick McCroy, Ralph Nadeau, Anna Nightser, Pete Iwen, Tony Sambol, Vicki Herrera, David Morgan, Sarah Trotter, Amy Kerby, Sue Peters, Timothy Southern, Caitlin Murphy, Rosanna Morris, Sue Nuss, Theresa Franco, Connie Ogden, Julie Lazure, Dawn Straub, Scott Koepsell, Steve Hinrichs, Troy Plumb, Marius Florescu, John Becker, Jenna Souchek, Jon Beck, Luann Larson, Peggy Heires, Bruce Gordon, Gail Paulsen, Barb Wolford, Jill Petersen, Nedra Marion, Kim Hayes, Kate Tyner, Taylor Wilson, Paul Baltes, Jenny Nowatzke, Jonathan Nguyen, Paul Turner, Barb Boonstra, Katelyn Jelden, Randy Portrey, Doug Stringfield, Bryan Scofield, Gary Svanda, Jolene Horihan, Chris Dahl, Megan Bruno, Kelsey Malm, Ron Litz, Jessica Fehringer, Katie Paladino, Tammy Opp, Sonia Bell, Anne Adams, Mary Beth Allen, Robert Bachman, William Bornstein, Dee Cantrell, Pam Cosper, Nancye Feistritzer, John Fox, Bryce Gartland, Jen Goodman, Susan Grant, Dallis Howard-Crow, Ira Horowitz, David Pugh, Chad Ritenour, Toni Ash, Christopher Barnes, Jason Calhoun, Lauren Chapman, Tracey Daye, Haley Durr, Shunasee Evans, Janice Gentry, Jan Ginnane, Susan Grant, Chris Haynes, Carolyn Hill, Dustin Hillis, Crystal Johnson, Jessica Loomis, Josia Mamora, Laura Mitchell, Jill Morgan, Nancy Osakwe, Jacqueline Owen, Sarah Piazza, Kristina Shirley, Jodi Siddens, Carrie Silas, Jason Slabach, Elaina Tirador, Donnette Todd, Sharon Vanairsdale, Nicole Brammer, Juli Buchanan, Eileen Burd, John Cardella, Brenda Eaves, Crystal Evans, Krista Hostetler, Karen Jenkins, Maureen Lindsey, Jordan Magee, Randall Powers, James Ritchie, Emily Ryan, Shannon Bonds, Amir Emamifar, Tish Kuban, Jan Pack, Susan Rogers, George Golston, Sean Kaufman, Patricia Olinger, Sean Olinger, Kalpana Rengarajan, Scott Thomaston, Emily Beck, Paula Desroches, Cynthia Hall, Celeste Walker, Connie Bryant, Betsy Hackman, Regina Howard, Marolyn Jones, Jeff Broughton, Brian Frisle, Robert Jackson, Jerry Lewis, Robin Brown-Haithco, Miranda Lynn Gartin, Erica Geralds-Washington, Rhonda James-Jones, Donald Miller, Dan Stark, Gentrice McGee, Porcia Jones, Linda Scott-Harris, James Cain, Roderick Davis, Tyrone Johnson, Tyrone Pickett, Anthony Shaw, Tenina Truesdale, Jim Blum, Laureen Hill, Jon Sevransky, Joel Zivot, Seth Walker, Matthew Klopman, Ricky Matkins, Cathy Meechan, Paul Meechan, Kathy Schwock, Jen Schuck, Kathy Stack, Francis Wolf, Bruce Bray, Alex Isakov, Sam Shartar, Wade Miles, Aaro Jamison, John Arevalo, Gail Stallings, Janet Christenbury, Vince Dollard, Melanie De Gennaro, Holly Korschun, Nancy Seideman, Tom Ziegler, Daniel P Griffith, Nisha Dave, Susan Wall, Melida Hall, Dwania McGhee, Tim Clarke, Rachel Vaught, Katrina Peterson-Pileri
Abstract
Background: The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management.
Methods: We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma.
Results: While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date.
Conclusions: It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.
Keywords: Ebola virus; Ebola virus disease; TKM-Ebola; convalescent plasma; convalescent serum.
© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
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Source: PubMed