BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers
Sébastien Couraud, Pierre-Jean Souquet, Christophe Paris, Pascal Dô, Hélène Doubre, Eric Pichon, Adrien Dixmier, Isabelle Monnet, Bénédicte Etienne-Mastroianni, Michel Vincent, Jean Trédaniel, Marielle Perrichon, Pascal Foucher, Bruno Coudert, Denis Moro-Sibilot, Eric Dansin, Stéphanie Labonne, Pascale Missy, Franck Morin, Hélène Blanché, Gérard Zalcman, French Cooperative Intergroup IFCT, Pierre-Jean Souquet, Radj Gervais, Hélène Doubre, Eric Pichon, Adrien Dixmier, Isabelle Monnet, Bénédicte Mastroianni, Louis Pradel, Michel Vincent, Jean Tredaniel, Pascal Foucher, Bruno Coudert, Denis Moro-Sibilot, Eric Dansin, Patrick Dumont, Lionel Moreau, Didier Debieuvre, Jacques Margery, Elisabeth Quoix, Bernard Duvert, Laurent Cellerin, Nathalie Baize, Bruno Taviot, Marie Coudurier, Jacques Cadranel, Patrick Chatellain, Virginie Westeel, Sylvie Labrune, Jean-Marc Dot, Sébastien Larive, Christos Chouaid, Daniel Coëtmeur, Clarisse Audigier-Valette, Jean-Pierre Gury, Luc Odier, Tsellina Desfemmes-Baleyte, Yannick Duval, Patrick Merle, Gilles Devouassoux, Reza Azarian, Patricia Barre, Olivier Raffy, Philippe Masson, Stephanie Dehette, Caroline Toussaint Batbedat, Gérard Oliviero, Marc Derollez, Nadine Paillot, Jérôme Dauba, Dominique Herman, Jean-Michel Rodier, Suzanna Bota, Philippe Brun, Geneviève Letanche, Mohamed Khomsi, Béatrice Gentil-Lepecq, Philippe Ravier, Yassine Hammou, Fabrice Barlesi, Hélène Laize, Pierre Fournel, Christelle Clement-Duchene, Joël Castelli, Sophie Schneider, Antoine Levy, Jérôme Dauba, Geneviève Jolimoy, Hervé Pegliasco, Michel Poudenx, Alain Prevost, Philippe Romand, Laurence Bigay-Game, Sébastien Couraud, Pierre-Jean Souquet, Christophe Paris, Pascal Dô, Hélène Doubre, Eric Pichon, Adrien Dixmier, Isabelle Monnet, Bénédicte Etienne-Mastroianni, Michel Vincent, Jean Trédaniel, Marielle Perrichon, Pascal Foucher, Bruno Coudert, Denis Moro-Sibilot, Eric Dansin, Stéphanie Labonne, Pascale Missy, Franck Morin, Hélène Blanché, Gérard Zalcman, French Cooperative Intergroup IFCT, Pierre-Jean Souquet, Radj Gervais, Hélène Doubre, Eric Pichon, Adrien Dixmier, Isabelle Monnet, Bénédicte Mastroianni, Louis Pradel, Michel Vincent, Jean Tredaniel, Pascal Foucher, Bruno Coudert, Denis Moro-Sibilot, Eric Dansin, Patrick Dumont, Lionel Moreau, Didier Debieuvre, Jacques Margery, Elisabeth Quoix, Bernard Duvert, Laurent Cellerin, Nathalie Baize, Bruno Taviot, Marie Coudurier, Jacques Cadranel, Patrick Chatellain, Virginie Westeel, Sylvie Labrune, Jean-Marc Dot, Sébastien Larive, Christos Chouaid, Daniel Coëtmeur, Clarisse Audigier-Valette, Jean-Pierre Gury, Luc Odier, Tsellina Desfemmes-Baleyte, Yannick Duval, Patrick Merle, Gilles Devouassoux, Reza Azarian, Patricia Barre, Olivier Raffy, Philippe Masson, Stephanie Dehette, Caroline Toussaint Batbedat, Gérard Oliviero, Marc Derollez, Nadine Paillot, Jérôme Dauba, Dominique Herman, Jean-Michel Rodier, Suzanna Bota, Philippe Brun, Geneviève Letanche, Mohamed Khomsi, Béatrice Gentil-Lepecq, Philippe Ravier, Yassine Hammou, Fabrice Barlesi, Hélène Laize, Pierre Fournel, Christelle Clement-Duchene, Joël Castelli, Sophie Schneider, Antoine Levy, Jérôme Dauba, Geneviève Jolimoy, Hervé Pegliasco, Michel Poudenx, Alain Prevost, Philippe Romand, Laurence Bigay-Game
Abstract
Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences. 384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35% versus 8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference): EGFR in 51%, ALK in 8%, KRAS in 6%, HER2 in 3%, BRAF in 3%, PI3KCA in less than 1%, and multiple in 2%. We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%).
Copyright ©ERS 2015.
Source: PubMed