Social well-being is associated with less pro-inflammatory and pro-metastatic leukocyte gene expression in women after surgery for breast cancer
Devika R Jutagir, Bonnie B Blomberg, Charles S Carver, Suzanne C Lechner, Kiara R Timpano, Laura C Bouchard, Lisa M Gudenkauf, Jamie M Jacobs, Alain Diaz, Susan K Lutgendorf, Steve W Cole, Aaron S Heller, Michael H Antoni, Devika R Jutagir, Bonnie B Blomberg, Charles S Carver, Suzanne C Lechner, Kiara R Timpano, Laura C Bouchard, Lisa M Gudenkauf, Jamie M Jacobs, Alain Diaz, Susan K Lutgendorf, Steve W Cole, Aaron S Heller, Michael H Antoni
Abstract
Purpose: Satisfaction with social resources, or "social well-being," relates to better adaptation and longer survival after breast cancer diagnosis. Biobehavioral mechanisms linking social well-being (SWB) to mental and physical health may involve inflammatory signaling. We tested whether reports of greater SWB were associated with lower levels of pro-inflammatory and pro-metastatic leukocyte gene expression after surgery for non-metastatic breast cancer.
Methods: Women (N = 50) diagnosed with non-metastatic (0-III) breast cancer were enrolled 2-8 weeks after surgery. SWB was assessed with the social/family well-being subscale of the FACT-B. Leukocyte gene expression for specific pro-inflammatory (cytokines, chemokines, and COX-2) and pro-metastatic genes (e.g., MMP9) was derived from microarray analysis.
Results: Multiple regression analyses controlling for age, stage of disease, days since surgery, education, and body mass index (BMI) found higher levels of SWB related to less leukocyte pro-inflammatory and pro-metastatic gene expression (p < 0.05). Emotional well-being, physical well-being, and functional well-being did not relate to leukocyte gene expression (p > 0.05). Greater SWB remained significantly associated with less leukocyte pro-inflammatory and pro-metastatic gene expression after controlling for depressive symptoms.
Conclusions: Results have implications for understanding mechanisms linking social resources to health-relevant biological processes in breast cancer patients undergoing primary treatment.
Clinical trial registration number: NCT01422551.
Keywords: Breast cancer; Inflammation; Leukocyte gene expression; Social support; Social well-being.
Conflict of interest statement
Conflict of interest: The authors declare that they have no conflicts of interest.
Figures
Source: PubMed