Effect and placental transfer of dexmedetomidine during caesarean section under epidural anaesthesia

Changsheng Wang, Shijiang Liu, Chuanbao Han, Min Yu, Youli Hu, Cunming Liu, Changsheng Wang, Shijiang Liu, Chuanbao Han, Min Yu, Youli Hu, Cunming Liu

Abstract

Objective To investigate the neonatal effect and placental transfer of dexmedetomidine during caesarean section under epidural anaesthesia. Methods Forty parturients with a single newborn who were scheduled for caesarean section were enrolled. Patients received 0.5 µg/kg dexmedetomidine 10 min after epidural anaesthesia, followed by 0.5 µg/kg/h until abdominal closure (Dex group) or infusion of normal saline (NS group). Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were monitored before infusion (T0), 10 min after infusion (T1), at delivery (T2), and at the end of the operation (T3). Umbilical vein and artery blood was collected. Apgar scores were evaluated at 1 and 5 min after delivery. Results SBP, DBP, and HR in the Dex group were decreased at T3 compared with T0 (116 ± 10.4 vs 111 ± 9.2 mmHg, 74 ± 6.7 vs 66 ± 7.9 mmHg, 91 ± 12.1 vs 71 ± 8.4 beats/min, respectively, P < 0.05). HR was lower at T1, T2, and T3 in the Dex group compared with the NS group ( P < 0.05). There were no significant differences in blood gases and Apgar scores between the groups ( P > 0.05). Conclusion Dexmedetomidine during caesarean section under epidural anaesthesia is beneficial to parturients. The placental transfer rate is 0.68.

Keywords: Dexmedetomidine; caesarean section; epidural anaesthesia; neonate; placenta.

Figures

Figure 1.
Figure 1.
Comparison of hemodynamic changes at each time point between the two groups T0: before anaesthesia; T1: 10 min after infusion; T2: at delivery of the neonate; T3: at the end of the operation. aP < 0.05 compared with T0, bP < 0.05 compared with the NS group.
Figure 2.
Figure 2.
Comparison of the Ramsay sedative score between the two groups (x¯ ± s) T0: before anaesthesia; T1: at skin incision; T2: 10 min after delivery. aP < 0.05 compared with the NS group.

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