Dose-dependent resorption of quinine after intrarectal administration to children with moderate Plasmodium falciparum malaria
Eric Pussard, Celine Straczek, Idrissa Kaboré, Auguste Bicaba, Tatiana Balima-Koussoube, Patrice Bouree, Hubert Barennes, Eric Pussard, Celine Straczek, Idrissa Kaboré, Auguste Bicaba, Tatiana Balima-Koussoube, Patrice Bouree, Hubert Barennes
Abstract
The pharmacokinetics of increasing doses of an intrarectal Cinchona alkaloid combination containing 96.1% quinine, 2.5% quinidine, 0.68% cinchonine, and 0.67% cinchonidine (Quinimax) was compared to that of parenteral regimens in 60 children with moderate malaria. Quinine exhibited a nonlinear pharmacokinetics, suggesting a saturation of rectal resorption. When early rejections appeared, blood quinine concentrations decreased by 30 to 50% and were restored by an immediate half-dose administration of the drug. Rectal administration of doses of 16 or 20 mg/kg of body weight led to concentration-time profiles in blood similar to those of parenteral regimens and could be an early treatment of childhood malaria.
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Source: PubMed