Pulp Revascularization: A Literature Review

Pollyana Rodrigues de Souza Araújo, Luciano Barreto Silva, Alexandrino Pereira Dos Santos Neto, José Alcides Almeida de Arruda, Pâmella Recco Álvares, Ana Paula Veras Sobral, Severino Alves Júnior, Jair Carneiro Leão, Rodivan Braz da Silva, Gerhilde Callou Sampaio, Pollyana Rodrigues de Souza Araújo, Luciano Barreto Silva, Alexandrino Pereira Dos Santos Neto, José Alcides Almeida de Arruda, Pâmella Recco Álvares, Ana Paula Veras Sobral, Severino Alves Júnior, Jair Carneiro Leão, Rodivan Braz da Silva, Gerhilde Callou Sampaio

Abstract

Reestablishing blood flow and allowing the continuation of root development are some of the objectives of pulp revascularization. This procedure is currently indicated for teeth with incomplete root formation as an alternative to the traditional treatment of apecification, which consists of inserting calcium hydroxide paste into the root canal for a determined time period in order to induce the formation of a calcified barrier. Although it is considered as the most classically employed therapy, the permanence of the paste for long time periods may lead to the weakening of the root due to hygroscopic properties, as well as proteolytic activities of calcium hydroxide. Therefore, there has been a permanent search for alternatives which allow the full development of immature teeth. Revascularization has emerged as such an alternative, and a range of treatment protocols can be found in the scientific literature. The aim of this paper is to accomplish a literature review concerning this issue.

Keywords: Endodontics; blood vessels; calcium hydroxide; therapeutics.

References

    1. Friedlander L.T., Cullinan M.P., Love R.M. Dental stem cells and their potential role in apexogenesis and apexification. Int. Endod. J. 2009;42(11):955–962. doi: 10.1111/j.1365-2591.2009.01622.x.
    1. Rafter M. Apexification: a review. Dent. Traumatol. 2005;21(1):1–8. doi: 10.1111/j.1600-9657.2004.00284.x.
    1. Moleri A.B., Moreira L.C., Rabello D.A. Complexo dentino-pulpar. In: Lopes H.P., editor. Siqueira Júnior, JF. Endodontia: biologia e técnica. 3rd ed. Rio de Janeiro: Ed. Santos; 2011. pp. 1–19.
    1. Nosrat A., Seifi A., Asgary S. Regenerative endodontic treatment (revascularization) for necrotic immature permanent molars: a review and report of two cases with a new biomaterial. J. Endod. 2011;37(4):562–567. doi: 10.1016/j.joen.2011.01.011.
    1. Okiji T. Pulp as a connective tissue. In: Hargreaves K.M., Goodis E.G., Tay F.R., editors. Seltzer and Bender’s Dental Pulp. 2nd ed. Quintessence Publishing; 2012. pp. 67–90.
    1. Ostby B.N. The role of the blood clot in endodontic therapy. An experimental histologic study. Acta Odontol. Scand. 1961;19:324–353. doi: 10.3109/00016356109043395.
    1. Nygaard-Ostby B., Hjortdal O. Tissue formation in the root canal following pulp removal. Scand. J. Dent. Res. 1971;79(5):333–349.
    1. Rule D.C., Winter G.B. Root growth and apical repair subsequent to pulpal necrosis in children. Br. Dent. J. 1966;120(12):586–590.
    1. Nevins A.J., Finkelstein F., Borden B.G., Laporta R. Revitalization of pulpless open apex teeth in rhesus monkeys, using collagen-calcium phosphate gel. J. Endod. 1976;2(6):159–165. doi: 10.1016/S0099-2399(76)80058-1.
    1. Nevins A., Wrobel W., Valachovic R., Finkelstein F. Hard tissue induction into pulpless open-apex teeth using collagen-calcium phosphate gel. J. Endod. 1977;3(11):431–433. doi: 10.1016/S0099-2399(77)80115-5.
    1. Murray P.E., Garcia-Godoy F., Hargreaves K.M. Regenerative endodontics: a review of current status and a call for action. J. Endod. 2007;33(4):377–390. doi: 10.1016/j.joen.2006.09.013.
    1. Silva L. Stem Cells in the Oral Cavity. Glob J Stem Cell Biol Transplant. 2015;1(1):12–16.
    1. Friedlander L.T., Cullinan M.P., Love R.M. Dental stem cells and their potential role in apexogenesis and apexification. Int. Endod. J. 2009;42(11):955–962. doi: 10.1111/j.1365-2591.2009.01622.x.
    1. Trope M. Regenerative potential of dental pulp. J. Endod. 2008;34(7) Suppl.:S13–S17. doi: 10.1016/j.joen.2008.04.001.
    1. Kvinnsland S.R., Bårdsen A., Fristad I. Apexogenesis after initial root canal treatment of an immature maxillary incisor - a case report. Int. Endod. J. 2010;43(1):76–83. doi: 10.1111/j.1365-2591.2009.01645.x.
    1. About I, Bottero MJ, de Danato P, Camps J, Franquin JC, Mitsiadis TA. Human dentin production in vitro. Exp Cel Res. 2000;10; 258(1):33–41.
    1. Couble M.L., Farges J.C., Bleicher F., Perrat-Mabillon B., Boudeulle M., Magloire H. Odontoblast differentiation of human dental pulp cells in explant cultures. Calcif. Tissue Int. 2000;66(2):129–138. doi: 10.1007/PL00005833.
    1. Shimizu E., Jong G., Partridge N., Rosenberg P.A., Lin L.M. Histologic observation of a human immature permanent tooth with irreversible pulpitis after revascularization/regeneration procedure. J. Endod. 2012;38(9):1293–1297. doi: 10.1016/j.joen.2012.06.017.
    1. Pramila R., Muthu M. Regeneration potential of pulp-dentin complex: Systematic review. J. Conserv. Dent. 2012;15(2):97–103. doi: 10.4103/0972-0707.94571.
    1. Aggarwal V., Miglani S., Singla M. Conventional apexification and revascularization induced maturogenesis of two non-vital, immature teeth in same patient: 24 months follow up of a case. J. Conserv. Dent. 2012;15(1):68–72. doi: 10.4103/0972-0707.92610.
    1. Lenzi R., Trope M. Revitalization procedures in two traumatized incisors with different biological outcomes. J. Endod. 2012;38(3):411–414. doi: 10.1016/j.joen.2011.12.003.
    1. Kim D.S., Park H.J., Yeom J.H., Seo J.S., Ryu G.J., Park K.H., Shin S.I., Kim S.Y. Long-term follow-ups of revascularized immature necrotic teeth: three case reports. Int. J. Oral Sci. 2012;4(2):109–113. doi: 10.1038/ijos.2012.23.
    1. Yang J., Zhao Y., Qin M., Ge L. Pulp revascularization of immature dens invaginatus with periapical periodontitis. J. Endod. 2013;39(2):288–292. doi: 10.1016/j.joen.2012.10.017.
    1. Forghani M., Parisay I., Maghsoudlou A. Apexogenesis and revascularization treatment procedures for two traumatized immature permanent maxillary incisors: a case report. Restor. Dent. Endod. 2013;38(3):178–181. doi: 10.5395/rde.2013.38.3.178.
    1. Jadhav G.R., Shah N., Logani A. Comparative outcome of revascularization in bilateral, non-vital, immature maxillary anterior teeth supplemented with or without platelet rich plasma: A case series. J. Conserv. Dent. 2013;16(6):568–572. doi: 10.4103/0972-0707.120932.
    1. Diogenes A., Ruparel N.B., Shiloah Y., Hargreaves K.M. Regenerative endodontics: A way forward. J. Am. Dent. Assoc. 2016;147(5):372–380. doi: 10.1016/j.adaj.2016.01.009.
    1. Cosme-Silva l. Nicoli NVV. Regenerative Endodontics: advances in endodontic therapy. FOL • Faculdade de Odontologia de Lins/Unimep. 2015;25(2):74–5.
    1. Lieberman J., Trowbridge H. Apical closure of nonvital permanent incisor teeth where no treatment was performed: case report. J. Endod. 1983;9(6):257–260. doi: 10.1016/S0099-2399(86)80025-5.
    1. Nevins A., Wrobel W., Valachovic R., Finkelstein F. Hard tissue induction into pulpless open-apex teeth using collagen-calcium phosphate gel. J. Endod. 1977;3(11):431–433. doi: 10.1016/S0099-2399(77)80115-5.
    1. Banchs F., Trope M. Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol? J. Endod. 2004;30(4):196–200. doi: 10.1097/00004770-200404000-00003.
    1. Heithersay G.S. Stimulation of root formation in incompletely developed pulpless teeth. Oral Surg. Oral Med. Oral Pathol. 1970;29(4):620–630. doi: 10.1016/0030-4220(70)90474-3.
    1. Saad A.Y. Calcium hydroxide and apexogenesis. Oral Surg. Oral Med. Oral Pathol. 1988;66(4):499–501. doi: 10.1016/0030-4220(88)90277-0.
    1. Kamal R., Dahiya P. Comparative analysis of mast cell count in normal oral mucosa and oral pyogenic granuloma. J. Clin. Exp. Dent. 2011;3(1):e1–e4. doi: 10.4317/jced.3.e1.
    1. Silva L. A literature review of inflammation and its relationship with the oral cavity. Glob J Infect Dis Clin Res. 2015;1(2):21–27.
    1. Krebsbach P.H., Kuznetsov S.A., Satomura K., Emmons R.V., Rowe D.W., Robey P.G. Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation. 1997;63(8):1059–1069. doi: 10.1097/00007890-199704270-00003.
    1. Gronthos S., Mankani M., Brahim J., Robey P.G., Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc. Natl. Acad. Sci. USA. 2000;97(25):13625–13630. doi: 10.1073/pnas.240309797.
    1. Silva L. Stem cells in the oral cavity. Glob J Stem Cell Biol Transplant. 2015;1(1):12–16.

Source: PubMed

3
Se inscrever